scholarly journals A Multicenter Open Study on the Tolerability and Efficacy of a Cosmetic Treatment in Mild Acne Vulgaris during the Summer Months

2003 ◽  
Vol 1 (2) ◽  
pp. 85-90 ◽  
Author(s):  
N. Cassano ◽  
M. Carbonara ◽  
M. Grandolfo ◽  
S. Calabretta ◽  
C. Castellana ◽  
...  
Keyword(s):  
Acne Vulgaris ◽  
Sun Exposure ◽  
Good Tolerability ◽  
Once Daily ◽  
Study Product ◽  
The Face ◽  
Alpha Hydroxy Acids ◽  
Patients Experience ◽  
Safe Approach ◽  
General Opinion

The improvement of acne vulgaris (AV) during summer months is a general opinion which is not universally accepted as some patients experience no change or even an aggravation of their AV during hot months. Therapeutic management of AV in summer is often difficult; in fact, most traditional anti-acne treatments are contraindicated or poorly tolerated during summer months. In this study we evaluated the tolerability and effectiveness of a cosmetic anti-acne treatment performed for 12 summer weeks in 347 patients (mean age, 19.4 yrs) with mild AV of the face. The study product (Exfoliac®) contained a mixture of alpha hydroxy acids and substances with moisturizing and/or lenitive effects. In the first 4 weeks, Exfoliac® 10 cream was applied twice a day (b.i.d.). The treatment in the following 8 weeks was decided on the basis of dermatologist's assessment of the clinical response and could consist in Exfoliac® 10 cream or Exfoliac® 15 cream, once daily (o.d.) or b.i.d. During the study period, patients used Exfoliac® cleansing gel. The cumulative results indicate a significant improvement of AV lesions and seborrhoea, irrespectively of sun exposure, and a good tolerability, even in sunbathed patients. Adverse reactions, mostly of mild severity, appeared to be independent of sunbathing or use of sunscreens and were observed in a small proportion of cases (6.8% in the first 4 weeks and 5.6% in the last 8 weeks). Our results suggest that this type of treatment is an effective and safe approach to patients with mild AV who require treatment in the summertime.

scholarly journals A Pharmacovigilance Study of Topical Acne Monotherapy with 0.1% Adapalene, and A Molecular Analytical Review of Adapalene in Evidence-Based Dermatopharmacological Treatment

2021 ◽  
Vol 70 (2) ◽  
Author(s):  
Dr. Moumita Hazra
Keyword(s):  
Adverse Effects ◽  
Acne Vulgaris ◽  
Global Evaluation ◽  
Evidence Based ◽  
Molecular Pharmacology ◽  
Once Daily ◽  
Significant Evidence ◽  
The Face ◽  
Analytical Review ◽  
User Friendly

Acne vulgaris causes cosmetic impairment. User-friendly anti-acne monotherapy with adapalene has activity against the acne pathophysiology, with very minimal adverse effects. Retinoids, like adapalene, are comedolytic and anti-inflammatory. This study was conducted as a pharmacovigilance study of topical acne monotherapy with 0.1% adapalene, and a molecular analytical review of adapalene in evidence-based dermatopharmacological treatment. A prospective, open- labelled study was done, on 75 patients, with mild to moderate acne. Patients applied 0.1% adapalene topical monotherapy, once daily in the evening, over affected areas on the face, and left overnight. Efficacy was measured by percentage reduction in non-inflammatory, inflammatory and total lesion counts on 0, 15, 30, 60 and 90 days; and severity of lesions was assessed by Investigator’s Global Evaluation Scale and the occurrence of adverse effects like erythyma, dryness, scaling, burning and pruritus, were assessed by the Local Irritation Scale, among the patients receiving the monotherapy. An analytical review of the molecular pharmacology of adapalene in evidence-based dermatopharmacological treatment was thoroughly performed. The patients showed highly significant reduction in total lesion counts from baseline. No serious adverse effects were observed; and the observations were statistically non-significant. The molecular analytical review described significantly effective evidence-based dermatopharmacological response mechanisms of adapalene therapeutics. Topical 0.1% adapalene monotherapy was effective and safe, with significant evidence-based molecular dermatopharmacological efficacy.

Sidharthakadi Lepa in Mukhadushika - A Clinical Study

2018 ◽  
Vol 3 (01) ◽  
Author(s):  
Ravindra Angadi ◽  
Rekha J.
Keyword(s):  
Skin Disorder ◽  
Acne Vulgaris ◽  
Response To Therapy ◽  
Inclusion Criteria ◽  
Pilosebaceous Unit ◽  
External Application ◽  
Acne Lesion ◽  
Common Skin ◽  
The Face ◽  
Inflammatory Component

Background: Acne vulgaris is a very common malady of adolescents. It is common enough to be called as a physiological process but is better regarded as a disease due to its inflammatory component and the disfigurement. Acne vulgaris is a common skin disorder of pilosebaceous unit that primarily affects the face which if not treated leads to pigmentation. Mukhadushika is a Kshudra Roga which mainly involves Kapha and Vatadosa with Raktha. This is a common illness affecting 80 % of adolescents. Lepa is one of the external therapies explained in Ayurvedic classics. Objectives: To evaluate the efficacy of Sidharthakadilepa in the management of mukhadushikaw.s.r. to acne vulgaris. Methods: 30 patients fulfilling the inclusion criteria were selected. They were given Sidharthakadi Lepa for external application over face for one month. Patients were observed for changes on 7th, 14th, 21st and 28th day. The response to therapy was evaluated at the end of 28 days by calculating acne lesion score and the efficacy was determined by the percentage reduction in ALS. Results: The analysis revealed that 40% of patients had complete remission, 30% patients showed marked improvement and 30% showed moderate improvement.

scholarly journals Oral Azithromycin Pulse Therapy and Daily Topical Adapalene in the Treatment of Acne Vulgaris: An Open Randomized Noncomparative Study

2017 ◽  
Vol 28 (2) ◽  
pp. 52-56
Author(s):  
Mohammod Abu Hena Chowdhury ◽  
Shameem Al Mamun ◽  
Mohammad Jamal Uddin ◽  
Rashed Md Khan ◽  
M Mujibul Hoque ◽  
...  
Keyword(s):  
Cystic Lesion ◽  
Acne Vulgaris ◽  
Severity Index ◽  
Pulse Therapy ◽  
Inclusion Criteria ◽  
Noncomparative Study ◽  
Percent Reduction ◽  
Once Daily ◽  
Acne Lesion ◽  
Oral Azithromycin

The safety and efficacy of oral azithromycin and topical adapalene are well documented. In this study, concomitant use of oral azithromycin pulse therapy and daily topical adapalene in the treatment of acne vulgaris is assessed. A total of 37 patients fulfilled the inclusion criteria were enrolled. Azithromycin, 500 mg orally once daily first 3 days of 10 days' cycle for 9 cycle & topical Adapalene (0.5%) at night. Patients evaluated at 4 weeks' interval by using Michaelsson acne severity index. The overall assessment was made by percent reduction of acne lesions and severity score. At the end of 12 weeks' treatment 99.8% of comedones, 98.7% papular lesion, 94.3% pustular lesion and 88.8% infiltrated lesion were cleared. Only 2.9% cystic lesion responded to the regimens. Percent reduction of Michaelsson acne severity index was 87%, which was statistically highly significant. Overall assessment revealed acne lesion cleared in 22% cases, excellent improvement observed in 65% and 13% showed good response. Adverse effect was minimal. So, azithromycin pulse therapy and topical adapalene is indeed effective and safe in the treatment of acne vulgaris.Medicine Today 2016 Vol.28(2): 52-56

scholarly journals Hubungan tingkat kepercayaan diri dengan jerawat (acne vulgaris) pada remaja di SMAN 7 Manado

2016 ◽  
Vol 4 (1) ◽  
Author(s):  
Elga Elfina Ompi ◽  
Lydia David ◽  
H. Opod
Keyword(s):  
Acne Vulgaris ◽  
Physical Appearance ◽  
Cross Sectional ◽  
Internal Factors ◽  
Purposive Sampling ◽  
Rank Analysis ◽  
Self Confidence ◽  
The Face ◽  
Experience Education ◽  
The Relationship

Abstrak. Remaja dengan penampilan fisik berjerawat yang tidak sesuai dengan gambaran idealnya, dikatakan memiliki kepercayaan diri tinggi apabila ia mampu menerima dengan realistis dan mensyukuri serta bertindak positif sedangkan kepercayaan diri rendah apabila remaja tersebut merasa tidak puas, malu, kecewa dan menolak keadaan dirinya. Jerawat atau acne vulgaris adalah peradangan folikel sebasea yang ditandai oleh komedo, papula, pustula, kista dan nodulus di wajah, leher, badan atas dan lengan atas. Jerawat cukup merisaukan karena berhubungan dengan menurunnya kepercayaan diri akibat berkurangnya keindahan wajah penderita. Penelitian ini bertujuan untuk menganalisis hubungan tingkat kepercayaan diri dengan jerawat. Jenis penelitian ini adalah korelasional dengan pendekatan waktu cross sectional (potong lintang). Subyek penelitian adalah siswa/i kelas X-XII SMA Negeri 7 Manado yang berjerawat dengan jumlah 90 responden yang dipilih dengan cara purposive sampling. Untuk menganalisis hubungan antara tingkat kepercayaan diri dengan jerawat digunakan teknik analisis Rank Spearman. Hasil penelitian menunjukkan bahwa nilai koefisien korelasi antara jerawat dengan kepercayaan diri sebesar -0,068, artinya jerawat dengan kepercayaan diri memiliki hubungan negatif dimana keeratan korelasinya sangat lemah (<0,20) sehingga dapat dikatakan tidak terdapat hubungan signifikan antara kepercayaan diri dengan jerawat (Sig=0,523). Artinya, kondisi fisik dalam hal ini jerawat bukan satu-satunya faktor yang mempengaruhi kepercayaan diri. Konsep diri, pengalaman, pendidikan merupakan faktor internal dan orang tua, teman sebaya dan masyarakat merupakan faktor eksternal yang bisa mempengaruhi kepercayaan diri. Responden yang memiliki kepercayaan diri tinggi walaupun berjerawat tidak berorientasi pada penampilan fisik semata, karena mereka merasa yakin akan kemampuan dan potensi dirinya pada hal-hal yang lain.Kata kunci: Remaja, Kepercayaan Diri, Jerawat.Abstract. Adolescents with acne in physical appearance that doesn’t like the ideal appearance, is said that have confidence when he can accept realistically, still feel grateful and act positively while low confidence if these adolescents are not satisfied, embarrassed, disappointed, and rejected themselves. Acne vulgaris is the inflammation of the sebaceous follicles characterized by comedones, papules, pustules, cysts and nodules on the face, neck, upper trunk and upper arms. Acne is troubling because it is related to the degradation of self confidence due to the beauty of the face.This study aimed to analyze the relationship between the level of confidence with acne. This type of study is correlational with cross sectional approach. The subjects are SMAN 7 Manado students who have acnes with 90 respondents chosen by purposive sampling. Spearman Rank analysis techniques is used to.The results showed that the correlation coefficient between acne with confidence at -0.068, meaning the relationship between acne and confidence is negative which the closeness of the correlation is very weak (<0.20) so that it canbe said there is no significant relationship between confidence with acne (Sig = 0.523). It means, the physical appearance in this case the acne is not the only factor affecting confidence. Self-concept, experience, education is the internal factors and their parents, peers and the community are the external factors that can affect confidence. Respondents with high self confidence eventhough have acnes are not oriented on their physical appearance alone, , because they feel confident in the ability and potential for him in other things.Keywords: Adolescents, Confidence, Acne.

scholarly journals Tretinoin 0.05% Lotion for the Once-Daily Treatment of Moderate-to-Severe Acne Vulgaris in Females: Effect of Age on Efficacy and Tolerability

2020 ◽  
Vol 4 (5) ◽  
pp. s59
Author(s):  
Linda Stein Gold ◽  
David M Pariser ◽  
Marci Levy ◽  
Eric Guenin
Keyword(s):  
Acne Vulgaris ◽  
Daily Treatment ◽  
Once Daily ◽  
Severe Acne ◽  
Effect Of Age

Abstract not available.

scholarly journals Steroid-induced Rosacea- A Study From a Tertiary Care Hospital of Eastern Nepal

2021 ◽  
Vol 19 (1) ◽  
pp. 25-29
Author(s):  
Manoj Chaudhary ◽  
Sudha Agrawal
Keyword(s):  
Tertiary Care ◽  
Age Groups ◽  
Case Series ◽  
Sun Exposure ◽  
Care Hospital ◽  
Facial Erythema ◽  
Case Series Study ◽  
The Face ◽  
Triggering Factor ◽  
Study Population

Introduction: Topical corticosteroids (TC) are useful for treatment of various dermatological conditions in all age groups. Due to its cosmetic application TCs misuse is intertwined with fairness creams in our colour conscious society where people are obsessed with fair colour.   Aims and Objectives: To find the clinical presentations of steroid induced rosacea like-dermatitis on the face and to evaluate the purpose behind misusing TCs on the face.   Materials and methods: Descriptive prospective questionnaire-type case series study was approved by Institutional Ethical Committee of BPKIHS which involved 205 patients diagnosed as Steroid Induced Rosacea who consulted Dermatology OPD between March to June 2017.   Results: Among 205 patients enrolled, majority were from second to fourth decade (87.31%) of their life and maximum being females I.e. 91.2%. Around 97% of the study population were unaware of side effects of TCs. Most patients use Mometasone fuorate (58.04%) for melisma (88.29%). Friends acted as source of prescription (29.75%), followed by Pharmacist (24.88%) & Beauty centers (20%). Dermatologists prescribed TCs in only 6.34% cases. Sun exposure was identified as the triggering factor for steroid induced rosacea in 73.17% patients. Cheek was the commonest site involve in 92.19%, followed by forehead (65.36%), perioral area (46.83%), and chin (9.75%). Mixed type of lesions was the commonest lesion found in 52.20% patients, followed by diffuse facial erythema (36.09%), & telangiectasia (33.17%).   Conclusion: TCs misuse in the younger people for the sake of fairer skin with little or no knowledge about the adverse effects of this medication should be stopped.

scholarly journals Lip Shaving in Carcinoma Lower Lip and Reconstruction by Local Advancement Mucosal Flap Under Local Anesthesia: A Case Report

2020 ◽  
Vol 5 (8) ◽  
pp. 905-909
Author(s):  
Tareq Mohammed ◽  
Mamoon TB ◽  
Md Sirajul Islam ◽  
Md Aminul Islam ◽  
Farid Uddin Milki ◽  
...  
Keyword(s):  
Sun Exposure ◽  
Squamous Cell Carcinomas ◽  
Careful Planning ◽  
Lower Lip ◽  
Verbal Expression ◽  
Lip Reconstruction ◽  
Mucosal Flap ◽  
The Face ◽  
Extensive Surgery ◽  
Oral Commissure

The lips are one of the most important features of the face; and are functionally and aesthetically very important. It serves as border of the oral commissure, provides access to oral cavity and contributes to oral competence. It is important for verbal expression and fundamental for facial expression and overall appearance of face1 . Excessive sun exposure and tobacco use, may develop cancer. The cancer can occur anywhere along the upper or lower lip, but is most common on the lower lip. Most lip cancers are squamous cell carcinomas. Surgery is the main stay of treatment and lip shave is an established modality for superficial lesion followed by reconstruction. Extensive surgery may be necessary for larger lesion. Careful planning and reconstruction can restore eating and speaking normally, and also achieve a satisfactory appearance after surgery. Evidence supports that the concept of lip reconstruction started as early as 1000 BC in the sacred texts of great Susruta, India2 . Lip mucosa is very special and it is recommended to reconstruct the surgical defect with lip tissue whenever possible, as any other tissue is never comparable or can replace the lip tissue3 . This is the example of this presented case.

scholarly journals Topical Isotretinoin in Acne Vulgaris

2018 ◽  
Vol 29 (2) ◽  
pp. 1-5
Author(s):  
M Moksedur Rahman ◽  
M Abdullah ◽  
M Moazzem Hossain ◽  
MA Siddique ◽  
M Nessa ◽  
...  
Keyword(s):  
Side Effects ◽  
Adverse Effects ◽  
Prospective Study ◽  
Acne Vulgaris ◽  
Topical Therapy ◽  
Outpatient Department ◽  
College Hospital ◽  
Once Daily ◽  
Medical College ◽  
Cutaneous Reactions

This study was carried out to evaluate the efficacy, safety and adverse effects of topical isotretinoin 0.05% gel in the treatment of acne vulgaris. This prospective study was undertaken in Skin & VD outpatient department of Rajshahi Medical College Hospital, Rajshahi. One hundred patients with mild tomoderate acne vulgaris were enrolled and were instructed to apply isotretinoin 0.05% gel once daily at night for 12 weeks. Patients were followed up at 2,4,8 and 12 weeks for efficacy and tolerability. Efficacy was measured by counting facial inflammatory and noninflammatory lesions and by grading acne severity. Cutaneous tolerance was assessed by determining erythema, scaling and burning with pruritus.Response was excellent in 80%of cases.None of the cutaneous reactions was severe, all were mild and well tolerated.Nobody had to discontinue the therapy for side effects. This study confirms that isotretinoin 0.05% gel is safe and effective topical therapy for mild to moderate acnevulgaris.TAJ 2016; 29(2): 1-5

Acne Vulgaris and Rosacea

2019 ◽  
Author(s):  
James Q Del Rosso
Keyword(s):  
Acne Vulgaris ◽  
Fibrous Tissue ◽  
Clinical Severity ◽  
European Ancestry ◽  
Laboratory Evaluation ◽  
Northern European ◽  
Chronic Disorder ◽  
Clinical Presentations ◽  
The Face

Acne vulgaris is the most common disorder seen in general dermatology practice, accounting for approximately 10% of visits each year. Both sexes and all ethnicities are affected, usually in the late preteenage or early teenage years. Both inflammatory and comedonal lesions of acne vulgaris characteristically involve the face, but truncal involvement is also relatively common. Multiple clinical presentations may be observed, with severity often progressing over time during adolescence. Severe forms of acne vulgaris can be especially disfiguring and debilitating, and are more likely to lead to permanent scarring. Therapeutic options are chosen primarily on the basis of clinical severity, with adjustments in treatment made on the basis of response or disease progression. Rosacea begins in adulthood, usually in the third decade of life or later. The disorder predominantly affects the central face in fair-skinned people, mostly those of northern European ancestry, although individuals of any race may be affected. Rosacea may present as one or more of a variety of clinical phenotypes (subtypes); it is a chronic disorder characterized by periods of exacerbation and remission. Fortunately, rosacea is not associated with scarring, although a subset of patients may develop localized proliferations of sebaceous and fibrous tissue called a phyma. Like acne vulgaris, rosacea may also adversely impact quality of life. Figures in this chapter illustrate acne vulgaris and inflammatory papules. Tables detail laboratory evaluation for women with acne vulgaris and hyperandrogenism, surgical/physical modality options for specific acne lesions and acne scars, major topical therapies for acne vulgaris, and commonly prescribed systemic therapies for acne. This chapter contains 50 references.

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