scholarly journals Professor Krystyna Kotełko and her contribution to the study of Proteus endotoxin

2018 ◽  
Vol 24 (3) ◽  
pp. 148-151
Author(s):  
Antoni W Różalski
Keyword(s):  
Amino Acids ◽  
Chemical Structure ◽  
Classification Scheme ◽  
Core Region ◽  
Uronic Acids ◽  
Specific Polysaccharide ◽  
Object Of Study ◽  
The University ◽  
First Time ◽  
Serological Specificity

Professor Krystyna Kotełko was working as a microbiologist at the University of Łódź (Poland). Her main object of study was the LPS (endotoxin) of opportunistic urinary pathogens from the genus Proteus. She demonstrated, for the first time, the presence of uronic acids and amino acids, as well as two heptoses (L- glycero-D- manno-heptose and D- glycero-D- manno-heptose) and hexosamines in Proteus LPS, and developed a classification scheme of the Proteus LPS into chemotypes. Prof Kotełko also initiated studies on the chemical structure of Proteus O-specific polysaccharide and investigations on the serological specificity of this part of LPS, as well its core region. She also analysed the virulence factors of these bacteria, such as haemolysin and invasiveness.

scholarly journals The amide of galacturonic acid with lysine as an immunodominant component of the lipopolysaccharide core region from Proteus penneri 42 strain.

2014 ◽  
Vol 61 (1) ◽  
Author(s):  
Agata Palusiak ◽  
Anna Maciejewska ◽  
Czesław Ługowski ◽  
Antoni Różalski
Keyword(s):  
Amino Acids ◽  
Galacturonic Acid ◽  
Core Region ◽  
Uronic Acids ◽  
O Antigens ◽  
Proteus Penneri ◽  
Serological Specificity

Most Proteus lipopolysaccharides (LPSs) contain uronic acids or their amides with different amino acids, which together with other negatively charged components account for the acidic character of such LPS molecules. Previous studies have shown the significance of an amide of galacturonic acid with lysine [D-GalA(L-Lys)] for serological specificity of O-antigens from few P. mirabilis strains. In this work, the immunodominant role of GalALys was indicated for the P. penneri 42 LPS core region. The studies also showed the serological identity of core oligosaccharides from P. penneri 42 (O71), P. mirabilis 51/57 (O28) and R14/S1959 strains.

scholarly journals Enantioenrichments of α -Amino Acids With High-Intensity Excimer Laser

1999 ◽  
Vol 18 (3) ◽  
pp. 143-154 ◽  
Author(s):  
Yuichi Shimizu
Keyword(s):  
Amino Acids ◽  
Intermolecular Interaction ◽  
Functional Groups ◽  
Excimer Laser ◽  
High Intensity ◽  
Chemical Structure ◽  
Polarized Light ◽  
Circularly Polarized Light ◽  
Circularly Polarized ◽  
First Time

It has been found that the irradiation with highly intense circularly polarized light (CPL) from an XeF (351 nm) laser can induce the enantiodifferentiation of racemic methionine with reasonable enantiocontrol by switching the sense of the CPL. Also, a similar result was obtained for threonine and it was newly revealed that the enantioenrichment is largely affected by the chemical structure, especially the functional groups, of α-amino acids, to cause photodecomposition such as decarboxylation and deamination. Furthermore, it was shown for the first time that the irradiation of a proline (Pro)-valine (Val) mixture with the CPL induces their enantioselective decomposition simultaneously, suggesting the occurrence of intermolecular interaction between Pro and Val.

Adam Zalužanský’s “De sexu plantarum” (1592): an early pioneering chapter on plant sexuality

2013 ◽  
Vol 40 (2) ◽  
pp. 244-256 ◽  
Author(s):  
Holger Funk
Keyword(s):  
Nineteenth Century ◽  
English Translation ◽  
History Of Botany ◽  
Main Work ◽  
Botanical History ◽  
History Of ◽  
The University ◽  
First Time

In the history of botany, Adam Zalužanský (d. 1613), a Bohemian physician, apothecary, botanist and professor at the University of Prague, is a little-known personality. Linnaeus's first biographers, for example, only knew Zalužanský from hearsay and suspected he was a native of Poland. This ignorance still pervades botanical history. Zalužanský is mentioned only peripherally or not at all. As late as the nineteenth century, a researcher would be unaware that Zalužanský’s main work Methodi herbariae libri tres actually existed in two editions from two different publishers (1592, Prague; 1604, Frankfurt). This paper introduces the life and work of Zalužanský. Special attention is paid to the chapter “De sexu plantarum” of Zalužanský’s Methodus, in which, more than one hundred years before the well-known De sexu plantarum epistola of R. J. Camerarius, the sexuality of plants is suggested. Additionally, for the first time, an English translation of Zalužanský’s chapter on plant sexuality is provided.

More Christian Apocrypha

2012 ◽  
Vol 41 (3) ◽  
pp. 16-21
Author(s):  
Tony Burke
Keyword(s):  
New Testament ◽  
Old Testament ◽  
North American ◽  
English Language ◽  
Primary Sources ◽  
University Of Edinburgh ◽  
The University ◽  
First Time ◽  
Medieval Christianity

Scholars interested in the Christian Apocrypha (CA) typically appeal to CA collections when in need of primary sources. But many of these collections limit themselves to material believed to have been written within the first to fourth centuries CE. As a result a large amount of non-canonical Christian texts important for the study of ancient and medieval Christianity have been neglected. The More Christian Apocrypha Project will address this neglect by providing a collection of new editions (some for the first time) of these texts for English readers. The project is inspired by the More Old Testament Pseudepigrapha Project headed by Richard Bauckham and Jim Davila from the University of Edinburgh. Like the MOTP, the MCAP is envisioned as a supplement to an earlier collection of texts—in this case J. K. Elliott’s The Apocryphal New Testament (Oxford 1991), the most recent English-language CA collection (but now almost two decades old). The texts to be included are either absent in Elliott or require significant revision. Many of the texts have scarcely been examined in over a century and are in dire need of new examination. One of the goals of the project is to spotlight the abilities and achievements of English (i.e., British and North American) scholars of the CA, so that English readers have access to material that has achieved some exposure in French, German, and Italian collections.

Single Amino Acid Based Self-Assemblies of Cysteine and Methionine

2018 ◽  
Author(s):  
Nidhi Gour ◽  
Bharti Koshti ◽  
Chandra Kanth P. ◽  
Dhruvi Shah ◽  
Vivek Shinh Kshatriya ◽  
...  
Keyword(s):  
Amino Acids ◽  
Amino Acid ◽  
Self Assembly ◽  
Aromatic Amino Acids ◽  
Neutral Condition ◽  
Single Amino Acid ◽  
Binding Assays ◽  
Human Neuroblastoma ◽  
Cytotoxicity Assays ◽  
First Time

We report for the very first time self-assembly of Cysteine and Methionine to discrenible strucutres under neutral condition. To get insights into the structure formation, thioflavin T and Congo red binding assays were done which revealed that aggregates may not have amyloid like characteristics. The nature of interactions which lead to such self-assemblies was purported by coincubating assemblies in urea and mercaptoethanol. Further interaction of aggregates with short amyloidogenic dipeptide diphenylalanine (FF) was assessed. While cysteine aggregates completely disrupted FF fibres, methionine albeit triggered fibrillation. The cytotoxicity assays of cysteine and methionine structures were performed on Human Neuroblastoma IMR-32 cells which suggested that aggregates are not cytotoxic in nature and thus, may not have amyloid like etiology. The results presented in the manuscript are striking, since to the best of our knowledge,this is the first report which demonstrates that even non-aromatic amino acids (cysteine and methionine) can undergo spontaneous self-assembly to form ordered aggregates.

A University Education

2017 ◽  
Author(s):  
David Willetts
Keyword(s):  
Higher Education ◽  
Modern Society ◽  
University Education ◽  
Modern World ◽  
Controversial Issues ◽  
The Us ◽  
The Individual ◽  
The University ◽  
First Time ◽  
The Relationship

Universities have a crucial role in the modern world. In England, entrance to universities is by nation-wide competition which means English universities have an exceptional influence on schools--a striking theme of the book. This important book first investigates the university as an institution and then tracks the individual on their journey to and through university. In A University Education, David Willetts presents a compelling case for the ongoing importance of the university, both as one of the great institutions of modern society and as a transformational experience for the individual. The book also makes illuminating comparisons with higher education in other countries, especially the US and Germany. Drawing on his experience as UK Minister for Universities and Science from 2010 to 2014, the author offers a powerful account of the value of higher education and the case for more expansion. He covers controversial issues in which he was involved from access for disadvantaged students to the introduction of L9,000 fees. The final section addresses some of the big questions for the future, such as the the relationship between universities and business, especially in promoting innovation.. He argues that the two great contemporary trends of globalisation and technological innovation will both change the university significantly. This is an authoritative account of English universities setting them for the first time in their new legal and regulatory framework.

scholarly journals Introduction: Transdiasporic Rencontres in Việt Kiều Literature

2018 ◽  
Vol 15 (1-2) ◽  
pp. 1-5
Author(s):  
Alexandra Kurmann ◽  
Tess Do
Keyword(s):  
New Caledonia ◽  
Literary Texts ◽  
Special Issue ◽  
Contemporary Writing ◽  
The University ◽  
First Time ◽  
Vietnamese Diaspora

This special issue follows a conference entitled ‘Rencontres: A Gathering of Voices of the Vietnamese Diaspora’ that was held at the University of Melbourne, December 1-2 in 2016 and which sought to enable, for the first time, the titular transdiasporic rencontres or encounters between international authors of the Vietnamese diaspora. The present amalgam of previously unpublished texts written by celebrated Francophone and Anglophone authors of Vietnamese descent writing in France, New Caledonia and Australia today is the result of the intercultural exchanges that took place during that event. Literary texts by Linda Lê, Anna Moï and Thanh-Van Tran-Nhut are followed by writerly reflections on the theme of transdiasporic encounters from Hoai Huong Nguyen, Jean Vanmai and Hoa Pham. Framing and enriching these texts, scholarly contributions by established experts in the field consider the literary, cultural and linguistic transfers that characterize contemporary writing by authors of Vietnamese origin across the Francophone world. Ce volume spécial réunit les Actes du colloque ‘Rencontres : A Gathering of Voices of the Vietnamese Diaspora’ qui s’est tenue à l’Université de Melbourne les 1er et 2 décembre 2016 et qui visait à faciliter, pour la première fois, les rencontres entre les auteurs, chercheurs et universitaires internationaux de la diaspora vietnamienne. Les fruits de leurs échanges interculturels y sont réunis dans ce présent recueil sous deux formes complémentaires : d’un côté, les articles d’experts en littérature francophone comparée ; de l’autre, les contributions créatives de célèbres auteurs francophones et anglophones d’origine vietnamienne basés aujourd’hui en France, en Nouvelle Calédonie et en Australie. Les textes littéraires de Linda Lê, Anna Moï et Thanh-Van Tran-Nhut, suivis de réflexions d’auteurs par Hoai Huong Nguyen, Hoa Pham et Jean Vanmai sur le thème des rencontres transdiasporiques, se retrouvent enrichis par les études savantes menées sur les transferts littéraires, culturelles et linguistiques qui caractérisent l’écriture contemporaine des écrivains d’origine vietnamienne dans le monde francophone.

scholarly journals Autophagy Deficiency by Atg4B Loss Leads to Metabolomic Alterations in Mice

Metabolites ◽  
2021 ◽  
Vol 11 (8) ◽  
pp. 481
Author(s):  
Gemma G. Martínez-García ◽  
Raúl F. Pérez ◽  
Álvaro F. Fernández ◽  
Sylvere Durand ◽  
Guido Kroemer ◽  
...  
Keyword(s):  
Skeletal Muscle ◽  
Amino Acids ◽  
Mammalian Cells ◽  
Tissue Homeostasis ◽  
In Vivo Studies ◽  
Protective Mechanism ◽  
Cardiac Damage ◽  
Wide Range ◽  
First Time

Autophagy is an essential protective mechanism that allows mammalian cells to cope with a variety of stressors and contributes to maintaining cellular and tissue homeostasis. Due to these crucial roles and also to the fact that autophagy malfunction has been described in a wide range of pathologies, an increasing number of in vivo studies involving animal models targeting autophagy genes have been developed. In mammals, total autophagy inactivation is lethal, and constitutive knockout models lacking effectors of this route are not viable, which has hindered so far the analysis of the consequences of a systemic autophagy decline. Here, we take advantage of atg4b−/− mice, an autophagy-deficient model with only partial disruption of the process, to assess the effects of systemic reduction of autophagy on the metabolome. We describe for the first time the metabolic footprint of systemic autophagy decline, showing that impaired autophagy results in highly tissue-dependent alterations that are more accentuated in the skeletal muscle and plasma. These changes, which include changes in the levels of amino-acids, lipids, or nucleosides, sometimes resemble those that are frequently described in conditions like aging, obesity, or cardiac damage. We also discuss different hypotheses on how impaired autophagy may affect the metabolism of several tissues in mammals.

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