scholarly journals Comparison between febuxostat and allopurinol uric acid-lowering therapy in patients with chronic heart failure and hyperuricemia: a multicenter randomized controlled trial

2021 ◽  
Vol 49 (12) ◽  
pp. 030006052110627
Author(s):  
Satoshi Suzuki ◽  
Akiomi Yoshihisa ◽  
Tetsuro Yokokawa ◽  
Atsushi Kobayashi ◽  
Takayoshi Yamaki ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Heart Failure ◽  
Uric Acid ◽  
Medical Information ◽  
Controlled Trial ◽  
University Hospital ◽  
Oxidative Stress Marker ◽  
Xanthine Oxidase Inhibitor ◽  
Stress Marker ◽  
Multicenter Randomized Controlled Trial

Objective Heart failure (HF) is a common and highly morbid cardiovascular disorder. Oxidative stress worsens HF, and uric acid (UA) is a useful oxidative stress marker. The novel anti-hyperuricemic drug febuxostat is a potent non-purine selective xanthine oxidase inhibitor. The present study examined the UA-lowering and prognostic effects of febuxostat in patients with HF compared with conventional allopurinol. Methods This multicenter, randomized trial included 263 patients with chronic HF who were randomly assigned to two groups and received allopurinol or febuxostat (UA >7.0 mg/dL). All patients were followed up for 3 years after enrollment. Results There were no significant differences in baseline clinical characteristics between the two groups. The UA level was significantly decreased after 3 years of drug administration compared with the baseline in both groups. Urine levels of the oxidative stress marker 8-hydroxy-2′-deoxyguanosine were lower in the febuxostat group than in the allopurinol group (11.0 ± 9.6 vs. 22.9 ± 15.9 ng/mL), and the rate of patients free from hospitalization due to worsening HF tended to be higher in the febuxostat group than in the allopurinol group (89.0% vs. 83.0%). Conclusions Febuxostat is potentially more effective than allopurinol for treating patients with chronic HF and hyperuricemia. This study was registered in the University Hospital Medical Information Network Clinical Trials Registry ( https://www.umin.ac.jp/ctr/ ; ID: 000009817).

Trace elements as an oxidative stress marker in women with gestational diabetes and their neonates

2017 ◽  
Author(s):  
Georgios Boutzios ◽  
Eleni Koukoulioti ◽  
Ioannis Papoutsis ◽  
Sotirios Athanaselis ◽  
Gerasimos Tsourouflis ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Trace Elements ◽  
Gestational Diabetes ◽  
Oxidative Stress Marker ◽  
Stress Marker

scholarly journals Uric Acid, Oxidative Stress and Inflammation in Chronic Heart Failure with Reduced Ejection Fraction

2015 ◽  
Vol 23 (4) ◽  
pp. 397-406 ◽  
Author(s):  
Adriana Iliesiu ◽  
Alexandru Campeanu ◽  
Daciana Marta ◽  
Irina Parvu ◽  
Gabriela Gheorghe
Keyword(s):  
Oxidative Stress ◽  
Heart Failure ◽  
Uric Acid ◽  
Chronic Heart Failure ◽  
Ejection Fraction ◽  
Xanthine Oxidase ◽  
Left Ventricular ◽  
Paraoxonase 1 ◽  
Lv Function ◽  
The Relationship

Abstract Background. Oxidative stress (OS) and inflammation are major mechanisms involved in the progression of chronic heart failure (CHF). Serum uric acid (sUA) is related to CHF severity and could represent a marker of xanthine-oxidase activation. The relationship between sUA, oxidative stress (OS) and inflammation markers was assessed in patients with moderate-severe CHF and reduced left ventricular (LV) ejection fraction (EF). Methods. In 57 patients with stable CHF, functional NYHA class III, with EF<40%, the LV function was assessed by N-terminal of the prohormone brain natriuretic peptide (NT-proBNP) levels and echocardiographically through the EF and E/e’ ratio, a marker of LV filling pressures. The relationship between LV function, sUA, malondialdehyde (MDA), myeloperoxidase (MPO), paraoxonase 1 (PON-1) as OS markers and high sensitivity C-reactive protein (hsCRP) and interleukin 6 (IL-6) as markers of systemic inflammation was evaluated. Results. The mean sUA level was 7.9 ± 2.2 mg/dl, and 61% of the CHF patients had hyperuricemia. CHF patients with elevated LV filling pressures (E/e’ ≥ 13) had higher sUA (8.6 ± 2.3 vs. 7.3 ± 1.4, p=0.08) and NT-proBNP levels (643±430 vs. 2531±709, p=0.003) and lower EF (29.8 ± 3.9 % vs. 36.3 ± 4.4 %, p=0.001). There was a significant correlation between sUA and IL-6 (r = 0.56, p<0.001), MDA (r= 0.49, p= 0.001), MPO (r=0.34, p=0.001) and PON-1 levels (r= −0.39, p= 0.003). Conclusion. In CHF, hyperuricemia is associated with disease severity. High sUA levels in CHF with normal renal function may reflect increased xanthine-oxidase activity linked with chronic inflammatory response.

The association of plasma prorenin level with an oxidative stress marker, 8-OHdG, in nondiabetic hemodialysis patients

2011 ◽  
Vol 15 (3) ◽  
pp. 398-404 ◽  
Author(s):  
Yoshiyuki Morishita ◽  
Shiho Hanawa ◽  
Takuya Miki ◽  
Taro Sugase ◽  
Yasuhiro Sugaya ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Hemodialysis Patients ◽  
Oxidative Stress Marker ◽  
Stress Marker

scholarly journals Hepatoprotective Property of Phyllanthus amarus Alkaloid-Rich Fraction with Respect to Oxidative Stress Marker Enzymes

2021 ◽  
Vol 68 (2) ◽  
Author(s):  
Doraswamy Gangaraju ◽  
Shanmugam Bhasha ◽  
Ravi Sahukari ◽  
Shanmugam Kondeti Ramudu ◽  
Srinivas Kurakula ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Normal Control ◽  
Male Rats ◽  
Oxidative Stress Marker ◽  
Phyllanthus Amarus ◽  
Marker Enzymes ◽  
Isolation And Identification ◽  
Stress Marker ◽  
Antioxidant Defense Enzymes ◽  
Alkaloid Fraction

A disruption in the equilibrium between the generation of reactive oxygen species and antioxidant defense enzymes is referred to as oxidative stress. In the present study, we planned to identify the hepatoprotective effect of Phyllanthus amarus alkaloid rich fraction in wistar strain albino male rats. The hepatic damage was induced by the D-galactosamine and ameliorative effect was tested with alkaloid rich fraction of P. amarus by measuring oxidative stress markers such as G6PDH, LDH, SDH, MDH and GDH in the liver tissue. Activity levels of G6PDH, SDH, MDH and GDH were significantly decreased in D-galactosamine induced hepatitis rats when compare to normal control rat group, while their activities were significantly increased in hepatitis rat group that supplemented with alkaloid rich fraction of P. amarus. In contrast, LDH enzyme activity of liver was significantly increased in the hepatitis rat group when compare to normal control rats, while its activity was significantly decreased in hepatitis rats treated with alkaloid fraction. In conclusion, it is very clear that alkaloid fraction of P. amarus has hepatoprotective property with respect of decreasing oxidative stress by regulating oxidative stress marker enzymes. The isolation and identification of specific alkaloid compounds with hepatoprotective properties and anti-oxidative stress will require much further research.

scholarly journals Oxidative stress and outcome of antioxidant supplementation in patients with polycystic ovarian syndrome (PCOS)

2018 ◽  
Vol 7 (5) ◽  
pp. 1667 ◽  
Author(s):  
Abubakar A. Panti ◽  
Constance E. Shehu ◽  
Yusuf Saidu ◽  
Karima A. Tunau ◽  
Emmanuel I. Nwobodo ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Antioxidant Enzymes ◽  
Serum Levels ◽  
Clinical Pregnancy ◽  
Oxidative Stress Marker ◽  
Randomised Control Trial ◽  
Antioxidant Supplementation ◽  
Control Groups ◽  
Stress Marker ◽  
And Control

Background: PCOS is a condition with significant decrease in antioxidant with an increased risk of oxidative stress. Antioxidant supplementation has been shown to improve insulin sensitivity in PCOS and may improve outcome of management of PCOS. Objectives of this study were to determine the oxidative stress level of PCOS patients, to assess the effect of antioxidant supplementation on the outcome of management of PCOS and to compare with a control group.Methods: The study was a single blind randomised control trial involving 200 patients with PCOS. The study was conducted at Usmanu Danfodiyo University Teaching Hospital Sokoto. They were randomly divided into intervention and control groups and base line serum levels of oxidative stress marker, antioxidant enzymes, vitamins and minerals were determined. Antioxidant supplementation and placebo were given to the intervention and control groups respectively. All the patients had ovulation induction with clomiphene citrate and were followed up for 6 months. Outcome measures were clinical pregnancy or menstrual regularisation. Level of significance was <0.05.Results: There was statistical significance in the serum levels of oxidative stress marker, antioxidant enzymes, vitamins and minerals between the two groups (post intervention). Glutathione peroxidase (p = 0.001), superoxide dismutase (p = 0.0001), catalase (p= 0.0369), melondialdehyde (p= 0.007), Vitamin A, Vitamin C, Vitamin E (p = 0.0001), zinc and copper (p = 0.0001). The clinical pregnancy outcomes were 22 (22%) versus 2 (2%); live births 18 (18%) versus 2 (2%) and menstrual regularisation 48 (48%) versus 46 (46%) in the intervention and control groups respectively.Conclusions: Antioxidant supplementation in this study significantly affected pregnancy rate in patients with PCOS. Larger studies are suggested to revisit the conclusion of the Cochrane review that antioxidants supplementation had no significant role in female infertility.

Significance of the urinary 8-OHdG level as an oxidative stress marker in lung cancer patients

Lung Cancer ◽  
2009 ◽  
Vol 63 (1) ◽  
pp. 111-114 ◽  
Author(s):  
Tokujiro Yano ◽  
Fumihiro Shoji ◽  
Hiromitsu Baba ◽  
Tadashi Koga ◽  
Takeshi Shiraishi ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Lung Cancer ◽  
Cancer Patients ◽  
Oxidative Stress Marker ◽  
Lung Cancer Patients ◽  
Stress Marker
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