Does periodontitis represent a risk factor for rheumatoid arthritis? A systematic review and meta-analysis

Periodontitis is an inflammatory disease of dental supporting tissues (gingiva, periodontal ligament, and bone) and it has been suggested as a possible etiology for rheumatoid arthritis (RA). In this systematic review, we aim to verify if periodontitis represents a risk factor for RA. Electronic databases were consulted until March 2018 considering eligibility criteria focusing on: (P, participants) adults; (E, exposure) with periodontitis; (C, comparison) without periodontitis; and (O, outcome) development of RA. Quality assessment of studies and risk-of-bias evaluation were also performed. To undertake a quantitative analysis, the number of persons with RA and a total number of participants for the case group (with periodontitis) and control group (without periodontitis) were used to calculate the odds ratio (OR) with a 95% confidence interval (CI). A total of 3888 articles were identified, and nine studies were considered eligible. Seven of 9 articles suggested an association among diseases by the common pro-inflammatory profiles. The pooled analysis of 3 articles showed a higher RA prevalence for persons with periodontitis ( n = 1177) than controls ( n = 254) (OR 1.97; CI 1.68–2.31; p < 0.00001). However, considerable heterogeneity among studies was verified (I2 = 96%, p < 0.00001). Periodontitis may represent a risk factor for RA by heredity, bacterial infection, and the pro-inflammatory profile shared between both diseases. Although most of the elective studies report an association between periodontitis and RA, the quantitative analysis showed a high heterogeneity, leading to the need for further studies.

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Tolerability of statin-based management of patients with a history of statin-associated muscle symptoms: protocol for a systematic review

BMJ Open ◽

10.1136/bmjopen-2021-052341 ◽

2021 ◽

Vol 11 (8) ◽

pp. e052341

Author(s):

Fanny Villoz ◽

Christina Lyko ◽

Cinzia Del Giovane ◽

Nicolas Rodondi ◽

Manuel R Blum

Keyword(s):

Systematic Review ◽

Meta Analysis ◽

Mean Difference ◽

Control Group ◽

Cochrane Central Register ◽

Eligibility Criteria ◽

Clinical Issue ◽

Standard Data ◽

Evaluation Approach ◽

History Of

IntroductionStatin-associated muscle symptoms (SAMSs) are a major clinical issue in the primary and secondary prevention of cardiovascular events. Current guidelines advise various approaches mainly based on expert opinion. We will lead a systematic review and meta-analysis to explore the tolerability and acceptability and effectiveness of statin-based therapy management of patients with a history of SAMS. We aim to provide evidence on the tolerability and different strategies of statin-based management of patients with a history of SAMS.Methods and analysisWe will conduct a systematic review of randomised controlled trials (RCTs) and non-randomised studies with a control group. We will search in Data sources MEDLINE, EMBASE, Cochrane Central Register of Controlled Clinical Trials, Scopus, Clinicaltrials.gov and Proquest from inception until April 2021. Two independent reviewers will carry out the study selection based on eligibility criteria. We will extract data following a standard data collection form. The reviewers will use the Cochrane Collaboration’s tools and Newcastle-Ottawa Scale to appraise the study risk of bias. Our primary outcome will be tolerability and our secondary outcomes will be acceptability and effectiveness. We will conduct a qualitative analysis of all included studies. In addition, if sufficient and homogeneous data are available, we will conduct quantitative analysis. We will synthesise dichotomous data using OR with 95% CI and continuous outcomes by using mean difference or standardised mean difference (with 95% CI). We will determine heterogeneity visually with forest plots and quantitatively with I2 and Q-test. We will summarise the confidence in the quantitative estimate by using Grading of Recommendations Assessment, Development and Evaluation approach.Ethics and disseminationAs a systematic review of literature without collection of new clinical data, there will be no requirement for ethical approval. We will disseminate findings through peer-reviewed publications.PROSPERO registration numberCRD42020202619.

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Association between apolipoprotein gene polymorphisms and hyperlipidemia: a meta-analysis

BMC Genomic Data ◽

10.1186/s12863-021-00968-1 ◽

2021 ◽

Vol 22 (1) ◽

Author(s):

Xiao-Ning Zhao ◽

Quan Sun ◽

You-Qin Cao ◽

Xiao Ran ◽

Yu Cao

Keyword(s):

Risk Factor ◽

Cerebrovascular Disease ◽

Gene Polymorphisms ◽

Meta Analysis ◽

Control Group ◽

Case Group ◽

Healthy Controls ◽

Ε4 Allele ◽

Different Populations ◽

The Impact

Abstract Background Hyperlipidemia plays an important role in the etiology of cardio-cerebrovascular disease. Over recent years, a number of studies have explored the impact of apolipoprotein genetic polymorphisms in hyperlipidemia, but considerable differences and uncertainty have been found in their association with different populations from different regions. Results A total of 59 articles were included, containing in total 13,843 hyperlipidemia patients in the case group and 15,398 healthy controls in the control group. Meta-analysis of the data indicated that APOA5–1131 T > C, APOA1 -75 bp, APOB XbaI, and APOE gene polymorphisms were significantly associated with hyperlipidemia, with OR values of 1.996, 1.228, 1.444, and 1.710, respectively. All P-values were less than 0.05. Conclusions Meta-analysis of the data indicated that the C allele of APOA5 1131 T > C, the A allele at APOA1-75 bp, the APOB XbaI T allele, and the ε2 and ε4 allele of APOE were each a risk factor for susceptibility for hyperlipidemia.

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The Efficacy of Acupuncture for Treating Depression-Related Insomnia Compared with a Control Group: A Systematic Review and Meta-Analysis

BioMed Research International ◽

10.1155/2017/9614810 ◽

2017 ◽

Vol 2017 ◽

pp. 1-11 ◽

Cited By ~ 20

Author(s):

Bo Dong ◽

Zeqin Chen ◽

Xuan Yin ◽

Danting Li ◽

Jie Ma ◽

...

Keyword(s):

Systematic Review ◽

Western Medicine ◽

Acupuncture Treatment ◽

Meta Analysis ◽

Alternative Therapy ◽

Control Group ◽

Eligibility Criteria ◽

Randomized Controlled Clinical Trials ◽

Randomized Controlled ◽

Hamd Score

Objective.To evaluate the effectiveness of acupuncture as monotherapy and as an alternative therapy in treating depression-related insomnia.Data Source.Seven databases were searched starting from 1946 to March 30, 2016.Study Eligibility Criteria.Randomized-controlled trials of adult subjects (18–75 y) who had depression-related insomnia and had received acupuncture.Results.18 randomized-controlled clinical trials (RCTs) were introduced in this meta-analysis. The findings determined that the acupuncture treatment made significant improvements in PSQI score (MD = −2.37, 95% CI −3.52 to −1.21) compared with Western medicine. Acupuncture combined with Western medicine had a better effect on improving sleep quality (MD = −2.63, 95% CI −4.40 to −0.86) compared with the treatment of Western medicine alone. There was no statistical difference (MD = −2.76, 95% CI −7.65 to 2.12) between acupuncture treatment and Western medicine towards improving the HAMD score. Acupuncture combined with Western medicine (MD = −5.46, CI −8.55 to −2.38) had more effect on improving depression degree compared with the Western medicine alone.Conclusion. This systematic review indicates that acupuncture could be an alternative therapy to medication for treating depression-related insomnia.

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Antibiotic Prophylaxis for Thyroid and Parathyroid Surgery: A Systematic Review and Meta-analysis

Otolaryngology ◽

10.1177/0194599820947700 ◽

2020 ◽

pp. 019459982094770

Author(s):

Fabio Medas ◽

Gian Luigi Canu ◽

Federico Cappellacci ◽

Giorgio Romano ◽

Giuseppe Amato ◽

...

Keyword(s):

Systematic Review ◽

Antibiotic Prophylaxis ◽

Science Studies ◽

Negative Impact ◽

Meta Analysis ◽

Surgical Site Infections ◽

Control Group ◽

Case Group ◽

Parathyroid Surgery ◽

Duration Of Surgery

Objective Although thyroid and parathyroid surgery is considered a clean procedure with a low incidence of surgical site infections (SSIs), a great number of endocrine surgeons use antibiotic prophylaxis (AP). The aim of this study was to assess whether AP is significantly effective in reducing the incidence of SSIs in this kind of surgery. Data Sources A systematic literature search was performed with PubMed, Scopus, and ISI–Web of Science. Studies addressing the efficacy of AP in reducing the incidence of SSIs in thyroid and parathyroid surgery were included in the systematic review and meta-analysis. Review Methods The random effects model was assumed to account for different sources of variation among studies. The overall effect size was computed through the inverse variance method. Heterogeneity across studies, possible outlier studies, and publication bias were evaluated. Results A total of 6 studies with 4428 patients were included in the quantitative analysis. The incidence of SSI was 0.6% in the case group and 0.4% in the control group (odds ratio, 1.07; 95% CI, 0.3-3.81; P = .915). There was no evidence of heterogeneity among the studies ( Q = 8.36, P = .138; I2 = 40.17). The analysis of several continuous moderators, including age, use of drain, and duration of surgery, did not generate any significant result. Conclusion AP is not effective in reducing the incidence of SSI in thyroid and parathyroid surgery and should be avoided, notwithstanding the negative impact on social costs and the risk of development of antibiotic resistance.

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Association between Hidradenitis Suppurativa and Inflammatory Arthritis: A Systematic Review and Meta-Analysis

Dermatology ◽

10.1159/000514582 ◽

2021 ◽

pp. 1-8

Author(s):

Nouf Almuhanna ◽

Alexandra Finstad ◽

Raed Alhusayen

Keyword(s):

Rheumatoid Arthritis ◽

Systematic Review ◽

Ankylosing Spondylitis ◽

Odds Ratio ◽

Inflammatory Arthritis ◽

Hidradenitis Suppurativa ◽

Meta Analysis ◽

Pooled Analysis ◽

Increased Risk ◽

High Prevalence

Background: Several studies report a high prevalence of inflammatory arthritis among hidradenitis suppurativa (HS) patients. Objectives: To study the association between HS and inflammatory arthritis. Methods: The systematic review and meta-analysis were performed according to the PRISMA guidelines to identify the association between HS and inflammatory arthritis, spondyloarthritis, ankylosing spondylitis (AS), and rheumatoid arthritis (RA). Results: Seven studies were entered in the analysis, with 200,361 HS patients and 385,599 controls. Pooled analysis illustrated a significantly increased risk of inflammatory arthritis in HS patients compared to controls (odds ratio [OR] 3.44; 95% confidence interval [CI] 1.92–6.17). There was also a statistically significant association between HS and spondyloarthritis (OR 2.10; 95% CI 1.40–3.15), and between HS and AS (OR 1.89; 95% CI 1.14–3.12). Moreover, pooled analysis showed a statistically significant association between HS and RA (OR 1.96; 95% CI 1.28–2.98). Conclusions: Our findings show that HS patients have a 3-fold increased risk of developing inflammatory arthritis. HS patients are specifically at a higher risk for spondyloarthritis, its subtype AS, and RA.

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The Association Between Asthma and Risk of Myasthenia Gravis: A Systematic Review and Meta-Analysis

10.21203/rs.3.rs-224462/v1 ◽

2021 ◽

Author(s):

Pitchaporn Yingchoncharoen ◽

Nipith Charoenngam ◽

Ben Ponvilawan ◽

Jerapas Thongpiya ◽

Thanat Chaikijurajai ◽

...

Keyword(s):

Systematic Review ◽

Myasthenia Gravis ◽

Meta Analysis ◽

Pooled Analysis ◽

Case Control ◽

Case Control Studies ◽

Eligibility Criteria ◽

Inverse Variance ◽

Increased Risk ◽

Independent Review

Abstract PurposeThis study aimed to investigate the association between asthma and risk of myasthenia gravis (MG) using the method of systematic review and meta-analysis.MethodsPotentially eligible studies were identified from Medline and EMBASE databases from inception to … using search strategy that comprised of terms for “Asthma” and “Myasthenia Gravis”. Eligible cohort study must consist of one cohort of individuals with asthma and another cohort of individuals without asthma. Then, the study must report relative risk (RR) with 95% confidence intervals (95% CIs) of incident MG between the groups. Eligible case-control studies must include cases with MG and controls without MG. Then, the study must explore their history of asthma. Odds ratio (OR) with 95% CIs of the association between asthma status and MG must be reported. Point estimates with standard errors were retrieved from each study and were combined together using the generic inverse variance method.ResultsA total of 6,835 articles were identified. After two rounds of independent review by five investigators, two cohort studies and three case-control studies met the eligibility criteria and were included into the meta-analysis. Pooled analysis showed that asthma was significantly associated with risk of MG with the pooled risk ratio of 1.38 (95%CI, 1.02 – 1.86). Funnel plot was symmetric.ConclusionThe current study found a significant association between asthma and increased risk of MG.

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Associations of childhood exposure to malaria with cognition and behaviour outcomes: a systematic review protocol

10.21203/rs.3.rs-19683/v3 ◽

2020 ◽

Author(s):

ANDREW SENTOOGO SSEMATA ◽

JACQUELLINE ANN NAKITENDE ◽

SIMON KIZITO ◽

ELIZABETH C WHIPPLE ◽

PAUL BANGIRANA ◽

...

Keyword(s):

Systematic Review ◽

Malaria Infection ◽

Meta Analysis ◽

Interrupted Time Series ◽

Bibliographic Databases ◽

Future Research ◽

Control Group ◽

Cochrane Central Register ◽

Eligibility Criteria ◽

Cross Sectional

Abstract Background: Malaria is one of the major contributing risk factors for poor development of children living in low- and middle- income countries (LMICs). However, little is known about the specific domains of cognition and behaviour that are impacted by malaria, the extent of these deficits, and the different types of the malaria spectrum that are associated with these deficits. The objective of this systematic review is to determine the association of the different type of malaria infection on cognition and behavioural outcomes among children living in LMICs. Methods and analysis: We will systematically search online bibliographic databases including MEDLINE (via PubMed), CINAHL (via EBSCO), PsycINFO (via EBSCO), Embase and The Cochrane Central Register of Controlled Trials (CENTRAL) as well as Google Scholar and bibliographies of pertinent articles. We will include studies with a comparison group (e.g., clinical trials, cohort, observational, cross-sectional case–control and controlled before and after or interrupted–time–series studies) involving children under 18 years of age living in LMICs, as determined by World Bank Criteria, with either an active malaria infection or history of malaria. Included articles must also measure cognitive and/or behaviour outcomes determined by standardized psychological assessments (questionnaire-based scales and or neurocognitive assessments). Studies will be excluded if they are not in English, lack a control group, take place in a high-income country, or if a standardized instrument was not used. Two reviewers will independently review all articles to determine if they meet eligibility criteria. Any conflicts will be resolved after discussion with a third reviewer. When a list of included articles is finalized, two reviewers will extract data to populate and then cross check within an electronic table. Risk of bias and the strength of evidence and recommendations will be assessed independently using the Grading of Recommendations Assessment, Development and Evaluation (GRADE) criteria, and a final score will be given upon consensus. For sufficiently homogeneous data on measured outcomes in multiple studies, we will investigate the possibility of pooling data to perform a meta-analysis. Discussion: This systematic review will evaluate the evidence of the association of malaria on the cognitive and behavioural outcomes. Findings from this planned review will generate insight on the domains affected by the different forms malaria infection and may inform subsequent malaria interventions and future research in paediatric care.Systematic review registration: This systematic review has been registered under the International Prospective Register of Systematic Reviews (PROSPERO; registration number: CRD42020154777)

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Sex Disparities in Efficacy in COVID-19 Vaccines: A Systematic Review and Meta-Analysis

Vaccines ◽

10.3390/vaccines9080825 ◽

2021 ◽

Vol 9 (8) ◽

pp. 825

Author(s):

Alessia Bignucolo ◽

Lucia Scarabel ◽

Silvia Mezzalira ◽

Jerry Polesel ◽

Erika Cecchin ◽

...

Keyword(s):

Systematic Review ◽

Sex Differences ◽

Vaccine Efficacy ◽

Meta Analysis ◽

Clinical Trial Design ◽

Pooled Analysis ◽

Control Group ◽

Innate Immune Responses ◽

Sex Disparities

Sex differences in adaptive and innate immune responses have been shown to occur and anecdotal reports suggest that vaccine efficacy and safety may be sex-dependent. We investigated the influence of sex on the efficacy of COVID-19 vaccines through a systematic review and meta-analysis of clinical trials on COVID-19 vaccines. The safety profile of COVID-19 vaccines was also investigated. A systematic review included eligible articles published in three databases and three websites. A meta-analysis of available data, stratified by sex, was conducted. Statistical analysis was performed using the Hartung–Knapp–Sidik–Jonkman method, as well as influence and heterogeneity analysis. Pooled analysis showed significantly higher efficacy, measured as the rate of new COVID-19 cases, in men compared to women in the vaccine group (OR = 0.67, 95% CI 0.48–0.94). No sex differences were found in the rate of new cases in the control group (OR = 0.92, 95% CI 0.78–1.09). Safety profiles derived from pharmacovigilance reports appear to indicate increased toxicity in women. In conclusion, evidence of a potential role of sex in COVID-19 vaccine efficacy was described. It strengthens the need to include sex as a core variable in the clinical trial design of COVID-19 vaccines.

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Strength training for throwing velocity enhancement in overhead throw: A systematic review and meta-analysis

International Journal of Sports Science & Coaching ◽

10.1177/17479541211002977 ◽

2021 ◽

pp. 174795412110029

Author(s):

D Martínez-García ◽

LJ Chirosa Ríos ◽

A Rodriguez-Perea ◽

D Ulloa-Díaz ◽

D Jerez-Mayorga ◽

...

Keyword(s):

Systematic Review ◽

Female Athletes ◽

Meta Analysis ◽

Pooled Analysis ◽

Control Group ◽

Inclusion Criteria ◽

Control Groups ◽

Minimum Duration ◽

Overhead Sports ◽

Velocity Enhancement

The overhead throw is a fundamental technical-tactical ability for overhead sports. The purposes of this review are to assess the effect of resistance training (RT) in enhancing throwing velocity in athletes and to investigate the relationships between age or gender in this effect. Control group trials were identified through looking up electronic databases with a search span of 10th December 2020. Only studies which have control groups within research design, subjects randomly assigned to groups, healthy athletes with experience in the sport, an intervention consisting of a supervised RT program of a minimum duration of 4 weeks, and assessment of sport-specific throwing velocity were taken into account for this meta-analysis. A total of 16 studies with 424 subjects were deemed eligible per the inclusion criteria. The overall pooled analysis demonstrated that a large effect was observed for throwing velocity outcomes (ES 1.10; 95% CI 0.64–1.57; p < 0.00001). Differences were due to gender, with male (ES 1.12; 95% CI 0.55–1.78; p < 0.0001) and female athletes (ES 1.22; 95% CI 0.25–2.20; p < 0.00001). And due to age, with teenager athletes (ES 0.49; 95% CI -0.18–1.17; p = 0.04) and adult athletes (ES 1.34; 95% CI 0.64–1.92; p < 0.00001). Throwing velocity enhancement after RT was greater for women than for men, and for adults more than underage subjects. RT should last at least four weeks, with 2–3 sessions each week, and with any available implement.

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Association Between Apolipoprotein Gene Polymorphisms and Hyperlipidemia: A Meta-analysis

10.21203/rs.3.rs-76751/v1 ◽

2020 ◽

Author(s):

Xiao-Ning Zhao ◽

Quan Sun ◽

You-Qin Cao ◽

Xiao Ran ◽

Yu Cao

Keyword(s):

Systematic Review ◽

Gene Polymorphisms ◽

Meta Analysis ◽

Case Control ◽

Control Group ◽

Case Group ◽

Case Control Studies ◽

Quality Of Data ◽

Different Populations ◽

The Impact

Abstract Background: Hyperlipidemia plays an important role in the etiology of cardio-cerebrovascular disease. Over recent years, a number of studies have explored the impact of apolipoprotein genetic polymorphisms in hyperlipidemia, but considerable differences and uncertainty have been found in their association for different populations from different regions. Objective: To correlate apolipoprotein gene expression with hyperlipidemia through a systematic review of case-control studies. Methods: Comprehensive identification of relevant articles in Pubmed, Web of Science, ScienceDirect, CNKI, Wangfang, and VIP published to June 9, 2020. A systematic review of hyperlipidemia case-control studies was conducted to evaluate the quality of data in articles included in the review, and a meta-analysis was conducted using Stata 11 software. Results: A total of 59 articles were included, containing in total 13843 hyperlipidemia patients in the case group and 15398 healthy controls in the control group. Meta-analysis of the data indicated that APOA5-1131T>C, APOA1 -75bp, APOB XbaⅠand APOE gene polymorphisms were significantly associated with hyperlipidemia, with OR values of 1.996, 1.228, 1.444 and 1.710, respectively, for allele models. All P values were less than 0.05. Conclusions: Meta-analysis of the data indicated that the C allele of APOA5 1131T>C, the A allele at APOA1-75bp, the APOB XbaⅠ T allele, and the ε4 allele of APOE were each a risk factor for susceptibility for hyperlipidemia.

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