Effects of sodium lactate infusion on cisternal lactate and carbon dioxide levels

1993 ◽  
Vol 150 (10) ◽  
pp. 1568a-1568
2021 ◽  
Author(s):  
Umit Tural ◽  
Dan V. Iosifescu

Abstract Background Sodium lactate (NaL) infusion and carbon dioxide (CO2) inhalation are proven to provoke acute panic attacks (PAs) in patients with panic disorder (PD). A systematic literature search and meta-analysis were performed to compare the effect sizes of these methods. Methods Odds ratios were calculated for each of the original studies and were pooled using the random-effects model. Results Either NaL or CO2 provocations significantly increased the rates of PAs in individuals with PD compared to those in healthy controls. However, the effect size of NaL infusion (OR=25.13, 95% CI=15.48–40.80) was significantly greater than that of CO2 inhalation (OR=10.58, 95%CI=7.88–14.21). Conclusion The evidence for the efficacy of the two panic provocation tests is very strong. Yet, the results support the superiority of NaL infusion over CO2 inhalation challenge as a panic provocation test. Thus, lactate seems a much stronger stimulus than CO2 for the brain suffocation detector.


Author(s):  
Sie Kei Wong ◽  
M. Chim ◽  
J. Allen ◽  
A. Butler ◽  
J. Tyrrell ◽  
...  

Abstract There is no consensus on the optimal pCO2 levels in the newborn. We reviewed the effects of hypercapnia and hypocapnia and existing carbon dioxide thresholds in neonates. A systematic review was conducted in accordance with the PRISMA statement and MOOSE guidelines. Two hundred and ninety-nine studies were screened and 37 studies included. Covidence online software was employed to streamline relevant articles. Hypocapnia was associated with predominantly neurological side effects while hypercapnia was linked with neurological, respiratory and gastrointestinal outcomes and Retinpathy of prematurity (ROP). Permissive hypercapnia did not decrease periventricular leukomalacia (PVL), ROP, hydrocephalus or air leaks. As safe pCO2 ranges were not explicitly concluded in the studies chosen, it was indirectly extrapolated with reference to pCO2 levels that were found to increase the risk of neonatal disease. Although PaCO2 ranges were reported from 2.6 to 8.7 kPa (19.5–64.3 mmHg) in both term and preterm infants, there are little data on the safety of these ranges. For permissive hypercapnia, parameters described for bronchopulmonary dysplasia (BPD; PaCO2 6.0–7.3 kPa: 45.0–54.8 mmHg) and congenital diaphragmatic hernia (CDH; PaCO2 ≤ 8.7 kPa: ≤65.3 mmHg) were identified. Contradictory findings on the effectiveness of permissive hypercapnia highlight the need for further data on appropriate CO2 parameters and correlation with outcomes. Impact There is no consensus on the optimal pCO2 levels in the newborn. There is no consensus on the effectiveness of permissive hypercapnia in neonates. A safe range of pCO2 of 5–7 kPa was inferred following systematic review.


2021 ◽  
Vol 2 (1) ◽  
Author(s):  
Philipp de Vrese ◽  
Tobias Stacke ◽  
Jeremy Caves Rugenstein ◽  
Jason Goodman ◽  
Victor Brovkin

AbstractSimple and complex climate models suggest a hard snowball – a completely ice-covered planet – is one of the steady-states of Earth’s climate. However, a seemingly insurmountable challenge to the hard-snowball hypothesis lies in the difficulty in explaining how the planet could have exited the glaciated state within a realistic range of atmospheric carbon dioxide concentrations. Here, we use simulations with the Earth system model MPI-ESM to demonstrate that terminal deglaciation could have been triggered by high dust deposition fluxes. In these simulations, deglaciation is not initiated in the tropics, where a strong hydrological cycle constantly regenerates fresh snow at the surface, which limits the dust accumulation and snow aging, resulting in a high surface albedo. Instead, comparatively low precipitation rates in the mid-latitudes in combination with high maximum temperatures facilitate lower albedos and snow dynamics that – for extreme dust fluxes – trigger deglaciation even at present-day carbon dioxide levels.


Author(s):  
Dui Ma ◽  
Ting Jin ◽  
Keyu Xie ◽  
Haitao Huang

Converting CO2 into value-added fuels or chemical feedstocks through electrochemical reduction is one of the several promising avenues to reduce atmospheric carbon dioxide levels and alleviate global warming. This approach...


1979 ◽  
Vol 19 (96) ◽  
pp. 102 ◽  
Author(s):  
HJ Banks ◽  
AK Sharp

The use of carbon dioxide, added as dry ice, was demonstrated as a means of disinfestation of bagged wheat and rye enclosed in a PVC membrane. The bag stack was dosed with dry ice giving an atmosphere of about 60% CO2. Carbon dioxide levels were maintained over 22 days with additional charges of dry ice added directly on top of the stack or enclosed within a polystyrene box to regulate the CO2 release rate. A natural infestation of Rhyzopertha dominica with small numbers of other stored product pest species was controlled, with complete mortality of adult insects, but slight survival of some early stages of R. dominica. Some of the hymenopterous parasitoids, Anisopteromalus calandrae and Choetospila elegans, survived the treatment, apparently as pupae. The treatment was successful under conditions where many other methods of pest control were inapplicable because of difficulty or expense of application, as in a small bulk (2.8 tonnes), at low temperature (11-13�C), when the commodity is close to working areas and when there is a requirement for freedom from pesticide residues.


2021 ◽  
Vol 14 (8) ◽  
pp. e243596
Author(s):  
Mohammad Salman Siddiqi ◽  
Adil H Al Kindi ◽  
Ahmed Fahmy Mandisha ◽  
Rashid Al Sukaiti

Extracorporeal membrane oxygenation (ECMO) is helpful in providing ventilatory support when other conventional methods of ventilation fail. We report a case of successful management of advanced tracheal malignancy with impeding airway obstruction where veno-venous ECMO (VV-ECMO) was instituted prior to performing critical endotracheal procedure. After securing the VV-ECMO through right jugular vein and left femoral vein under local anaesthesia, the tracheal stent placement was conducted under flexible bronchoscope and fluoroscope control. Oxygenation and carbon dioxide levels were maintained by the ECMO. VV-ECMO is a useful adjunct in the management of subglottic difficult airway obstruction due to complex tracheal pathology where conventional ventilation may not be possible or adequate.


2009 ◽  
Vol 27 (05) ◽  
pp. 361-365 ◽  
Author(s):  
Montasser Nadeem ◽  
Deirdre Murray ◽  
Geraldine Boylan ◽  
Eugene Dempsey ◽  
C. Anthony Ryan

2006 ◽  
Vol 2006 ◽  
pp. 1-12
Author(s):  
A. Korobeinikov ◽  
P. Read ◽  
A. Parshotam ◽  
J. Lermit

It has been suggested that the large scale use of biofuel, that is, fuel derived from biological materials, especially in combination with reforestation of large areas, can lead to a low-cost reduction of atmospheric carbon dioxide levels. In this paper, a model of three markets: fuel, wood products, and land are considered with the aim of evaluating the impact of large scale biofuel production and forestry on these markets, and to estimate the cost of a policy aimed at the reduction of carbon dioxide in the atmosphere. It is shown that the costs are lower than had been previously expected.


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