Cue Use in Distal Autism Spectrum Assessment: A Lens Model Analysis of the Efficacy of Telehealth Technologies

Author(s):  
David A. Illingworth ◽  
Rick P. Thomas ◽  
Agata Rozga ◽  
Christopher J. Smith

Recent developments in the field of telehealth suggest that novel technologies may ameliorate patients’ limited access to clinicians capable of conducting ASD assessments (Koch, 2006). Specifically, studies have shown that parents can capture informative behaviors that aid in autism assessment by using phone-based applications, and use of these videos result in diagnoses that are consistent with those of clinicians who interact with the same child in person (Nazneen et al., 2015; Smith et al., In press). It is yet unknown how clinicians make use of the information gleaned from videos uploaded to a store-and-forward system. Given that clinicians and physicians often exhibit bias in their use of available information, we sought to understand how cues were utilized when direct contact or observation of the patient is not possible. We used lens model analyses to evaluate one store-and-forward approach: the Naturalistic Observation Diagnostic Assessment (NODA; Smith et al., 2009). Brunswik’s (1952, 1955) lens model provides a computational approach to evaluating use of information while formulating decisions (Karelaia & Hogarth, 2008), such as in the assessment and diagnosis of ASD in children. The parents of 51 children used the NODA procedure to upload four 10-minute long videos depicting the child’s behavior in familiar in-home scenarios. Eleven children were typically developing, and the remaining 40 were seeking an Autism evaluation. Each child was observed twice: One clinician performed a standard in-person assessment (IPA), while the other performed an assessment via videos uploaded to the NODA tool. Observations for 65 classes of behavior (e.g., limited conversation, speaking volume too loud, lack of peer play, echolalia, lining up toys, preoccupation with activity) were clustered into eight nominal variables representing the seven sub-criteria associated with ASD (American Psychiatric Association, 2013) and an additional criterion for behavior labeled as typical. We computed a count for each ASD variable that represented the frequency with which the NODA clinician used the label when tagging the videos. Three pairs of linear regressions were run to estimate the weight clinicians placed on observations associated with each sub-criterion for ASD. Each pair of regressions consisted of one analysis where NODA tag counts were regressed onto the decision made by the IPA clinician and another that regressed NODA tag counts onto the NODA clinician’s decision. The three sets of regressions modeled the clinicians’ use of cues as an equal weight strategy, a conjunctive strategy, and a disjunctive strategy respectively. Our results suggest that clinicians consistently derive their decisions from a limited number of the cues available to them, as no analysis found more than two classes of observation to be predictive of diagnosis. Specifically, we found that IPA and NODA clinicians appeared to adopt a conjunctive rule, and relied most heavily on the number of typical behaviors observed. We also found a high level of agreement between the IPA and NODA clinicians with respect to use of information and diagnosis. These findings suggests that there is no dearth of information available to clinicians for distal ASD assessment when observations are made through pre-recorded video provided by parents via the NODA system as compared to IPA. The results of the reported study illustrate the promise of telehealth technology adoption for distal patient assessment and diagnosis.

1995 ◽  
Vol 11 (3) ◽  
pp. 203-212 ◽  
Author(s):  
Frank C. Verhulst

In this article, recent developments in the assessment and diagnosis of child psychopathology are discussed with an emphasis on standardized methodologies that provide data that can be scored on empirically derived groupings of problems that tend to co-occur. Assessment methodologies are highlighted that especially take account of the following three basic characteristics of child psychopathology: (1) the quantitative nature of child psychopathology; (2) the role of developmental differences in the occurrence of problem behaviors, and (3) the need for multiple informants. Cross-cultural research is needed to test the applicability of assessment procedures across different settings as well as the generalizability of taxonomic constructs. Assessments of children in different cultures can be compared or pooled to arrive at a multicultural knowledge base which may be much stronger than knowledge based on only one culture. It is essential to avoid assuming that data from any single source reveal the significance of particular problems. Instead, comprehensive assessment of psychopathology requires coordination of multisource data using a multiaxial assessment approach.


2020 ◽  
Author(s):  
James McDonagh ◽  
William Swope ◽  
Richard L. Anderson ◽  
Michael Johnston ◽  
David J. Bray

Digitization offers significant opportunities for the formulated product industry to transform the way it works and develop new methods of business. R&D is one area of operation that is challenging to take advantage of these technologies due to its high level of domain specialisation and creativity but the benefits could be significant. Recent developments of base level technologies such as artificial intelligence (AI)/machine learning (ML), robotics and high performance computing (HPC), to name a few, present disruptive and transformative technologies which could offer new insights, discovery methods and enhanced chemical control when combined in a digital ecosystem of connectivity, distributive services and decentralisation. At the fundamental level, research in these technologies has shown that new physical and chemical insights can be gained, which in turn can augment experimental R&D approaches through physics-based chemical simulation, data driven models and hybrid approaches. In all of these cases, high quality data is required to build and validate models in addition to the skills and expertise to exploit such methods. In this article we give an overview of some of the digital technology demonstrators we have developed for formulated product R&D. We discuss the challenges in building and deploying these demonstrators.<br>


2020 ◽  
Vol 16 (3) ◽  
pp. 182-195
Author(s):  
Sarah Baker ◽  
Natalie Logie ◽  
Kim Paulson ◽  
Adele Duimering ◽  
Albert Murtha

Radiotherapy is an important component of the treatment for primary and metastatic brain tumors. Due to the close proximity of critical structures and normal brain parenchyma, Central Nervous System (CNS) radiotherapy is associated with adverse effects such as neurocognitive deficits, which must be weighed against the benefit of improved tumor control. Advanced radiotherapy technology may help to mitigate toxicity risks, although there is a paucity of high-level evidence to support its use. Recent advances have been made in the treatment for gliomas, meningiomas, benign tumors, and metastases, although outcomes remain poor for many high grade tumors. This review highlights recent developments in CNS radiotherapy, discusses common treatment toxicities, critically reviews advanced radiotherapy technologies, and highlights promising treatment strategies to improve clinical outcomes in the future.


2021 ◽  
Vol 20 (1) ◽  
Author(s):  
Marceline F. Finda ◽  
Fredros O. Okumu ◽  
Elihaika Minja ◽  
Rukiyah Njalambaha ◽  
Winfrida Mponzi ◽  
...  

Abstract Background Different forms of mosquito modifications are being considered as potential high-impact and low-cost tools for future malaria control in Africa. Although still under evaluation, the eventual success of these technologies will require high-level public acceptance. Understanding prevailing community perceptions of mosquito modification is, therefore, crucial for effective design and implementation of these interventions. This study investigated community perceptions regarding genetically-modified mosquitoes (GMMs) and their potential for malaria control in Tanzanian villages where no research or campaign for such technologies has yet been undertaken. Methods A mixed-methods design was used, involving: (i) focus group discussions (FGD) with community leaders to get insights on how they frame and would respond to GMMs, and (ii) structured questionnaires administered to 490 community members to assess awareness, perceptions and support for GMMs for malaria control. Descriptive statistics were used to summarize the findings and thematic content analysis was used to identify key concepts and interpret the findings. Results Nearly all survey respondents were unaware of mosquito modification technologies for malaria control (94.3%), and reported no knowledge of their specific characteristics (97.3%). However, community leaders participating in FGDs offered a set of distinctive interpretive frames to conceptualize interventions relying on GMMs for malaria control. The participants commonly referenced their experiences of cross-breeding for selecting preferred traits in domestic plants and animals. Preferred GMMs attributes included the expected reductions in insecticide use and human labour. Population suppression approaches, requiring as few releases as possible, were favoured. Common concerns included whether the GMMs would look or behave differently than wild mosquitoes, and how the technology would be integrated into current malaria control policies. The participants emphasised the importance and the challenge of educating and engaging communities during the technology development. Conclusions Understanding how communities perceive and interpret novel technologies is crucial to the design and effective implementation of new vector control programmes. This study offers vital clues on how communities with no prior experience of modified mosquitoes might conceptualize or respond to such technologies when deployed in the context of malaria control programmes. Drawing upon existing interpretive frames and locally-resonant analogies when deploying such technologies may provide a basis for more durable public support in the future.


Foods ◽  
2020 ◽  
Vol 10 (1) ◽  
pp. 49
Author(s):  
Hae Jin Park ◽  
Su Jin Choi ◽  
Yuri Kim ◽  
Mi Sook Cho ◽  
Yu-Ri Kim ◽  
...  

Autism spectrum disorder (ASD) is a neurodevelopmental disorder characterized by a lack of social communication and restrictive, repetitive behaviors or interests. This study aimed to examine the mealtime behaviors and food preferences of students with ASD. An online questionnaire on mealtime behavior and food preferences of ASD students was conducted by caregivers including parents, and the average age of ASD students was 14.1 ± 6.1. The analysis of mealtime behavior resulted in classification into three clusters: cluster 1, the “low-level problematic mealtime behavior group”; cluster 2, the “mid-level problematic mealtime behavior group”; and cluster 3, the “high-level problematic mealtime behavior group”. Cluster 1 included older students than other clusters and their own specific dietary rituals. Meanwhile, cluster 3 included younger students than other clusters, high-level problematic mealtime behavior, and a low preference for food. In particular, there were significant differences in age and food preference for each subdivided ASD group according to their eating behaviors. Therefore, the content and method of nutrition education for ASD students’ needs a detailed approach according to the characteristics of each group.


Author(s):  
Jean-François Lemay ◽  
Shauna Langenberger ◽  
Scott McLeod

Abstract Background The Alberta Children’s Hospital-Autism Spectrum Disorder Diagnostic Clinic (ACH-ASDC) was restructured due to long wait times and unsustainable clinic workflow. Major changes included the initiation of pre- and post-ASD parent education sessions and distinct ASD screening appointments before the ASD diagnostic appointment. Methods We conducted a parental program evaluation in summer 2018 of the ACH-ASDC. We used a cross-sectional survey to evaluate key outcomes including parental satisfaction, and the percentage of families obtaining access to government supports and early intervention programs. Results For the 101 eligible patients diagnosed with ASD under 36 months of age 70 (69.3%) parents agreed to participate. The mean diagnostic age of the children diagnosed with ASD was 30.6 months (SD=4.1 months). There were no statistically significant age differences between biological sexes. Ninety-three per cent of parents felt that ASD educational sessions were useful, and 92% of parents were satisfied to very satisfied with the overall ASD diagnostic process. Ninety per cent of parents had access to at least one of the key resources available for ASD early intervention in our province following diagnosis. Parents reported a positive impact on intervention provided to their child in the areas of communication, social interaction, and behaviour. Conclusion Parents of children diagnosed with ASD expressed a high level of satisfaction with the restructured ACH-ASDC process. Implementing parent education sessions was well received and met parents’ needs. Parents were able to access intervention services following diagnosis and reported positive impacts for their child. Re-envisioning program approaches to incorporate novel strategies to support families should be encouraged.


2021 ◽  
Author(s):  
Marek A. Pedziwiatr ◽  
Elisabeth von dem Hagen ◽  
Christoph Teufel

Humans constantly move their eyes to explore the environment and obtain information. Competing theories of gaze guidance consider the factors driving eye movements within a dichotomy between low-level visual features and high-level object representations. However, recent developments in object perception indicate a complex and intricate relationship between features and objects. Specifically, image-independent object-knowledge can generate objecthood by dynamically reconfiguring how feature space is carved up by the visual system. Here, we adopt this emerging perspective of object perception, moving away from the simplifying dichotomy between features and objects in explanations of gaze guidance. We recorded eye movements in response to stimuli that appear as meaningless patches on initial viewing but are experienced as coherent objects once relevant object-knowledge has been acquired. We demonstrate that gaze guidance differs substantially depending on whether observers experienced the same stimuli as meaningless patches or organised them into object representations. In particular, fixations on identical images became object-centred, less dispersed, and more consistent across observers once exposed to relevant prior object-knowledge. Observers' gaze behaviour also indicated a shift from exploratory information-sampling to a strategy of extracting information mainly from selected, object-related image areas. These effects were evident from the first fixations on the image. Importantly, however, eye-movements were not fully determined by object representations but were best explained by a simple model that integrates image-computable features and high-level, knowledge-dependent object representations. Overall, the results show how information sampling via eye-movements in humans is guided by a dynamic interaction between image-computable features and knowledge-driven perceptual organisation.


2021 ◽  
Vol 22 (19) ◽  
pp. 10276
Author(s):  
Julia Hofmann ◽  
Verena Hackl ◽  
Hannah Esser ◽  
Andras T. Meszaros ◽  
Margot Fodor ◽  
...  

The liver, in combination with a functional biliary system, is responsible for maintaining a great number of vital body functions. However, acute and chronic liver diseases may lead to irreversible liver damage and, ultimately, liver failure. At the moment, the best curative option for patients suffering from end-stage liver disease is liver transplantation. However, the number of donor livers required by far surpasses the supply, leading to a significant organ shortage. Cellular therapies play an increasing role in the restoration of organ function and can be integrated into organ transplantation protocols. Different types and sources of stem cells are considered for this purpose, but highly specific immune cells are also the focus of attention when developing individualized therapies. In-depth knowledge of the underlying mechanisms governing cell differentiation and engraftment is crucial for clinical implementation. Additionally, novel technologies such as ex vivo machine perfusion and recent developments in tissue engineering may hold promising potential for the implementation of cell-based therapies to restore proper organ function.


2021 ◽  
Vol 11 (12) ◽  
pp. 1555
Author(s):  
Gianpaolo Alvari ◽  
Luca Coviello ◽  
Cesare Furlanello

The high level of heterogeneity in Autism Spectrum Disorder (ASD) and the lack of systematic measurements complicate predicting outcomes of early intervention and the identification of better-tailored treatment programs. Computational phenotyping may assist therapists in monitoring child behavior through quantitative measures and personalizing the intervention based on individual characteristics; still, real-world behavioral analysis is an ongoing challenge. For this purpose, we designed EYE-C, a system based on OpenPose and Gaze360 for fine-grained analysis of eye-contact episodes in unconstrained therapist-child interactions via a single video camera. The model was validated on video data varying in resolution and setting, achieving promising performance. We further tested EYE-C on a clinical sample of 62 preschoolers with ASD for spectrum stratification based on eye-contact features and age. By unsupervised clustering, three distinct sub-groups were identified, differentiated by eye-contact dynamics and a specific clinical phenotype. Overall, this study highlights the potential of Artificial Intelligence in categorizing atypical behavior and providing translational solutions that might assist clinical practice.


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