Serum cystatin C is closely associated with euthyroid Hashimoto’s thyroiditis in adult female Chinese patients

Objective The aim of our study was to explore the association between serum cystatin C (CysC) and euthyroid Hashimoto’s thyroiditis. Methods There were 119 female euthyroid Hashimoto’s thyroiditis patients and 225 healthy controls who were recruited. Serum CysC, thyroid function, thyroid autoantibodies, fasting glucose, liver enzymes, and lipid profile were determined. Clinical parameters were compared between two groups. Results Serum CysC levels were significantly higher in euthyroid Hashimoto’s thyroiditis patients compared with controls. In the lowest, middle, and highest tertile groups of CysC, the percentage of Hashimoto’s thyroiditis was 15.9%, 34.2%, and 53.5%, respectively. The percentage of Hashimoto’s thyroiditis was significantly higher in the highest tertile than in the lowest and middle tertiles. Spearman’s correlation analysis showed that serum CysC levels were negatively correlated with free triiodothyronine (FT3), and positively correlated with serum thyroid peroxidase antibody (TPOAb) and thyroglobulin antibody (TGAb). Logistic regression analysis showed that serum CysC was independently related to the status of euthyroid Hashimoto’s thyroiditis. Conclusions The present study shows the first evidence suggesting that serum CysC levels are positively correlated with TPOAb and TGAb. Serum CysC might underlie the pathophysiologic features of euthyroid Hashimoto’s thyroiditis.

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The Effect of Hypolipidemic Agents on Thyroid Autoimmunity in Women with Hashimoto’s Thyroiditis Treated with Levothyroxine and Selenomethionine

Experimental and Clinical Endocrinology & Diabetes ◽

10.1055/s-0043-120342 ◽

2017 ◽

Vol 126 (05) ◽

pp. 321-326 ◽

Cited By ~ 1

Author(s):

Robert Krysiak ◽

Witold Szkróbka ◽

Bogusław Okopień

Keyword(s):

Hashimoto’S Thyroiditis ◽

Plasma Lipids ◽

Thyroid Autoimmunity ◽

Hdl Cholesterol ◽

Hashimoto's Thyroiditis ◽

Thyroid Peroxidase ◽

Free Triiodothyronine ◽

Hypolipidemic Agents ◽

Antibody Titers ◽

Group B

Abstract Background Levothyroxine and selenomethionine were found to reduce thyroid antibody titers in patients with Hashimoto’s thyroiditis. The same effect was produced by intensive statin therapy. The aim of the present study was to assess whether hypolipidemic agents modulate the impact of thyroid hormone supplementation and selenomethionine on thyroid autoimmunity. Methods The study included 62 women with Hashimoto's thyroiditis treated for at least 6 months with levothyroxine and selenomethionine. On the basis of plasma lipids, women were divided into three groups: women with isolated hypercholesterolemia (group A; n=20), women with isolated hypertriglyceridemia (group B; n=17), and women with normal plasma lipids (group C; n=25). Group A were then treated with atorvastatin (20 mg daily), while group B received micronized fenofibrate (200 mg daily). Serum titers of thyroid peroxidase and thyroglobulin antibodies, as well as serum levels of thyrotropin, free thyroxine and free triiodothyronine were measured at the beginning of the study and 6 months later. Results Fenofibrate decreased triglycerides and increased HDL cholesterol, while simvastatin decreased total and LDL cholesterol. Fenofibrate reduced titers of thyroid peroxidase and, to a lesser extent, thyroglobulin antibodies. Atorvastatin tended to increase thyroid peroxidase antibodies. No changes in thyrotropin, free thyroxine and free triiodothyronine were observed in any treatment group. Fenofibrate-induced changes in thyroid antibody titers correlated with baseline antibody titers, as well as with treatment-induced changes in HDL cholesterol and insulin sensitivity. Conclusions The obtained results indicate that only fibrates may potentiate the effect of selenomethionine and levothyroxine on thyroid autoimmunity in women.

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Serum Cystatin C and the Risk of Coronary Heart Disease in Ethnic Chinese Patients With Normal Renal Function

Laboratory Medicine ◽

10.1093/labmed/lmv004 ◽

2016 ◽

Vol 47 (1) ◽

pp. 13-19 ◽

Cited By ~ 1

Author(s):

Rui Zhao ◽

Yan Li ◽

Wen Dai

Keyword(s):

Coronary Heart Disease ◽

Renal Function ◽

Heart Disease ◽

Cystatin C ◽

Normal Renal Function ◽

Chinese Patients ◽

Serum Cystatin C ◽

Serum Cystatin ◽

Ethnic Chinese

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Inverse Relationship Between Serum Cystatin C and Sudomotor Function Detected by SUDOSCAN in Chinese Patients With Type 2 Diabetes Mellitus

10.21203/rs.3.rs-128671/v1 ◽

2020 ◽

Author(s):

Qingyu Guo ◽

Bin Lu ◽

Liping Wang ◽

Zhanhong Guo ◽

Wenjing Song ◽

...

Keyword(s):

Diabetes Mellitus ◽

Type 2 Diabetes ◽

Type 2 Diabetes Mellitus ◽

Cystatin C ◽

Chinese Patients ◽

Diabetic Patients ◽

Serum Cystatin C ◽

Serum Cystatin ◽

Sudomotor Function

Abstract Background and aims:To explore the relationship between serum cystatin C and sudomotor function produced by the SUDOSCAN in subjects with type 2 diabetes mellitus.Methods:The research incorporated 917 Chinese individuals with type 2 diabetes mellitus from May 2017 to May 2019. All patients underwent SUDOSCAN and examined cystatin C. SUDOSCAN was evaluated with electrochemical skin conductance in hands (HESC) and feet (FESC), asymmetry ratio in hands (HASYM) and feet (FASYM). Average FESC <60 µS was defined as sudomotor dysfunction. 917 patients were classified into 791 diabetic patients without sudomotor dysfunction, and 126 diabetic patients complicated with sudomotor dysfunction. The difference of cystatin C between two groups was compared firstly, the difference of SUDOSCAN metrics among tertiles of serum cystatin C was also compared. The spearman and multiple linear regression analyses were applied to analyze the association between serum cystatin C and SUDOSCAN metrics. Results:The total prevalence of sudomotor dysfunction was 13.74%. Patients with sudomotor dysfunction had a higher level of cystatin C (P<0.001). With increasing tertiles of serum cystatin C, ESC declined, ASYM elevated, and the prevalence of sudomotor dysfunction increased (P<0.001).The spearman analysis performed an association between serum cystatin C and SUDOSCAN metrics including HESC (r=-0.143, P<0.001), FESC(r=-0.178, P<0.001), HASYM (r=0.169, P<0.001), FASYM (r=0.174, P<0.001). Multivariate regression linear analyses demonstrated cystatin C was independently linked with HESC (B=-14.657, P<0.001) and FESC (B=-10.015, P=0.022) levels after controlling for potential confounders. Conclusions:Serum cystatin C is inversely linked with sudomotor function detected by SUDOSCAN in Chinese patients with type 2 diabetes mellitus.

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Amelioration of iodine supply is notably associated with thyroid function in healthy subjects and in patients with euthyroid Hashimoto’s thyroiditis

Slovenian Medical Journal ◽

10.6016/zdravvestn.1750 ◽

2016 ◽

Vol 85 (10) ◽

Author(s):

Nadja Novak ◽

Ajda Biček ◽

Katja Zaletel ◽

Simona Gaberšček

Keyword(s):

Thyroid Function ◽

Hashimoto’S Thyroiditis ◽

Healthy Subjects ◽

Hashimoto's Thyroiditis ◽

Thyroid Peroxidase ◽

Free Triiodothyronine ◽

Tertiary Referral Centre ◽

Salt Iodization ◽

Iodine Supply ◽

First Time

Background: Our aim was to establish how healthy subjects (HS) and patients with euthyroid Hashimoto's thyroiditis (EuHT) faced the increase in mandatory salt iodization in Slovenia in 1999 from previous 10 mg of potassium iodide to 25 mg per kg since data about thyroid function with respect to iodine supply are scant.Methods: In this retrospective study we reviewed records of 24,899 patients referred for the first time between 1995 and 2002 to our tertiary referral centre with a stable catchment area for more than 20 years. HS were negative and patients with EuHT positive for thyroid peroxidase antibodies and/or thyroglobulin antibodies. Thyrotropin (TSH), free thyroxine (fT4), and free triiodothyronine (fT3) levels were obtained. The fT4/fT3 ratio was calculated.Results: In the period 1995-1998, 917 HS had significantly lower fT4/fT3 ratio than 644 HS in the period 1999-2002 (2.6±0.6 and 2.9±0.9, respectively, p<0.001) on account of significantly higher fT3 (median 5.7 and 5.2 pmol/L, p<0.001). Similarly, in 1995-1998, 482 patients with EuHT had a lower fT4/fT3 ratio than 846 EuHT in 1999-2002 (2.4±0.6 and 2.8±0.7, respectively, p<0.001) on account of significantly higher fT3 (median 5.8 and 4.9, respectively, p=0.018). HS had a higher fT4/fT3 ratio than patients with EuHT in 1995-1998 but not in 1999-2002 (p<0.001 and p=0.206, respectively).Conclusions: Amelioration of iodine supply is associated with an increase in the fT4/fT3 ratio on account of lower fT3, and with a similar thyroid function in HS and in patients with EuHT.

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Serum Resolvin E1 Levels and Its Relationship with Thyroid Autoimmunity in Hashimoto's Thyroiditis

10.21203/rs.3.rs-80993/v1 ◽

2020 ◽

Author(s):

Jing Song ◽

Rongxin Sun ◽

Yuanyuan Zhang ◽

Jing Ke ◽

Dong Zhao

Keyword(s):

Hashimoto’S Thyroiditis ◽

Protective Factor ◽

Thyroid Autoimmunity ◽

Thyroid Stimulating Hormone ◽

Hashimoto's Thyroiditis ◽

Thyroid Peroxidase ◽

Omega 3 ◽

Clinical Indicators ◽

Thyroglobulin Antibody ◽

Ordinal Logistic Regression Analysis

Abstract Objective: Omega-3 polyunsaturated fatty acids (PUFAs) can produce lipid mediators with both anti-inflammatory and pro-resolution properties, including resolvins. Resolvins have been associated with autoimmune disorders. This study aimed to measure the level of resolvin E1 (RVE1) in the serum of Hashimoto's thyroiditis (HT) patients and healthy controls (HCs) and to further analyze its correlation with thyroid autoantibodies and other clinical indicators.Design, patients and measurements: Fifty-seven participants were recruited—30 untreated HT patients and 27 sex‐ and age‐matched HCs. Levels of serum RVE1 were measured by ELISA according to the manufacturer’s protocol. Serum total T3 (TT3), TT4, free T3 (FT3), FT4, thyroglobulin antibody (TgAb), thyroid peroxidase antibody (TPOAb) and thyroid-stimulating hormone (TSH) levels were measured using an electrochemiluminescence immunoassay. Routine biochemical and hemogram tests were performed on each sample.Results: Serum RVE1 levels in HT patients (24.09, 15.76-34.38 pg/mL) were significantly lower than those in HCs (28.51, 20.76-51.23 pg/mL) (P=0.027). As the TgAb level increased, the RVE1 content showed a decreasing trend (P for trend=0.001). Multivariable ordinal logistic regression analysis showed that RVE1 was negatively correlated with increasing TgAb in both the unadjusted (OR=0.9446, 95% CI=0.9111-0.9782, P=0.002) and adjusted models (OR=0.9380, 95% CI=0.8967-0.9811, P=0.005).Conclusions: Decreased RVE1 levels indicate impaired resolution of inflammation in HT patients. RVE1 may be a protective factor for elevated TgAb levels.

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Improving Hashimoto’s thyroiditis by eradicating Blastocystis hominis: Relation to IL-17

Therapeutic Advances in Endocrinology and Metabolism ◽

10.1177/2042018820907013 ◽

2020 ◽

Vol 11 ◽

pp. 204201882090701

Author(s):

Hanaa Tarek El-Zawawy ◽

Huda Fahmy Farag ◽

Mona Mohamed Tolba ◽

Hanaa Abdalbasit Abdalsamea

Keyword(s):

Hashimoto’S Thyroiditis ◽

Autoimmune Disorder ◽

Thyroid Stimulating Hormone ◽

Hashimoto's Thyroiditis ◽

Thyroid Peroxidase ◽

Blastocystis Hominis ◽

Free Triiodothyronine ◽

Clinical Trial Registration ◽

Group I ◽

Group Ii

Background: Hashimoto’s thyroiditis (HT) is a common autoimmune disorder that causes significant morbidity. Interleukin (IL)-17 was identified as a major contributing factor in the pathogenesis of HT. Blastocystis hominis (BH) is a very common infection and has been shown to be associated with several diseases. Our aim was to determine serum IL-17 level in HT patients with and without BH infection and the effect of eradicating BH in patients with HT. Methods: A prospective cohort study was conducted on 20 HT patients not infected with BH (group I), 20 HT patients infected with BH (group II), and 20 healthy patients (group III). Serum free triiodothyronine (FT3), free thyroxine (FT4), thyroid stimulating hormone (TSH), thyroid peroxidase antibodies (anti-TPO), and IL-17 were performed by ELISA method and were repeated in group II after 6 weeks of eradication of BH. Results: Patients with HT showed a significantly higher serum IL-17 compared with controls. IL-17 was significantly higher in HT patients infected with BH compared with HT patients not BH infected (mean 6.93 ± 2.83 pg/ml versus 3.25 ± 1.55 pg/ml, p = 0.003). After BH eradication TSH, anti-TPO, and IL-17 were significantly decreased (mean 14.76 ± 11.11 µIU/ml versus 9.39 ± 7.11 µIU/ml, p < 0.001; mean 308 ± 175.6 IU/ml versus 295.4 ± 167.1 IU/ml, p = 0.006; and mean 6.93 ± 2.83 pg/ml versus 6.45 ± 2.48 pg/ml, p < 0.001), respectively. Multivariate analysis after treating BH infection showed that IL-17 was significantly negatively correlated with FT3 (adjusted p = 0.002) and significantly positively correlated with anti-TPO (adjusted p = 0.045). Conclusion: Treatment of BH infection ameliorates HT through reduction in IL-17, anti-TPO, and TSH. Clinical trial registration number: PACTR201909495111649

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Recovery of thyroid function with a decreased titre of antimicrosomal antibody in a hypothyroid man with Hashimoto's thyroiditis

Acta Endocrinologica ◽

10.1530/acta.0.1020531 ◽

1983 ◽

Vol 102 (4) ◽

pp. 531-534 ◽

Cited By ~ 9

Author(s):

Makiko Yamamoto ◽

Kazuro Kaise ◽

Hirofumi Kitaoka ◽

Katsumi Yoshida ◽

Nobuko Kaise ◽

...

Keyword(s):

Hashimoto’S Thyroiditis ◽

Serum Levels ◽

Hashimoto's Thyroiditis ◽

Thyroid Peroxidase ◽

Normal Range ◽

Surgical Biopsy ◽

Low Levels ◽

Serum Thyroid Hormones ◽

Antimicrosomal Antibody ◽

Serum Tsh

Abstract. A 36 year old man with a diffuse goitre, signs of mild hypothyroidism, strikingly low levels of T4 (0.9 μg/dl) and T3 (24 ng/dl), elevated TSH (140 μU/ml) and elevated microsomal haemagglutination antibody (MCHA, 1:409 600), subsequently became non-goitrous and euthyroid with a decreased titre of antimicrosomal antibody without any medication. At the time of surgical biopsy, serum levels of T4 and T3 had risen to the normal range (4.6 μg/dl and 73 ng/dl, respectively), serum TSH had decreased to 30 μU/ml and the titre of MCHA to 1:25 600. Thyroid specimens showed Hashimoto's thyroiditis. The activity of thyroid peroxidase (TPO) was normal. The latest examination, 1 year and 3 months after initial evaluation, showed that the patient remained euthyroid with no goitre, that serum thyroid hormones were within the normal range (T4 7.7 μg/dl and T3 97 ng/dl), and that TSH was not detectable. The titre of MCHA decreased strikingly to 1:400.

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