Biophysical properties of electrospun chitosan-grafted poly(lactic acid) nanofibrous scaffolds loaded with chondroitin sulfate and silver nanoparticles

The aim of this work was to study the biophysical properties of the chitosan-grafted poly(lactic acid) (CH-g-PLA) nanofibers loaded with silver nanoparticles (AgNPs) and chondroitin-4-sulfate (C4S). The electrospun CH-g-PLA:AgNP:C4S nanofibers were manufactured using the electrospinning technique. The microstructure of the CH-g-PLA:AgNP:C4S nanofibers was investigated by proton nuclear magnetic resonance (1H-NMR), scanning electron microscopy (SEM), UV-Visible spectroscopy (UV-Vis), X-ray diffraction (XRD), and Fourier transform infrared (ATR-FTIR) spectroscopy. ATR-FTIR and 1H-NMR confirm the CH grafting successfully by PLA with a substitution degree of 33.4%. The SEM measurement results indicated apparently smooth nanofibers having a diameter range of 340 ± 18 nm with porosity of 89 ± 3.08% and an average pore area of 0.27 μm2. UV-Vis and XRD suggest that silver nanoparticles with the size distribution of 30 nm were successfully incorporated into the electrospun nanofibers. The water contact angle of 12.8 ± 2.7° reveals the hydrophilic nature of the CH-g-PLA:AgNP:C4S nanofibers has been improved by C4S. The electrospun CH-g-PLA:AgNP:C4S nanofibers are found to release ions Ag+ at a concentration level capable of rendering an antimicrobial efficacy. Gram-positive bacteria ( S.aureus) were more sensitive to CH-g-PLA:AgNP:C4S than Gram-negative bacteria ( E. coli). The electrospun CH-g-PLA:AgNP:C4S nanofibers exhibited no cytotoxicity to the L-929 fibroblast cells, suggesting cytocompatibility. Fluorescence microscopy demonstrated that C4S promotes the adhesion and proliferation of fibroblast cells onto electrospun CH-g-PLA:AgNP:C4S nanofibers.

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Synthesis and Characterization of Polyphosphazenes Modified with Hydroxyethyl Methacrylate and Lactic Acid

International Journal of Polymer Science ◽

10.1155/2013/645869 ◽

2013 ◽

Vol 2013 ◽

pp. 1-7 ◽

Cited By ~ 1

Author(s):

Evelyn Carolina Martínez Ceballos ◽

Ricardo Vera Graziano ◽

Gonzalo Martínez Barrera ◽

Oscar Olea Mejía

Keyword(s):

Lactic Acid ◽

Ring Opening ◽

Room Temperature ◽

Block Structure ◽

Ring Opening Polymerization ◽

Synthesis And Characterization ◽

Poly Lactic Acid ◽

Hydroxyethyl Methacrylate ◽

H Nmr

Poly(dichlorophosphazene) was prepared by melt ring-opening polymerization of the hexachlorocyclotriphosphazene. Poly[bis(2-hydroxyethyl-methacrylate)-phosphazene] and poly[(2-hydroxyethyl-methacrylate)-graft-poly(lactic-acid)-phosphazene] were obtained by nucleophilic condensation reactions at different concentrations of the substituents. The properties of the synthesized copolymers were assessed by FTIR,1H-NMR and31P-NMR, thermal analysis (DSC-TGA), and electron microscopy (SEM). The copolymers have a block structure and show twoTg's below room temperature. They are stable up to a temperature of 100°C. The type of the substituents attached to the PZ backbone determines the morphology of the polymers.

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Multifunctional PLA Blends Containing Chitosan Mediated Silver Nanoparticles: Thermal, Mechanical, Antibacterial, and Degradation Properties

Nanomaterials ◽

10.3390/nano10010022 ◽

2019 ◽

Vol 10 (1) ◽

pp. 22 ◽

Cited By ~ 8

Author(s):

Agueda Sonseca ◽

Salim Madani ◽

Gema Rodríguez ◽

Víctor Hevilla ◽

Coro Echeverría ◽

...

Keyword(s):

Thermal Stability ◽

Silver Nanoparticles ◽

Lactic Acid ◽

Food Packaging ◽

Synthesis Method ◽

Crystallization Rate ◽

Poly Lactic Acid ◽

Scanning Calorimetry ◽

The Matrix ◽

Degradation Properties

Poly(lactic acid) (PLA) is one of the most commonly employed synthetic biopolymers for facing plastic waste problems. Despite its numerous strengths, its inherent brittleness, low toughness, and thermal stability, as well as a relatively slow crystallization rate represent some limiting properties when packaging is its final intended application. In the present work, silver nanoparticles obtained from a facile and green synthesis method, mediated with chitosan as a reducing and stabilizing agent, have been introduced in the oligomeric lactic acid (OLA) plasticized PLA in order to obtain nanocomposites with enhanced properties to find potential application as antibacterial food packaging materials. In this way, the green character of the matrix and plasticizer was preserved by using an eco-friendly synthesis protocol of the nanofiller. The X-ray diffraction (XRD) and differential scanning calorimetry (DSC) results proved the modification of the crystalline structure as well as the crystallinity of the pristine matrix when chitosan mediated silver nanoparticles (AgCH-NPs) were present. The final effect over the thermal stability, mechanical properties, degradation under composting conditions, and antimicrobial behavior when AgCH-NPs were added to the neat plasticized PLA matrix was also investigated. The obtained results revealed interesting properties of the final nanocomposites to be applied as materials for the targeted application.

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Modulation of Biodegradation Rate of Poly(lactic acid) by Silver Nanoparticles

Journal of Polymers and the Environment ◽

10.1007/s10924-015-0720-0 ◽

2015 ◽

Vol 23 (3) ◽

pp. 316-320 ◽

Cited By ~ 10

Author(s):

Giuliana Gorrasi ◽

Andrea Sorrentino ◽

Roberto Pantani

Keyword(s):

Silver Nanoparticles ◽

Lactic Acid ◽

Poly Lactic Acid ◽

Biodegradation Rate

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Improved cellular response of ion modified poly(lactic acid-co-glycolic acid) substrates for mouse fibroblast cells

Materials Science and Engineering C ◽

10.1016/j.msec.2015.11.020 ◽

2016 ◽

Vol 60 ◽

pp. 151-155 ◽

Cited By ~ 2

Author(s):

Ananta Raj Adhikari ◽

Tanya Geranpayeh ◽

Wei Kan Chu ◽

Deborah C. Otteson

Keyword(s):

Lactic Acid ◽

Cellular Response ◽

Glycolic Acid ◽

Mouse Fibroblast ◽

Poly Lactic Acid ◽

Fibroblast Cells

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Characterization of Poly(Diethylene Glycol Adipate -co- Neopentylglycol Adipate) as a New Plasticizer for Poly(Lactic Acid)

Advanced Materials Research ◽

10.4028/www.scientific.net/amr.706-708.28 ◽

2013 ◽

Vol 706-708 ◽

pp. 28-31

Author(s):

Tong Wan ◽

Si Zhang ◽

Tao Du

Keyword(s):

Lactic Acid ◽

Shear Rate ◽

Diethylene Glycol ◽

Parallel Plate ◽

Chemical Structure ◽

Poly Lactic Acid ◽

Glycol Adipate ◽

H Nmr ◽

Biodegradable Blends

A new poly (diethylene glycol adipate -co- neopentylglycol adipate) (PDNA) was synthesized from diethylene glycol adipate (DEAP) with neopentylglycol adipate (NPAP). The chemical structure of PDNA was characterized by 1H-NMR. PLA was plasticized by various amount of PDNA to obtain biodegradable blends. The effects of both temperature and shear rate on the rheologies of PLA/PDNA blends were evaluated by a parallel plate rheometer.

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Synthesis of a Compatibilizer and the Effects of Monomer Concentrations

Applied Mechanics and Materials ◽

10.4028/www.scientific.net/amm.554.96 ◽

2014 ◽

Vol 554 ◽

pp. 96-100 ◽

Cited By ~ 2

Author(s):

Nur Syazana Abdullah Sani ◽

Agus Arsad ◽

Abdul Razak Rahmat

Keyword(s):

Nuclear Magnetic Resonance ◽

Lactic Acid ◽

Fourier Transforms ◽

Poly Lactic Acid ◽

H Nmr ◽

Grafting Reaction ◽

Melt Grafting ◽

Infrared Spectrometer ◽

Internal Mixer ◽

Grafting Degree

The aim of this research was to modify Poly (lactic acid) (PLA) and Natural Rubber (NR) using maleic anhydride (MA). The preparation was carried out using internal mixer by free radical melt grafting reaction to produce PLA-g-MA and NR-g-MA as a compatibilizer. The effects of concentrations of MA (3-12 phr) were studied in details. The samples structure of copolymers were then characterized using 1H nuclear magnetic resonance (1H-NMR) and Fourier transforms infrared spectrometer (FTIR). Quantities of grafted MA (% grafting) were characterized by titration analysis and when increasing the monomer used, the quantities of the grafted MA on PLA and NR molecules also increased. The optimum grafting degree for PLA-g-MA and NR-g-MA was at 9 phr of MA with value of 1.63% and 5.02%, respectively.

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Effect of Glycidyl Methacrylate (GMA) Content on Grafting Yield and Mechanical Properties of GMA Grafted Poly(Lactic Acid) Prepared by Melt Mixing Method

Key Engineering Materials ◽

10.4028/www.scientific.net/kem.709.27 ◽

2016 ◽

Vol 709 ◽

pp. 27-31

Author(s):

Thanh Chi Nguyen ◽

Ruksakulpiwat Chaiwat ◽

Yupaporn Ruksakulpiwat

Keyword(s):

Mechanical Properties ◽

Lactic Acid ◽

Glycidyl Methacrylate ◽

Fracture Behaviour ◽

Industrial Applications ◽

Proton Nuclear Magnetic Resonance ◽

Poly Lactic Acid ◽

Melt Mixing ◽

Molecular Weights ◽

Grafting Reaction

Glycidyl methacrylate (GMA) was grafted onto poly (lactic acid) (PLA) by internal mixer using dicumyl peroxide (DCP) as an initiator. The results from proton nuclear magnetic resonance (1H-NMR) and gel permeation chromatograph (GPC) indicated that the grafting reaction of GMA onto PLA took place successfully. In order to obtain the optimal GMA content used to graft onto PLA chain, the GMA content was varied into 5, 10 and 15 wt% of PLA. GMA content of 10 wt% was found to give the highest elongation at break of glycidyl methacrylate grafted poly (lactic acid) (PLA-g-GMA). The weight-average molecular weights, the number-average molecular weights and polydispersity index of PLA increased after grafting with GMA. After grafting, the brittle fracture behaviour of PLA was changed to ductile fracture behaviour of PLA-g-GMA. With its superior mechanical properties compared to those of pure PLA, PLA-g-GMA can be considered to be used as a new generation of biodegradable polymer, which can be applied in many industrial applications.

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The Effect of Processing Parameters Onpoly (Lactic Acid)/Poly(Ethylene Oxide)Bicomponentultrafine Fibersby Co-Electrospinning

Advanced Materials Research ◽

10.4028/www.scientific.net/amr.701.254 ◽

2013 ◽

Vol 701 ◽

pp. 254-258 ◽

Cited By ~ 1

Author(s):

Suttipan Pavasupree ◽

Kawee Srikulkit ◽

Ratthapol Rangkupan

Keyword(s):

Lactic Acid ◽

Flow Rate ◽

Applied Voltage ◽

Water Soluble ◽

Flow Rate Ratio ◽

Poly Lactic Acid ◽

Solution Flow Rate ◽

Electrospinning Technique ◽

Solution Flow ◽

Water Soluble Polymer

Poly (lactic acid) (PLA)/polyethylene oxide (PEO) bicomponent fibers werefabricated by co-electrospinning technique in a side by side configuration. Effect of PEO concentration, PLA and PEO solution flow rate and an applied voltage on formation, size and morphology of the fibers were investigated. The results showed that the fibers size increased with increasing PEO concentration, PEO flow rate ratio and applied voltage. The composition of the fibers was confirmed by IR spectrum. Additionally, by pairing PEO, which is a water soluble polymer, with PLA, follow by PEO phase removal in water, a C-shaped ultrafine fiber was prepared.

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