Association of Urinary Arsenic and Sleep Disorder in the U.S. Population: NHANES 2015-2016

Mapping Intimacies ◽

10.21203/rs.3.rs-308747/v1 ◽

2021 ◽

Author(s):

Humairat H Rahman ◽

Danielle Niemann ◽

Korede K Yusuf

Keyword(s):

Sleep Disturbance ◽

Sleep Disorder ◽

Neurodegenerative Disorder ◽

Arsenic Concentration ◽

Arsenic Exposure ◽

Multivariate Logistic Regression Analysis ◽

Total Sample ◽

Dimethylarsinic Acid ◽

Urinary Arsenic ◽

Study Participants

Abstract Arsenic is a known carcinogen and neurotoxin and is found in the natural earth crust. Arsenic exposure can develop depression, memory dysfunction, and neurodegenerative disorder. The mechanism of arsenic toxicity on the nervous system is not known. There is a lack of research on the association between arsenic exposure and sleep disturbance in humans. This study aims to investigate the relationship between six types of urinary speciated arsenic exposure and sleep disturbance in adults from the general population using the National Health and Nutrition Examination Survey (NHANES) 2015–2016 dataset. Sleep disturbance was measured using self-reported questionnaires, asking participants if they had ever told a doctor they had trouble sleeping. We utilized multivariate logistic regression analysis using complex survey procedures to examine the association between six types of urinary arsenic concentration and trouble sleeping. The total sample included 1,611 adults who were 20 years and older. Of the study participants, 30.0% had trouble sleeping. Urinary arsenous acid was associated with an increased odds of had trouble sleeping [odds ratio: 1.47 (95% confidence interval 1.02–2.11). The other five types of urinary speciated arsenic (arsenic acid, arsenobetaine, arsenocholine, dimethylarsinic acid, monomethylacrsonic acid) were not associated with a sleep disorder.

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Variation in Arsenic metabolism in schistosomiasis associated bladder pathology in a rural community, Eggua, Ogun State, Nigeria

Journal of Applied Sciences and Environmental Management ◽

10.4314/jasem.v25i9.16 ◽

2021 ◽

Vol 25 (9) ◽

pp. 1645-1652

Author(s):

A.T. Adeboye ◽

H.O. Awobode ◽

A.S. Adebayo ◽

J.R. Djouaka ◽

R.D. Isokpehi ◽

...

Keyword(s):

Arsenic Concentration ◽

Arsenic Exposure ◽

Inorganic Arsenic ◽

Urogenital Schistosomiasis ◽

Arsenic Metabolism ◽

Ogun State ◽

Specific Pcr ◽

Urinary Arsenic ◽

Increased Risk ◽

Bladder Pathology

Exposure to toxic inorganic Arsenic (iAs) in areas endemic for urogenital schistosomiasis may confer increased risk for bladder cancer. The severity of the adverse effects of iAs however depends on its metabolism, which is highly variable among individuals. Genetic polymorphism in Arsenic (+3) Methyl Transferase enzyme, accounts significantly for these variations. To investigate the relationship of AS3MT gene polymorphisms and Arsenic metabolism to schistosomiasis and/or associated bladder pathology, 119 individualsfrom Eggua in southwest Nigeria were recruited for this study. Screening for schistosomiasis and bladder pathology was done by microscopy and ultrasonography respectively. Wagtech Digital Arsenator was used to assess total urinary arsenic concentrations and thus determine the level of arsenic exposure. The single nucleotide polymorphism AS3MT/Met287Thr T>C (rs11191439) was genotyped using Alelle-Specific PCR. Of the participants who tested positive for schistosomiasis, 33.3% exhibited bladder pathology. Total urinary arsenic concentration in 80% of the participants was above the WHO limit of 0.05mg/L. The Met287Thr allelic distribution conformed to the Hardy-Weinberg equilibrium (X2= 0.161, P> 0.05). Observed allelic frequencies were 0.96 and 0.04 for wild-type T and mutant C alleles respectively. There was no significant relationship between AS3MT SNP, arsenic concentrations and schistosomiasis associated bladder pathology. In conclusion, the community is highly exposed to arsenic, although with a possible genetic advantage of increased AS3MT catalytic activity. However, we see the need for urgent intervention as inter-individual differences in arsenic metabolism may influence the bladder pathology status of individuals in the community. And although urogenital schistosomiasis is waning in Eggua, it is not known what synergy the infection and high arsenic exposure may wield on bladder pathology.

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Vitamin B-6 Intake Is Modestly Associated with Arsenic Methylation in Uruguayan Children with Low-Level Arsenic Exposure

Journal of Nutrition ◽

10.1093/jn/nxz331 ◽

2020 ◽

Vol 150 (5) ◽

pp. 1223-1229 ◽

Cited By ~ 1

Author(s):

Gauri Desai ◽

Marie Vahter ◽

Elena I Queirolo ◽

Fabiana Peregalli ◽

Nelly Mañay ◽

...

Keyword(s):

Arsenic Exposure ◽

B Vitamins ◽

Vitamin B ◽

Dimethylarsinic Acid ◽

Study Objective ◽

Low Level ◽

Urinary Arsenic ◽

Vitamin Intake ◽

Vitamin B 12 ◽

B Vitamin

ABSTRACT Background Detoxification of inorganic arsenic (iAs) occurs when it methylates to form monomethylarsonic acid (MMA) and dimethylarsinic acid (DMA). Lower proportions of urinary iAs and MMA, and higher proportions of DMA indicate efficient methylation. The role of B-vitamins in iAs methylation in children with low-level arsenic exposure is understudied. Objectives Our study objective was to assess the association between B-vitamin intake and iAs methylation in children with low-level arsenic exposure (<50 µg/L in water; urinary arsenic 5–50 µg/L). Methods We conducted a cross-sectional study in 290 ∼7-y-old children in Montevideo. Intake of thiamin, riboflavin, niacin, vitamin B-6, and vitamin B-12 was calculated by averaging 2 nonconsecutive 24-h recalls. Total urinary arsenic concentration was measured as the sum of urinary iAs, MMA, and DMA, and adjusted for urinary specific gravity; iAs methylation was measured as urinary percentage As, percentage MMA, and percentage DMA. Arsenic concentrations from household water sources were assessed. Linear regressions tested the relationships between individual energy-adjusted B-vitamins and iAs methylation. Results Median (range) arsenic concentrations in urine and water were 9.9 (2.2–48.7) and 0.45 (0.1–18.9) µg/L, respectively. The median (range) of urinary percentage iAs, percentage MMA, and percentage DMA was 10.6% (0.0–33.8), 9.7% (2.6–24.8), and 79.1% (58.5–95.4), respectively. The median (range) intake levels of thiamin, riboflavin, niacin, and vitamin B-6 were 0.81 (0.19–2.56), 1.0 (0.30–2.24), 8.6 (3.5–23.3), and 0.67 (0.25–1.73) mg/1000 kcal, respectively, whereas those of folate and vitamin B-12 were 216 (75–466) and 1.7 (0.34–8.3) µg/1000 kcal, respectively. Vitamin B-6 intake was inversely associated with urinary percentage MMA (β = −1.60; 95% CI: −3.07, −0.15). No other statistically significant associations were observed. Conclusions Although vitamin B-6 intake was inversely associated with urinary percentage MMA, our findings suggest limited support for a relation between B-vitamin intake and iAs methylation in children exposed to low-level arsenic.

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As3MT and GST Polymorphisms Influencing Arsenic Metabolism in Human Exposure to Drinking Groundwater

International Journal of Molecular Sciences ◽

10.3390/ijms21144832 ◽

2020 ◽

Vol 21 (14) ◽

pp. 4832 ◽

Cited By ~ 1

Author(s):

Farith González-Martínez ◽

Daniel Sánchez-Rodas ◽

Nelson M. Varela ◽

Christopher A. Sandoval ◽

Luis A. Quiñones ◽

...

Keyword(s):

Genetic Polymorphisms ◽

Multivariate Analyses ◽

Arsenic Concentration ◽

Human Consumption ◽

Dimethylarsinic Acid ◽

Wild Type ◽

High Exposure ◽

Urinary Arsenic ◽

Polymorphic Variants ◽

Arsenic Metabolites

The urinary arsenic metabolites may vary among individuals and the genetic factors have been reported to explain part of the variation. We assessed the influence of polymorphic variants of Arsenic-3-methyl-transferase and Glutathione-S-transferase on urinary arsenic metabolites. Twenty-two groundwater wells for human consumption from municipalities of Colombia were analyzed for assessed the exposure by lifetime average daily dose (LADD) (µg/kg bw/day). Surveys on 151 participants aged between 18 and 81 years old were applied to collect demographic information and other factors. In addition, genetic polymorphisms (GSTO2-rs156697, GSTP1-rs1695, As3MT-rs3740400, GSTT1 and GSTM1) were evaluated by real time and/or conventional PCR. Arsenic metabolites: AsIII, AsV, monomethylarsonic acid (MMA), and dimethylarsinic acid (DMA) were measured using HPLC-HG-AFS. The influence of polymorphic variants, LADD and other factors were tested using multivariate analyses. The median of total arsenic concentration in groundwater was of 33.3 μg/L and the median of LADD for the high exposure dose was 0.33 µg/kg bw/day. Univariate analyses among arsenic metabolites and genetic polymorphisms showed MMA concentrations higher in heterozygous and/or homozygous genotypes of As3MT compared to the wild-type genotype. Besides, DMA concentrations were lower in heterozygous and/or homozygous genotypes of GSTP1 compared to the wild-type genotype. Both DMA and MMA concentrations were higher in GSTM1-null genotypes compared to the active genotype. Multivariate analyses showed statistically significant association among interactions gene-gene and gene-covariates to modify the MMA and DMA excretion. Interactions between polymorphic variants As3MT*GSTM1 and GSTO2*GSTP1 could be potential modifiers of urinary excretion of arsenic and covariates as age, LADD, and alcohol consumption contribute to largely vary the arsenic individual metabolic capacity in exposed people.

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The relationship between PNP, GSTO-1, AS3MT and ADRB3 gene polymorphisms and urinary arsenic concentration among copper smelter and refinery employers

Human & Experimental Toxicology ◽

10.1177/0960327120925891 ◽

2020 ◽

Vol 39 (11) ◽

pp. 1443-1453

Author(s):

A Szymańska-Chabowska ◽

T Matys ◽

Ł Łaczmański ◽

K Czerwińska ◽

A Janus ◽

...

Keyword(s):

Arsenic Concentration ◽

Arsenic Exposure ◽

Copper Smelter ◽

Urinary Arsenic ◽

Lead And Zinc ◽

Genes Encoding ◽

Occupationally Exposed ◽

Cadmium Lead ◽

The Relationship ◽

Harmful Effects

Introduction: The aim of this study was to assess the relationship between polymorphisms of genes encoding enzymes involved in arsenic metabolism and urinary arsenic concentration in people occupationally exposed to arsenic. Materials and Methods: The data from 113 employers directly exposed to lead, cadmium, and arsenic in copper smelter in Legnica and Glogow were collected. Urinary arsenic concentration was measured. In addition, blood level of cadmium, lead, and zinc protoporphyrins was assayed. Genetic analyses included polymorphism of PNP (rs 1130650), GSTO-1 (rs 4925), AS3MT (rs 11191439), and ADRB3 (rs4994) genes. Results: Individuals occupationally exposed to arsenic compounds, who have allele T in homozygous constellation in locus rs 1130650 of PNP gene, are predisposed to lower urinary arsenic concentration, while AA homozygosity in locus rs 4925 of GSTO-1 gene may result in statistically significant higher urinary arsenic concentration. Polymorphisms of AS3MT and ADRB3 genes showed no statistically significant correlation with urinary arsenic, however, there was a tendency to higher arsenic concentration in allele A carriers in locus rs4994 of ADRB3 gene and in allele T carriers in rs 11191439 of AS3MT gene. Conclusion: This study indicates that arsenic absorption and metabolism depend on polymorphisms of genes encoding PNP and GSTO-1. Individuals with disadvantageous constellation of polymorphisms are more susceptible to harmful effects of arsenic exposure.

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Effects of low-level arsenic exposure on urinary N-acetyl-β-D-glucosaminidase activity

Human & Experimental Toxicology ◽

10.1177/0960327111402239 ◽

2011 ◽

Vol 30 (12) ◽

pp. 1885-1891 ◽

Cited By ~ 8

Author(s):

S-Y Eom ◽

Y-C Lee ◽

D-H Yim ◽

C-H Lee ◽

Y-D Kim ◽

...

Keyword(s):

Arsenic Concentration ◽

Arsenic Exposure ◽

Inorganic Arsenic ◽

Tubular Damage ◽

Seafood Consumption ◽

Arsenic Level ◽

Urine Sampling ◽

Low Level ◽

Urinary Arsenic ◽

Renal Tubular

This study was aimed to evaluate whether renal tubular function is impaired by exposure to relatively low concentrations of arsenic. Mean urinary arsenic concentrations and N-acetyl-β-d-glucosaminidase (NAG) activities were compared among 365 and 502 Korean men and women, respectively, in relation to gender, smoking, alcohol consumption, and recent seafood consumption. The study subjects were divided into 4 groups according to urinary NAG activity and seafood consumption prior to urine sampling, and the correlation between arsenic concentration and urinary NAG activity was tested for each group. The mean urinary arsenic level was higher in women, non-smokers, and non-drinkers in comparison to men, smokers, and drinkers, respectively. Individuals who consumed seafood within 3 days prior to urine sampling showed a higher mean urinary arsenic level than those who did not. The correlation between urinary arsenic concentration and NAG activity in urine was significant only in subjects who did not consume seafood within 3 days prior to urine sampling and whose urinary NAG activity was 7.44 U/g creatinine (75th percentile) or higher. The urinary arsenic concentration was a significant determinant of urinary NAG activity in subjects with NAG activity higher than 7.44 U/g creatinine and especially in those who had not consumed seafood recently. These facts suggest that a relatively low-level exposure to inorganic arsenic produces renal tubular damage in humans.

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Arsenic exposure and type 2 diabetes: results from the 2007–2009 Canadian Health Measures Survey

Health Promotion and Chronic Disease Prevention in Canada ◽

10.24095/hpcdp.35.4.01 ◽

2015 ◽

Vol 35 (4) ◽

pp. 63-72 ◽

Cited By ~ 20

Author(s):

SK Feseke ◽

J St-Laurent ◽

E Anassour-Sidi ◽

P Ayotte ◽

M Bouchard ◽

...

Keyword(s):

Glycated Hemoglobin ◽

Arsenic Concentration ◽

Arsenic Exposure ◽

Total Arsenic ◽

Health Measures ◽

Urinary Arsenic ◽

Canadian Population ◽

Canadian Health ◽

Canadian Health Measures Survey

Introduction Inorganic arsenic and its metabolites are considered dangerous to human health. Although several studies have reported associations between low-level arsenic exposure and diabetes mellitus in the United States and Mexico, this association has not been studied in the Canadian population. We evaluated the association between arsenic exposure, as measured by total arsenic concentration in urine, and the prevalence of type 2 diabetes (T2D) in 3151 adult participants in Cycle 1 (2007–2009) of the Canadian Health Measures Survey (CHMS). Methods All participants were tested to determine blood glucose and glycated hemoglobin. Urine analysis was also performed to measure total arsenic. In addition, participants answered a detailed questionnaire about their lifestyle and medical history. We assessed the association between urinary arsenic levels and T2D and prediabetes using multivariate logistic regression while adjusting for potential confounders. Results Total urinary arsenic concentration was positively associated with the prevalence of T2D and prediabetes: adjusted odds ratios were 1.81 (95% CI: 1.12–2.95) and 2.04 (95% CI: 1.03–4.05), respectively, when comparing the highest (fourth) urinary arsenic concentration quartile with the lowest (first) quartile. Total urinary arsenic was also associated with glycated hemoglobin levels in people with untreated diabetes. Conclusion We found significant associations between arsenic exposure and the prevalence of T2D and prediabetes in the Canadian population. Causal inference is limited due to the cross-sectional design of the study and the absence of long-term exposure assessment.

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Groundwater Irrigation and Arsenic Speciation in Rice in Cambodia

Journal of Health and Pollution ◽

10.5696/2156-9614-8.19.180911 ◽

2018 ◽

Vol 8 (19) ◽

Cited By ~ 4

Author(s):

Tom Murphy ◽

Kongkea Phan ◽

Emmanuel Yumvihoze ◽

Kim Irvine ◽

Ken Wilson ◽

...

Keyword(s):

Arsenic Speciation ◽

Arsenic Concentration ◽

Arsenic Exposure ◽

Inorganic Arsenic ◽

Arsenic Species ◽

Dimethylarsinic Acid ◽

Total Arsenic ◽

Groundwater Irrigation ◽

Financial Interests ◽

Rice Consumption

Background. Arsenic bioaccumulation in rice is a global concern affecting food security and public health. Objective. The present study examined arsenic species in rice in Cambodia to characterize health risks with rice consumption and to clarify uncertainties with Codex guidelines. Methods. The present study collected 61 well water samples, 105 rice samples, 70 soil samples, and conducted interviews with 44 families in Preak Russey near the Bassac River and Kandal Province along the Mekong River in Cambodia. Analyses of metals, total arsenic and arsenic species were conducted in laboratories in Canada, Cambodia and Singapore. Results. Unlike in Bangladesh, rice with the highest total arsenic concentrations in Cambodia contains mostly organic arsenic, dimethylarsinic acid (DMA), which is unregulated and much less toxic than inorganic arsenic. The present study found that storing surface runoff in ditches prior to irrigation can significantly reduce the arsenic concentration in rice. It is possible to remove > 95% of arsenic from groundwater prior to irrigation with natural reactions. Conclusions. The provision of high quality drinking water in 2015 to Preak Russey removed about 95% of the dietary inorganic arsenic exposure. The extremes in arsenic toxicity that are still obvious in these farmers should become less common. Rice from the site with the highest documented levels of arsenic in soils and water in Cambodia passes current Codex guidelines for arsenic. Informed Consent. Obtained Competing Interests. The authors declare no competing financial interests.

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Association of breastfeeding and risk of metabolic syndrome and its components in postmenopausal parous women: Korea national health and nutrition examination survey (2010 ~ 2016)

Archives of Public Health ◽

10.1186/s13690-021-00607-2 ◽

2021 ◽

Vol 79 (1) ◽

Author(s):

Jusuk Lee ◽

Taehong Kim

Keyword(s):

Metabolic Syndrome ◽

Laboratory Data ◽

Multivariate Logistic Regression Analysis ◽

Density Lipoprotein ◽

Cross Sectional Study ◽

Korean Women ◽

Cross Sectional ◽

Increased Risk ◽

Nationally Representative ◽

Study Participants

Abstract Background Understanding the relationship between breastfeeding (BF) and metabolic syndrome (Mets) is important for maternal long-term health benefits and disease prevention. This study aimed to examine the association between BF and Mets and its components among postmenopausal parous Korean women. Methods This cross-sectional study on 10,356 Korean women used nationally representative data from the KNHANES from 2010 to 2016. Anthropometric, laboratory data and manual BP were measured. A multivariate logistic regression analysis was conducted to examine the association of BF with Mets and its components after adjusting for potential confounding variables. A p-value < 0.05 was to be considered statistically significant. Results Mets was present in 42% of the study participants. The BF group had low household income and education level. The prevalence of Mets in the BF group was higher than that in the non-BF group (42.69% vs. 34.76%, p < 0.001). BF was associated with increased risk of Mets (odds ratio [OR]: 1.4, 95% confidence interval [CI]: 1.18–1.65, p < 0.001). The BF group was at higher risks for diabetes (OR: 1.5, 95%CI: 1.14–1.98), hypertension (OR: 1.32, 95%CI: 1.03–1.68), hypertriglyceridemia (OR: 1.42, 95%CI: 1.02–1.99) and low high-density lipoprotein cholesterol (OR: 1.32, 95%CI: 1.06–1.65). Conclusion In this study, BF did not affect decreasing the prevalence of Mets and its components.

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