Predicting Gag, Discomfort, and Laryngeal Visualization in Patients Undergoing Flexible Laryngoscopy with Stroboscopy

2021 ◽  
pp. 000348942110114
Author(s):  
Patrick Kiessling ◽  
Semirra Bayan ◽  
Christine Lohse ◽  
Diana Orbelo

Objective: To investigate potential associations between the Predictive Gagging Survey (PGS) with patient experience of gag and discomfort as well as provider perception of patient gag and level of laryngeal visualization during flexible laryngoscopy with stroboscopy (FL-S). Methods: A total of 53 adult patients undergoing FL-S were recruited for this prospective non-controlled study. PGS was completed before FL-S. Patients rated perceived level of gag and discomfort on a 10-point severity scale after FL-S. Additionally, providers completed a Gagging Severity Index (GSI) reflecting their impression of patient gag and level of laryngeal visualization following FL-S. Spearman rank correlation coefficients were used to assess associations. Results: There was a positive association with PGS score and patient perception of gagging (0.34; P = .013) and patient perception of discomfort (0.38; P = .005). No significant association was found between PGS score and provider GSI (−0.12; P = .39) or level of laryngeal visualization (0.15; P = .29). A negative association was found between level of laryngeal visualization and patient perception of gagging (−0.34; P = .012) and discomfort (−0.44; P = .001). No significant differences were found between current and former smokers compared to never smokers for GSI or patient-perceived gag or discomfort. Conclusions: While not predictive of GSI or level of laryngeal visualization, the PGS was found to be a useful tool in predicting patient experience of gagging and discomfort during FL-S, further reinforcing the subjective experience of this procedure. Use of the PGS may be helpful in identifying specific candidates who may struggle with subjective discomfort or gagging during FL-S for future studies considering interventions to manage and meaningfully decrease discomfort. Having such an instrument is important given the low number of individuals who struggle with discomfort during the exam.

PeerJ ◽  
2020 ◽  
Vol 8 ◽  
pp. e10112 ◽  
Author(s):  
Christian Wehenkel

Background The coronavirus disease 2019 (COVID-19) pandemic, caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), is an ongoing global health crisis, directly and indirectly impacting all spheres of human life. Some pharmacological measures have been proposed to prevent COVID-19 or reduce its severity, such as vaccinations. Previous reports indicate that influenza vaccination appears to be negatively correlated with COVID-19-associated mortality, perhaps as a result of heterologous immunity or changes in innate immunity. The understanding of such trends in correlations could prevent deaths from COVID-19 in the future. The aim of this study was therefore to analyze the association between COVID-19 related deaths and influenza vaccination rate (IVR) in elderly people worldwide. Methods To determine the association between COVID-19 deaths and influenza vaccination, available data sets from countries with more than 0.5 million inhabitants were analyzed (in total 39 countries). To accurately estimate the influence of IVR on COVID-19 deaths and mitigate effects of confounding variables, a sophisticated ranking of the importance of different variables was performed, including as predictor variables IVR and some potentially important geographical and socioeconomic variables as well as variables related to non-pharmaceutical intervention. The associations were measured by non-parametric Spearman rank correlation coefficients and random forest functions. Results The results showed a positive association between COVID-19 deaths and IVR of people ≥65 years-old. There is a significant increase in COVID-19 deaths from eastern to western regions in the world. Further exploration is needed to explain these findings, and additional work on this line of research may lead to prevention of deaths associated with COVID-19.


2016 ◽  
Vol 27 (2) ◽  
pp. 1-8
Author(s):  
A. Iqbal ◽  
L. Rahman ◽  
M. H. Kabir

The present research works were conducted to find out the variation in morphological traits and their relationship in Brassica materials at C7 (Colchiploid) alloplasmic populations and F5 generations with respect to their parents. Among the 19 Brassica progeny lines representing the cross products (Brassica napojuncea) of C7 generation of Brassica napus and Brassica juncea (BINA sharisha 5 x Daulot: colchiploid-C7) and F5 generations with their parents, inter-species EG2 (Brassica napus x Brassica juncea) and EG1 (Brassica napus x Brassica juncea) showed better agronomic performance. Phenotypic characters of the genotypes were closely associated with each other for both normal correlation coefficients and Spearman’s rank correlation coefficients. The total relative ranking ranged from 1 to 20 and the first rank was estimated for the genotype EG2 genotypes. The last rank was estimated for the genotype ED1 (Brassica napus x Brassica napus). Out of 55 associations, which found in the correlation study, 10 associations were found highly significant at the morphological level. Flower set per plant (self) showed highly significant positive association with total number of siliqua per plant (self) (r = 0.934**) but the significant negative association of the total number of siliqua per plant (self) with siliqua length was very strong (-0.489*). There was a genetic basis of association in most of the cases of pairs of relations. The Spearman’s rank correlation test was studied to compare the morphological characterization for distinguishing genotypes. In this present study, this test presented 12 relationships that showed 10 positive significant and two negative significant correlations. In normal correlation coefficients 10 significant associations were found but 12 associations in Spearman’s rank correlation. In these techniques, number of flower set per plant (self) had highly significant positive correlation with total number of siliqua per plant (rs = 0.817**). The days to 50 % flowering and number of seed per siliqua (self) had significant negative correlation with number of seed per siliqua (open) (rs = -0.546**) and number of flowers set per plant (open) (rs = -0.563*), respectively. Finally, the study suggested that some yield related traits such as flower set per plant, number of siliqua per plant, seed per siliqua and days to 50% flowering can be selected and used in breeding program for future increasing the grain yield of rapeseed.


Energies ◽  
2021 ◽  
Vol 14 (11) ◽  
pp. 3119
Author(s):  
Yinjiao Su ◽  
Xuan Liu ◽  
Yang Teng ◽  
Kai Zhang

Mercury (Hg) is a toxic trace element emitted from coal conversion and utilization. Samples with different coal ranks and gangue from Ningwu Coalfield are selected and investigated in this study. For understanding dependence of mercury distribution characteristics on coalification degree, Pearson regression analysis coupled with Spearman rank correlation is employed to explore the relationship between mercury and sulfur, mercury and ash in coal, and sequential chemical extraction method is adopted to recognize the Hg speciation in the samples of coal and gangue. The measured results show that Hg is positively related to total sulfur content in coal and the affinity of Hg to different sulfur forms varies with the coalification degree. Organic sulfur has the biggest impact on Hg in peat, which becomes weak with increasing the coalification degree from lignite to bituminous coal. Sulfate sulfur is only related to Hg in peat or lignite as little content in coal. However, the Pearson linear correlation coefficients of Hg and pyritic sulfur are relatively high with 0.479 for lignite, 0.709 for sub-bituminous coal and 0.887 for bituminous coal. Hg is also related to ash content in coal, whose Pearson linear correlation coefficients are 0.504, 0.774 and 0.827 respectively, in lignite, sub-bituminous coal and bituminous coal. Furthermore, Hg distribution is directly depended on own speciation in coal. The total proportion of F2 + F3 + F4 is increased from 41.5% in peat to 87.4% in bituminous coal, but the average proportion of F5 is decreased from 56.8% in peat to 12.4% in bituminous coal. The above findings imply that both Hg and sulfur enrich in coal largely due to the migration from organic state to inorganic state with the increase of coalification degree in Ningwu Coalfield.


2021 ◽  
pp. tobaccocontrol-2021-056528
Author(s):  
Thomas Martinelli ◽  
Math J J M Candel ◽  
Hein de Vries ◽  
Reinskje Talhout ◽  
Vera Knapen ◽  
...  

BackgroundStudies demonstrated that adolescent e-cigarette use is associated with subsequent tobacco smoking, commonly referred to as the gateway effect. However, most studies only investigated gateways from e-cigarettes to tobacco smoking. This study replicates a cornerstone study revealing a positive association between both adolescent e-cigarette use and subsequent tobacco use; and tobacco and subsequent e-cigarette use in the Netherlands and Flanders.DesignThe longitudinal design included baseline (n=2839) and 6-month (n=1276) and 12-month (n=1025) follow-up surveys among a school-based cohort (mean age: 13.62). Ten high schools were recruited as a convenience sample. The analyses involved (1) associations of baseline e-cigarette use and subsequent tobacco smoking among never smokers; (2) associations of e-cigarette use frequency at baseline and tobacco smoking frequency at follow-up; and (3) the association of baseline tobacco smoking and subsequent e-cigarette use among non-users of e-cigarettes.FindingsConsistent with prior findings, baseline e-cigarette use was associated with higher odds of tobacco smoking at 6-month (OR=1.89; 95% CI 1.05 to 3.37) and 12-month (OR=5.63; 95% CI 3.04 to 10.42) follow-ups. More frequent use of e-cigarettes at baseline was associated with more frequent smoking at follow-ups. Baseline tobacco smoking was associated with subsequent e-cigarette use (OR=3.10; 95% CI 1.58 to 6.06 at both follow-ups).ConclusionOur study replicated the positive relation between e-cigarette use and tobacco smoking in both directions for adolescents. This may mean that the gateway works in two directions, that e-cigarette and tobacco use share common risk factors, or that both mechanisms apply.


2001 ◽  
Vol 4 (5) ◽  
pp. 961-970 ◽  
Author(s):  
Heidi J Wengreen ◽  
Ronald G Munger ◽  
Siew Sun Wong ◽  
Nancy A West ◽  
Richard Cutler

AbstractObjective:To evaluate the 137-item Utah Picture-sort Food-frequency Questionnaire (FFQ) in the measurement of usual dietary intake in older adults.Design:The picture-sort FFQ was administered at baseline and again one year later. Three seasonal 24-hour dietary recall interviews were collected during the year between the two FFQs. Mean nutrient intakes were compared between methods and between administrations of the FFQ.Setting:The FFQ interviews were administered in respondents' homes or care-centres. The 24-hour diet recalls were conducted by telephone interview on random days of the week.Subjects:Two-hundred-and-eight men and women aged 55–84 years were recruited by random sample of controls from a case–control study of nutrition and bone health in Utah.Results:After adjustment for total energy intake, median Spearman rank correlation coefficients between the two picture-sort FFQs were 0.69 for men aged ≤69 years, 0.66 for men aged >69 years; and 0.68 for women aged ≤69 years, 0.67 for women aged >69 years. Median correlation coefficients between methods were 0.50 for men ≤69 years old, 0.52 for men >69 years old; 0.55 for women ≤69 years old, 0.46 for women >69 years old.Conclusions:We report intake correlations between methods and administrations comparable to those reported in the literature for traditional paper-and-pencil FFQs and one other picture-sort method of FFQ. This dietary assessment method may improve ease and accuracy of response in this and other populations with low literacy levels, poor memory skill, impaired hearing, or poor vision.


2012 ◽  
Vol 37 (1) ◽  
pp. 65-69 ◽  
Author(s):  
Prasath Jayakaran ◽  
Gillian M Johnson ◽  
S John Sullivan

Background and Aim: The physical asymmetries associated with a prosthesis raises the question of validity of the Sensory Organization Test (SOT) measures (equilibrium score (ES) and strategy score (SS)) in lower limb amputees. This study explores the validity of these measures in transtibial amputees by correlating with their corresponding centre of pressure (COP) excursion/velocity measures. Technique: Fifteen transtibial amputees (69.5 ± 6.5 years) completed three trials for each of the six SOT conditions. Discussion: The Spearman’s rank correlation coefficients between ESs and global COP excursion/velocity measures ranged from 0.52 to 0.71 for Conditions 1, 4 and 5, 0.79 to 0.85 for Conditions 2 and 3, and 0.39 to 0.43 for Condition 6. The coefficients for SSs ranged between 0.78 and 0.97 for Conditions 1 to 5 and 0.55 to 0.67 for Condition 6. The corresponding sound and prosthetic side COP variables demonstrated varying strengths of association with ES and SS. Clinical relevance Of the two clinical measures examined, the SSs are strongly reflective of COP excursion/velocity measures and these findings have application in the interpretation of SOT when evaluating balance in transtibial amputees.


2020 ◽  
pp. 1-4
Author(s):  
Shubhi Agarwal ◽  
Usha Devi C

BACKGROUND Polycystic ovary syndrome (PCOS) is the most common endocrine disorder amongst women of reproductive age associated with various clinical and psychological manifestations. Promoting awareness and lifestyle modifications is essential to empower the female PCOS population to take health care decisions for the treatment and management. OBJECTIVE Assessment of knowledge, attitude and practice(KAP) among PCOS population is significant in behavioral and lifestyle modification. Thus, the present study was undertaken to develop a KAP tool. METHODS An observational, non-controlled study was conducted using random sampling in the age range of 15-25 years. A total of 600 subjects were screened with the help of a standardized screening questionnaire and the presence of PCOS was confirmed using the Rotterdam criteria (2003).A KAP tool validated by an expert panel was given to the subjects confirmed for PCOS to assess knowledge, attitude and practices. The validity was assessed using exploratory factor analysis. The Spearman-Brown correlation coefficients helped to assess reliability for knowledge, attitude and practice domains, which were found to be 0.83, 0.63 and 0.47 respectively. RESULTS Significant knowledge was found among confirmed PCOS subjects, but had low attitudes and their practices did not commensurate with their knowledge about PCOS and Nutrition. CONCLUSION The present research contributes to the understanding of a growing PCOS epidemic in urban India and document the need to screen knowledge, attitude and practice, to develop supportive interventions addressing quality of life issues to reduce the distress among women with PCOS.


2017 ◽  
Author(s):  
Ming Kei Chung ◽  
Kurunthachalam Kannan ◽  
Germaine M. Buck Louis ◽  
Chirag J. Patel

AbstractBACKGROUND:Along with time, variation in the exposome is dependent on the location and sex of study participants. One specific factor that may influence exposure co-variations is a shared household environment.OBJECTIVES:To examine the influence of shared household and partner’s sex in relation to the variation in 128 endocrine disrupting chemical (EDC) exposures among couples.METHODS:In a cohort comprising 501 couples trying for pregnancy, we measured 128 (13 chemical classes) persistent and non-persistent EDCs and estimated 1) sex-specific differences; 2) variance explained by shared household; and 3) Spearman’s rank correlation coefficients (rs) for females, males, and couples’ exposures.RESULTS:Sex was correlated with 8 EDCs including polyfluoroalkyl substances (PFASs) (p< 0.05). Shared household explained 43% and 41% of the total variance for PFASs and blood metals, respectively, but less than 20% for the remaining 11 EDC classes. Co-exposure patterns of the exposome were similar between females and males, with within-classrs higher for persistent and lower for non-persistent chemicals. Medianrss of polybrominated compounds and urine metalloids were 0.45 and 0.09, respectively, for females (0.41 and 0.08 for males), whereas lowerrss for these 2 classes were found for couples (0.21 and 0.04).CONCLUSIONS:Overall, sex did not significantly affect EDC levels in couples. Individual, rather than shared environment, could be a major factor influencing the co-variation of 128 markers of the exposome. Correlations between exposures are lower in couples than in individual partners and have important analytical and sampling implications for epidemiological study.


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