Sex-specific risk factors determine the survivorship of female and male patients after metal-on-metal hip resurfacing

2019 ◽  
Vol 30 (3) ◽  
pp. 309-318
Author(s):  
Harlan C Amstutz ◽  
Michel J Le Duff
Keyword(s):  
Risk Factors ◽  
Revision Surgery ◽  
Hip Resurfacing ◽  
Female Group ◽  
Severe Dysplasia ◽  
Preparation Technique ◽  
Contact Patch ◽  
Female Patients ◽  
Specific Risk ◽  
Male Patients

Background: The need for revision surgery after hip resurfacing arthroplasty (HRA) is more prevalent for women than for men. However, there is a paucity of information to explain this observation. We aimed (1) to determine sex-specific risk factors leading to revision surgery; and (2) to correlate these risk factors to the dominant modes of failure of HRA. Methods: 1101 patients (1375 consecutive hips) including 292 women (355 hips) and 809 men (1020 hips) with a mean age of 51.3 years were included regardless of bone quality. The contact patch to rim distance was computed. Results: A contact patch to rim (CPR) distance of ⩽7 mm, an aetiology of developmental dysplasia, a postoperative abduction-adduction arc of ⩾95°, and a metaphyseal stem left uncemented were risk factors associated with revision surgery for female patients, while a CPR distance of ⩽10 mm, a component size of ⩽46 mm, an age at surgery of ⩽55 years, and an early femoral preparation technique were risk factors for male patients. Hips with no risk factors from the female group had a survivorship of 98.7% at 15 years, matching or exceeding the results of all male subgroups. However the risk factors in the female group increased the risk of revision much more than in the male group. Conclusions: In the absence of risk factors, the survivorship of HRA in female patients is equal to that of males. Many female patients can safely benefit from HRA by excluding severe dysplasia and optimising surgical technique.

scholarly journals Female Versus Male Oral Cavity Cancer: is There a Difference?

2020 ◽  
Author(s):  
Yi-Chieh Lee ◽  
Huei-Tzu Chien ◽  
Chi-Kuang Young ◽  
Shy-Chyi Chin ◽  
Andrea Iandelli ◽  
...  
Keyword(s):  
Risk Factors ◽  
Oral Cancer ◽  
Oral Cavity ◽  
Treatment Outcomes ◽  
Tongue Cancer ◽  
Female Group ◽  
Female Ratio ◽  
Female Patients ◽  
Significant Difference ◽  
Male Patients

Abstract Objectives: Oral cavity squamous cell carcinoma (OSCC) is a leading cause of death in Taiwan, and most of the patients are male. Little is known about the differences in risk factors, cancer characteristics and treatment outcomes in female patients. The study aim is to investigate the clinicopathological and outcome differences between gender in patients affected by oral cancer in Taiwan.Methods: This is a retrospective study based on data obtained between 1995 and 2019. A total of 2,046 patients were recruited for analysis. Cancer characteristics, risk factors and treatment outcomes in patients with oral cancer between genders were collected. Results: Female patients represented the 6.7% of the entire cohort of study. Females were diagnosed at an older age and at an earlier local stage compared to male patients (p < 0.001). The female patients were less exposed to cigarette, alcohol, and betel-nut (BQ) (all p-values < 0.001). Tongue (55.1%) was the most frequent subsite involved in the female group, while buccal (38.4%) and tongue (35.3%) were more likely (p < 0.001) to be associated with male gender. In tongue cancer subgroup, female patients presented less frequently extra-nodal extension compared with male patients (p = 0.040). During the follow-up period, there was no significant difference in recurrence and overall deaths between genders.Conclusion:In Taiwan, the male to female ratio in OSCC is 14:1. The tumor subsite distribution, environment exposure and stage distribution are different between females and male. There are no differences in term of survival between female and male OSCC patients.

scholarly journals SND Rs1799889(-) In The Promotor Of The Plasminogen Activator Inhibitor-1 Gene Contributes To The Risk Of DVT In Women

2015 ◽  
Vol 8 (2) ◽  
pp. 124-132
Author(s):  
Regina S. Komsa-Penkova ◽  
Georgi M. Golemanov ◽  
Boris D. Cankov ◽  
Lubomir C. Beshev ◽  
Petar D. Ivanov ◽  
...  
Keyword(s):  
Risk Factors ◽  
Young Women ◽  
Significant Contribution ◽  
Plasminogen Activator Inhibitor ◽  
Plasminogen Activator Inhibitor 1 ◽  
Female Patients ◽  
Chi Squared ◽  
Male Patients ◽  
Activator Inhibitor ◽  
Pai 1

Summary The incidence of deep venous thrombosis (DVT) depends on the specific genotype, inheritance of prothrombotic polymorphisms and the influence of environmental risk factors. Rs1799889(-) polymorphism in the promotor of PAI-1 gene has been described as a risk factor for hypercoagulable state. Objective: To evaluate the contribution of thrombophilic rs1799889 (-) in the promotor of PAI-1 gene on the incidence of DVT in women and men in groups below and above 45 years of age. Тhere was significantly higher rs1799889 (-) polymorphism carriage among female patients with DVT vs controls (Chi squared =5.506, OR=2.170, p=0.021) but not in male patients (Chi squared =0.090 OR=1.147, p=0.825). A significant contribution of rs1799889 (-) polymorphism to early onset of the disease was found in female patients aged 45+ and carriers of the polymorphism (Chi squared =7.476, p=0.006), but not in young women.

scholarly journals Prevalence and risk factors for bone loss in Southern Chinese with rheumatic diseases

2020 ◽  
Author(s):  
Zhuoran Hu ◽  
Shuiming Xu ◽  
Qingyuan Yang ◽  
Jun Qi ◽  
He Lin ◽  
...  
Keyword(s):  
Risk Factors ◽  
Bone Mineral Density ◽  
Bone Loss ◽  
Bone Mineral ◽  
Young Patients ◽  
Mineral Density ◽  
Female Patients ◽  
Southern Chinese ◽  
Male Patients ◽  
Rheumatic Patients

Abstract Objectives: This study is to explore the prevalence of different stages of bone loss and the potential risk factors in rheumatic patients.Method: A cross-sectional study recruits 1,398 rheumatic patients and 302 healthy subjects. Demographic data, blood, and bone mineral density (BMD) tests are collected. Risk factors for bone loss in rheumatic patients are analyzed by logistic regression.Results: (1) Rheumatic patients are consisted of 40.0% rheumatoid arthritis (RA), 14.7% systemic lupus erythematosus (SLE), 14.2% osteoarthritis (OA), 9.2% ankylosing spondylosis (AS), 7.9% gout, 7.0% primary Sjogren syndrome (pSS), 3.8% systemic sclerosis (SSc), and 3.2% mixed connective tissue disease (MCTD). (2) In male patients aged under 50 and premenopausal female patients, the bone mineral density score of AS (53.9%, P<0.001) and SLE (39.6%, P=0.034) patients is lower than the healthy controls (18.2%). (3) Osteopenia and osteoporosis are more prevailing in male patients aged or older than 50 and postmenopausal female patients with RA (P<0.001), OA (P=0.02) and SLE (P =0.011) than healthy counterparts. (4) Those with SLE, RA and AS gain the highest odd ratio of ‘score below the expected range for age’, osteopenia and osteoporosis, respectively. (5) Age, female, low BMI and hypovitaminosis D are found negatively associated with bone loss. Dyslipidemia and hyperuricemia could be protective factors.Conclusion: Young patients with AS and SLE have a significant higher occurrence of bone loss, and older patients with RA, OA and SLE had higher prevalence than healthy counterparts. SLE, RA, SSc and AS were founded significant higher risks to develop into bone loss after adjustment. Age, BMI and gender were commonly-associated with bone loss in all age-stratified rheumatic patients. These findings were not markedly different from those of previous studies.

Association of specific risk factors for osteoporosis in Saudi female patients referred from DEXA scan in Riyadh city

2019 ◽  
pp. 353-357
Author(s):  
Ghada Gouhar ◽  
Rajaa Tamimm ◽  
Weam Alhemaidi ◽  
Nouf Abdulwahed ◽  
Kholoud Alharbi ◽  
...  
Keyword(s):  
Risk Factors ◽  
Dexa Scan ◽  
Female Patients ◽  
Riyadh City ◽  
Specific Risk

scholarly journals Study of Gender-based In-Hospital Mortality Difference in Patients with Acute Myocardial Infarction

2018 ◽  
Vol 32 (2) ◽  
pp. 119-124
Author(s):  
NK Majumder ◽  
MR Khan ◽  
Nupur Kar ◽  
M Akhtaruzzaman ◽  
TA Choudhury ◽  
...  
Keyword(s):  
Myocardial Infarction ◽  
Acute Myocardial Infarction ◽  
Hospital Mortality ◽  
Female Group ◽  
Male Counterpart ◽  
Factors Affecting ◽  
Female Patients ◽  
Significant Difference ◽  
Male Patients ◽  
Gender Based

Background: In-hospital mortality in female patients with acute myocardial infarction (AMI) and factors affecting this may be different from those of their male counterpart. The aim of the current study was to compare the in-hospital mortality between female and male patients with AMI and to compare the differences in age, risk factors, treatment given and complications between them.Methods: Total 200 nonrandomised patients with a definite diagnosis of AMI admittedover a period of one year (January 2008 - December 2008) were enrolled in the study, in which 100 female patients were considered as cases and 100 male patients as controls. Both groups were studied prospectively.Datawere collected in prefixed questionnaire and data sheet and were analysed using SPSS software.Results: mean age of the female patients was significantly higher than that of their male counterpart (57.0±10.1 years and 53.3±10.3 years respectively, p=0.029). Diabetes mellitus and hyperlipidemia were significantly higher in females than those in males (39% vs 24%, p=0.022 and 45% vs 32%, p=0.040 respectively), while smoking was staggeringly higher among the males (59%) compared to the females (4%) (p<0.001). However, no significant difference was observed between the groups in terms of hypertension (p=0.666).Pre-hospital delay (more than 12 hours after onset of chest pain) was significantly higher in the female group than that in the male group (72% vs 58%,p=0.038). Streptokinase was significantly underused in females (15.6%) compared to that used in males (32.2%) (p=0.011). The use of b-receptor blockerswas also significantly less in females than that in males (63% vs 75%, p=0.046).Death was significantly higher in the females (21%) than that in the males (10%) (p=0.032). Unstable angina, re-infarction and congestive heart failure were somewhat higher in the female subjects compared to their male counterparts (40% vs 34%, 2% vs 1% and 32% vs 23% respectively) though the differences did not seem significant (p=0.380, p=0.561 and p=0.154 respectively). Arrhythmias did not differ significantly between the groups (p1>0.05).Conclusion: Female patients with AMI had significantly higher in-hospital mortality. Early hospitalization and optimal treatment are crucial to decrease mortality in female patients.Bangladesh Heart Journal 2017; 32(2) : 119-124

scholarly journals A Retrospective Cohort Study of Oral Leukoplakia in Female Patients—Analysis of Risk Factors Related to Treatment Outcomes

2021 ◽  
Vol 18 (16) ◽  
pp. 8319
Author(s):  
Shih-Wei Yang ◽  
Yun-Shien Lee ◽  
Pei-Wen Wu ◽  
Liang-Che Chang ◽  
Cheng-Cheng Hwang
Keyword(s):  
Risk Factors ◽  
Treatment Outcomes ◽  
Malignant Transformation ◽  
Carbon Dioxide Laser ◽  
Postoperative Recurrence ◽  
Clinicopathological Characteristics ◽  
Oral Leukoplakia ◽  
Female Patients ◽  
Significant Difference ◽  
Male Patients

Background: The aim of this study was to make a comparison of clinicopathological characteristics of oral leukoplakia between male and female patients following carbon dioxide laser excision for oral leukoplakia and analyze the factors associated with the treatment outcomes in female patients. Methods: Medical records of patients with oral leukoplakia receiving laser surgery from 2002 to 2020 were retrospectively reviewed and analyzed statistically. Results: A total of 485 patients were enrolled, including 412 male (84.95%) and 73 female (15.05%). Regarding the locations, the predilection site of oral leukoplakia in male patients was buccal mucosa (p = 0.0001) and that for women patients was tongue (p = 0.033). The differences of recurrence and malignant transformation between both sexes were not significant (p > 0.05). Among female patients, area of oral leukoplakia was the risk factor related to recurrence (p < 0.05). Clinical morphology and postoperative recurrence were the risk factors related to malignant transformation (p < 0.05). Conclusions: In comparison with male patients, there was no significant difference of the postoperative recurrence and malignant transformation of oral leukoplakia in female patients. Among the female patients, clinicians should pay more attention to large-sized and non-homogeneous leukoplakia, and postoperative recurrent lesions.

Incidences and risk factors for post--dural puncture headache after neuraxial anaesthesia: A national inpatient database study in Japan

2020 ◽  
Vol 48 (5) ◽  
pp. 381-388
Author(s):  
Kanako Makito ◽  
Hiroki Matsui ◽  
Kiyohide Fushimi ◽  
Hideo Yasunaga
Keyword(s):  
Risk Factors ◽  
Spinal Anaesthesia ◽  
Epidural Anaesthesia ◽  
Dural Puncture ◽  
Academic Hospital ◽  
Post Dural Puncture Headache ◽  
Factors Associated ◽  
Female Patients ◽  
Neuraxial Anaesthesia ◽  
Male Patients

The reported incidence of post--dural puncture headache (PDPH) after neuraxial anaesthesia varies widely, depending on patient and procedural risk factors. Most previous studies have had small sample sizes and focused on obstetric patients. This study aimed to investigate the incidence of PDPH and factors associated with PDPH in non-obstetric and obstetric patients after neuraxial anaesthesia. We identified patients who underwent surgery with neuraxial anaesthesia between July 2010 and December 2017 from a Japanese nationwide inpatient administrative claims and discharge database. Factors associated with PDPH (body mass index (BMI), depression, spinal abnormalities, academic hospital and location of epidural anaesthesia) were examined using multivariable logistic analyses. The incidence of PDPH in non-obstetric patients after spinal anaesthesia, epidural anaesthesia and combined spinal epidural anaesthesia was 0.16%, 0.13% and 0.23% and in obstetric patients was 1.16%, 0.99% and 1.05%, respectively. Higher BMI was associated with decreased incidence of PDPH in non-obstetric patients receiving spinal anaesthesia and obstetric patients receiving epidural anaesthesia. In female patients receiving spinal anaesthesia, a history of depression was associated with increased incidence of PDPH. Being in an academic hospital was associated with decreased incidence of PDPH in male patients receiving spinal anaesthesia and female patients receiving spinal or epidural anaesthesia, but increased incidence of PDPH in male patients receiving epidural anaesthesia. Lumbar epidural anaesthesia was associated with increased incidence of PDPH in male patients, but decreased incidence of PDPH in obstetric patients compared with thoracic epidural anaesthesia. The present study identified several potential new risk factors for PDPH, and revealed that the incidence of PDPH in non-obstetric patients after neuraxial anaesthesia was lower than in obstetric patients.

Risk Factors of Carpal Tunnel Syndrome for Male Patient Undergoing Carpal Tunnel Release

2018 ◽  
Vol 50 (05) ◽  
pp. 335-340
Author(s):  
Jun-Ku Lee ◽  
Soo-Hyun Lee ◽  
Banghyun Kim ◽  
Kyunghun Jung ◽  
Inkeun Park ◽  
...  
Keyword(s):  
Risk Factors ◽  
Carpal Tunnel Syndrome ◽  
Carpal Tunnel ◽  
Fluid Balance ◽  
Occupational Risk ◽  
Occupational Risk Factors ◽  
Factors Associated ◽  
Female Patients ◽  
Tunnel Syndrome ◽  
Male Patients

Abstract Introduction Although the major cause of carpal tunnel syndrome (CTS) remains idiopathic, many male CTS patients are clinically different from female patients and often have specific risk factors associated with their conditions. An accurate analysis of such propensity has yet to be established. The purpose of this study is to compare male and female patients by analyzing the risk factors associated with CTS patients who underwent surgical treatment, with focus on their occupation. Patients/Material and Methods retrospective chart review of 818 patients with CTS was performed to identify the associated risk factors. Patients were stratified by gender: female (n = 707, 86.4 %) and male (n = 111, 13.6 %). The mean patient age was 54.5 (range: 16–85 yr.) for all groups. The medical history and risk factors of each patient was thoroughly reviewed by medical charts and telephone survey. We categorized the risk factors of CTS into 7 categories: anatomic, neuropathic, inflammatory, alteration of fluid balance, distal radius fracture associated, occupational risk factor related, and idiopathic. Occupations of CTS patients were divided into high risk occupations (vibratory tools, assembly jobs, and food processing and packaging jobs, and other occupations of repetitive wrist motion and forceful gripping) and nonrisk occupations. All variables were analyzed with chi-square or Fisher’s exact test for differences between men and women. Results The number of individuals with known risk factors of CTS was greater in male, compared to that of female patients; 97 (87.4 %) male patients had the risk factors of CTS, while 361 (51.1 %) female patients (p < 0.001) did. In subgroup analysis of risk factors, male patients had frequent risk factors in neuropathic, inflammatory, and alteration of fluid balance (p < 0.001). Occupational risk was strongly associated with male gender (p < 0.001). Conclusion Male CTS patients who underwent surgery are more likely to have a reason and have many occupational risk factors than women.

scholarly journals Cerebrovascular insult hospital cases in West Hercegovina Canton from 1998 to 2002

2005 ◽  
Vol 5 (2) ◽  
pp. 49-52
Author(s):  
Ivan Vasilj ◽  
Semra Čavaljuga ◽  
Tomo Lučić ◽  
Ferdo Kvesić
Keyword(s):  
Risk Factors ◽  
Epidemiological Study ◽  
Medical Documentation ◽  
Clinical Hospital ◽  
Female Patients ◽  
National Insurance ◽  
Male Patients ◽  
Cerebrovascular Insult

Analysis of a cerebro-vascular insult hospitalised cases from West Herzegovina Canton as a retrospective epidemiological study was done in Clinical hospital Mostar for the period from 1998 to 2002. The major source of data was medical documentation of this hospital, the only hospital for the treatment of 88,257 inhabitants from this Canton. The study included a total of 393 cerebro-vascular insult cases from this Canton treated in the Clinical hospital Mostar Among them 189 (48.1%) were male patients, while 204 (51.9%) cases were female. The majority of the cases were above 50 years of life. Majority of treated female patients were older then 65, while among male patients the majority were between 50 and 65 years old. The least number of cases was under 50 years in both groups. During the same period risk factors research for entire FBiH was performed on the sample of 2,750 national insurance holders. Out of them 1.7% was found to suffer of cerebro vascular insult.

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