The Ability of Patients to Provide Standardized, Patient-Taken Photographs for the Remote Assessment of Dupuytren Disease

Hand ◽  
2021 ◽  
pp. 155894472110068
Author(s):  
Esmee Irvine ◽  
Leela Sayed ◽  
Nick Johnson ◽  
Joseph Dias
Keyword(s):  
Reliable Method ◽  
Computer Software ◽  
Standardized Patient ◽  
Universal Method ◽  
Current Health ◽  
Severity Of Disease ◽  
Remote Assessment ◽  
Severity Of The Disease ◽  
Remote Consultations ◽  
Dupuytren Disease

Background Clinical goniometry for the assessment of contracture in Dupuytren disease is time-consuming and costly, and there is no universal method for evaluating the severity of the disease. This study aims to evaluate the feasibility of patient-taken photography for the remote assessment of Dupuytren disease. Methods Patients at our unit were provided with instructions on how to take standardized photographs of their diseased hand(s), which were subsequently analyzed by computer software to obtain formal measurements of the severity of disease. Compliance with photography instructions and ability to provide a photo of sufficient quality for analysis were measured. Results In all, 222 patients supplied photos for analysis; 158 patients (71.2%) were able to take the photographs as instructed. The remaining 28.8% took 1 or more of the images incorrectly or of insufficient quality. There were no statistically significant differences between those able to take the photos as directly versus those who took the photos incorrectly when compared by sex, age, or severity of disease. Conclusions Patient-taken photography used to estimate disease severity in Dupuytren disease is an achievable, efficient, and reliable method of remotely assessing and monitoring patients and may be increasingly useful given the current health care climate and preference for remote consultations.

scholarly journals LDH as a prognostic marker in hypertensive pregnancy

2017 ◽  
Vol 6 (6) ◽  
pp. 2444
Author(s):  
Prathap Talwar ◽  
Triveni Kondareddy ◽  
Pranidha Shree C. A.
Keyword(s):  
Lactic Dehydrogenase ◽  
High Serum ◽  
Pregnancy Induced Hypertension ◽  
Intracellular Enzyme ◽  
Cellular Death ◽  
Severity Of Disease ◽  
Induced Hypertension ◽  
Prospective Comparative Study ◽  
Severity Of The Disease ◽  
Poor Outcomes

Background: Pregnancy induced hypertension (PIH) is a global problem with a 5-15% incidence rate in India and complicating 10-17% of all pregnancies. These are multisystem disorders and lead to a lot of cellular death. LDH is an intracellular enzyme and its level is increased in these women due to cellular death. So, serum LDH levels can be used to assess the extent of cellular death and thereby the severity of disease in this group of women. The objective of the study was to correlate the severity of the disease, maternal and perinatal outcome with Lactic Dehydrogenase (LDH) levels in serum in patients of preeclampsia and eclampsia.Methods: A prospective comparative study was conducted in the department of Obstetrics and Gynecology, JSS Medical Hospital, Mysore.Results: LDH levels were significantly elevated in women with preeclampsia and eclampsia (<0.001). Higher LDH levels had significant correlation with high blood pressure (P <0.10) as well as poor maternal and perinatal outcome.Conclusions: High serum LDH levels correlate well with the severity of the disease and poor outcomes in patients of preeclampsia and eclampsia.

Comparison of Severity of Symptoms and Outcome among Vaccinated and Non-Vaccinated Covid 19 Patients in Khyber Pakhtunkhwa, Pakistan

2021 ◽  
Vol 15 (7) ◽  
pp. 2334-2337
Author(s):  
Wali Gul ◽  
Kashif Ali Samin ◽  
Rashid Ahmad ◽  
Khalil Ullah ◽  
Gul Mehnaz ◽  
...  
Keyword(s):  
Economic Status ◽  
Adverse Outcomes ◽  
Medicine Department ◽  
Khyber Pakhtunkhwa ◽  
Icu Admission ◽  
Severity Of Disease ◽  
Group I ◽  
Group Ii ◽  
Severity Of The Disease ◽  
Retrospective Comparative Study

Objective: The aim of this study is to compare the severity of symptoms and outcomes among vaccinated and non-vaccinated COVID 19 patients in Khyber Pakhtunkhwa, Pakistan Study Design: A Retrospective/ Comparative study Place and Duration: The study was conducted at Medicine department of Lady Reading Hospital, Peshawar and DHQ Category A Hospital, Batkhela for duration of six months between December 2020 and May 2021. Methods: Total 170 patients of both genders had coronavirus disease were presented in this study. Patients were aged between 20-80 years. Demographical details of patients including age, sex, body mass index, residency and socio-economic status were recorded after taking informed written consent. Patients were admitted in COVID 19 ward. There were 70 vaccinated patients in group I and 100 non-vaccinated patients in group II. Co-morbidities among both groups were assessed. Effectiveness and outcomes among both groups were calculated in terms of mortality and reduction in severity of disease. Complete data was analyzed by SPSS 19.0 version. Results: There were 114 (67.1%) patients were males (50 in group I and 64 in group II) and 56 (32.4%) were females (28 in each group). Mean age of the vaccinated patients was 49.16 ±8.55 years with mean BMI 33.16 ±4.64 kg/m2 and in group II mean age was 47.18 ±4.77 years with mean BMI 31.12±12.73 kg/m2.Among 70 cases of group I, 40 (57.1%) were fully vaccinated and 30 (42.9%) patients received their first dose. 50 (71.4%) were educated in group I and in group II 46 (46%) patients were literate. Co-morbidities were diabetes mellitus, hypertension, ischaemic heart and chronic lung disease. Effectiveness among patients of group I was greater 55 (78.6%) as compared to non-vaccinated 36 (36%). Frequency of adverse outcomes hospitalization 10 (10%), ICU admission 14 (14%) and mortality 40 (40%) among non-vaccinated patients were significantly higher as compared to vaccinated patients in which hospitalization 3 (4.3%), ICU admission 2 (2.9%) and mortality was found in 10 (14.3%) cases. Conclusion: We concluded in this study that vaccination against coronavirus disease was effective and helpful for the reduction in severity of the disease. Except this the frequency of adverse outcomes (hospitalization, ICU admission and mortality) can be minimized by vaccination and there is need to give awareness among people to get vaccinated early. Keywords: COVID 19, Vaccination, Pandemic, Mortality

AMNIOTIC FLUID SPECTROPHOTOMETRY AND EARLY DELIVERY IN THE MANAGEMENT OF ERYTHROBLASTOSIS FETALIS

PEDIATRICS ◽  
1965 ◽  
Vol 35 (5) ◽  
pp. 815-835
Author(s):  
John M. Bowman ◽  
Janet M. Pollock
Keyword(s):  
Amniotic Fluid ◽  
Antibody Titer ◽  
Severe Disease ◽  
Intrauterine Death ◽  
Perinatal Deaths ◽  
Severity Of Disease ◽  
History Of Disease ◽  
History Of ◽  
Severity Of The Disease ◽  
Accuracy Of Prediction

Accuracy of prediction of intrauterine death in erythroblastosis fetalis, using history of disease and antibody titer alone, is limited (62% accuracy in a series of 121 perinatal deaths and babies who survived only because they were delivered early). Chief sources of error are in first sensitized pregnancies and in isoimmunized pregnancies where the mother has a bad history and a heterozygous husband. Spectrophotometric examination of amniotic fluid obtained transabdominally as early as 24 weeks' gestation has increased our accuracy of prediction of severity of disease to 96.8% in a series of 252 Rh negative isoimmunized pregnancies from whom 402 suitable fluids were obtained and examined. Only one of the eight inaccuracies was of such a degree that the infant's life was threatened. In 32 pregnancies with histories of severe disease on high titers and heterozygous husbands, accuracy of prediction of the Rh status of the fetus was 100 per cent. The procedure carries no risk to the mother, but if the placenta is traversed, her antibody titer may rise and the severity of the disease in the fetus may be increased. Liquor examination allows more accurate timing of induction in threatened intrauterine death and saves less severely affected babies from the hazards of prematurity. It has also proven of value in determining the fetus so severely affected that survival is only possible through intraperitoneal fetal transfusions.

scholarly journals Computational wrapping: A universal method to wrap 3D-curved surfaces with nonstretchable materials for conformal devices

2020 ◽  
Vol 6 (15) ◽  
pp. eaax6212 ◽  
Author(s):  
Yu-Ki Lee ◽  
Zhonghua Xi ◽  
Young-Joo Lee ◽  
Yun-Hyeong Kim ◽  
Yue Hao ◽  
...  
Keyword(s):  
Computer Aided Design ◽  
Reliable Method ◽  
Design Method ◽  
Universal Method ◽  
Curved Surfaces ◽  
Two Dimensional ◽  
Steel Sheets ◽  
Computer Aided ◽  
Conformal Structures ◽  
Aided Design

This study starts from the counterintuitive question of how we can render conventional stiff, nonstretchable, and even brittle materials sufficiently conformable to fully wrap curved surfaces, such as spheres, without failure. Here, we extend the geometrical design method of computational origami to wrapping. Our computational wrapping approach provides a robust and reliable method for fabricating conformal devices for arbitrary curved surfaces with a computationally designed nonpolyhedral developable net. This computer-aided design transforms two-dimensional (2D)–based materials, such as Si wafers and steel sheets, into various targeted conformal structures that can fully wrap desired 3D structures without fracture or severe plastic deformation. We further demonstrate that our computational wrapping approach enables a design platform that can transform conventional nonstretchable 2D-based devices, such as electroluminescent lighting and flexible batteries, into conformal 3D curved devices.

The impact of the severity of disease and social disadvantage on quality of life in families with congenital cardiac disease

2006 ◽  
Vol 16 (1) ◽  
pp. 67-75 ◽  
Author(s):  
Lutz Goldbeck ◽  
Juliane Melches
Keyword(s):  
Quality Of Life ◽  
Cardiac Disease ◽  
Parental Education ◽  
Social Disadvantage ◽  
Computer Assisted ◽  
Severity Of Disease ◽  
Congenital Cardiac Disease ◽  
Severity Of The Disease ◽  
The Impact

Objective: Increasing rates of survival have raised the question of medical and psychosocial factors contributing to quality of life of patients with congenital cardiac disease. We investigated the impact of the severity of disease, and social disadvantage, on the quality of life of patients and their primary caregivers. Methods: One hundred and thirty two families participated in a computer-assisted evaluation of their quality of life in a German outpatient centre for paediatric cardiac diseases. Quality of life for the patients was evaluated by a multi-dimensional proxy-measure. The quality of life of the caregivers was evaluated by a multi-dimensional self-reporting measure. Severity of the disease was evaluated by the responsible paediatrician. Social disadvantage was defined as single-parent status, ethnic minority status, unfinished parental education or professional training, and/or unemployment. Analyses of variance were calculated with mild, moderate, or severe forms of disease, and risk as opposed to no risk for social status, both factors being treated independently, and the quality of life of the patients and their caregivers as dependent variables. Results: We demonstrated significant effects of the severity of disease on the quality of life of the children, and of social disadvantage on the quality of life of both the children and their parents. A significant interactive effect indicated a cumulative negative impact of the severity of the disease and social disadvantage on the quality of life of the patients. Conclusion: Programmes providing psychosocial support for children with cardiac disease and their caregivers should consider risk factors which are both medical and social.

scholarly journals The serum eosinophil cationic protein concentration in patients with bronchial asthma and its correlation with severity and exacerbation of the disease

2003 ◽  
Vol 22 (3) ◽  
pp. 249-253
Author(s):  
Snezana Kovacevic ◽  
Mirjana Bogic ◽  
Aleksandra Peric-Popadic ◽  
Sanvila Raskovic ◽  
Zikica Jovicic ◽  
...  
Keyword(s):  
Bronchial Asthma ◽  
Clinical Picture ◽  
Healthy Subjects ◽  
Protein Concentration ◽  
Geometric Mean ◽  
Eosinophil Cationic Protein ◽  
Cationic Protein ◽  
Asthmatic Patients ◽  
Severity Of Disease ◽  
Severity Of The Disease

Activated eosinophilic leukocyte in asthma secretes numerous mediators, among which is ECP as well. The object of our study was to measure the serum ECP concentrations in 46 asthmatic patients with exacerabating and stable asthma, and to correlate the serum ECP concentrations with severity and exacerbation of the disease. Geometric mean of ECP in serum (Gecp) in our group of patients was 7.5 mcg/l, while it was 3.05 mcg/l in the 15 healthy subjects (controls). Highly significant correlation of serum ECP concentrations with the activity of the disease (R=0.897) and the severity of clinical picture (R=0.79) was found. The patients with stable asthma had significant correlation of ECP and the severity of disease (R=0.6). The patients with exacerbating asthma have significantly higher serum ECP concentrations than the patients with stable asthma. Serum ECP concentrations in patients with exacerbating asthma correlate with the severity of the disease.

scholarly journals Association between symptoms and severity of disease in hospitalised novel coronavirus (COVID-19) patients: A systemic review and meta-analysis

2020 ◽  
Author(s):  
Ashis Talukder ◽  
Shaharior Rahman Razu ◽  
Sheikh Alif ◽  
Muhammad Aziz Rahman ◽  
Sheikh Mohammed Shariful Islam
Keyword(s):  
Meta Analysis ◽  
Viral Disease ◽  
Systemic Review ◽  
Cochrane Library ◽  
Medical Attention ◽  
Chronic Obstructive ◽  
Respiratory Illnesses ◽  
Severity Of Disease ◽  
Severity Of The Disease ◽  
Novel Coronavirus

Abstract Background Symptoms of the novel coronavirus disease (COVD-19) are well known, although asymptomatic cases were also reported due to this rapidly evolving viral disease. However, there has been limited research with inconsistent findings on symptoms of COVID-19 and diseases severity. We aimed to evaluate the association between symptoms and severity of disease in confirmed COVID-19 cases by performing a meta-analysis.Methods We conducted a systematic review by searching four online databases (Medline, Web of Science, EMBASE and Cochrane library) of published studies that included symptoms of COVID-19 cases and severity of the disease between 01-Jan-2020 and 20-Apr-2020. PRISMA and MOOSE guidelines were followed, and only articles published in English were selected. We performed meta-analysis using Mantel-Haenszel random-effects model. Degree of heterogeneity among studies and quality of the selected studies were evaluated.Results Out of 153 articles identified, a total of seven articles, including 3,168 participants, met the inclusion criteria and were included. The median age of the patients was 49 years, 1818 (57.38%) were males, and 574 (18.11%) reported severe conditions. Fever was the most commonly reported symptom in the reported COVID-19 confirmed cases (87.89%, 95% CI: 83.22–81.39%), which was followed by cough, myalgia or fatigue, and less proportionally dyspnea and headache. Dyspnea was the only symptom, which was associated with severity of COVID-19 (OR 2.38, 95% CI: 1.83–3.10).Conclusions Dyspnoea was found to be associated with severity of COVID-19. People with existing respiratory illnesses, such as chronic obstructive pulmonary diseases need to be careful about the onset of such symptom and should seek medical attention.

Pentagalloylglucose, a phytochemical from Terminalia chebula can efficiently prevent SARS-CoV-2 entry: In Silico study

2021 ◽  
pp. 1-9
Author(s):  
Rajani Sharma ◽  
Gopal Kumar Prajapati ◽  
Gargi Akhoury
Keyword(s):  
Terminalia Chebula ◽  
Rna Dependent Rna Polymerase ◽  
Discovery Studio ◽  
Current Health ◽  
Severity Of Disease ◽  
Chebulic Acid ◽  
Chebulagic Acid ◽  
In Silico Study ◽  
The World ◽  
Potential Component

Abstract COVID-19 is the current health challenge across the world. It originated in Wuhan, China, and has now spread to more than 180 countries. It is a zoonotic disease which spreads through droplets. The severity of disease is likely to end with the discovery of vaccines only. Researchers are repurposing drugs to fill the gap between COVID-19 and vaccine designing. Broad-spectrum antiviral drugs are preferred but they exhibit side effects. We have screened pentagalloylglucose present in Terminalia chebula which can prevent SARS-CoV-2 entry to the host cell. In this study, we have taken 8 active phytochemicals of Terminalia chebula which include gallic acid, chebulic acid, chebulanin, neochebulinic acid, ellagic acid, chebulagic acid, chebulinic acid, and pentagalloyglucose against spike proteins (S1 and S2), Replicase Polyprotein, 3C-like protease (3CL pro), Papain-like protease (PLpro), RNA dependent RNA polymerase (RdRp) of SARS-CoV-2. HADDOCK online server, Discovery Studio Visualizer and PyRx Vina tools were used to screen the potential component from T. chebula. It was analysed that pentagalloylglucose can be a better phytochemical against spike protein S1 similar to hemagglutinin of influenza virus. This phytochemical can be further used as a drug against SARS-CoV-2.

scholarly journals Association of Interferon-Alpha and Ribavirin-Induced Thyroid Dysfunction with Severity of Disease and Response to Treatment in Pakistani Asian Patients of Chronic Hepatitis C

2012 ◽  
Vol 2012 ◽  
pp. 1-6
Author(s):  
Amina Nadeem ◽  
Muhammad Aslam
Keyword(s):  
Chronic Hepatitis ◽  
Hepatitis C ◽  
Chronic Hepatitis C ◽  
Interferon Alpha ◽  
Thyroid Dysfunction ◽  
Response To Therapy ◽  
Response To Treatment ◽  
Severity Of Disease ◽  
Severity Of The Disease ◽  
Chronic Hepatitis C Patients

Objective. To determine the association of thyroid dysfunction with the severity of the disease and response to treatment in patients of chronic hepatitis C. Design. Cohort study. Patients. One hundred and sixty seven noncirrhotic chronic hepatitis C patients were grouped into treatment group (n=107) and control group (n=60). Measurements. Baseline S. ALT and S. AST by IFCC and S. TSH, S. free T4, and S.T3 level were measured by chemiluminescence method. The severity of the disease was measured by Knodell histopathological index (HPI) on liver biopsy. Study group patients underwent 24-weeks IFN and ribavirin therapy and thyroid functions were determined at weeks 0, 12, and 24. Response to therapy was determined by PCR-HCV test. Results. 20 treated patients (18.69%) developed thyroid dysfunction with relative risk (RR) of 11.25 and attributable risk (AR) of 91%. Females were at higher risk. Hypothyroidism was common than hyperthyroidism. There was no significant association between thyroid dysfunction and severity of the disease (P=0.81) and response to therapy (P=0.79). Conclusion. Interferon-alpha and ribavirin therapy induces thyroid dysfunction in chronic hepatitis C patients. There is no association between severity of disease and response to therapy with interferon-induced thyroid dysfunction.

scholarly journals Determining the Effectiveness of Different Reconstruction Method and Mandibular Implants for Fracture in the Mandible

2021 ◽  
pp. 237-257
Author(s):  
Maryam Hassannia ◽  
Sajad Ghorbanizadeh
Keyword(s):  
Gold Standard ◽  
Reliable Method ◽  
Malignant Tumors ◽  
Case Reports ◽  
Computer Software ◽  
Reconstruction Method ◽  
Inclusion Criteria ◽  
Complementary Technique ◽  
Fibular Flap ◽  
Review Study

Introduction: Every year, many people suffer from mandibular defects due to various reasons such as trauma or malignant tumors. Various techniques for reconstructing mandibular defects have always been considered by surgeons and maxillofacial specialists to select the best option and achieve the desired results for the patient. In this study, various articles and their techniques for reconstruction of mandibular defects were reviewed and their results were reported. Materials and Methods: The present study is a systematic review study in which the keywords implants, mandibular, trauma, reconstruction of the desired articles in two databases pubmed and science direct from January 1, 2010 to August 31, 2018 And were selected and then examined. Results: 33 articles met the inclusion criteria on which the final review was performed. 17 articles were clinical studies, 9 articles were case reports and 7 articles were reviews. In these 33 studies, various techniques were examined, including the use of free vascularized fibular flap, the use of computer software, and the prototyping technique. Conclusion: Among the existing methods, the use of free vascularized fibular flap has been approved as a widely used and reliable method in various studies, and many researchers believe that this technique is the gold standard for the reconstruction of mandibular defects. The use of computer software was also used as a complementary technique to improve surgical outcomes.

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