The relationship between PNP, GSTO-1, AS3MT and ADRB3 gene polymorphisms and urinary arsenic concentration among copper smelter and refinery employers

2020 ◽  
Vol 39 (11) ◽  
pp. 1443-1453
Author(s):  
A Szymańska-Chabowska ◽  
T Matys ◽  
Ł Łaczmański ◽  
K Czerwińska ◽  
A Janus ◽  
...  
Keyword(s):  
Arsenic Concentration ◽  
Arsenic Exposure ◽  
Copper Smelter ◽  
Urinary Arsenic ◽  
Lead And Zinc ◽  
Genes Encoding ◽  
Occupationally Exposed ◽  
Cadmium Lead ◽  
The Relationship ◽  
Harmful Effects

Introduction: The aim of this study was to assess the relationship between polymorphisms of genes encoding enzymes involved in arsenic metabolism and urinary arsenic concentration in people occupationally exposed to arsenic. Materials and Methods: The data from 113 employers directly exposed to lead, cadmium, and arsenic in copper smelter in Legnica and Glogow were collected. Urinary arsenic concentration was measured. In addition, blood level of cadmium, lead, and zinc protoporphyrins was assayed. Genetic analyses included polymorphism of PNP (rs 1130650), GSTO-1 (rs 4925), AS3MT (rs 11191439), and ADRB3 (rs4994) genes. Results: Individuals occupationally exposed to arsenic compounds, who have allele T in homozygous constellation in locus rs 1130650 of PNP gene, are predisposed to lower urinary arsenic concentration, while AA homozygosity in locus rs 4925 of GSTO-1 gene may result in statistically significant higher urinary arsenic concentration. Polymorphisms of AS3MT and ADRB3 genes showed no statistically significant correlation with urinary arsenic, however, there was a tendency to higher arsenic concentration in allele A carriers in locus rs4994 of ADRB3 gene and in allele T carriers in rs 11191439 of AS3MT gene. Conclusion: This study indicates that arsenic absorption and metabolism depend on polymorphisms of genes encoding PNP and GSTO-1. Individuals with disadvantageous constellation of polymorphisms are more susceptible to harmful effects of arsenic exposure.

scholarly journals Variation in Arsenic metabolism in schistosomiasis associated bladder pathology in a rural community, Eggua, Ogun State, Nigeria

2021 ◽  
Vol 25 (9) ◽  
pp. 1645-1652
Author(s):  
A.T. Adeboye ◽  
H.O. Awobode ◽  
A.S. Adebayo ◽  
J.R. Djouaka ◽  
R.D. Isokpehi ◽  
...  
Keyword(s):  
Arsenic Concentration ◽  
Arsenic Exposure ◽  
Inorganic Arsenic ◽  
Urogenital Schistosomiasis ◽  
Arsenic Metabolism ◽  
Ogun State ◽  
Specific Pcr ◽  
Urinary Arsenic ◽  
Increased Risk ◽  
Bladder Pathology

Exposure to toxic inorganic Arsenic (iAs) in areas endemic for urogenital schistosomiasis may confer increased risk for bladder cancer. The severity of the adverse effects of iAs however depends on its metabolism, which is highly variable among individuals. Genetic polymorphism in Arsenic (+3) Methyl Transferase enzyme, accounts significantly for these variations. To investigate the relationship of AS3MT gene polymorphisms and Arsenic metabolism to schistosomiasis and/or associated bladder pathology, 119 individualsfrom Eggua in southwest Nigeria were recruited for this study. Screening for schistosomiasis and bladder pathology was done by microscopy and ultrasonography respectively. Wagtech Digital Arsenator was used to assess total urinary arsenic concentrations and thus determine the level of arsenic exposure. The single nucleotide polymorphism AS3MT/Met287Thr T>C (rs11191439) was genotyped using Alelle-Specific PCR. Of the participants who tested positive for schistosomiasis, 33.3% exhibited bladder pathology. Total urinary arsenic concentration in 80% of the participants was above the WHO limit of 0.05mg/L. The Met287Thr allelic distribution conformed to the Hardy-Weinberg equilibrium (X2= 0.161, P> 0.05). Observed allelic frequencies were 0.96 and 0.04 for wild-type T and mutant C alleles respectively. There was no significant relationship between AS3MT SNP, arsenic concentrations and schistosomiasis associated bladder pathology. In conclusion, the community is highly exposed to arsenic, although with a possible genetic advantage of increased AS3MT catalytic activity. However, we see the need for urgent intervention as inter-individual differences in arsenic metabolism may influence the bladder pathology status of individuals in the community. And although urogenital schistosomiasis is waning in Eggua, it is not known what synergy the infection and high arsenic exposure may wield on bladder pathology.

The relationship between children's non-nutrient exposure to cadmium, lead and zinc and the location of recreational areas - Based on the Upper Silesia region case (Poland)

Chemosphere ◽  
2019 ◽  
Vol 223 ◽  
pp. 544-550 ◽  
Author(s):  
Agata Piekut ◽  
Klaudia Gut ◽  
Małgorzata Ćwieląg-Drabek ◽  
Joanna Domagalska ◽  
Ewa Marchwińska-Wyrwał
Keyword(s):  
Upper Silesia ◽  
Lead And Zinc ◽  
Cadmium Lead ◽  
The Relationship

Association of Urinary Arsenic and Sleep Disorder in the U.S. Population: NHANES 2015-2016

2021 ◽  
Author(s):  
Humairat H Rahman ◽  
Danielle Niemann ◽  
Korede K Yusuf
Keyword(s):  
Sleep Disturbance ◽  
Sleep Disorder ◽  
Neurodegenerative Disorder ◽  
Arsenic Concentration ◽  
Arsenic Exposure ◽  
Multivariate Logistic Regression Analysis ◽  
Total Sample ◽  
Dimethylarsinic Acid ◽  
Urinary Arsenic ◽  
Study Participants

Abstract Arsenic is a known carcinogen and neurotoxin and is found in the natural earth crust. Arsenic exposure can develop depression, memory dysfunction, and neurodegenerative disorder. The mechanism of arsenic toxicity on the nervous system is not known. There is a lack of research on the association between arsenic exposure and sleep disturbance in humans. This study aims to investigate the relationship between six types of urinary speciated arsenic exposure and sleep disturbance in adults from the general population using the National Health and Nutrition Examination Survey (NHANES) 2015–2016 dataset. Sleep disturbance was measured using self-reported questionnaires, asking participants if they had ever told a doctor they had trouble sleeping. We utilized multivariate logistic regression analysis using complex survey procedures to examine the association between six types of urinary arsenic concentration and trouble sleeping. The total sample included 1,611 adults who were 20 years and older. Of the study participants, 30.0% had trouble sleeping. Urinary arsenous acid was associated with an increased odds of had trouble sleeping [odds ratio: 1.47 (95% confidence interval 1.02–2.11). The other five types of urinary speciated arsenic (arsenic acid, arsenobetaine, arsenocholine, dimethylarsinic acid, monomethylacrsonic acid) were not associated with a sleep disorder.

Effects of low-level arsenic exposure on urinary N-acetyl-β-D-glucosaminidase activity

2011 ◽  
Vol 30 (12) ◽  
pp. 1885-1891 ◽  
Author(s):  
S-Y Eom ◽  
Y-C Lee ◽  
D-H Yim ◽  
C-H Lee ◽  
Y-D Kim ◽  
...  
Keyword(s):  
Arsenic Concentration ◽  
Arsenic Exposure ◽  
Inorganic Arsenic ◽  
Tubular Damage ◽  
Seafood Consumption ◽  
Arsenic Level ◽  
Urine Sampling ◽  
Low Level ◽  
Urinary Arsenic ◽  
Renal Tubular

This study was aimed to evaluate whether renal tubular function is impaired by exposure to relatively low concentrations of arsenic. Mean urinary arsenic concentrations and N-acetyl-β-d-glucosaminidase (NAG) activities were compared among 365 and 502 Korean men and women, respectively, in relation to gender, smoking, alcohol consumption, and recent seafood consumption. The study subjects were divided into 4 groups according to urinary NAG activity and seafood consumption prior to urine sampling, and the correlation between arsenic concentration and urinary NAG activity was tested for each group. The mean urinary arsenic level was higher in women, non-smokers, and non-drinkers in comparison to men, smokers, and drinkers, respectively. Individuals who consumed seafood within 3 days prior to urine sampling showed a higher mean urinary arsenic level than those who did not. The correlation between urinary arsenic concentration and NAG activity in urine was significant only in subjects who did not consume seafood within 3 days prior to urine sampling and whose urinary NAG activity was 7.44 U/g creatinine (75th percentile) or higher. The urinary arsenic concentration was a significant determinant of urinary NAG activity in subjects with NAG activity higher than 7.44 U/g creatinine and especially in those who had not consumed seafood recently. These facts suggest that a relatively low-level exposure to inorganic arsenic produces renal tubular damage in humans.

scholarly journals Arsenic exposure and type 2 diabetes: results from the 2007–2009 Canadian Health Measures Survey

2015 ◽  
Vol 35 (4) ◽  
pp. 63-72 ◽  
Author(s):  
SK Feseke ◽  
J St-Laurent ◽  
E Anassour-Sidi ◽  
P Ayotte ◽  
M Bouchard ◽  
...  
Keyword(s):  
Glycated Hemoglobin ◽  
Arsenic Concentration ◽  
Arsenic Exposure ◽  
Total Arsenic ◽  
Health Measures ◽  
Urinary Arsenic ◽  
Canadian Population ◽  
Canadian Health ◽  
Canadian Health Measures Survey

Introduction Inorganic arsenic and its metabolites are considered dangerous to human health. Although several studies have reported associations between low-level arsenic exposure and diabetes mellitus in the United States and Mexico, this association has not been studied in the Canadian population. We evaluated the association between arsenic exposure, as measured by total arsenic concentration in urine, and the prevalence of type 2 diabetes (T2D) in 3151 adult participants in Cycle 1 (2007–2009) of the Canadian Health Measures Survey (CHMS). Methods All participants were tested to determine blood glucose and glycated hemoglobin. Urine analysis was also performed to measure total arsenic. In addition, participants answered a detailed questionnaire about their lifestyle and medical history. We assessed the association between urinary arsenic levels and T2D and prediabetes using multivariate logistic regression while adjusting for potential confounders. Results Total urinary arsenic concentration was positively associated with the prevalence of T2D and prediabetes: adjusted odds ratios were 1.81 (95% CI: 1.12–2.95) and 2.04 (95% CI: 1.03–4.05), respectively, when comparing the highest (fourth) urinary arsenic concentration quartile with the lowest (first) quartile. Total urinary arsenic was also associated with glycated hemoglobin levels in people with untreated diabetes. Conclusion We found significant associations between arsenic exposure and the prevalence of T2D and prediabetes in the Canadian population. Causal inference is limited due to the cross-sectional design of the study and the absence of long-term exposure assessment.

Novas Considerações sobre a Fotoproteção no Brasil: Revisão de Literatura/New Considerations on the Photoprotection in Brazil: Literature Review

1970 ◽  
Vol 5 (3) ◽  
pp. 80-96
Author(s):  
Mayara Motta Melo ◽  
Clarissa Santos de Carvalho Ribeiro
Keyword(s):  
Skin Cancer ◽  
Solar Radiation ◽  
Literature Review ◽  
Sun Exposure ◽  
International Consensus ◽  
De Se ◽  
Literature Reviews ◽  
Relationship Of ◽  
The Relationship ◽  
Harmful Effects

RESUMOA incidência do câncer de pele vem aumentando a cada ano. Sabe-se que entre outros fatores, a radiação solar é a principal responsável pelo desenvolvimento dessa patologia. A prevenção, feita através da fotoproteção, teria grande impacto nesse cenário. No entanto, as orientações sobre como se proteger dos malefícios do sol devem ser coerentes com a incidência solar da região, os hábitos da população e o fototipo da pele. Os conceitos sobre fotoproteção foram definidos por entidades européias e norte americanas e não devem ser reproduzidos para o Brasil de forma aleatória, pois a incidência solar no Brasil é muito maior, a população tem fototipos diferentes e o hábito de se expor ao sol é muito mais frequente. Portanto, faz-se necessário elaborar conceitos próprios para o Brasil e conscientizar a população sobre os perigos da radiação solar para que a incidência do câncer de pele reduza definitivamente. Essa revisão visa mostrar a relação da radiação solar no Brasil com a pele dos brasileiros e evidenciar a importância da fotoproteção para essa população. Para isso foi feito um levantamento de artigos originais, revisões de literatura, consensos brasileiros e internacionais e livros de dermatologia.Palavras-chave: Fotoproteção, Câncer de pele, Exposição solar, Radiação ultravioleta, Vitamina D. ABSTRACTThe incidence of skin cancer is increasing every year. It is known that among other factors, solar radiation is the main responsible for the development of this pathology. Prevention, made by photoprotection, would have great impact in this scenario. However, the guidelines on how to protect themselves from the sun's harmful effects should be consistent with the sunlight of the region, the habits of the population and the phototype skin. The concepts of photoprotection were defined by European and North American entities and should not be played for Brazil at random, as the solar incidence in Brazil is much higher, people have different skin types and the habit of sun exposure is much more frequent. Therefore, it is necessary to draw up own concepts for Brazil and raise awareness about the dangers of solar radiation, so that the incidence of skin cancer can be definitely reduced. This review aims to show the relationship of solar radiation in Brazil with the skin of Brazilian and to highlight the importance of sun protection for this population. With this purpose, it was  made a survey of original articles, literature reviews , Brazilian and international consensus and dermatology books.Keywords: Photoprotection, Skin cancer, Sun exposure, Ultraviolet radiation, D vitamin.

scholarly journals Removal of Pb, Cu, Cd, and Zn Present in Aqueous Solution Using Coupled Electrocoagulation-Phytoremediation Treatment

2017 ◽  
Vol 2017 ◽  
pp. 1-11 ◽  
Author(s):  
Francisco Ferniza-García ◽  
Araceli Amaya-Chávez ◽  
Gabriela Roa-Morales ◽  
Carlos E. Barrera-Díaz
Keyword(s):  
Aqueous Solution ◽  
Current Density ◽  
Batch Reactor ◽  
Operating Time ◽  
Typha Latifolia ◽  
Optimal Conditions ◽  
Lead And Zinc ◽  
Parallel Arrangement ◽  
Aluminum Electrodes ◽  
Cadmium Lead

This study presents the results of a coupled electrocoagulation-phytoremediation treatment for the reduction of copper, cadmium, lead, and zinc, present in aqueous solution. The electrocoagulation was carried out in a batch reactor using aluminum electrodes in parallel arrangement; the optimal conditions were current density of 8 mA/cm2 and operating time of 180 minutes. For phytoremediation the macrophytes, Typha latifolia L., were used during seven days of treatment. The results indicated that the coupled treatment reduced metal concentrations by 99.2% Cu, 81.3% Cd, and 99.4% Pb, while Zn increased due to the natural concentrations of the plant used.

Experimental Hypercholesterolemia and Auditory Function in the Chinchilla

1982 ◽  
Vol 90 (6) ◽  
pp. 814-818 ◽  
Author(s):  
Tetsuo Morizono ◽  
Michael A. Sikora
Keyword(s):  
Differential Susceptibility ◽  
Control Group ◽  
High Cholesterol Diet ◽  
Auditory Function ◽  
Cholesterol Levels ◽  
Auditory Dysfunction ◽  
Experimental Hypercholesterolemia ◽  
Susceptibility To Noise ◽  
The Relationship ◽  
Harmful Effects

Possible harmful effects of a high-cholesterol diet on auditory function were suggested by our previous work in rabbits, in which evoked potentials were measured from a chronic electrode inserted into the inferior colliculus. However, serum cholesterol levels in those rabbits tended to be extraordinarily high, ie, more than 1,500 mg/dL. Chinchillas were used in the present work as an animal model to study the relationship between hypercholesterolemia and auditory dysfunction. One percent cholesterol in standard Chinchow was fed to chinchillas for three months. The experimental groups showed a high mean cholesterol level of 437 ± 394 mg/dL (N = 9). Isopotential curve of the cochlear microphonics, threshold of action potentials (AP), and endocochlear DC potential did not differ from those in the control group. When moderately intense sound (12 kHz, 95 dB SPL) was given for ten minutes, however, the reduction in AP threshold was significantly greater (P=.036) in the cholesterol group. It is postulated that hypercholesterolemia may be one of the factors involved in differential susceptibility to noise.

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