Clinical Presentation, Imaging and Treatment of Cerebral Venous Thrombosis (CVT)

Isolated cortical venous thrombosis (ICVT) occurring in the absence of dural venous thrombosis, constitutes about 2%–5% of all cerebral venous thrombosis. Its vague, non-specific presentation makes it a difficult and challenging diagnosis that needs an extensive workup especially in young patients. Outcome and prognosis depend mainly on early diagnosis and treatment. Here we discuss the clinical presentation, diagnosis and the treatment of a young woman diagnosed with ICVT with acute ischaemic venous stroke, in the setting of eclampsia and family history of coagulation disease.

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A prospective study of demography, clinical presentation and risk factors of cerebral venous thrombosis in pregnant and postpartum women

Indian Journal of Obstetrics and Gynecology Research ◽

10.18231/2394-2754.2019.0007 ◽

2019 ◽

Vol 6 (1) ◽

pp. 29-32

Author(s):

Neelam Singh ◽

◽

Sonal Kulshreshtha ◽

Dinesh Udainiya ◽

Jyoti Bindal ◽

...

Keyword(s):

Risk Factors ◽

Prospective Study ◽

Venous Thrombosis ◽

Cerebral Venous Thrombosis ◽

Clinical Presentation ◽

Postpartum Women ◽

A Prospective Study

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Abstract 3920: Epilepsy as a Long-Term Complication After Cerebral Venous Thrombosis

Stroke ◽

10.1161/str.43.suppl_1.a3920 ◽

2012 ◽

Vol 43 (suppl_1) ◽

Author(s):

Carlos Cantu-Brito ◽

Erwin Chiquete ◽

Antonio Arauz ◽

Marlon Merloz-Benitez

Keyword(s):

Risk Factors ◽

Venous Thrombosis ◽

Cerebral Venous Thrombosis ◽

Clinical Presentation ◽

Thrombotic Event ◽

Long Run ◽

Increased Risk ◽

Long Term Follow Up

Background. Seizures is a very common clinical presentation of cerebral venous thrombosis (CVT); however, little is known about the future risk of epilepsy in patients suffering CVT. Our objective was to analyze risk factors for epilepsy in a long-term follow-up after CVT. Methods. This is a cohort descriptive study of consecutive non-selected patients with acute cerebrovascular disease, systematically registered from 1986 to 2010 in a third-level referral center of Mexico City. Here we analyzed 340 patients who survived the first 6 months after CVT, who were not epileptic at baseline and for whom complete long-term information on neurological outcome was available. Results. Seizures occurred in 183 (54%) patients, in 26% of them as a clinical presentation and 74% at some point during follow-up. Focal motor seizures occurred in 6.5%, secondary generalized focal seizures in 13.8% and generalized tonic-clonic seizures in 22.4%. Status epilepticus occurred in 13 (7%) cases. In all, during a median follow-up of 28 months (range 2 to 288 months), epilepsy was present in 14.7% (27.3% of those who presented seizures). In a multivariate analysis adjusted for multiple confounders, risk factors associated with an increased risk of epilepsy during follow-up were presenting seizures as a clinical presentation [odds ratio (OR): 4.32, 95% confidence interval (CI): 2.20-8.48], pregnancy and puerperium (OR: 2.03, 95% CI: 1.11-3.71) and thrombosis of the longitudinal sinus (OR: 1.86, 95% CI: 1.01-3.41). Conclusion. Seizures are common at CVT presentation, but risk increases during the acute phase after thrombotic event. Most seizures resolve during the first month, but epilepsy occurred in 15% of patients with CVT in the long run.

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Cerebral Venous Thrombosis in the Superior Sagittal Sinus as a Rare Cause of a Paroxysmal Kinetic Tremor

Case Reports in Neurology ◽

10.1159/000455022 ◽

2017 ◽

Vol 8 (3) ◽

pp. 276-281 ◽

Cited By ~ 1

Author(s):

Kei Murao ◽

Shuji Arakawa ◽

Yoshihiko Furuta ◽

Masahiro Shijo ◽

Tetsuro Ago ◽

...

Keyword(s):

Venous Thrombosis ◽

Cerebral Venous Thrombosis ◽

Clinical Presentation ◽

Superior Sagittal Sinus ◽

Epileptic Seizures ◽

Repetitive Movement ◽

Sagittal Sinus ◽

Kinetic Tremor ◽

History Of ◽

The Common

Cerebral venous thrombosis (CVT) has a broad spectrum of clinical presentation compared to arterial etiology. Seizure is one of the common symptoms and is more frequent than in other stroke types. Hence, transient neurological symptoms in CVT patients are usually due to epileptic seizures, while transient repetitive movement disorder is extremely rare except as a complication of epilepsy. We report a case of CVT in the superior sagittal sinus with a 1-year history of paroxysmal kinetic tremor without evident epilepsy.

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Genetic Screening of Cerebral Venous Thrombosis Susceptible Women, an Effective Step in Identifying Women at Risk for Obstetric CVT

Journal of Shahid Sadoughi University of Medical Sciences ◽

10.18502/ssu.v29i6.6988 ◽

2021 ◽

Author(s):

Khalil Khashei Varnamkhasti

Keyword(s):

Risk Factors ◽

At Risk ◽

High Risk ◽

Venous Thrombosis ◽

Genetic Variants ◽

Genetic Screening ◽

Cerebral Venous Thrombosis ◽

Genetic Basis ◽

Clinical Presentation

Introduction: Predisposition to cerebral venous thrombosis (CVT) also has a genetic basis and inherited thrombophilias constitute 22.4 % of the CVT cases. CVT with a varied clinical presentation and pathogenesis is one of the important causes of stroke which is not very common. Inherited thrombophilias with concomitant acquired risk factors like pregnancy may increase the risk of CVT manifold. Identification of a number of genetic variants increasing susceptibility to CVT and related traits opened up opportunity, to screening of women at high risk of developing obstetric CVT.

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Cerebral venous thrombosis in Argentina: clinical presentation, predisposing factors, outcomes and literature review

Journal of Stroke and Cerebrovascular Diseases ◽

10.1016/j.jstrokecerebrovasdis.2020.105145 ◽

2020 ◽

Vol 29 (10) ◽

pp. 105145

Author(s):

Matías Alet ◽

Celina Ciardi ◽

Alberto Alemán ◽

Lucrecia Bandeo ◽

Pablo Bonardo ◽

...

Keyword(s):

Literature Review ◽

Venous Thrombosis ◽

Cerebral Venous Thrombosis ◽

Clinical Presentation ◽

Predisposing Factors

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Prognosis of fasting in patients with cerebral venous thrombosis using oral contraceptives

Iranian Journal of Neurology ◽

10.18502/ijnl.v18i2.1293 ◽

2019 ◽

Author(s):

Masoud Ghiasian ◽

Maryam Mansour ◽

Nasrin Moradian

Keyword(s):

Risk Factors ◽

Risk Factor ◽

Venous Thrombosis ◽

Oral Contraceptives ◽

Neurological Deficit ◽

Cerebral Venous Thrombosis ◽

Clinical Presentation ◽

Modified Rankin Scale ◽

Focal Neurological Deficit ◽

Muslim Countries

Background: There have been studies that showed a higher incidence of cerebral venous thrombosis (CVT) in Ramadan, a month in which people fast in Muslim countries, which was associated with increasing use of oral contraceptives (OCPs) in women. We aimed to evaluate the effect and prognosis of fasting in patients with CVT using OCPs. Methods: Consecutive patients with diagnosis of CVT in Sina hospital, Hamadan, West of Iran, from May of 2009 to June of 2016 were evaluated, and women using OCPs were included. Other risk factors except fasting were excluded. Clinical presentation and outcomes of CVT was assessed. Patients were followed up for 12 months. Results: 58 patients were included in this study. 31 of these patients had fasting simultaneously. Fasting in patients using OCPs caused significantly higher focal neurological deficit (64.5%, P = 0.018), and higher hemorrhage (66.7%, P = 0.042). At discharge, 51.6% and after three months, 25.8% of patients with fasting had disability [6 > modified Rankin Scale (mRS) >1]. In patients who used OCPs as sole risk factor, 25.9% at discharge and 11.1% after three months had disability. Conclusion: Fasting in patients with CVT using OCPs causes significant increase in focal neurological deficit and hemorrhage, which also increases the hospital stay and lengthens recovery. However, longterm prognosis and mortality of CVT is similar between the two groups.

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Severe COVID-19 Complicated by Cerebral Venous Thrombosis in a Newborn Successfully Treated with Remdesivir, Glucocorticoids, and Hyperimmune Plasma

International Journal of Environmental Research and Public Health ◽

10.3390/ijerph182413201 ◽

2021 ◽

Vol 18 (24) ◽

pp. 13201

Author(s):

Laura Cursi ◽

Francesca Ippolita Calo Carducci ◽

Sara Chiurchiu ◽

Lorenza Romani ◽

Francesca Stoppa ◽

...

Keyword(s):

Severe Acute Respiratory Syndrome ◽

Venous Thrombosis ◽

Preterm Infant ◽

Interstitial Pneumonia ◽

Cerebral Venous Thrombosis ◽

Clinical Presentation ◽

Wide Spectrum ◽

Age Groups ◽

Severe Form

Severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) is responsible for the coronavirus disease 2019 (COVID-19) pandemic, affecting all age groups with a wide spectrum of clinical presentation ranging from asymptomatic to severe interstitial pneumonia, hyperinflammation, and death. Children and infants generally show a mild course of the disease, although infants have been observed to have a higher risk of hospitalization and severe outcomes. Here, we report the case of a preterm infant with a severe form of SARS-CoV-2 infection complicated by cerebral venous thrombosis successfully treated with steroids, hyperimmune plasma, and remdesivir.

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Clinical Presentation and Long-Term Outcome of Cerebral Venous Thrombosis

Neurocritical Care ◽

10.1007/s12028-009-9234-8 ◽

2009 ◽

Vol 11 (3) ◽

pp. 330-337 ◽

Cited By ~ 15

Author(s):

Joey D. English ◽

Jeremy D. Fields ◽

Scheherazade Le ◽

Vineeta Singh

Keyword(s):

Venous Thrombosis ◽

Cerebral Venous Thrombosis ◽

Clinical Presentation ◽

Term Outcome ◽

Long Term Outcome

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Clinical presentation, risk factors and factors affecting short term outcome in patients with cerebral venous thrombosis

International Journal of Advances in Medicine ◽

10.18203/2349-3933.ijam20202574 ◽

2020 ◽

Vol 7 (7) ◽

pp. 1100

Author(s):

Josy J. Vallippalam ◽

Balakrishnan R. ◽

Saloni Krishna ◽

Karthik Thamaraikannan ◽

Nitya Suresh

Keyword(s):

Risk Factors ◽

Venous Thrombosis ◽

Cerebral Venous Thrombosis ◽

Clinical Presentation ◽

Tertiary Care ◽

P Value ◽

Short Term ◽

Term Outcome ◽

Factors Influencing ◽

Short Term Outcome

Background: Cerebral venous thrombosis is a rare cause of stroke, with a predilection to females. Since the past two decades its morbidity and mortality had decreased because of the new effective diagnostic and therapeutic interventions. This study mainly intends to assess, the clinical and aetiological factors of cerebral venous thrombosis and the factors predicting its short-term outcome. Objective was to study the factors influencing the short-term outcome of CVT and to study the pattern of clinical presentation and risk factors for CVT.Methods: It was a cross-sectional study done at a tertiary care Centre in Tamil Nadu, in adult CVT patients from august 2018 to august 2019. Clinical, aetiological and radiological data were collected from patients and assessed and factors influencing the short-term outcome at discharge and at 15 days after discharge were studied. Data was analysed using SPSS16 software. Analysis of the descriptive data was performed and independent factors influencing the short-term outcome were analysed subsequently.Results: Males predominated in the study with a mean age of 38yrs. Most common presentation was headache. Infarct was present in 61 (56.5%). The most common site of venous involvement was superior sagittal sinus 81 (75%). Short term outcome had shown a significant association with hypertension (p value -0.019 and odds ratio-65.439) and baseline MRS (p value- 0.000, OR - 0.004) only.Conclusions: Nowadays, the mortality and morbidity of CVT has decreased. Hypertension has emerged as an independent predictive factor in the short -term outcome of CVT.

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