scholarly journals No Difference in Neck Pain or Health-Related Quality Measures Between Patients With or Without Degenerative Cervical Spondylolisthesis

2021 ◽  
pp. 219256822110469
Author(s):  
Ian David Kaye ◽  
Arjun S. Sebastian ◽  
Scott C. Wagner ◽  
Nicholas Semenza ◽  
Daniel Bowles ◽  
...  
Keyword(s):  
Neck Pain ◽  
Linear Regression Analysis ◽  
Univariate Analysis ◽  
Degenerative Spondylolisthesis ◽  
Multiple Linear Regression Analysis ◽  
Retrospective Case ◽  
Related Condition ◽  
Arm Pain ◽  
Age Related ◽  
Related Quality

Study Design This study is a retrospective case control. Objectives This study aims to determine whether cervical degenerative spondylolisthesis (DS) is associated with increased baseline neck/arm pain and inferior health quality states compared to a similar population without DS. Methods Patient demographics, pre-operative radiographs, and baseline PROMs were reviewed for 315 patients undergoing anterior cervical decompression and fusion (ACDF) with at least 1 year of follow-up. Patients were categorized based on the presence (S) or absence of a spondylolisthesis (NS). Statistically significant variables were further explored using multiple linear regression analysis. Results 49/242 (20%) patients were diagnosed with DS, most commonly at the C4–5 level (27/49). The S group was significantly older than the NS group (58.0 ± 10.7 vs 51.9 ± 9.81, P = .001), but otherwise, no demographic differences were identified. Although a higher degree of C2 slope was found among the S cohort (22.5 ± 8.63 vs 19.8 ± 7.78, P = .044), no differences were identified in terms of preoperative visual analogue scale (VAS) neck pain or NDI. In the univariate analysis, the NS group had significantly increased VAS arm pain relative to the S group (4.93 ± 3.16 vs 3.86 ± 3.30, P = .045), which was no longer significant in the multivariate analysis. Conclusions Although previous reports have suggested an association between cervical DS and neck pain, we could not associate the presence of DS with increased baseline neck or arm pain. Instead, DS appears to be a relatively frequent (20% in this series) age-related condition reflecting radiographic, rather than necessarily clinical, disease.

scholarly journals Leptin and Aging: Correlation with Endocrine Changes in Male and Female Healthy Adult Populations of Different Body Weights

2000 ◽  
Vol 85 (5) ◽  
pp. 1954-1962 ◽  
Author(s):  
Andrea M. Isidori ◽  
Felice Strollo ◽  
Michele Morè ◽  
Massimiliano Caprio ◽  
Antonio Aversa ◽  
...  
Keyword(s):  
Plasma Levels ◽  
Linear Regression Analysis ◽  
Age Groups ◽  
Dehydroepiandrosterone Sulfate ◽  
Multiple Linear Regression Analysis ◽  
Multiple Regression Model ◽  
Sex Hormone Binding Globulin ◽  
Obese Women ◽  
Age Related ◽  
Plasma Leptin

Abstract Aging is associated with changes in plasma levels of several hormones. There are conflicting reports on whether circulating leptin levels change during aging, the possible explanation for which is that alterations in adiposity and body mass index (BMI) also occur. In this study we measured plasma leptin and other hormonal parameters known to influence leptin in 150 men and 320 women of a wide age (18–77 yr) and BMI (18.5–61.1 kg/m2) range. Subjects of each gender were separated into 2 groups of similar BMI, i.e. nonobese (BMI, <30) and obese (BMI, >30), and treated separately. Statistical analysis was performed, treating each group of subjects as a whole population or divided into age groups (<30, 30–50, and >50 yr). BMI-adjusted leptin levels were progressively lower with increasing age in women, with a consistent fall after menopause (−21%; P < 0.001); in men, leptin levels also tended to be lower in subjects more than 50 yr of age, but the reduction was not significant. Multiple linear regression analysis, performed on subjects treated either as a whole population or divided into obese and nonobese, showed that in both genders BMI and age were independent contributors of leptin levels, and there was an inverse relationship between leptin and age in both obese (standardized coefficient β = −0.25 in women and −0.23 in men; P < 0.01) and nonobese (−0.22 in women and −0.20 in men; P < 0.05) subjects. The correlation of leptin and age with plasma levels of sex and thyroid hormones, GH, insulin-like growth factor I, PRL, and insulin was also evaluated. The variables that correlated with leptin were included in a multiple regression model that included BMI and age. Testosterone in men (−0.43 in nonobese and −0.19 in obese; P < 0.05) and estradiol in women (0.22 in nonobese and 0.24 in obese; P < 0.05) were important contributors to leptin levels; also, dehydroepiandrosterone sulfate in obese women (−0.16) and sex hormone-binding globulin in obese subjects of both genders (0.15 in women and 0.19 in men) were significant determinants in the model. However, none of the hormonal parameters abolished the negative correlation between leptin and age or the gender difference in leptin levels. In conclusion, our data show that in adult humans of different body weight, serum leptin gradually declines during aging; leptin reduction is higher in women than in men, but it is independent from BMI and other age-related endocrine changes.

scholarly journals Variables associated with health-related quality of life in a Brazilian sample of patients from a tertiary outpatient clinic for depression and anxiety disorders

2015 ◽  
Vol 37 (4) ◽  
pp. 202-208 ◽  
Author(s):  
Bianca Schwab ◽  
Heloisa Silveira Daniel ◽  
Carine Lutkemeyer ◽  
João Arthur Lange Lins Neves ◽  
Louise Nassif Zilli ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Social Relationships ◽  
Psychological Health ◽  
Linear Regression Analysis ◽  
Multiple Linear Regression Analysis ◽  
Depression And Anxiety ◽  
Brazilian Sample ◽  
Related Quality ◽  
Health Related

Introduction: Health-related quality of life (HRQOL) assessment tools have been broadly used in the medical context. These tools are used to measure the subjective impact of the disease on patients. The objective of this study was to evaluate the variables associated with HRQOL in a Brazilian sample of patients followed up in a tertiary outpatient clinic for depression and anxiety disorders. Method: Cross-sectional study. Independent variables were those included in a sociodemographic questionnaire and the Hospital Anxiety and Depression Scale (HADS) scores. Dependent variables were those included in the short version of the World Health Organization Quality of Life (WHOQOL-BREF) and the scores for its subdomains (overall quality of life and general health, physical health, psychological health, social relationships, and environment). A multiple linear regression analysis was used to find the variables independently associated with each outcome. Results: Seventy-five adult patients were evaluated. After multiple linear regression analysis, the HADS scores were associated with all outcomes, except social relationships (p = 0.08). Female gender was associated with poor total scores, as well as psychological health and environment. Unemployment was associated with poor physical health. Conclusion: Identifying the factors associated with HRQOL and recognizing that depression and anxiety are major factors are essential to improve the care of patients.

scholarly journals Poorly recognized age-related downward deviation of the inguinal ligament

2016 ◽  
Vol 4 ◽  
pp. 205031211667556 ◽  
Author(s):  
Yassir Nawaz ◽  
Mihir Barvalia ◽  
Gurinder Rana ◽  
M Zain Khakwani ◽  
Khizr Azim ◽  
...  
Keyword(s):  
Human Subjects ◽  
A Priori ◽  
Linear Regression Analysis ◽  
Age Groups ◽  
Vascular Complications ◽  
Multiple Linear Regression Analysis ◽  
Inguinal Ligament ◽  
Mean Deviation ◽  
Factors Affecting ◽  
Age Related

Objective: To determine factors affecting actual inguinal ligament course in live human subjects. Introduction and hypothesis: Although the expected inguinal ligament course is supposedly a straight line extending from anterior superior iliac spine to pubic tubercle, the actual inguinal ligament course is frequently depicted a priori by a downward bowing dotted line. There are no studies in a live subject supporting this assumption. We hypothesized this assumption is indeed valid and is related to among other factors a lifelong effect of gravity and lax abdominal musculature on the inguinal ligament course. Methods: We retrospectively reviewed 54 consecutive computed tomography scans of the abdomen and pelvis randomly distributed across all age groups. Actual inguinal ligament course was visualized by reconstructing images using Terracon software. Vertical distance from the lowest point of actual inguinal ligament course to the expected inguinal ligament course was measured. We used multiple linear regression analysis to study the correlation between degree of inguinal ligament deviation and several variables. Results: Actual inguinal ligament course was below the expected inguinal ligament course in 52 of 54 patients. The mean deviation was 8.2 ± 5.9 mm. Advanced age was significantly associated with greater downward bowing of the inguinal ligament (p = 0.001). Conclusion: Actual inguinal ligament course is often well below the expected inguinal ligament course; this downward bowing of the inguinal ligament is especially pronounced with advancing age. Operators need to be mindful as this downward bowing can lead to supra-inguinal sticks causing vascular complications.

scholarly journals Health-related quality of life among Syrian refugees resettled in Sweden

2019 ◽  
Vol 29 (2) ◽  
pp. 505-514 ◽  
Author(s):  
Maria Gottvall ◽  
Sara Sjölund ◽  
Charlotta Arwidson ◽  
Fredrik Saboonchi
Keyword(s):  
Quality Of Life ◽  
Social Support ◽  
Linear Regression Analysis ◽  
Multiple Linear Regression Analysis ◽  
Syrian Refugees ◽  
Health Related Quality ◽  
Cross Sectional ◽  
Related Quality ◽  
Health Related

Abstract Purpose The main purpose of this study was to assess health-related quality of life (HRQoL) among Syrian refugees resettled in Sweden. Further, we wanted to investigate whether sex, age, education, area of residence, cohabitation and social support were associated with HRQoL in this population. Methods This is a cross-sectional study including 1215 Syrian refugees from a randomly selected sample frame resettled in Sweden between the years 2011 and 2013. HRQoL was measured by the EQ-5D-5L descriptive system, and EQ-5D-5L index values were calculated. Associations between sex, age, education, area of residence, cohabitation, social support and EQ-5D-5L were investigated using multiple linear regression analysis. Results Depression/anxiety was the most commonly (61.9%) reported EQ-5D-5L problem among the group of Syrian refugees. The mean EQ-5D-5L index value was found to be 0.754. Male sex, younger age, cohabitation and social support were found associated with a higher EQ-5D-5L index score. Conclusions Our results concerning long-lasting health problems among the study population indicate that there is a profound need for policies and interventions promoting refugees’ health. Our results also show that social support, a modifiable factor, is relevant to refugees’ overall health, pointing to the importance of public health interventions and policies targeting the facilitation, mobilization and enhancing of refugees’ social support.

Association Between Moderate and Vigorous Physical Activity and Gross Motor Coordination in Preschool Children

2019 ◽  
Vol 7 (2) ◽  
pp. 273-285 ◽  
Author(s):  
Sandra Silva-Santos ◽  
Amanda Santos ◽  
Michael Duncan ◽  
Susana Vale ◽  
Jorge Mota
Keyword(s):  
Physical Activity ◽  
Sedentary Behavior ◽  
Motor Coordination ◽  
Vigorous Physical Activity ◽  
Linear Regression Analysis ◽  
Multiple Linear Regression Analysis ◽  
Activity Levels ◽  
Gross Motor ◽  
Age Related ◽  
Movement Assessment

Introduction: Adequate gross motor coordination is essential for children participating in age-related physical activities and has an important role in maintaining sufficient physical activity levels during the life course. Aim: To examine the association between moderate-to-vigorous physical activity (MVPA) and gross motor coordination during sedentary behavior in early childhood (ages 3–6 y). Methods: The sample comprised 209 children aged 3–6 y. Gross motor coordination was assessed according to the Movement Assessment Battery for Children (MABC-2). The battery to assess gross motor coordination comprised the aiming and catching, and balance components. MVPA was measured by accelerometry worn for 7 consecutive days (Monday to Sunday). Results: Our data indicated that 31.5% of the sample had low, 32.5% medium, and 36.0% high gross motor coordination. Multiple linear regression analysis showed that MVPA was positively associated with gross motor coordination, adjusted for gender and sedentary behavior. Conclusions: Preschoolers with high gross motor coordination spend more time in MVPA. Gross motor coordination development should therefore be a key strategy in childhood interventions aiming to promote physical activity.

scholarly journals Association Between Patient Activation and Medication Adherence in Patients With Stroke: A Cross-Sectional Study

2021 ◽  
Vol 12 ◽  
Author(s):  
Weijing Sui ◽  
Li-hong Wan
Keyword(s):  
Regression Analysis ◽  
Medication Adherence ◽  
Influencing Factor ◽  
Linear Regression Analysis ◽  
Univariate Analysis ◽  
Patient Activation ◽  
Multiple Linear Regression Analysis ◽  
Improve Medication Adherence ◽  
Cross Sectional ◽  
Low Level

Background: Medication adherence is key to secondary prevention in patients with stroke. Poor medication adherence can lead to recurrence, disability, or even death in stroke survivors. Patient activation is associated with increased healthy behaviors and improved clinical outcomes in many chronic diseases. However, the association between patient activation and medication adherence in patients with stroke remains unclear.Objective: The study aimed to explore the influence of patient activation on the medication adherence of patients with stroke and to analyze the reasons for medication nonadherence.Materials and Methods: A cross-sectional design with convenience sampling was used in this study. A total of 119 patients with stroke were recruited from a tertiary hospital in Guangzhou. A social-demographic and clinical data form, a self-developed medication adherence questionnaire, and the 13-item Patient Activation Measure (PAM-13) were used. Univariate analysis and multiple linear regression analysis with dummy variables were conducted to investigate the associations between medication adherence and patient activation. Data were analyzed with IBM® SPSS® version 25.0.Results: The mean PAM-13 score in patients with stroke was 51.56 ± 12.58. A low level of patient activation was reported by up to 66.4% of the patients. The self-reported medication adherence questionnaire score was 5.59 ± 1.52. A low level of medication adherence was reported by up to 59.7% of the patients, while a moderate level was reported by 34.4%, and a high level was reported by only 5.9%. In the multiple stepwise regression analysis, patient activation was found to be an independent influencing factor of medication adherence in patients with stroke (p < 0.05).Conclusion: Medication adherence was poor in patients in Guangzhou, China, following an ischemic stroke. Patient activation as the independent influencing factor identified in this study will support healthcare givers to develop the tailored intervention to improve medication adherence among patients with stroke in China.

Abstract P376: Cardiometabolic Abnormalities, Systemic Inflammation, and Oxidative Stress in Children

Circulation ◽  
2012 ◽  
Vol 125 (suppl_10) ◽  
Author(s):  
Stephanie J Frisbee ◽  
Jefferson C Frisbee ◽  
Alan Ducatman
Keyword(s):  
Oxidative Stress ◽  
Regression Analysis ◽  
Systemic Inflammation ◽  
Linear Regression Analysis ◽  
Univariate Analysis ◽  
Class Action ◽  
Large Sample Size ◽  
Metabolic Disturbances ◽  
Cvd Risk ◽  
Age Related

The increasing prevalence of childhood obesity has been well documented & is predictive of increased severity in obesity-related CVD risk factors & metabolic disorders, such as systemic inflammation & oxidative stress. While the poor long-term vascular consequences of these conditions are better understood in adults, the consequences of these obesity-associated metabolic disturbances are less studied in children. This study utilized the 12,476 children (<18 years) enrolled in the C8 Health Project, which resulted from the pretrial settlement of a class action lawsuit pursuant to contamination of the drinking water supply; we have recently published a complete description of this study (Frisbee et al, 2009). The current analysis used the large sample size available from this study to determine the severity of chronic inflammation & oxidative stress associated with cardiometabolic abnormalities, including obesity, dyslipidemia, & hyperglycemia, present either singly or in combination, in children. In this population, median age was 11.6 years, 48% were female, 40% were overweight or obese (OWT-OB; BMI≥85th percentile), 2% had glucose ≥126 mg/dL (HypGly), & 34% had total cholesterol ≥170 mg/dL or LDL cholesterol ≥110 mg/dL (DysLip), Additionally, median CRP, a biomarker of systemic inflammation, was 0.4 mg/L with 16% having CRP≥2 mg/L, & median GGT, a biomarker of oxidative stress, was 12.0 IU/L with 1.7% having GGT≥35 IU/L. In univariate analysis: CRP & GGT were statistically significantly higher in participants with OWT-OB; GGT but not CRP was higher in children with HypGly or DysLip; & both CRP & GGT were higher in children with any cardiometabolic abnormality. In linear regression analysis controlling for age, gender, SES (household income), a regular exercise program, & while simultaneously considering OWT-OB, HypGly, & DysLip: OWT-OB statistically significantly predicted CRP (b-coefficient±SE/adj R-square; 1.0±0.1/1.4%) though HypGly & DysLip were not, ceteris paribus, associated with CRP; OWT-OB (3.5±0.2/16.6%), HypGly (1.2±0.6/16.6%), & DysLip (2.1±0.2/16.6%) were all simultaneously predictive of GGT. In logistic regression analysis controlling for the same covariates & also simultaneously considering the same cardiometabolic abnormalities: OWT-OB (OR (95%CI); 3.8 (3.4-4.4)) & DysLip (1.2 (1.0=1.3)) but not HypGly increased the risk for CRP≥2 mg/L; similarly, OWT-OB (5.6 (3.5-8.7)) & DysLip (3.4 (2.3-5.0)) but not HypGly were associated with increased for oxidative stress (GGT≥35 IU/L). This study suggests that different cardiometabolic abnormalities have different associations with systemic inflammation & oxidative stress; obesity & dyslipidemia rather than hyperglycemia are more strongly associated with systemic inflammation & oxidative stress in children. Futher study is needed to elucidate gender & age-related differences in these associations.

Normal reference interval for thyrotropin response to thyroliberin: dependence on age, sex, free thyroxin index, and basal concentrations of thyrotropin.

1984 ◽  
Vol 30 (2) ◽  
pp. 196-199 ◽  
Author(s):  
E M Erfurth ◽  
N E Nordén ◽  
P Hedner ◽  
A Nilsson ◽  
L Ek
Keyword(s):  
Linear Regression Analysis ◽  
Reference Interval ◽  
Multiple Linear Regression Analysis ◽  
Reference Intervals ◽  
Multivariate Statistical Methods ◽  
Individual Values ◽  
Multivariate Statistical ◽  
Normal Reference ◽  
Age Related ◽  
Basal Concentration

Abstract We measured the thyrotropin response (delta TSH) to 200 micrograms of thyroliberin in 131 subjects without thyroid dysfunction or other disease and with basal values for thyroid function that were within the normal reference intervals for our laboratory. By univariate and multivariate statistical methods we found delta TSH to be significantly influenced by the basal concentration of thyrotropin (TSH0) and the free thyroxin index (FT4I). When the effects of variations in TSH0 and FT4I were eliminated, delta TSH in men under 40 years of age did not differ from that in women. A decrease in delta TSH with increasing age was found in men but not in women. Thus a reference interval for delta TSH should consider TSH0, FT4I, and, in men, age. On the basis of multiple linear regression analysis, we constructed a formula for delta TSH reference intervals that takes into account individual values for TSH0 and FT4I. The formula should be applicable for women, regardless of age, up to 77 years and for men under 40 years. For older men a correction for the age-related decrease in delta TSH must be applied.

scholarly journals Biomarkers of Hemodynamic Stress and Aortic Stiffness after STEMI: A Cross-Sectional Analysis

2015 ◽  
Vol 2015 ◽  
pp. 1-7 ◽  
Author(s):  
Sebastian Johannes Reinstadler ◽  
Hans-Josef Feistritzer ◽  
Gert Klug ◽  
Agnes Mayr ◽  
Luc Huybrechts ◽  
...  
Keyword(s):  
Natriuretic Peptide ◽  
Aortic Stiffness ◽  
Linear Regression Analysis ◽  
Univariate Analysis ◽  
Area Under The Curve ◽  
Multiple Linear Regression Analysis ◽  
Cross Sectional ◽  
Chronic Stage ◽  
St Segment Elevation ◽  
Hemodynamic Stress

Aim. Increased aortic stiffness might adversely affect cardiac structure, function, and perfusion. Release of biomarkers of hemodynamic stress is thought to be enhanced by these alterations. We aimed to evaluate the association between biomarkers of hemodynamic stress and aortic stiffness assessed at a chronic stage after ST-segment elevation myocardial infarction (STEMI).Methods. Fifty-four patients four months after STEMI were enrolled in this cross-sectional, single-center study. N-terminal pro–B-type natriuretic peptide (NT-proBNP), mid-regional pro–A-type natriuretic peptide (MR-proANP), and mid-regional proadrenomedullin (MR-proADM) levels were measured by established assays. Aortic stiffness was assessed by the measurement of pulse wave velocity using phase-contrast cardiovascular magnetic resonance.Results. NT-proBNP, MR-proANP, and MR-proADM concentrations were all correlated with aortic stiffness in univariate analysis (r=0.378,r=0.425, andr=0.532; allP<0.005, resp.). In multiple linear regression analysis, NT-proBNP (β=0.316,P=0.005) and MR-proADM (β=0.284,P<0.020) levels were associated with increased aortic stiffness independently of age, blood pressure, and renal function. NT-proBNP was the strongest predictor for high aortic stiffness (area under the curve: 0.82, 95% CI 0.67–0.96).Conclusion. At a chronic stage after STEMI, concentrations of biomarkers for hemodynamic stress, especially NT-proBNP, are positively correlated with aortic stiffness. These biomarkers might also be useful as predictors of high aortic stiffness after STEMI.

scholarly journals Age-Related Changes in the Characteristics of the Elderly Females Using the Signal Features of an Earlobe Photoplethysmogram

Sensors ◽  
2021 ◽  
Vol 21 (23) ◽  
pp. 7782
Author(s):  
Jeong-Woo Seo ◽  
Jungmi Choi ◽  
Kunho Lee ◽  
Jaeuk U. Kim
Keyword(s):  
Deep Learning ◽  
Linear Regression Analysis ◽  
Differential Forms ◽  
The Elderly ◽  
Multiple Linear Regression Analysis ◽  
Non Invasive ◽  
Aging Index ◽  
Age Related ◽  
Signal Features ◽  
Learning Techniques

Non-invasive measurement of physiological parameters and indicators, specifically among the elderly, is of utmost importance for personal health monitoring. In this study, we focused on photoplethysmography (PPG), and developed a regression model that calculates variables from the second (SDPPG) and third (TDPPG) derivatives of the PPG pulse that can observe the inflection point of the pulse wave measured by a wearable PPG device. The PPG pulse at the earlobe was measured for 3 min in 84 elderly Korean women (age: 71.19 ± 6.97 years old). Based on the PPG-based cardiovascular function, we derived additional variables from TDPPG, in addition to the aging variable to predict the age. The Aging Index (AI) from SDPPG and Sum of TDPPG variables were calculated in the second and third differential forms of PPG. The variables that significantly correlated with age were c/a, Tac, AI of SDPPG, sum of TDPPG, and correlation coefficient ‘r’ of the model. In multiple linear regression analysis, the r value of the model was 0.308, and that using deep learning on the model was 0.839. Moreover, the possibility of improving the accuracy of the model using supervised deep learning techniques, rather than the addition of datasets, was confirmed.

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