Approaches to Automating the Dereplication of Bioactive Natural Products—The Key Step in High Throughput Screening of Bioactive Materials From Natural Sources
1997 ◽
Vol 2
(3)
◽
pp. 145-152
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Keyword(s):
The rapid identification of the bioactive component(s) of natural product mixtures in high throughput screening programs has become a critical factor to ensure that this source of diverse chemotypes can compete effectively with chemical compound libraries and combinatorial synthetic efforts. The effective use of automated procedures and databases in the isolation, identification and biological profiling of bioactive compounds will be described. In addition, the potential of new technologies to enhance this process will be discussed as well as the possible reintroduction of TLC as a parallel dereplication method.
2000 ◽
Vol 22
(5)
◽
pp. 149-157
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2002 ◽
Vol 30
(4)
◽
pp. 794-797
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A Fully Automated High-Throughput Flow Cytometry Screening System Enabling Phenotypic Drug Discovery
2018 ◽
Vol 23
(7)
◽
pp. 697-707
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2014 ◽
1998 ◽
Vol 3
(1)
◽
pp. 13-17
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2011 ◽
Vol 16
(9)
◽
pp. 1007-1017
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2001 ◽
Vol 6
(6)
◽
pp. 429-440
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2005 ◽
Vol 10
(4)
◽
pp. 374-382
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2006 ◽
Vol 11
(5)
◽
pp. 481-487
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