scholarly journals Single Center Experience of Sirolimus Therapy in Head and Neck Low-flow Vascular Malformations

2021 ◽  
pp. 153857442110103
Author(s):  
Calver Pang ◽  
Nicholas Evans ◽  
Poonam Jethwa ◽  
Anthie Papadopoulou ◽  
Mohamed Khalifa ◽  
...  

Objective: Recently, studies have shown that sirolimus is clinically efficacious in the treatment of some low-flow vascular malformations (LFVM). This study aimed to assess the efficacy and safety of sirolimus in treating complex head and neck (H&N) LFVM that were challenging and/or refractory to standard treatment. Methods: Each patient had baseline and 6-months assessments consisting of clinical history and examination, quality of life (QoL) questionnaires, laboratory investigations, MRI and medical photography. Patients were followed up 1-week and then 1-monthly for 6-months. Wilcoxon signed-rank test was used to compare pre-and 6-months treatment in all 8 domains of RAND 36-Item Short Form Health Survey (SF-36), hospital anxiety and depression scale (HADS), and visual analog score for pain (VAS-P). P < 0.05 was considered significant. Results: Seven patients (median age 43 years, range 23-65 years) were recruited. Six patients completed the six-months course of therapy with 1 patient withdrawing due to intolerable side effects. All six patients reported reduction of swelling with and without other symptom improvement related to the vascular malformations while on treatment. However, at 1-month review after discontinuation of sirolimus, 5 patients reported return of initial symptoms. Overall, patients demonstrated an improvement in QoL six-months treatment but there was no statistical significance (P > 0.05) in all 8 domains of SF-36, HADS and VAS-P. Five patients demonstrated a minimum 10% decrease in lesion size six-months treatment (median 21%, range 13-40%). A Wilcoxon signed-rank test showed that sirolimus treatment did elicit a statistically significant change in lesion size in either direction (Z = -1.992, P = 0.046). The most common side effects found were dyslipidaemia (n-4) and mouth ulcers (n = 2). Conclusion: In our preliminary experience, sirolimus is effective and safe in treating patients with complex H&N LFVM. This provides an alternative treatment where standard treatment is challenging and/or refractory.

2020 ◽  
Author(s):  
Χρήστος Παπασιδέρης

Σκοπός: Η μελέτη σχεδιάστηκε για να αξιολογήσει την επίδραση της χειρουργικής αντιμετώπισης της υποτροπής κιρσών στην ποιότητα ζωής των ασθενών. Η ποιότητα ζωής των παραπάνω ασθενών μετά την επέμβαση συγκρίθηκε με την ποιότητα ζωής ασθενών που υποβλήθηκαν για πρώτη φορά σε χειρουργική επέμβαση αντιμετώπισης κιρσών. Υλικό-Μέθοδος: Πρόκειται για προοπτική μελέτη στην οποία συμμετείχαν 100 διαδοχικοί ασθενείς. Όλοι οι ασθενείς έπασχαν από χρόνια φλεβική νόσο για την οποία υποβλήθηκαν σε χειρουργική επέμβαση και έδωσαν γραπτή συγκατάθεση μετά από ενημέρωση για συμμετοχή στην έρευνα. Οι ασθενείς χωρίστηκαν σε 2 ομάδες. Η Α ομάδα (30 ασθενείς) περιλάμβανε ασθενείς με υποτροπή κιρσών, και η Β ομάδα (70 ασθενείς) ασθενείς που είχαν πρωτοπαθή νόσο. Όλοι οι ασθενείς κλήθηκαν να απαντήσουν σε ερωτηματολόγιο που σχετίζεται με την ποιότητα ζωής τους (ΑVVQ, SF-36), πριν την υποβολή τους στη χειρουργική επέμβαση και ένα χρόνο μετά. Για τη σύγκριση των σκορ AVVQ, SF-36, πριν το χειρουργείο και ένα χρόνο μετά χρησιμοποιήθηκε Wilcoxon signed rank test. Στατιστικά σημαντική θεωρήθηκε η διαφορά για p< 0.05. Αποτελέσματα: Τελικά στην ανάλυση των αποτελεσμάτων συμμετείχαν 75 ασθενείς (25 στην ομάδα Α και 50 στην ομάδα Β), που ολοκλήρωσαν τη συμπλήρωση των ερωτηματολογίων. Συγκρίνοντας τα AVVQ σκορ, φαίνεται ότι η ομάδα Α παρουσίαζε στατιστικά χειρότερα σκορ από την Ομάδα Β, τόσο προεγχειρητικά όσο και ένα χρόνο μετεγχειρητικά. Τα AVVQ σκορ και των 2 ομάδων ένα χρόνο μετά το χειρουργείο ήταν σημαντικά βελτιωμένα σε σχέση με τις προεγχειρητικές τιμές τους. Όσον αφορά τα σκορ SF-36 πριν το χειρουργείο ήταν συγκρίσιμα σε όλους τους τομείς, χωρίς στατιστικά σημαντικές διαφορές. Συγκρίνοντας τα προεγχειρητικά σκορ με αυτά που διαπιστώθηκαν 1 χρόνο μετά την επέμβαση παρατηρήθηκε βελτίωση σε όλους τους τομείς και στις 2 ομάδες, που έφτασε στατιστική σημαντικότητα σε έξι από αυτούς. Συμπεράσματα: Η ποιότητα ζωής των ασθενών που υποβάλλονται σε χειρουργικές επεμβάσεις για την αντιμετώπιση της φλεβικής νόσου των κάτω άκρων βελτιώνεται μετά την επέμβαση, είτε πρόκειται για πρωτοπαθή ή για υποτροπιάζουσα νόσο. Επομένως, καθώς η υποτροπιάζουσα φλεβική νόσος, όπως φαίνεται από τη μελέτη μας, επηρεάζει αρνητικά την ποιότητα ζωής των ασθενών, και μάλιστα σε μεγαλύτερο βαθμό από την πρωτοπαθή νόσο, η επανεπέμβαση για την αντιμετώπισή της είναι αιτιολογημένη, αφού αποδεικνύεται ότι βελτιώνει την ποιότητα ζωής των ασθενών.


2019 ◽  
Vol 3 (1) ◽  
pp. 25
Author(s):  
Dewi Nurhanifah ◽  
Desy Noor Latifah Sari ◽  
Rahmawati Rahmawati

Salah satu masalah kesehatan yang sering dialami adalah penyakit gastritis. Gejala yang sering dikeluhkan oleh penderita gastritis adalah mual. Salah satu penatalaksanaan keperawatan yang dapat mengurangi rasa mual adalah tirah baring. Penelitian ini bertujuan untuk mengetahui pengaruh tirah baring terhadap penurunan rasa mual pada klien gastritis di Pelayanan Kesehatan. Metode penelitian menggunakan eksperimental dengan bentuk penelitian one group pretest-posttest design. Populasi dan sampel adalah klien yang mengalami mual di Wilayah Kerja Puskesmas  yang berjumlah 15 orang. Sampel diambil dengan teknik purposive sampling. Alat pengumpul data menggunakan observasi. Analisa data melalui uji Wilcoxon Signed Rank Test. Hasil penelitian menujukkan klien gastritis sebelum tirah baring mengalami mual ringan sebanyak 7 orang (46,7%), sesudah tirah baring mengalami tidak mual sebanyak 7 orang (46,7%). Ada pengaruh tirah baring terhadap penurunan rasa mual pada klien gastritis di Pelayanan Kesehatan (ρ value = 0,001).


2017 ◽  
Vol 5 (1) ◽  
Author(s):  
Ferawato Ferawati

ABSTRAKReumatoid Artritis (RA) merupakan penyakit muscoloskelektal yang sering terjadi pada usia lanjut. Gangguan pada system muscoloskelektal yang ditandai dengan munculnya nyeri sendi dan kekakuan yang mengakibatkan penurunan kemampuan fisiologis atau kualitas hidup lansia. Dampak dari Reumatoid Artritis dapat menimbulkan beberapa keluhan dan dapat menyebabkan kelumpuhan. Untuk menganalisis efektifitas kompres jahe merah hangat dan kompres serai hangat terhadap penurunan intensitas nyeri artitris remauthoid pada lanjut usia.Metode Penelitian: Jenis penelitian adalah quasy experimental dengan two group pre – post test design. Subjek adalah sebagian lansia yang penderita Arthritis Remathoid di Desa Sumberagung Kecamatan Dander Kabupaten Bojonegoro. Subjek dibagi menjadi dua kelompok yaitu kelompok I (n=15) diberi perlakuan kompres jahe hangat dan II (n=15) diberi perlakuan kompres serai hangat. Analisis yang digunakan uji Mann Whitney U Test dan Wilcoxon Signed Ranks Test dengan ingkat kemaknaan α = 0,05.Hasil uji Wilcoxon Signed Rank Test, didapat keduanya mempunyai nilai kemaknaan yaitu ρ value = 0,000. Nilai ρ = 0,031 pada kelompok kompres serai hangat dan kelompok kompres jahe merah ρ value = 0,165. Hasil uji Mann Withney U Test pada Post perlakuan kedua terapi diperoleh selisih nilai nyeri pada kompres jahe ρ= 0,003 dan selisih nilai nyeri kompres serai ρ value = 0,001.Penggunaan kompres jahe merah lebih efektif dibandingkan dengan kompres serai terhadap penurunan intensitas nyeri arthritis remathoid. Kata Kunci: usia lanjut, Reumatoid Artritis (RA), jahe merah, serai, perbedaan efektifitas.    ABSTRACTReumatoid Artritis (RA) is a musculoskeletal which frequently occurs in the elderly. The disorders in the musculoskeletal system are noted by the occurrence of pain in the joints and stiffness which reduces the physiological abilities or life quality of the elderly. The disease causes many such complaints and  consequences of the disease rheumatoid arthritis may experience paralysis. The aims of this study is to analyze the effect of warm red ginger compress therapy and warm lemongrass compress therapy against of  Decreased pain intensity in  the elderly  with  artitris remauthoid. The study was Queasy experimental with two group pre – post test design. Subjects were some elderly people with Arthritis Remathoid in Sumberagung Village, Dander Sub District, Bojonegoro District. Subjects were divided into two groups: group I (n-15) with warm ginger compress therapy, and II (n=15) with warm lemongrass compress therapy. The analyses used in this study were the Mann Whitney U Test and Wilcoxon Signed Ranks Test with α of 0.05. Results of Wilcoxon Signed Rank Test obtained Both have meaning p value of  0.000. ρ value = 0,031 in a warm lemongrass compress therapy group and obtained of warm ginger compress therapy group ρ value = 0,165. The results of Mann Withney U Test on Post treatment second therapy, obtained difference of warm ginger compress therapy with ρ value= 0,003 and difference of warm lemongrass compress therapy with ρ value = 0,001.The use of warm ginger compresses therapy are more effective than a warm lemongrass compress therapy against decreased pain intensity in  the elderly  with  artitris remauthoid.  Keywords: elderly, artitris remauthoid, red ginger, lemongrass, differences in effectiveness


2010 ◽  
Vol 1 (1) ◽  
Author(s):  
Sri Sumaryani ◽  
Indri Nurasa

PENGARUH PEMBACAAN DZIKIR PADA IBU MELAHIRKAN TERHADAP TINGKAT NYERI INTRA NATAL DI RUMAH BERSALIN FAJAR YOGYAKARTAEffect of Reading Dhikr Women On The Level Of Birth Pain Intra Christmas At Home Delivery Dawn YogyakartaSri Sumaryani1 & Indri Nurasa21, 2)Program Studi Ilmu Keperawatan Fakultas Kedokteran Universitas Muhammadiyah YogyakartaJl. Lingkar Barat Taman Tirto Kasihan Bantul Yogyakarta 55182*)e-mail: [email protected] atau yang biasa disebut dengan proses persalinan merupakan suatu proses membuka dan menipisnya serviks, dan janin turun ke dalam jalan lahir. Gejala awal persalinan akan menimbulkan nyeri yang sangat hebat karena adanya kontraksi uterus dan otot abdomen. Nyeri intra natal adalah suatu nyeri yang dirasakan saat terjadinya proses persalinan (melahirkan). Saat nyeri persalinan muncul, ada baiknya bagi ibu untuk membaca dzikir. Dzikir adalah mengingat Allah SWT dan menghadirkan apa yang tadinya ada di dalam benak untuk kemudian dilafadzkan atau disebut-sebut yang dapat dilakukan secara lisan dengan menggunakan lidah atau bisa juga diucapkan tanpa adanya keterlibatan lidah, yaitu melalui hati. Penelitian ini bertujuan untuk mengetahui pengaruh pembacaan dzikir pada ibu melahirkan terhadap tingkat nyeri intra natal. Teknik pengambilan sampel menggunakan purposive sampling. Desain penelitian pra eksperimen, dengan rancangan pre test-post test tanpa kelompok kontrol. Sampel penelitian berjumlah 30 responden. Pengumpulan data dilakukan dengan observasi langsung kepada responden untuk mengukur tingkat nyeri. Analisa data menggunakan uji statistik wilcoxon signed rank test dan regresi linier dengan menggunakan SPSS 14. Hasil penelitian menunjukkan bahwa hasil uji statistik untuk nilai pre test dan post test tingkat nyeri diperoleh nilai signifikansi 0,02 dengan p < 0,05.Kata kunci: pembacaan dzikir, melahirkan, nyeri intra natal, tingkat nyeriABSTRACTThe delivery or usually called labor process is a process open and thin the cervix, and descent of the fetus into the way of birth. The early symptom of delivery will be appearing very heavy because there are uterus contraction and abdomen muscle. In partum pain is a pain which feel when delivery process happening (labor). When labor pain appears, there is a good for the mother to read dzikir. Dzikir is remembering Allah SWT and make present what before in the mind and then pronounced or make cal can do spoken by tongue or pronounced without there are involving tongue, by heart. The purpose of this research is to know about the influence of reading dzikir to the delivery mother toward in partum level of pain. Technique sampling used purpose sampling. The research of design pre experiment, with pre test-post test without control group design. The sample in this research’s total is 30 respondents. The manner of data was did by direct observation to the respondents to measure pain level. Data analysis used statistic test wilcoxon signed rank test and regression linier in SPSS 14. The results of research showed that results of the statistic pretest and posttest of pain level show significance value 0,02 with p < 0,05.Keywords: reading dzikir, delivery, in partum pain, pain level


Dose-Response ◽  
2021 ◽  
Vol 19 (2) ◽  
pp. 155932582110113
Author(s):  
Luca Basso ◽  
Dario Baldi ◽  
Lorenzo Mannelli ◽  
Carlo Cavaliere ◽  
Marco Salvatore ◽  
...  

Background and Purpose: Quantification of hepatic virtual iron content (VIC) by using Multidetector Dual Energy Computed Tomography (DECT) has been recently investigated since this technique could offer a good compromise between accuracy and non-invasiveness for liver iron content quantification. The aim of our study is to investigate differences in VIC at different DECT time points (namely baseline and arterial, venous and tardive phases), identifying the most reliable and also exploring the underlying temporal trend of these values. Materials and Methods: Eleven patients who underwent DECT examination and were characterized by low liver fat content were included in this retrospective study. By using the Syngo.via Frontier–DE IronVNC tool, regions of interest (ROI) were placed on the VIC images at 3 hepatic levels, both in left and right liver lobes, at each DECT time point. Friedman’s test followed by Bonferroni-adjusted Wilcoxon signed-rank test for post-hoc analysis was performed to assess differences between DECT timepoints. Page’s L test was performed to test the temporal trend of VIC across the 4 examined timepoints. Results: For both liver lobes, Friedman’s test followed by Bonferroni-adjusted Wilcoxon signed-rank test revealed that VIC values differed significantly when extracted from ROIs placed at the 4 different timepoints. The Page’s L test for multiple comparison revealed a significant growing trend for VIC, from baseline acquisition to the fourth and last time point post-contrast agent injection. Conclusions: The extraction of hepatic VIC in healthy subjects was found to be significantly influenced by the DECT time point chosen for the extrapolation of the VIC values.


2021 ◽  
pp. 279
Author(s):  
Angelita Afina Arif Putri ◽  
Amirah Salwa ◽  
Utami Wahyuningsih

One of the nutritional problems that often occurs among adolescents is iron deficiency anemia. Especially for adolescent girls who have a higher risk of anemia than adolescent boys. Based on data from Riskesdas 2018, the prevalence of anemia in adolescents aged 15-24 years is 32%, meaning that there are still anemia problems in Indonesia that have not been resolved. The purpose of this community dedication activity is to provide education about iron deficiency anemia for adolescent girls using leaflet media. The target of this community dedication activity is adolescent girls aged 12-19 years in the JABODETABEK area. The community dedication activity is carried out online through the WhatsApp group due to the COVID-19 pandemic. There are 31 adolescent girls who participated in this community dedication activity. This community dedication activity consists of three stages including pretest, education with leaflets, and posttest. The amount and types of pretest and posttest questions are the same. The amount of questions given is 15 questions. The correct answer is given a score of 10 and the wrong one is given a score of 0. The level of knowledge of adolescent girls is categorized as 3 groups, which is less if the correct answer is <60%, sufficient if the correct answer is 60-80%, and good if the correct answer is >80%. Most of the adolescent girls are in the age range of 17-19 years (54.8%). The results showed that there was an increase in knowledge about iron deficiency anemia in adolescent girls. The results of the Wilcoxon signed rank test showed significantly different pretest and posttest results (p-value = 0.000), so it can be concluded that providing education using leaflets can help increase knowledge of iron deficiency anemia for adolescent girls.Salah satu masalah gizi yang sering terjadi pada kalangan remaja yaitu anemia defisiensi besi. Khususnya bagi remaja putri yang memiliki risiko lebih tinggi mengalami anemia dibandingkan remaja putra. Berdasarkan data Riskesdas 2018, prevalensi anemia pada remaja berusia 15-24 tahun sebesar 32%, artinya masih terdapat permasalahan anemia di Indonesia yang belum teratasi. Tujuan dari pengabdian masyarakat ini adalah untuk memberikan edukasi mengenai anemia defisiensi besi bagi remaja putri dengan media leaflet. Sasaran dari kegiatan pengabdian masyarakat ini adalah remaja putri berusia 12-19 tahun di wilayah JABODETABEK. Kegiatan pengabdian masyarakat dilakukan secara online melalui grup whatsappkarena kondisi pandemi covid-19. Total remaja putri yang mengikuti kegiatan pengabdian masyarakat berjumlah 31 orang. Kegiatan pengabdian masyarakat ini terdiri dari tiga tahapan diantaranya pretest, edukasi dengan leaflet, dan posttest.  Jumlah dan jenis pertanyaan pretest dan posttest sama. Jumlah pertanyaan yang diberikan adalah 15 soal. Jawaban yang benar diberikan nilai 10 dan yang salah diberikan nilai 0. Tingkat pengetahuan remaja putri dikelompokkan menjadi 3 diantaranya kurang jika jawaban yang benar < 60%, cukup jika jawaban yang benar 60-80%, dan baik jika jawaban yang benar > 80%. Sebagian besar remaja putri berada pada rentang usia 17-19 tahun (54,8%). Hasil menunjukkan bahwa terdapat peningkatan pengetahuan mengenai anemia defisiensi besi pada remaja putri. Hasil uji Wilcoxon signed rank test menunjukkan hasil pretest dan posttest yang berbeda nyata (p-value = 0,000), sehingga dapat disimpulkan bahwa pemberian edukasi menggunakan leaflet dapat membantu meningkatkan pengetahuan anemia defisiensi besi bagi remaja putri.


2018 ◽  
Vol 1 (2) ◽  
pp. 39-51
Author(s):  
Sira Te'dang Patandean

This study aims to determine the effectiveness of Cognitive Behavioral Therapy to  reduce inmates’ prerelease anxiety in Narcotics Prison Class II A Pamekasan using a  quasi-experimental single subject design (A-B) in 5 inmates. Instrument used is Taylor  Manifest Anxiety Scale (TMAS) of Janet Taylor Spence which has been widely used in  Indonesia, including in prisons. Analysis of data using visual analysis and Wilcoxon  Signed Rank Test and calculating the value of r to determine effect size. The trend line  on the visual analysis showed a decrease in inmates’ prerelease anxiety after the  intervention Cognitive Behavior Therapy (CBT) is given. Wilcoxon Signed Rank Test  showed that there are significant differences in inmates’ prerelease anxiety levels before  and after Cognitive Behavior Therapy (CBT) is given (p = 0.042). Wilcoxon Signed Rank  Test results in post test 1 and post test 2 showed that no significant differences in  inmates’ prerelease anxiety levels (p = 0.785). This means that the results of intervention  is likely to be maintained. The results of effect size calculation is done by calculating the  value of r (r = 0.65) showed that CBT provides large effect to reduce the level of inmates’  prerelease anxiety. It can be concluded that CBT is effective to reduce the level of  inmates'prerelease anxiety with large effect. 


2021 ◽  
Vol 2 (1) ◽  
pp. 64-69
Author(s):  
HIJRA HIDAYANA ◽  
Suswati Suswati

Hemoglobin is the red pigment-protein contained in red blood cells. The function of hemoglobin is to transport oxygen from the lungs and in the bloodstream to be carried to the tissues. Hemoglobin can increase by increasing the intake of iron in the body. One way to increase hemoglobin can be done by giving method Infused Water Dates. Infused water is a drink consisting of plain water with fresh fruit added and soaking or settling together for a certain time. The making of infused water is carried out by soaking for a period of 0 to 12 hours, so that the infused water becomes a liquid medium that carries more nutrients than ordinary water and will be more easily absorbed by cells and distributed throughout the body (Sidauruk, 2018 ). In several studies, it is stated that dates can increase hemoglobin levels in the blood. Where dates contain iron, vitamin A, vitamin C, protein to form red blood cells. With the method, Infused Water the date palm water becomes alkaline so that it can accelerate the absorption process in the body. The purpose of this study was to determine the effectiveness of dates infused water provision to increase hemoglobin levels of midwifery adolescent girls at Medan Health Polytechnic in 2020. This research was quasi-experimental study using the One Group Pretest-Posttest Without Control Design approach. The sample in this study were 20 respondents of midwifery adolescent girls from Medan Health Polytechnic, using the technique of purposive sampling. The statistical test used wa the Wilcoxon Signed Rank Test because the data was not normal. The results of the Wilcoxon Signed Rank Test obtained the value of P-Value = 0.001. So it can be concluded that the date infused water  is effective in increasing hemoglobin levels of midwifery adolescent girls at Medan Health Polytechnic in 2020.   Keywords: Dates Infused Water, Increased Hemoglobin Levels, Girls Adolescent


2018 ◽  
Vol 35 (4) ◽  
pp. 706-712 ◽  
Author(s):  
Anjana Srinivasan ◽  
Alex Al Khoury ◽  
Svetlana Puzhko ◽  
Carole Dobrich ◽  
Meira Stern ◽  
...  

Background: Infant tongue-tie can cause breastfeeding problems, which may be improved by frenotomy. However, controversy exists among the medical community. Research aim: To examine the influence of frenotomy on infants with posterior ankyloglossia, by quantifying the changes in breastfeeding and maternal nipple pain using standardized tools. Methods: Newborns ( N = 30) below 12 weeks of age were recruited from the Herzl–Goldfarb Breastfeeding Clinic between April 2014 and April 2015. Diagnosis of posterior ankyloglossia was made clinically. Frenotomy was performed. Mothers received breastfeeding counseling before and after the procedure. Pain and breastfeeding were assessed before the procedure, immediately after the procedure, and after 2 days, 7 days and 14 days. Breastfeeding was assessed using the LATCH Tool and by subjective questioning. Maternal nipple pain was assessed using the Numeric Rating System. Results: No complications were reported with frenotomy. There was a significant improvement in LATCH score immediately post-frenotomy, with an increase in median scores from 7.5 to 8.5 ( p < .0001, Wilcoxon signed rank test). There was a significant decrease in median pain score immediately post-frenotomy, from 3.0 on the left nipple and 3.25 on the right nipple, to 0 bilaterally ( p < .0001, Wilcoxon signed rank test). Subjective improvement in breastfeeding was reported by 90% of mothers immediately after frenotomy and 83% of mothers at Day 14. Conclusion: Frenotomy for posterior ankyloglossia may improve breastfeeding and nipple pain.


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