Identification of Potential Predisposition to Clinical Atherosclerosis: A Clinical Concept Based on Integration of Significant Blood Parameters with Platelet Aggregation Scores

1997 ◽  
Vol 3 (3) ◽  
pp. 174-182
Author(s):  
Alexander Kaplan ◽  
Svetlana Kaplan ◽  
Karen F. Marcoe ◽  
Lester R. Sauvage ◽  
William P. Hammond
Keyword(s):  
Healthy Volunteers ◽  
Blood Platelets ◽  
Subsequent Development ◽  
Hdl Cholesterol ◽  
Blood Parameters ◽  
Integrated Analysis ◽  
Algebraic Expression ◽  
Prospective Evaluation ◽  
Key Words Atherosclerosis ◽  
Apparently Healthy

We sought to develop a predictive method, based on the integration of blood parameters found to be significantly associated with thrombosis and progression of atherosclerosis, that would be more accurate than primary reliance on elevation of separate risk factors. The study involved 1,034 male subjects. Lipid profiles and fibrinogen levels were determined for 123 men with documented clinical atherosclerosis and 123 apparently healthy volunteers. There were significant differences between these groups for fibrinogen, triglycerides, and HDL cholesterol. An algebraic expression was then developed which combined normalized values of fibrinogen, HDL cholesterol, and triglycerides with platelet count and aggregation data to yield a numerical value, the clinical atheroscterosis predisposition (CAP) factor. We then tested this CAP factor with a validation group of 788 men, 372 of whom were patients with documented clinical atherosclerosis; the rest were apparently healthy. A 3-year prospective evaluation was done for 72 of the 123 apparently healthy volunteers. The CAP factor was 90% indicative of patient status for the 372 men with documented complications of atherosclerosis and appeared to predict severe coronary disease in the 3-year prospective evaluation. This initial study suggests that integrated analysis of thrombotic factors in white males. provides a useful estimate of an individual's risk for subsequent development of clinical atherosclerosis. Key Words: Atherosclerosis-Prevention and control-Blood-Platelets-Cholesterol-Triglycerides--Fibrinogen.

scholarly journals Relationship between Blood Lipids, Lipoproteins and Ischemic Stroke

2014 ◽  
Vol 30 (2) ◽  
pp. 96-103
Author(s):  
Md Rezaul Karim Khan ◽  
AKM Anwarullah ◽  
Md Shafiqus Saleheen ◽  
SK Mahbub Alam ◽  
Md Rafiqul Islam ◽  
...  
Keyword(s):  
Ischemic Stroke ◽  
Healthy Volunteers ◽  
Total Cholesterol ◽  
Ldl Cholesterol ◽  
Case Control Study ◽  
Hdl Cholesterol ◽  
Stroke Patients ◽  
Lipids And Lipoproteins ◽  
Control Study ◽  
Apparently Healthy

Objective: To find out the relationship of different lipids, lipoproteins and ischemic stroke patients in Bangladesh. Methodology: This case control study was conducted among the patients having ischemic stroke who were admitted in Department of Neurology, Bangabandhu Sheikh Mujib Medical University (BSMMU), Dhaka, Bangladesh during the period from July, 1997 to June, 1999 and age, sex matched apparently healthy volunteers. Sixty ischemic stroke patients confirmed by CT scan of brain and sixty age and sex matched apparently healthy volunteers were enrolled as controls. 12 hours fasting lipid profile (Total cholesterol, LDL-cholesterol, HDLcholesterol and Triglyceride) was done for both ischemic stroke patients and healthy volunteers for comparison. The students (unpaired) t test was used to compare group means for lipids and lipoproteins. Chi square test, odds ratio with confidence interval were done to evaluate differences between the groups for other variables. P<0.05 was considered as minimum level of significance. Result: The mean age (±SD) of the patients and controls were 58.45±10.12 and 59.40±10.41 years respectively and 44 (73.3%) were male and 16 (26.7%) were female and male- female ratio was 2.75:1 in both cases and controls. Total cholesterol (Means) was 201.62±5.52 mg/dl and 169.13±3.49 mg/dl in cases and controls respectively (P<0.001). HDL cholesterol (Means) was 38.36±0.81 mg/dl and 44.03±0.84 mg/dl in cases and controls respectively (P<0.001). LDL cholesterol (Mean±SE) in ischemic stroke patients and controls were 125.45±4.63 mg/dl and 96.40±3.23 mg/dl respectively (P<0.001). Triglyceride (Mean±SE) in cases and controls were 188.50±9.35 mg/dl and 142.85±4.72 mg/dl respectively (P<0.001). Conclusion: This case-control study showed significant differences of serum lipids and lipoproteins (Total cholesterol, HDL cholesterol, LDL cholesterol and triglyceride) in ischemic stroke patients than the controls in our community. Bangladesh Journal of Neuroscience 2014; Vol. 30 (2): 96-103

A prospective evaluation of oral Yunnan Baiyao therapy on thromboleastographic parameters in apparently healthy dogs

2018 ◽  
Vol 28 (3) ◽  
pp. 221-225 ◽  
Author(s):  
Colleen Tansey ◽  
Melissa L. Wiebe ◽  
Gabrielle C. Hybki ◽  
Jeffrey E. Patlogar ◽  
Lisa A. Murphy ◽  
...  
Keyword(s):  
Prospective Evaluation ◽  
Healthy Dogs ◽  
Yunnan Baiyao ◽  
Apparently Healthy

Seasonal variations in binding of 3H-paroxetine to blood platelets in healthy volunteers: Indications for a gender difference

1990 ◽  
Vol 28 (6) ◽  
pp. 509-517 ◽  
Author(s):  
J.-L. Klompenhouwer ◽  
D. Fekkes A.M. ◽  
A.M. van Hulst ◽  
P. Moleman ◽  
L. Pepplinkhuizen ◽  
...  
Keyword(s):  
Gender Difference ◽  
Healthy Volunteers ◽  
Seasonal Variations ◽  
Blood Platelets

scholarly journals Assessment of Gut Microbiota and Selected Blood Parameters in Weaned Piglets Following Supplementation with a Probiotic and Vitamin C

2020 ◽  
Vol 20 (1) ◽  
pp. 179-189
Author(s):  
Leszek Tymczyna ◽  
Beata Trawińska ◽  
Marta Kowaleczko ◽  
Anna Chmielowiec-Korzeniowska ◽  
Jerzy Lechowski
Keyword(s):  
Vitamin C ◽  
Gut Microbiota ◽  
Total Cholesterol ◽  
Hdl Cholesterol ◽  
Blood Parameters ◽  
Control Group ◽  
Weaned Piglets ◽  
E Coli ◽  
Experimental Group ◽  
Control Group Group

AbstractThe aim of the study was to assess the gut microbiota and selected haematological and biochemical blood parameters of weaned piglets following dietary supplementation with a probiotic and vitamin C. the piglets were divided into a control group (group C) and an experimental group (group E), with 30 piglets in each group. All animals received the same feed ad libitum. The animals in the control group (group C) received feed with no added probiotic and vitamin C. the piglets in the experimental group (group E) were given a supplement containing a probiotic (Bacillus cereus 1×109 CFU/kg) in the amount of 1.5 g/piglet/day and vitamin c in the amount of 300 mg/piglet/day. The supplement was administered for 28 days. The total numbers of bacteria of the family Enterobacteriaceae and of the genus Lactobacillus were determined in faeces. The erythrocyte count, haemoglobin level, haematocrit, leukocyte count, and percentages of neutrophils and lymphocytes were determined in the blood. The biochemical analysis concerned the concentration of triacylglycerols, total cholesterol, and LDL and HDL cholesterol. In group E a significant decrease (P<0.01) in the total number of Enterobacteriaceae bacteria was observed in the faeces of the piglets, accompanied by an increase in the number of lactobacilli relative to group C. E. coli was found to predominate over other microorganisms. Salmonella choleraesuis bacteria were present in the faeces of both groups before administration of the supplement, but were not found after its use. The supplement with probiotic and vitamin C caused a significant increase in the erythrocyte, haemoglobin and haematocrit levels in the blood of the piglets and a significant decrease in the concentration of triacylglycerols, total cholesterol and LDL cholesterol.

scholarly journals Effect of increased content of animal protein in feed mixtures based on extruded rice on rearing performance and blood parameters of piglets

2014 ◽  
Vol 14 (1) ◽  
pp. 117-126 ◽  
Author(s):  
Anna Czech ◽  
Jerzy Pastuszak ◽  
Grażyna Kusior
Keyword(s):  
Ldl Cholesterol ◽  
Hdl Cholesterol ◽  
Blood Parameters ◽  
Animal Protein ◽  
Animal Origin ◽  
Blood Levels ◽  
Feed Conversion ◽  
Group Iii ◽  
Group I ◽  
Protein Components

Abstract The aim of this study was to compare the effects of three feed mixtures based on various feed components, including extruded rice, and differing in the source and level of animal protein on rearing performance and biochemical and haematological blood parameters of piglets in the peri-weaning period. The experiments covered 96 piglets, crosses of PIC hybrid sows with a P76 boar that were divided into three experimental groups. The piglets from group I received a prestarter diet based on extruded wheat and protein of both plant and animal origin, whilst those from groups II and III were fed prestarter diets containing: group II - extruded rice (protein as in group I), and group III - extruded rice with protein components of exclusively animal origin. The addition of extruded rice and the increased content of animal protein in feed mixture improved the rearing performance of piglets (higher body weight gains and more efficient feed conversion ratio). The feeding of piglets with the diets containing extruded rice and increased animal protein components (III group) was also observed to stimulate lipid metabolism, which resulted in reduced plasma levels of LDL-cholesterol and in increased percentage of HDL-cholesterol, which contributed to increased blood levels of urea compared to the other experimental groups.

HDL Cholesterol concentrations in healthy volunteers

1994 ◽  
Vol 22 (4) ◽  
pp. 437S-437S
Author(s):  
Paul H Whiting ◽  
John Robertson ◽  
Ronald J Maughan
Keyword(s):  
Healthy Volunteers ◽  
Hdl Cholesterol

scholarly journals Postprandial Hypertriglyceridemia Is Associated with the Variant 54 Threonine FABP2 Gene

2018 ◽  
Vol 5 (3) ◽  
pp. 47 ◽  
Author(s):  
María Garcés Da Silva ◽  
Yamil Guarin ◽  
Yenny Carrero ◽  
Hilda Stekman ◽  
María Núñez Bello ◽  
...  
Keyword(s):  
Intracellular Transport ◽  
Hdl Cholesterol ◽  
Control Group ◽  
Normal Body Mass Index ◽  
Cvd Risk ◽  
Fatty Acid Binding ◽  
Plasma Triglycerides ◽  
Postprandial Hypertriglyceridemia ◽  
Fabp2 Gene ◽  
Apparently Healthy

Purpose: Fasting or postprandial hypertriglyceridemia is considered an independent cardiovascular disease (CVD) risk factor. The intestinal fatty acid binding protein (FABP2) is involved in the intracellular transport and metabolism of fatty acids. The presence of the Ala54Thr polymorphism of the FABP2 gene appears to be involved in postprandial hypertriglyceridemia. We explored the possible association of the Ala54Thr polymorphism with fat intolerance in apparently healthy, fasting, normolipidemic subjects with normal body-mass index and without diabetes. Methodology: A total of 158 apparently healthy individuals were classified as fat tolerant (n = 123) or intolerant (n = 35) according to their response (plasma triglycerides) to an oral abbreviated tolerance test with blood samples taken at 0, 2 and 4 h. At 0 h, all subjects ingested 26.3 g of fats. Presence of the Ala54Thr polymorphism of the FABP2 gene was evaluated by polymerase chain reaction–restriction fragment length (PCR–RFLP). Results: The group with fat intolerance (postprandial hypertriglyceridemia group) showed an increased frequency of the Thr54Thr genotype when compared with the group with normal fat tolerance (control group) (23% vs. 4%, respectively, OR: 16.53, 95% CI: 4.09–66.82, p: 0.0001, pc: 0.0003). Carriers of at least one Thr54 allele were up to six times more prevalent in the fat intolerant group than in the non-carriers. (OR: 6.35; 95% CI: 1.86–21.59, p: 0.0003, pc: 0.0009). The levels of plasma triglycerides (Tg) at 4 h after the test meal were higher in carriers of at least one 54Thr allele than in carriers of the Ala54 allele (p < 0.05). Conclusions: There is a significant association between postprandial hypertriglyceridemia and the presence of at least one 54Thr allele of the FABP2 gene. In addition, subjects with this genotype showed an increased ratio of Tg/HDL-cholesterol. This parameter is a marker of increased CVD risk and insulin resistance.

scholarly journals Assessment of monoethylglycinexylidide as measure of liver function for patients with chronic viral hepatitis

1997 ◽  
Vol 43 (10) ◽  
pp. 1952-1957 ◽  
Author(s):  
Ronald J Elin ◽  
Michael W Fried ◽  
Maureen Sampson ◽  
Mark Ruddel ◽  
David E Kleiner ◽  
...  
Keyword(s):  
Liver Function ◽  
Viral Hepatitis ◽  
Healthy Volunteers ◽  
Prothrombin Time ◽  
Total Bilirubin ◽  
Activity Index ◽  
Chronic Viral Hepatitis ◽  
Significant Difference ◽  
Histology Activity Index ◽  
Apparently Healthy

Abstract The liver metabolizes lidocaine by oxidative deethylation to form monoethylglycinexylidide (MEGX), an analyte proposed as an index of liver function. We determined MEGX and lidocaine serum concentrations with the TDx (Abbott Laboratories) at baseline and 15, 30, 60, and 90 min after the intravenous administration of lidocaine (1 mg/kg), analyzing specimens from 12 apparently healthy volunteers and 40 patients with chronic viral hepatitis diagnosed by liver biopsy and serum tests. The patients were grouped on the basis of the histology activity index. The following laboratory tests were performed on serum specimens from all subjects: albumin (ALB), alanine aminotransferase (ALT), aspartate aminotransferase (AST), alkaline phosphatase, total bilirubin, and prothrombin time. The results showed no significant difference among the four groups for the concentrations of MEGX, lidocaine, and lidocaine/MEGX at the four time points. However, the concentrations of ALB, ALT, AST, AST/ALT, and prothrombin time were substantially different among the four groups. Thus, we conclude that assay of MEGX in our patients with chronic viral hepatitis did not contribute to the assessment of liver function when compared with apparently healthy volunteers and traditional tests of liver function.

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