Neurology Update: “Recent Developments in the Understanding of the Nervous System”

1980 ◽  
Vol 47 (2) ◽  
pp. 61-66
Author(s):  
M. Jean Gillespie
Keyword(s):  
Nervous System ◽  
Motor Response ◽  
Neural Mechanisms ◽  
Membrane Properties ◽  
Excitable Cells ◽  
Sensory Inputs ◽  
New Methods ◽  
Nucleus Plus ◽  
Recent Developments ◽  
The Central Nervous System

Neural Mechanisms of Sensori-Motor Integration New methods of investigation have enlarged understanding of the mechanisms underlying activity in the nervous system. Excitable cells transmit impulses by means of their special membrane properties and excitation is transmitted from cell to cell across specialized sites called synapses. In the nuclei of the central nervous system there are many small neurons that have no axon or only very short axons and dendrites. These are referred to as interneurons and the chemical transmitters they release may be excitatory or inhibitory to the cells with which they synapse. Cells with axons ending in a nucleus and cells with dendrites in the nucleus plus the interneurons which may intervene between the input of the message by an axon reaching the nucleus and its transmission onwards, form networks of cells that act as micro-circuits, affecting the nature of the neural signal. Control of transmission by these networks is the means by which sensory and motor impulses may be modified, enhanced, suppressed or facilitated. The integration of many sensory inputs, and the feedback during movement modulate and shape the motor response. An understanding of the mechanisms of inhibition and facilitation becomes increasingly important for therapists who use techniques based on “sensori-motor integration“.

Mechanisms for generating temporal filters in the electrosensory system

1999 ◽  
Vol 202 (10) ◽  
pp. 1281-1289 ◽  
Author(s):  
G.J. Rose ◽  
E.S. Fortune
Keyword(s):  
Nervous System ◽  
Discharge Rate ◽  
Temporal Structure ◽  
Sensory Information ◽  
Gain Control ◽  
Membrane Properties ◽  
Control Mechanisms ◽  
Temporal Features ◽  
Level Of Activity ◽  
The Central Nervous System

Temporal patterns of sensory information are important cues in behaviors ranging from spatial analyses to communication. Neural representations of the temporal structure of sensory signals include fluctuations in the discharge rate of neurons over time (peripheral nervous system) and the differential level of activity in neurons tuned to particular temporal features (temporal filters in the central nervous system). This paper presents our current understanding of the mechanisms responsible for the transformations between these representations in electric fish of the genus Eigenmannia. The roles of passive and active membrane properties of neurons, and frequency-dependent gain-control mechanisms are discussed.

scholarly journals Recent Developments in Microfluidic Technologies for Central Nervous System Targeted Studies

Pharmaceutics ◽  
2020 ◽  
Vol 12 (6) ◽  
pp. 542
Author(s):  
Maria Inês Teixeira ◽  
Maria Helena Amaral ◽  
Paulo C. Costa ◽  
Carla M. Lopes ◽  
Dimitrios A. Lamprou
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
State Of The Art ◽  
Physicochemical Characteristics ◽  
Future Perspectives ◽  
Invaluable Tool ◽  
Recent Developments ◽  
The Central Nervous System ◽  
Cns Delivery ◽  
Reproducible Manner

Neurodegenerative diseases (NDs) bear a lot of weight in public health. By studying the properties of the blood-brain barrier (BBB) and its fundamental interactions with the central nervous system (CNS), it is possible to improve the understanding of the pathological mechanisms behind these disorders and create new and better strategies to improve bioavailability and therapeutic efficiency, such as nanocarriers. Microfluidics is an intersectional field with many applications. Microfluidic systems can be an invaluable tool to accurately simulate the BBB microenvironment, as well as develop, in a reproducible manner, drug delivery systems with well-defined physicochemical characteristics. This review provides an overview of the most recent advances on microfluidic devices for CNS-targeted studies. Firstly, the importance of the BBB will be addressed, and different experimental BBB models will be briefly discussed. Subsequently, microfluidic-integrated BBB models (BBB/brain-on-a-chip) are introduced and the state of the art reviewed, with special emphasis on their use to study NDs. Additionally, the microfluidic preparation of nanocarriers and other compounds for CNS delivery has been covered. The last section focuses on current challenges and future perspectives of microfluidic experimentation.

scholarly journals Reduced motoneuron excitability in a rat model of sepsis

2013 ◽  
Vol 109 (7) ◽  
pp. 1775-1781 ◽  
Author(s):  
Paul Nardelli ◽  
Jaffar Khan ◽  
Randall Powers ◽  
Tim C. Cope ◽  
Mark M. Rich
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Intensive Care ◽  
Motor Unit ◽  
Action Potentials ◽  
Cecal Ligation ◽  
Membrane Properties ◽  
Whole Body ◽  
Repetitive Firing ◽  
The Central Nervous System

Many critically ill patients in intensive care units suffer from an infection-induced whole body inflammatory state known as sepsis, which causes severe weakness in patients who survive. The mechanisms by which sepsis triggers intensive care unit-acquired weakness (ICUAW) remain unclear. Currently, research into ICUAW is focused on dysfunction of the peripheral nervous system. During electromyographic studies of patients with ICUAW, we noticed that recruitment was limited to few motor units, which fired at low rates. The reduction in motor unit rate modulation suggested that functional impairment within the central nervous system contributes to ICUAW. To understand better the mechanism underlying reduced firing motor unit firing rates, we moved to the rat cecal ligation and puncture model of sepsis. In isoflurane-anesthetized rats, we studied the response of spinal motoneurons to injected current to determine their capacity for initiating and firing action potentials repetitively. Properties of single action potentials and passive membrane properties of motoneurons from septic rats were normal, suggesting excitability was normal. However, motoneurons exhibited striking dysfunction during repetitive firing. The sustained firing that underlies normal motor unit activity and smooth force generation was slower, more erratic, and often intermittent in septic rats. Our data are the first to suggest that reduced excitability of neurons within the central nervous system may contribute to ICUAW.

scholarly journals Aging, the Central Nervous System, and Mobility in Older Adults: Neural Mechanisms of Mobility Impairment

2015 ◽  
Vol 70 (12) ◽  
pp. 1526-1532 ◽  
Author(s):  
Farzaneh A. Sorond ◽  
Yenisel Cruz-Almeida ◽  
David J. Clark ◽  
Anand Viswanathan ◽  
Clemens R. Scherzer ◽  
...  
Keyword(s):  
Older Adults ◽  
Central Nervous System ◽  
Nervous System ◽  
Neural Mechanisms ◽  
Mobility Impairment ◽  
The Central Nervous System

scholarly journals PSYCHOPHYSIOLOGICAL ADAPTATION POTENTIAL TO STUDYING AT THE PEDAGOGICAL UNIVERSITY IN RUSSIAN AND KAZAKH STUDENTS

2019 ◽  
Vol 12 (3) ◽  
pp. 72-82
Author(s):  
Victor Petrovich Maltsev ◽  
Zhanar Tuleutayevna Suyundikova
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Functional Status ◽  
Cognitive Performance ◽  
Motor Response ◽  
Female Students ◽  
First Year ◽  
Functional Abilities ◽  
First Year Students ◽  
The Central Nervous System

Aim. The Federal State Educational Standard of Higher Education prescribes providing the educational process in accordance with the individual and typological features of students. The nature of adaptation shifts in students depends on ethnic, ecological, and morphological indicators determining the functional status of the body. Its functional status and functional abilities conditioned by academic and professional activities are determined by the cerebral process, which influences the efficiency of adaptation and cognitive performance in general. The article deals with studying the features of psychophysiological potential in Russian and Kazakh first-year female students during their adaptation to studying at the pedagogical university. Materials and methods. We conducted the diagnostics of the functional status of the central nervous system and cognitive performance in first-year female students at pedagogical universities. The average age of participants was 17.9 years. The total sample (n = 120) consisted of the Russian and Kazakh students living in Kostanay (Kazakhstan) and Chelyabinsk (Russia). A simple eye motor response (SEMR) and a complex eye motor response (CEMR) to a light stimulus were measured with the NS-Psychotest equipment. The calculated data are the following: the functional status of the system; response stability; level of functional abilities. These data were used as a basis for the assessment of cognitive performance in the participants of the study. Results. The results obtained characterize the neuro-dynamic basis of first-year students’ adaptation expressed in the average level of CNS activity, mobility of nervous processes, and optimal functional abilities. In the conditions of the average intragroup expression of the functional criteria of the central nervous system better cognitive processes for the processing of sensory information were revealed in students from Chelyabinsk compared to Kostanay. Conclusion. The analysis of the data obtained revealed the regional specifics of the average values of chronoreflexometry in first-year students, namely a significantly higher level of neural interaction and sensorimotor processing in first-year students from Chelyabinsk.

scholarly journals THE NERVOUS SYSTEM DAMAGE IN COVID-19 PATIENTS

2020 ◽  
Author(s):  
Vladimir V. Belopasov ◽  
Ekaterina M. Samoilova ◽  
Vladimir P. Baklaushev
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
International Cooperation ◽  
Clinical Manifestations ◽  
Interdisciplinary Approach ◽  
Radiological Diagnosis ◽  
Diagnosis And Treatment ◽  
New Methods ◽  
The Central Nervous System ◽  
Course Outcomes

Based on the available publications, the article systematizes the forms of damage to the central nervous system in СOVID-19patients. Along with a description of clinical manifestations, pathogenesis, methods of laboratory, instrumental and radiological diagnosis with the discussion of the nosological forms. An interdisciplinary approach and international cooperation are required to study the problems pathogenesis, course, outcomes, and the development of new methods of diagnosis and treatment.

Disorders of hearing and balance

1998 ◽  
Vol 8 (1) ◽  
pp. 31-43
Author(s):  
Linda M Luxon
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Hearing Loss ◽  
Great Britain ◽  
Hearing Impairment ◽  
Elderly Population ◽  
The Elderly ◽  
Sensory Inputs ◽  
The Central Nervous System ◽  
Eighth Decade

The cochleovestibular system is unique in that the peripheral labyrinth subserves two senses, hearing and balance, while the central auditory and vestibular connections diverge within the central nervous system and interact with a multiplicity of information from other sensory inputs. During the seventh decade of life, approximately 40% of people in Great Britain have a significant hearing impairment while in the eighth decade of life this figure rises to 60%. By the age of 65, 35% of people have experienced episodes of dizziness and by the age of 80, two-thirds of women and one-third of men have suffered episodes of vertigo. The elderly population is reported to be increasing by approximately 30% every 20 years and the prevalence of vertigo and hearing loss has been reported to rise in parallel with advancing age.

Kynurenines in the Central Nervous System: Recent Developments

2007 ◽  
Vol 7 (1) ◽  
pp. 45-56 ◽  
Author(s):  
Hajnalka Nemeth ◽  
Hermina Robotka ◽  
Jozsef Toldi ◽  
Laszlo Vecsei
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Recent Developments ◽  
The Central Nervous System

scholarly journals Nanotechnology in Neurology—Current Status and Future Possibilities

US Neurology ◽  
2010 ◽  
Vol 06 (01) ◽  
pp. 12 ◽  
Author(s):  
James M Provenzale ◽  
Aaron M Mohs ◽  
◽  
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Ex Vivo ◽  
Current Status ◽  
Medical Applications ◽  
Nanoparticle Delivery ◽  
New Methods ◽  
The Central Nervous System ◽  
Neuro Protection

The field of nanomedicine is rapidly emerging and will provide many novel methods for diagnosis and treatment. In this article the applications of nanotechnology to the central nervous system (CNS) will be described. Nanotechnology provides many potential solutions to various problems encountered in CNS diseases. Specifically, nanomedicine offers the possibility of new methods of drug delivery, more sensitive and specific means for diagnosis of disease at earlier stages and assessment of treatment response, and also potential techniques for neuro-protection and neuro-engineering. In this article, information is provided on the various types of nanoparticles involved in medical applications, the principles of nanoparticle delivery and targeting, and bothin vivoandex vivouses of nanoscale materials.

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