scholarly journals Clinical Presentation of Patients Infected with Coronavirus Disease 19: A Systematic Review

2020 ◽  
Vol 13 ◽  
pp. 117863372095207
Author(s):  
Tadesse Sheleme ◽  
Firomsa Bekele ◽  
Tasissa Ayela
Keyword(s):  
Systematic Review ◽  
English Language ◽  
Clinical Symptoms ◽  
Case Series ◽  
World Health ◽  
Cross Sectional ◽  
Sputum Production ◽  
Novel Coronavirus ◽  
Health Organization ◽  
Study Designs

Background: The coronavirus disease-19 has been labeled a pandemic by World Health Organization. By virtue of its highly contagious attribution, this virus has spread across over the world and the numbers are still rapidly increasing. Increasing numbers of confirmed cases and mortality rates of coronavirus disease 2019 are occurring in several countries. The aim of this systematic review was to summarize clinical presentations of this newly emerging coronavirus disease. Methods: A systematic review of published articles was conducted using databases such as PubMed, Scopus, and Google Scholar. A search was conducted on 18 to 25 April 2020. Search terms included “novel coronavirus,” “2019 novel coronavirus,” “Coronavirus disease 2019,” “COVID-19,” “severe acute respiratory syndrome coronavirus 2.” The studies published in the English language and their full texts available were included. The eligible study designs were cross-sectional, case-control, cohort, and case series. Results: Thirty (30) studies which contain 4829 participants were included in this review. From included studies, the age of infected patients were found in range 0.25 to 94 years. The main clinical symptoms of COVID-19 patients were fever (77.6%), cough (64.8%), fatigue (27.2%), dyspnea (21.2%) and sputum production (18.0%). Conclusion: This systematic review identified that fever, cough, fatigue, and dyspnea were the most common reported clinical features of coronavirus disease 19. Understanding of the clinical spectrum and impact of this novel disease is important for all individuals, especially for healthcare workers to manage and prevent it.

Is SARS-CoV-2 transmitted by asymptomatic and pre-symptomatic infected individuals?

2021 ◽  
Vol 54 ◽  
Author(s):  
Abigail F. Melicor ◽  
Katrina Loren R. Rey ◽  
Leonila F. Dans
Keyword(s):  
Case Reports ◽  
Case Series ◽  
The Philippines ◽  
World Health ◽  
Current Evidence ◽  
Wide Confidence Interval ◽  
Cross Sectional ◽  
Viral Shedding ◽  
Asymptomatic Patients ◽  
Health Organization

KEY FINDINGSAsymptomatic and pre-symptomatic transmission of SARS-CoV-2 may occur.• Manifestations of COVID-19 are highly varied and may include asymptomatic cases, who do not manifest with anysigns and symptoms despite testing positive for COVID-19 by viral nucleic acid tests. Pre-symptomatic cases areinfected individuals who are still in their incubation period, hence do not exhibit any symptoms yet but eventuallydevelop symptoms.• As of June 2020, only 586 (2.8%) of the 20,990 active cases in the Philippines were classified as asymptomatic,but it is unclear whether cases are pre-symptomatic or carriers (true asymptomatic).• Based on 36 observational studies (case reports, case series, cross-sectional and cohort studies) and 9 statisticalmodeling analysis, asymptomatic and pre-symptomatic transmission of SARS-CoV-2 may occur. However, 3studies reported no transmission from pre-symptomatic and asymptomatic cases.• Studies on viral load comparing symptomatic cases with pre-symptomatic and asymptomatic cases reportedcontradicting results. The duration of viral shedding was significantly longer for symptomatic patients comparedto asymptomatic patients but similar for asymptomatic and pre-symptomatic patients.• Therewas no difference in the transmission rates of symptomatic and asymptomatic cases. However,the estimatedinfectivity and probability of transmission was higherfor symptomatic cases compared to asymptomatic cases, butresults were imprecise due to a wide confidence interval.• The World Health Organization (WHO) and Centers for Disease Control and Prevention (CDC) recognize thepossibility of pre-symptomatic and asymptomatic transmission. According to WHO, current evidence suggestsasymptomatic cases are less likely to transmit the virus than symptomatic cases.

scholarly journals Evaluating Trauma Care Capabilities using the Essential Trauma Care Guidelines of the World Health Organization

2021 ◽  
Author(s):  
Aisha Al Balushi ◽  
Zaleikha Al Balushi ◽  
Asma Ali Al Salmani
Keyword(s):  
World Health Organization ◽  
Trauma Care ◽  
English Language ◽  
Health Centre ◽  
Medical Officer ◽  
Health Resources ◽  
World Health ◽  
National Guidelines ◽  
Cross Sectional ◽  
Health Organization

Objectives: This study aimed to evaluate trauma care capabilities at the primary care level in Muscat, Oman, using World Health Organization guidelines. Methods: This descriptive cross-sectional study was conducted between January and March 2015 at eight primary health centres in Seeb. An English-language questionnaire was distributed to the medical officer or nurse in charge at each centre to determine the number of staff, total population being served, number of emergency trauma cases and availability of ambulances. Subsequently, 10 doctors from each health centre were randomly selected to assess the availability of physical resources as well as their trauma skills and knowledge. Results: There were limited physical and human resources for the management of trauma and a complete absence of trauma administrative functions, such as local trauma registries or quality improvement activities. Conclusion: This study highlighted the need to introduce national guidelines and improve the delivery of trauma services in Oman. Keywords: Primary Healthcare; Trauma; Emergency Medicine; Capacity Building; Health Resources; Delivery of Health Care; Oman.

scholarly journals Respiratory Viral Co-infection with Novel Coronavirus in Children: A Case Series

2020 ◽  
Author(s):  
Emily Hertzberg ◽  
C. Anthoney Lim ◽  
Erick Eiting ◽  
Steven Yung ◽  
Jeranil Nunez ◽  
...  
Keyword(s):  
Clinical Presentation ◽  
Case Series ◽  
Respiratory Viruses ◽  
World Health ◽  
Clinical Implications ◽  
The Novel ◽  
Global Pandemic ◽  
Surgical Evaluation ◽  
Novel Coronavirus ◽  
Health Organization

Abstract Background:The novel coronavirus, COVID-19 was identified in January 2020 initially in Wuhan, China but quickly spread worldwide and was declared a global pandemic by the World Health Organization on March 11, 2020. There are more than 185 countries impacted and the numbers of cases and deaths continues to rise. The rate of coinfections with COVID-19 in children and the clinical implications are unknown.Case Presentation:We describe the clinical presentation and course of three patients with COVID-19 and coinfections with other common respiratory viruses. Two cases were diagnosed with COVID-19 as well as rhinovirus/enterovirus and the third case was COVID-19 and pertussis. Each case had a unique presentations and hospital courses including an emergency room discharge, urgent surgical evaluation and an intensive care unit admission.Conclusions:This is the first US-based case report to discuss coinfections with COVID-19 and other respiratory viruses. Decisions regarding diagnosis and management of children in the setting of the current pandemic should account for the possibility of coinfections. We also highlight publish health challenged resulting from children with the novel coronavirus.

scholarly journals Use of Low-Molecular-Weight Heparin and Peak anti-Xa Monitoring In Severe SARS-CoV-2 Disease: A Brief Report

2020 ◽  
pp. 001857872095415
Author(s):  
Rebecca Toor ◽  
Francis J. Zamora ◽  
Naaz Fatteh ◽  
Nathan Drexler ◽  
Jose Lozada
Keyword(s):  
Low Molecular Weight Heparin ◽  
Anticoagulation Therapy ◽  
Case Series ◽  
World Health ◽  
Low Molecular Weight ◽  
The World ◽  
Novel Coronavirus ◽  
Health Organization ◽  
Level Monitoring ◽  
D Dimer

In 2019, a novel coronavirus was identified in Wuhan, China. This strain was classified as a pandemic in early 2020 by the World Health Organization (WHO), rapidly reaching millions of cases worldwide and overwhelming intensive care units. One distinct feature identified in severe SARS-CoV-2 is abnormal and complex coagulation and hematologic abnormalities, including significantly elevated D-dimer and fibrin/fibrinogen values possibly increasing morbidity and mortality in this patient population. Aggressive anticoagulation therapy with appropriate peak anti-Xa level monitoring has produce satisfactory results at our institution. Our intent is to present a case series of our strategy to highlight the benefits of this approach.

scholarly journals ASSESS THE AWARENESS AND ATTITUDE REGARDING PREVENTION OF CORONAVIRUS DISEASE 2019

2020 ◽  
pp. 95-98
Author(s):  
SAHBANATHUL MISSRIYA MA ◽  
SUHAIL HASSAN
Keyword(s):  
Negative Attitude ◽  
Sampling Technique ◽  
World Health ◽  
Cross Sectional ◽  
Public Authorities ◽  
The People ◽  
Study Results ◽  
Novel Coronavirus ◽  
Health Organization ◽  
The Impact

Objective: Coronavirus disease is the first pandemic caused by a novel coronavirus. The World Health Organization announced a name for the novel coronavirus disease 2019 (COVID-19). This epidemic must stop, contain, control, delay, and reduce the impact of this virus by the people at every opportunity. Every person has the responsibility to contribute, to protect themselves, to protect others, whether in the home, the community, the health-care system, the workplace, or in the transport system. The study was aimed to assess the level of awareness and attitude regarding the prevention of novel coronavirus disease among people and to associate the knowledge level about the prevention of novel coronavirus disease with selected demographic variables of people. Methods: A cross-sectional descriptive design was adopted. Using a convenient sampling technique, 950 samples were selected. The data were collected, analyzed in terms of both descriptive, and inferential statistics. Results: The study results showed that among the total number of people (950) surveyed, 499 (52.6%) were having poor knowledge, whereas 348 (36.6%) were having an average level of knowledge and 103 (10.8%) were showing good knowledge regarding prevention of COVID-19. Some of the people (40.7%) had a negative attitude on the overall aspects of COVID-19 prevention. Conclusion: The study concluded that there were inadequate awareness and poor attitude among the people about coronavirus diseases, and hence there is a need to create awareness through campaigns by public authorities and media.

scholarly journals Compliance and Surgical Team Perceptions of WHO Surgical Safety Checklist; Systematic Review

2016 ◽  
Vol 101 (1-2) ◽  
pp. 35-49 ◽  
Author(s):  
Laltaksh Wangoo ◽  
Robin A. Ray ◽  
Yik-Hong Ho
Keyword(s):  
Systematic Review ◽  
English Language ◽  
Implementation Strategies ◽  
World Health ◽  
Surgical Team ◽  
Initiation Rate ◽  
Surgical Safety Checklist ◽  
Surgical Safety ◽  
Checklist Implementation ◽  
Health Organization

This systematic review aimed to assess surgical safety checklist compliance and evaluate surgical team perceptions and attitudes, post-checklist implementation in the operating room. The World Health Organization (WHO) surgical safety checklist (SSC) has decreased complications and mortality. However, it is unclear whether this reduction is influenced by the vicarious enhancement in teamwork, communication, and staff awareness established by SSC implementation. The preferred reporting items for systematic reviews and meta-analyses model of review guided a search across MEDLINE, PubMed, and Embase databases. English-language studies using any adapted form of the WHO-SSC in operating rooms were reviewed by abstract and full text. Twenty-six studies, 13 assessing SSC compliance and 13 investigating surgical team perceptions of SSC, were evaluated. Compliance studies showed a checklist initiation rate of >90%, but actual observed completion rate varied widely across studies. Sign out was the most poorly performed phase of the checklist (<50%) with time out being the best. Verification of patient identity and procedure demonstrated a high degree (>90%) of compliance across studies, but “verification of team-members” was significantly less compliant. Studies assessing surgical team perceptions found that SSC improved participants' perception of teamwork, communication, patient safety, and staff awareness of adverse events. However, when stakeholders placed differing degrees of importance on SSC completion, results indicated the SSC might actually antagonize team relationships. SSC compliance varies significantly across studies, being highly dependent on staff perceptions, training, and effective leadership. Surgical teams have positive perceptions of SSC; thus with effective implementation strategies, compliance rates across all phases can be substantially improved.

scholarly journals Association of hearing loss in the patients with treated with lamivudine: a systematic review protocol

2020 ◽  
Vol 7 (4) ◽  
pp. 262
Author(s):  
Kalpesh Joshi ◽  
Mahesh Belhekar
Keyword(s):  
Systematic Review ◽  
Hearing Loss ◽  
English Language ◽  
Case Series ◽  
World Health ◽  
Study Cohort ◽  
Lamivudine Therapy ◽  
Screening Process ◽  
Manual Search ◽  
Cochrane Reviews

<p class="abstract"><strong>Background:</strong> Hearing loss has been reported with lamivudine therapy. The World Health Organization (WHO) international database of suspected adverse drug reactions (Vigibase) prioritised clinical review of lamivudine and hearing loss in 2015. This manuscript provides the details of research protocol for a systematic review of association of lamivudine with hearing loss.</p><p class="abstract"><strong>Methods: </strong>English-language publications that assess hearing loss within patients who are receiving lamivudine therapy will be included. All study types like clinical trial designs, case-control study, cohort study, retrospective study, case-series or a case report will be included. Preclinical studies, studies enrolling patients with known differential diagnosis such as presbycusis etc will be excluded. Electronic databases (PubMed, Cochrane reviews, Embase and Google scholar), international clinical trials registry, clinicaltrials.gov and pharmaceutical company clinical study registries will be searched for key words related to lamivudine and hearing loss. After a thorough electronic/manual search of manuscript they will undergo a screening process and selected articles will be assessed for risk of bias using online ROBINS-I tool. We will explore outcomes as an observational systematic review.</p><p class="abstract"><strong>Conclusions:</strong> This review will provide detailed benefit-risk analysis of lamivudine with respect to hearing loss in patients with chronic conditions such as Human immunodeficiency virus (HIV) and Hepatitis B virus (HBV) infection.</p><p class="abstract"><strong>Trial Registration:</strong> PROSPERO registration number is CRD42018112205.0.001.</p>

scholarly journals Knowledge and awareness on usage of mouth masks among dental fraternity during this pandemic COVID-19: A cross-sectional study

2020 ◽  
Vol 11 (6) ◽  
pp. 9-14
Author(s):  
Ravichandra Ravi ◽  
Srividya Athkuri ◽  
Charishma Chowdary Ponugubati ◽  
Roopesh Borugadda ◽  
Sahithi Pamidimukkala ◽  
...  
Keyword(s):  
Infection Control ◽  
Cross Sectional Study ◽  
Control Measures ◽  
World Health ◽  
Global Public Health ◽  
Cross Sectional ◽  
Infection Control Measures ◽  
Significant Difference ◽  
Novel Coronavirus ◽  
Health Organization

Background: The pandemic caused by novel coronavirus (SARS-CoV-2) in Wuhan, China, in December 2019 is a highly infectious disease. The World Health Organization (WHO) has declared the outbreak of Corona Virus Diseases (COVID 19) as a global public health emergency. Currently, research on novel coronaviruses is still in the primary stage. Aims and Objective: The aim of this study is to assess knowledge and awareness on the usage of mouth masks among dental fraternity during this pandemic COVID-19. Materials and Methods: A total of 507 dentists from the Andhra Pradesh (India) region completed a questionnaire-based survey on knowledge, awareness, and infection control measures, such as usage of mouth masks during the pandemic COVID -19. The questionnaire was tailored from the guidance and the information provided for healthcare workers issued by the US Centres for Disease Control and Prevention (CDC). A suitable sampling method was used for the collection of data, and the distribution of responses was presented as percentages. Explanatory statistics were performed for all groups based on the percentage of correct responses. Results: A total of 530 participated in the survey, out of which 507 dentists completely answered the survey, and the response rate was 95.6%. Among the respondents, general practitioners and postgraduates accounted for 58.8% and 41.2%, respectively. There was a statistically significant difference for all the questions solicited among the respondents. General or private practitioners seem to be more aware than postgraduates, as they have answered correctly (>65%) for almost all the questions. Conclusion: The inputs from the study help us to throw some light and fill up space where required. There is a specific and strong need to implement periodic educational programmes and training sessions on infection control practices for COVID-19 among dentists in particular.

scholarly journals COVID-19 Vaccines Programs: adverse events following immunization (AEFI) among medical Clerkship Student in Jember, Indonesia

2021 ◽  
Vol 22 (1) ◽  
Author(s):  
Supangat ◽  
Elly Nurus Sakinah ◽  
Muhammad Yuda Nugraha ◽  
Tegar Syaiful Qodar ◽  
Bagus Wahyu Mulyono ◽  
...  
Keyword(s):  
Adverse Events ◽  
Booster Dose ◽  
Cross Sectional Study ◽  
World Health ◽  
Chi Square ◽  
Cross Sectional ◽  
Care Workers ◽  
Chi Square Test ◽  
Novel Coronavirus ◽  
Health Organization

Abstract Introduction Coronavirus Disease (COVID-19) caused by Novel Coronavirus named as Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-CoV-2) was declared Pandemic by The World Health Organization (WHO) and a Public Health Emergency of International Concern (PHEIC) on January 30, 2020. Many COVID-19 vaccines have been developed, including CoronaVac vaccines by Sinovac. Health care workers, along with medical clerkship students are the priority to receive the vaccine. However, the Adverse Events Following Immunization (AEFI) of the CoronaVac remains unclear. This study aims to describe and analyze the adverse events following immunization (AEFI) of COVID-19 vaccination in medical students in clerkship programs. Method We conducted a cross-sectional study using a questionnaire to assess AEFI after CoronaVac vaccination among medical clerkship students. A Chi-Square test with 95 % of CI was used to determine whether gender correlated with symptoms of AEFI. Result We identified 144 medical clerkship students. The most common AEFI of SARS-CoV-2 vaccinations was localized pain in the injection site during the first dose with 25 (45 %) reports and the booster dose with 34 (67 %) reports. Then followed by malaise, the first dose with 20 (36 %) reports and the booster dose with 21 (41 %) reports. Other symptoms like headache, fever, shivering, sleepiness, nausea, dysphagia, and cold were also reported. Conclusions CoronaVac SARS-COV-2 vaccine has several mild symptoms of AEFI and not correlated with gender. Nevertheless, follow-up after vaccination is needed to prevent immunologic responses that may occur in some patients.

scholarly journals COVID-19 Seroepidemiology Study of Yazd Province, First Peak, Spring 2020: A Population-Based Cross-Sectional Study

2021 ◽  
Author(s):  
Mohammad Reza Mirjalili ◽  
Seyedeh Mahdieh Namayandeh ◽  
Mohammad Hasan Lotfi ◽  
Mohammad Reza Dehghani ◽  
Mohsen Mirzaei ◽  
...  
Keyword(s):  
Clinical Symptoms ◽  
Population Based ◽  
Cross Sectional Study ◽  
World Health ◽  
Chi Square ◽  
Cross Sectional ◽  
First Case ◽  
History Of ◽  
Health Organization ◽  
Chi Square Analysis

Introduction: SARS-COV 19 is a new coronavirus that was reported first time in 30 December 2019 in Wuhan, China. The first case of coronary heart disease in Iran was reported with a definitive test on February 18 in Qom province and the first case in Yazd province on 24 February. The World Health Organization (WHO) declared a Covid infection on March 11 a pandemic. The aim of this study was to investigate the seroepidemiology of COVID 19 in Yazd province. Methods: The present study was a cross-sectional population-based study of seroepidemiological type that was conducted to investigate the serological prevalence of Covid-19 in the period of 3 to 20 May 2020 in Yazd Province. Sampling was clustered and it was without age and sex restrictions. Information was collected including demographic information, adherence to health protocols, and history of clinical symptoms of COVID 19."Pishtaz ELISA Kit" was used to evaluate the IgG and IgM antibody titers against Covid 19. Chi-square, analysis of variance and T tests were used via SPSS.version.16 software Results: Mean age of the participants was 34.3± 17.5. Among the study participants, 507 (54.5%) were women. The serological prevalence of definite cases was 14.91% (95% CI: 12.91-16.91%) and suspicious cases were 2.85% (95% CI:1.85-3.85%). Ardakan City with 32% had the highest and Taft, Mehriz, Khatam with 7% had the lowest prevalence of COVID 19 (P <0.05). Conclusion: By June 2020, nearly 18% of the population of the province was definitively or suspiciously infected with COVID 19. Unfortunately, up to 25% of the population does not follow the early prevention protocols of COVID 19.

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