scholarly journals A practical and scalable synthesis of KRN7000 using glycosyl iodide as the glycosyl donor

2020 ◽  
pp. 174751982096101
Author(s):  
Yang Zhang ◽  
Jia Guo ◽  
Xiaoyan Xu ◽  
Qi Gao ◽  
Xianglai Liu ◽  
...  
Keyword(s):  
High Price ◽  
Methodology Development ◽  
The Past ◽  
Pure Product ◽  
Glycosyl Donor ◽  
Scalable Synthesis ◽  
Almost All ◽  
Column Chromatographic

KRN7000 is particularly useful because it is a powerful and specific CD1d agonist and has prompted intense interest in the context of immunology in the past 25 years. Its limited commercial availability and high price has led to the publication of many different syntheses. However, almost all of them focused on the methodology development rather than a scalable synthesis. Herein, we have described a practical and scalable procedure for the synthesis of KRN7000 basing on the glycosyl iodide method. This procedure involves total of eight steps to obtain the highly pure product KNR7000 on gram scale from the commercially available starting materials (d-galactose and the phytosphingosine) with only three column chromatographic purifications.

BP Global Energy Outlook 2030

2013 ◽  
pp. 109-128 ◽  
Author(s):  
C. Rühl
Keyword(s):  
Emerging Economies ◽  
Energy Demand ◽  
Fossil Fuels ◽  
Net Energy ◽  
Global Energy ◽  
The Past ◽  
Market Shares ◽  
The Us ◽  
Almost All ◽  
Oil Gas

This paper presents the highlights of the third annual edition of the BP Energy Outlook, which sets out BP’s view of the most likely developments in global energy markets to 2030, based on up-to-date analysis and taking into account developments of the past year. The Outlook’s overall expectation for growth in global energy demand is to be 36% higher in 2030 than in 2011 and almost all the growth coming from emerging economies. It also reflects shifting expectations of the pattern of supply, with unconventional sources — shale gas and tight oil together with heavy oil and biofuels — playing an increasingly important role and, in particular, transforming the energy balance of the US. While the fuel mix is evolving, fossil fuels will continue to be dominant. Oil, gas and coal are expected to converge on market shares of around 26—28% each by 2030, and non-fossil fuels — nuclear, hydro and renewables — on a share of around 6—7% each. By 2030, increasing production and moderating demand will result in the US being 99% self-sufficient in net energy. Meanwhile, with continuing steep economic growth, major emerging economies such as China and India will become increasingly reliant on energy imports. These shifts will have major impacts on trade balances.

Building Research Teams

2017 ◽  
Author(s):  
Ken Peach
Keyword(s):  
Common Goal ◽  
Research Teams ◽  
Building Research ◽  
The Past ◽  
Collective Activity ◽  
Research Administrators ◽  
Working Together ◽  
Common Goals ◽  
Almost All ◽  
Century Science

This chapter discusses the process of building research teams. Increasingly over the past three-quarters of a century, science has become a collective activity, with teams of tens, hundreds or even thousands of scientists, engineers and technicians working together on a common goal. Consequently, almost all research involves building, motivating and maintaining a research team. Even a theoretical group is likely to have one or two postdocs, graduate students and visitors, but research teams will, in addition, have engineers and technicians, as well as, possibly, research administrators. The chapter also addresses the importance of creating and maintaining a good team and team spirit, as large projects are assembled from a large number of small teams working on common goals, usually in a loose federated structure with some overall coordination and leadership.

scholarly journals Improved PrEP Awareness and Use among Trans Women in San Francisco, California

2021 ◽  
Author(s):  
Erin C. Wilson ◽  
Christopher J. Hernandez ◽  
Susan Scheer ◽  
Dillon Trujillo ◽  
Sean Arayasirikul ◽  
...  
Keyword(s):  
San Francisco ◽  
Anal Intercourse ◽  
Receptive Anal Intercourse ◽  
The Past ◽  
National Hiv Behavioral Surveillance ◽  
Trans Women ◽  
Gender Based ◽  
Prep Awareness ◽  
Almost All ◽  
Exposure Prophylaxis

AbstractTransgender women face a serious risk of HIV infection. Despite this, there is limited knowledge and use of Pre-exposure prophylaxis (PrEP). We measured the continuity of prevention across services in the PrEP cascade and correlates of PrEP use among trans women in San Francisco enrolled in the 2019/20 National HIV Behavioral Surveillance Study. Knowledge and use of PrEP among trans women in San Francisco increased in recent years; almost all (94.0%) had heard about PrEP, 64.7% had discussed PrEP with a healthcare provider, and 44.8% had taken PrEP in the past 12 months. PrEP use was associated with participation in a PrEP demonstration project (aOR = 31.44, p = 0.001) and condomless receptive anal intercourse (aOR = 3.63, p = 0.024). Injection drug use was negatively associated (aOR = 0.19, p = 0.014). Efforts are needed to combat the gender-based stigma and discrimination faced by trans women, which can result in avoidance and mistrust of the medical system.

Fast Text Processing for Interlaced Sports or News Videos

2015 ◽  
Vol 740 ◽  
pp. 652-655
Author(s):  
Qian Huang ◽  
Feng Xu
Keyword(s):  
Unsolved Problem ◽  
Text Processing ◽  
Picture Quality ◽  
Trade Off ◽  
Coding Efficiency ◽  
The Past ◽  
Processing Strategies ◽  
Visual Artifacts ◽  
Text Content ◽  
Almost All

Interlaced scanning has been widely used as a trade-off solution between picture quality and transmission bandwidth since the invention of television. During the past decades, various interlaced-to-progressive conversion algorithms have been proposed to improve subjective quality or coding efficiency. However, almost all the researchers concentrate on general cases, without making full use of specific application scenarios. Based on extensive investigations, eliminating visual artifacts in areas of subtitles and station captions for interlaced sports and news videos is still an unsolved problem, which will be addressed in this paper. Firstly, motion estimation is performed between field pictures. Secondly, text edge detection is proposed for sports and news videos. Finally, different processing strategies are applied to text regions and non-text regions. Experimental results show that the proposed method can generate much better text content than existing algorithms. In addition, it is quite stable for non-text parts.

scholarly journals Clinical Characterisation and Management of the Main Treatment-Induced Toxicities in Patients with Hepatocellular Carcinoma and Cirrhosis

Cancers ◽  
2021 ◽  
Vol 13 (3) ◽  
pp. 584
Author(s):  
Fausto Meriggi ◽  
Massimo Graffeo
Keyword(s):  
Hepatocellular Carcinoma ◽  
Hepatic Impairment ◽  
Hepatic Cirrhosis ◽  
Disease Stage ◽  
The Past ◽  
Systemic Treatments ◽  
Key Points ◽  
Locoregional Therapies ◽  
Almost All ◽  
Selection Of

The incidence of hepatocellular carcinoma (HCC) continues to increase worldwide, particularly in Western countries. In almost all cases, HCC develops in subjects with hepatic cirrhosis, often as the result of hepatitis B or C virus infection, alcohol abuse or metabolic forms secondary to non-alcoholic steatohepatitis. Patients with HCC and hepatic symptoms can therefore present symptoms that are attributable to both conditions. These patients require multidisciplinary management, calling for close interaction between the hepatologist and the oncologist. Indeed, the treatment of HCC requires, depending on the disease stage and the degree of hepatic impairment, locoregional therapies that can in turn be broken down into surgical and nonsurgical treatments and systemic treatments used in the event of progression after the administration of locoregional treatments. The past decade has seen the publication of countless papers of great interest that have radically changed the scenario of treatment for HCC. Novel therapies with biological agents and immunotherapy have come to be standard options in the approach to treatment of this cancer, obtaining very promising results where in the past chemotherapy was almost never able to have an impact on the course of the disease. However, in addition to being costly, these drugs are not devoid of adverse effects and their management cannot forgo the consideration of the underlying hepatic impairment. Patients with HCC and cirrhosis therefore require special attention, starting from the initial characterisation needed for an appropriate selection of those to be referred for treatment, as these patients are almost never fit. In this chapter, we will attempt to investigate and clarify the key points of the management of the main toxicities induced by locoregional and systemic treatments for HCC secondary to cirrhosis.

115 An Audit on Dexamethasone Prescribing Practice on Surgically Managed Metastatic Spinal Cord Compression Patients in the Manchester Centre for Clinical Neurosciences: Lessons Learned in Closing the Loop

2021 ◽  
Vol 108 (Supplement_2) ◽  
Author(s):  
R Laurente ◽  
R Mohammed ◽  
M Elmalky
Keyword(s):  
Spinal Cord ◽  
Spinal Cord Compression ◽  
Cord Compression ◽  
Lessons Learned ◽  
Metastatic Spinal Cord Compression ◽  
Loading Dose ◽  
The Past ◽  
Prescribing Practice ◽  
Closing The Loop ◽  
Almost All

Abstract Metastatic Spinal Cord Compression is a surgical emergency owing to its propensity to cause significant morbidity and mortality. Dexamethasone is prescribed to reduce oedema and promote vascular membrane stabilization. The is done so until a more definitive management has been performed. This is a retrospective study evaluating the steroid-prescribing practice for MSCC patients in 2018 at a tertiary spinal unit in Greater Manchester. Thirty-three patients who underwent stabilisation were evaluated in terms of both steroid prescribing and weaning practices. Standards used against for both were the NICE guidelines and the Edinburgh/Christie’s guidelines. Of the 33 patients evaluated, only 1 patient received the correct loading dose of 16mg, whilst 27 went straight to being given 8mg BD. 5 did not receive dexamethasone at all. In terms of discontinuation/weaning, 26 were weaned accordingly and 2 were not weaned to continue as adjuvant treatment. Dexamethasone prescribing practises has since improved over the past two years. 93% of the patients have been correctly weaned as compared to 38% in the past. In terms of prescription, much needs to be done as almost all the patients evaluated did not get the correct loading dose despite receiving the appropriate maintenance.

Modeling Habitat Suitability and Management Options for Maintaining Round Whitefish (Prosopium cylindraceum) in Adirondack Ponds

2021 ◽  
Author(s):  
Amy Kathleen Conley ◽  
Matthew D. Schlesinger ◽  
James G. Daley ◽  
Lisa K. Holst ◽  
Timothy G. Howard
Keyword(s):  
Species Distribution Model ◽  
Management Strategies ◽  
Distribution Model ◽  
Nonnative Species ◽  
Simulated Population ◽  
Management Options ◽  
The Past ◽  
Almost All ◽  
Reintroduction Success ◽  
Maximum Air Temperature

Habitat loss, acid precipitation, and nonnative species have drastically reduced the number of Adirondack waterbodies occupied by round whitefish (Prosopium cylindraceum). The goal of this study was to 1) increase the probability of reintroduction success by modeling the suitability of ponds for reintroduction and 2) better understand the effects of different rates of pond reclamation. We created a species distribution model that identified 70 waterbodies that were physically similar to occupied ponds. The most influential variables for describing round whitefish habitat included trophic, temperature, and alkalinity classes; waterbody maximum depth; maximum air temperature; and surrounding soil texture and impervious surface. Next, we simulated population dynamics under a variety of treatment scenarios and compared the probability of complete extirpation using a modified Markov model. Under almost all management strategies, and under pressure from nonnative competitors like that observed in the past 30 years, the number of occupied ponds will decline over the next 100 years. However, restoring one pond every 3 years would result in a 99% chance of round whitefish persistence after 100 years.

BACTERIAL MENINGITIS

PEDIATRICS ◽  
1973 ◽  
Vol 52 (4) ◽  
pp. 586-600
Author(s):  
David H. Smith ◽  
David L. Ingram ◽  
Arnold L. Smith ◽  
Floyd Gilles ◽  
M. J. Bresnan
Keyword(s):  
Bacterial Meningitis ◽  
Medical Care ◽  
Newborn Infant ◽  
Antibacterial Therapy ◽  
Tuberculous Meningitis ◽  
Current Knowledge ◽  
The Past ◽  
Meningococcal Group ◽  
Group A ◽  
Almost All

Prior to the introduction of specific antibacterial therapy, bacterial meningitis was a disease with a universally fatal or disastrous outcome. The introduction of typespecific antiserum, and then of the antibacterial drugs, improved this situation dramatically. Improvements in the general medical care of acutely ill children, and the introduction of a series of more potent antibiotics against its bacterial causes helped to generate an attitude that bacterial meningitis was, or soon would be, a disease of the past. The experience of the past two decades belies this thesis. Today, interest in many facets of this disease has been renewed by many physicians concerned with the health of children: the epidemiology, pathophysiology, diagnosis, and treatment. This symposium attempts to summarize for the practitioner the highlights of current knowledge in this area, and to outline certain areas in which recent advances can be anticipated, or will be studied. Tuberculous meningitis will be omitted for the sake of brevity, as will the special problems of meningitis in the newborn infant. There has been a resurgence of interest in developing vaccines to prevent Hemophilus influenzae b, pneumococcal, and meningococcal Group A, B, and C meningitis. These organisms cause almost all the bacterial meningitis after the first two months of life. If, as now seems possible, vaccines against most or all of these organisms will soon become available, those children having the greatest risk must be defined to determine who, and at what age should have priority in receiving the vaccine(s). A. THE CURRENT MAGNITUDE OF THE PROBLEM

ROOT END FILLING MATERIALS – A REVIEW

2021 ◽  
pp. 5-9
Author(s):  
Bynagari Chandra Shekar ◽  
Veerendra Uppin ◽  
Madhu Pujar
Keyword(s):  
Root Canal ◽  
Gold Standard ◽  
The Past ◽  
Filling Materials ◽  
Restorative Materials ◽  
The Creation ◽  
Almost All

The aim of a root end lling is to prevent irritants from the root canal from leaking into the periapical region and to improve the apical seal created by nonsurgical endodontic care. Various restorative materials that have been used for coronal restorations have been tried and tested as root end lling materials, as well as the creation of restorative materials designed specically for root end lling. In the past, amalgam was the preferred material for root end lling. MTA, a recently established material that meets almost all of the criteria for an ideal root end lling material, has become the gold standard against which newer materials are measured. This article examines traditional endodontic root end materials and provides an overview of recent advancements in root end lling

scholarly journals Higher education after neoliberalism: Student activism as a guiding light

2018 ◽  
Vol 18 (1) ◽  
pp. 90-116 ◽  
Author(s):  
Rose M Cole ◽  
Walter F Heinecke
Keyword(s):  
Higher Education ◽  
College Student ◽  
Student Activism ◽  
Social Imaginary ◽  
Racial Justice ◽  
Creative Imagination ◽  
Student Activists ◽  
The Past ◽  
College Student Activism ◽  
Almost All

Contemporary college student activism has been particularly visible and effective in the past few years at US institutions of higher education and is projected only to grow in future years. Almost all of these protests and demands, while explicitly linked to social and racial justice, are sites of resistance to the neoliberalization of the academy. These activists are imagining a post-neoliberal society, and are building their demands around these potential new social imaginaries. Based on a discourse analysis of contemporary college student activist demands, to examine more closely the ways that student activists understand, resist, critique, and offer new alternatives to current (neoliberal) structures in higher education, it is suggested that student activists might be one key to understanding what’s next for higher education in a post-neoliberal context. The activists’ critiques of the structure of higher education reveal a sophisticated understanding of the current socio-political, cultural, and economic realities. Their demands show an optimistic, creative imagination that could serve educators well as we grapple with our first steps down a new road. Using their critiques and demands as a jumping-off point, this paper offers the blueprint for a new social imaginary in higher education, one that is focused on community and justice.

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