scholarly journals The correlation of routine hematological indices with pterygium

2019 ◽  
Vol 11 ◽  
pp. 251584141984892 ◽  
Author(s):  
Bengi Ece Kurtul ◽  
Emrah Utku Kabatas ◽  
Serdar Ozates
Keyword(s):  
Oxidative Stress ◽  
Blood Count ◽  
Complete Blood Count ◽  
Density Lipoprotein ◽  
Control Group ◽  
Red Cell ◽  
Cell Distribution ◽  
Distribution Width ◽  
Hematological Indices ◽  
And Oxidative Stress

Purpose:Increased systemic/local inflammation and oxidative stress play a key role in the pathophysiology of pterygium, but there is limited information regarding routine hematological indices’ levels in patients with pterygium. In this study, we aimed to evaluate the levels of complete blood count parameters in patients with pterygium.Material and Method:In all, 61 patients with pterygium (pterygium group; mean age = 51.4 ± 13.8 years) and 55 healthy individuals (control group; mean age = 50.2 ± 13.1 years) were included in the study. Participants were given routine ophthalmic examinations; complete blood count parameters were assayed.Results:Compared to the control group, red cell distribution width level was significantly higher in patients with pterygium ( p = 0.009), but the difference between the groups in terms of the other complete blood count parameters was not statistically significant. However, high-density lipoprotein cholesterol level was significantly lower in the pterygium group than control group ( p = 0.015). In the pterygium group, low-density lipoprotein cholesterol levels were lower, but this difference was not statistically significant ( p = 0.079).Conclusion:Red cell distribution width levels were significantly increased in patients with pterygium. Our data support the idea that inflammation cytokines and oxidative stress may play an important role in the pathogenesis of this disorder.

scholarly journals Combined Inositol Hexakisphosphate and Inositol Supplement Consumption Improves Serum Alpha-Amylase Activity and Hematological Parameters in Streptozotocin-Induced Type 2 Diabetic Rats

2019 ◽  
Vol 2019 ◽  
pp. 1-7 ◽  
Author(s):  
Shadae R. Foster ◽  
Lowell L. Dilworth ◽  
Jean Sparks ◽  
Ruby L. Alexander-Lindo ◽  
Felix O. Omoruyi
Keyword(s):  
Blood Count ◽  
Complete Blood Count ◽  
Amylase Activity ◽  
Diabetic Rats ◽  
Red Cell Distribution Width ◽  
Red Cell ◽  
Cell Distribution ◽  
Distribution Width ◽  
Type 2 Diabetic

This study evaluated the effect of combined inositol hexakisphosphate (IP6) and inositol supplement on organ weight, intestinal ATPase activities, complete blood count, and serum analytes in streptozotocin (STZ)-induced type 2 diabetic rats. High-fat diet and a single intraperitoneal injection of streptozotocin (35 mg/kg body weight) were used to induce type 2 diabetes mellitus in Sprague–Dawley rats. The diabetic groups were then treated with either combined IP6 and inositol supplement or glibenclamide for four weeks. Organ weights, intestinal ATPase activities, complete blood count, serum α-amylase, total protein, albumin, and globulin content were determined. Pancreatic weight was significantly reduced while relative kidney and liver weights were elevated in the group treated with combined IP6 and inositol supplement compared to the nondiabetic control. Serum α-amylase activity for the glibenclamide and combination treated groups was significantly improved compared to that of the untreated diabetic group. Red cell distribution width percentage was significantly lower in the combination treated group compared to that in the untreated diabetic group, while intestinal ATPase activities were unaffected by the treatment regime. Combined IP6 and inositol supplement consumption may protect people with diabetes from increased risk of cardiovascular diseases due to the supplement's ability to maintain red cell distribution width percentage towards the normal control group.

Mean platellet volume and red cell distribution width values in children with recurrent epistaxis

2021 ◽  
pp. 90-92
Keyword(s):  
Pediatric Patients ◽  
Complete Blood Count ◽  
Control Group ◽  
P Value ◽  
Red Cell ◽  
Cell Distribution ◽  
Platelet Volume ◽  
Distribution Width ◽  
Recurrent Epistaxis ◽  
The Difference

Objective: This study aimed to evaluate the relationship between mean platelet volume and red blood cell distribution width, recurrent epistaxis in children. Material and Method:This study was conducted with 60 pediatric patients who applied to our clinic between complaint of epistaxis. The control group consisted of 60 pediatric patients with similar number of age and gender characteristics as the study group. mean platelet volume (MPV) and red cell distribution width (RDW) values measured routinely in the complete blood count (CBC) were investigated Results: Mean RDW value was founded 11.98±0.75% in patients with epistaxis and 12.44±0.78% in the control group. Since the p-value calculated according to these data was found to be 0.02, the difference was found to be statistically significant. The MPV value was 6.65±1.31 femtoliter in patients with epistaxis and 6.41±1.22 femtoliter in the control group. The difference was not statistically significant since the p-value was higher than 0.05. Conclusion: It is thought that the high values of RDW and MPV, which are among the parameters measured in complete blood count, may be associated with the increase in thrombotic activity. It is also observed that MPV and RDW values are high in cerebrovascular cases and coronary artery diseases. The low RDW value in patients who with recurrent epistaxis gives rise to thought that this value may not be a result of bleeding, but a cause.

scholarly journals Red cell distribution width: a new tool for the severity prediction of sleep apnoea syndrome in children

2020 ◽  
Vol 6 (4) ◽  
pp. 00278-2019
Author(s):  
Daniel Morell-Garcia ◽  
Núria Toledo-Pons ◽  
Pilar Sanchis ◽  
Josep Miquel Bauça ◽  
José María Sánchez ◽  
...  
Keyword(s):  
Blood Count ◽  
Complete Blood Count ◽  
Sleep Apnoea ◽  
Red Cell Distribution Width ◽  
Red Cell ◽  
Cell Distribution ◽  
C Reactive Protein ◽  
Distribution Width ◽  
Reactive Protein ◽  
Severity Prediction

IntroductionRed cell distribution width (RDW) is a parameter included in the complete blood count which informs about the size of the circulating red blood cell population and its distribution. In adults, an increase in RDW was shown to be associated both with obstructive sleep apnoea (OSA) and with an increase in cardiovascular mortality. The aim of this study was to determine whether RDW is a potential biomarker for screening children with moderate–severe OSA.MethodsAn observational study in snoring patients was performed. All patients underwent a sleep study and were classified either as simple snorers (apnoea–hypopnoea index (AHI) <1 event·h−1) or as patients with OSA (mild AHI ≥1 to <5 events·h−1; moderate–severe AHI ≥5 events·h−1). Blood analyses (complete blood count and C-reactive protein) were performed for every individual.ResultsA total of 175 individuals were recruited. The mean age was 8.3±3.6 years. Correlation studies between RDW and several sleep-related parameters showed negative significant associations with minimum oxygen saturation, and positive significant associations with oxygen desaturation index (≥3% and ≥4%), AHI and the arousal index. A predictive model for paediatric severe OSA (AHI ≥5 events·h−1) was found based on mean corpuscular haemoglobin concentration (MCHC) <34.9 g·dL−1 and RDW >13.1% values, adjusting for body mass index z-score and age (area under the curve 0.657; p=0.004). In addition, differences were found in eosinophil count and C-reactive protein concentrations among the three subgroups.ConclusionsIn children, RDW stands out as a biomarker associated with the severity of OSA. The use of RDW and MCHC could be a simple but useful tool for the severity prediction of paediatric OSA in snoring patients.

scholarly journals Red cell distribution width and mortality in pediatric sepsis

2017 ◽  
Vol 56 (6) ◽  
pp. 320 ◽  
Author(s):  
Trina Devina ◽  
Munar Lubis ◽  
Erna Mutiara ◽  
Gema Nazri Yanni ◽  
Rina Amalia C. Saragih ◽  
...  
Keyword(s):  
Complete Blood Count ◽  
Cross Sectional Study ◽  
Red Cell Distribution Width ◽  
Hematological Parameter ◽  
Red Cell ◽  
Cell Distribution ◽  
Chi Square ◽  
Cross Sectional ◽  
Distribution Width ◽  
Pediatric Sepsis

Background Red cell distribution width (RDW) is a hematological parameter routinely obtained as part of the complete blood count. Recently, RDW has emerged as a potential independent predictor of clinical outcomes in adults with sepsis. However, RDW as a mortality predictor in pediatric populations has not been well established.Objective To determine the relationship between RDW value and mortality outcomes in pediatric sepsis patients.Methods We performed a cross-sectional study of 40 consecutive pediatric patients with sepsis admitted to the PICU from December 2013 to March 2014. All patients’ RDW were collected within 24 hours of sepsis diagnosis. We determined the association between RDW and hemoglobin (Hb) using Spearman’s correlation. The RDW values of 11.5-14.5% were considered to be normal while those > 14.5% were considered to be elevated. We compared mortality and PICU length of stay (LoS) between the normal and elevated RDW groups using Chi-square and Mann-Whitney tests.Results The median age of patients was 34 months (range 2 months to 17 years). There were 28 (70%) male subjects. Subjects’ median RDW was 14.8% (range 11.2-27.8%) and was not correlated with Hb (r=0.056; P=0.73). Mortality rates in the normal and elevated RDW groups were 40% and 45%, respectively. There were no significant associations between RDW group and mortality (P=0.749) or PICU LoS (P=0.350).Conclusion Unlike in adults, RDW values are not correlated with mortality in pediatric sepsis patients. 

scholarly journals A Novel Parameter for Predicting Therapeutic Response in Iron Deficiency Anemia: Red Blood Cell Distribution Width

2019 ◽  
Vol 8 (3) ◽  
pp. 107-112
Author(s):  
Aslı Korur ◽  
Didar Yanardag Acik ◽  
Soner Solmaz ◽  
Cigdem Gereklioglu ◽  
Suheyl Asma ◽  
...  
Keyword(s):  
Blood Cell ◽  
Red Blood Cell ◽  
Blood Count ◽  
Complete Blood Count ◽  
Reticulocyte Count ◽  
Iron Therapy ◽  
Deficiency Anemia ◽  
Cell Distribution ◽  
Distribution Width ◽  
Red Blood Cell Distribution

Aim: Anemia is a public health problem worldwide. Cost effectiveness and efficient use of resources are vitally important. Red blood cell distribution width, which can be obtained from a standard complete blood count, is a measure of the variability in size of circulating erythrocytes. The present study was performed to investigate whether red blood cell distribution width can be used to predict response to iron therapy. Methods: This study was conducted in 50 patients admitted to hematology and family medicine clinics. Complete blood count and reticulocyte count were determined on day 5; complete blood count was examined 1 month after commencement of therapy. Results: Statistically significant differences were detected between hemoglobin levels and red blood cell distribution width values at the time of diagnosis and on day 5 and after 1 month of therapy. A significant positive correlation was found between the increase in red blood cell distribution width and the increase in hemoglobin. Conclusion: Red blood cell distribution width may be used in place of reticulocyte count to predict response to iron therapy. Red blood cell distribution width is the best biomarker for this purpose as a component of complete blood count, and therefore it may be accepted as superior to reticulocyte count.

scholarly journals Chlorogenic and Caftaric Acids in Liver Toxicity and Oxidative Stress Induced by Methamphetamine

2014 ◽  
Vol 2014 ◽  
pp. 1-10 ◽  
Author(s):  
Khaled M. M. Koriem ◽  
Rowan E. Soliman
Keyword(s):  
Oxidative Stress ◽  
Chlorogenic Acid ◽  
Liver Toxicity ◽  
Density Lipoprotein ◽  
Acute Hepatic Failure ◽  
Protective Role ◽  
Control Group ◽  
Albino Rats ◽  
Dietary Polyphenols ◽  
And Oxidative Stress

Methamphetamine intoxication can cause acute hepatic failure. Chlorogenic and caftaric acids are the major dietary polyphenols present in various foods. The aim of this study was to evaluate the protective role of chlorogenic and caftaric acids in liver toxicity and oxidative stress induced by methamphetamine in rats. Thirty-two male albino rats were divided into 4 equal groups. Group 1, which was control group, was injected (i.p) with saline (1 mL/kg) twice a day over seven-day period. Groups 2, 3, and 4 were injected (i.p) with methamphetamine (10 mg/kg) twice a day over seven-day period, where groups 3 and 4 were injected (i.p) with 60 mg/kg chlorogenic acid and 40 mg/kg caftaric acid, respectively, one day before methamphetamine injections. Methamphetamine increased serum aspartate aminotransferase, alanine aminotransferase, alkaline phosphatase, bilirubin, cholesterol, low-density lipoprotein, and triglycerides. Also, malondialdehyde in serum, liver, and brain and plasma and liver nitric oxide levels were increased while methamphetamine induced a significant decrease in serum total protein, albumin, globulin, albumin/globulin ratio, brain serotonin, norepinephrine and dopamine, blood and liver superoxide dismutase, and glutathione peroxidase levels. Chlorogenic and caftaric acids prior to methamphetamine injections restored all the above parameters to normal values. In conclusion, chlorogenic and caftaric acids before methamphetamine injections prevented liver toxicity and oxidative stress where chlorogenic acid was more effective.

scholarly journals Markers of Anemia in Children with Type 1 Diabetes

2018 ◽  
Vol 2018 ◽  
pp. 1-7 ◽  
Author(s):  
Ewa Rusak ◽  
Anna Rotarska-Mizera ◽  
Piotr Adamczyk ◽  
Bogdan Mazur ◽  
Joanna Polanska ◽  
...  
Keyword(s):  
Type 1 Diabetes ◽  
Vitamin B12 ◽  
Hemoglobin Concentration ◽  
Control Group ◽  
Mean Corpuscular Hemoglobin ◽  
Red Cell ◽  
Cell Distribution ◽  
Corpuscular Hemoglobin ◽  
Distribution Width

Aim. The aim of the study was to assess markers of anemia in type 1 diabetes (T1D) children, compare them to results obtained in the control group, and estimate their relation to BMI SDS. Methods. 94 (59% ♀) T1D children without other autoimmune disorders, aged 12.5 ± 4.1 years, T1D duration: 4.2 ± 3.6 years, HbA1c 7.3 ± 1.5% (57 ± 12.6 mmol/mol). Sex- and age-matched controls (43 children). In all children, anthropometric measurements, the blood count, iron turnover parameters, and vitamin B12 concentration were taken. Results. T1DM children had significantly higher red cell distribution width (RDW) (13.6 versus 12.6%; p<0.001), hepcidin (0.25 versus 0.12 ng/ml; p<0.001), and vitamin B12 concentrations (459 versus 397 pg/ml; p<0.01) and lower TIBC (59.09 versus 68.15 μmol/l; p<0.001) than in the control group. Logistic regression revealed that RDW, TIBC (both p<0.001), and hepcidin (p<0.05) significantly differentiated both groups. In T1DM children, BMI SDS negatively correlated with vitamin B12 (p<0.01) concentration and mean corpuscular hemoglobin concentration (p<0.05) and positively with TIBC (p<0.01) and HbA1c (p<0.001). Conclusions. Patients and controls differed especially in terms of RDW and TIBC. In studied T1DM children, BMI SDS was associated to iron metabolism parameters and vitamin B12 concentration.

scholarly journals Preferential Metabolic Improvement by Intermittent Fasting in People with Elevated Baseline Red Cell Distribution Width: A Secondary Analysis of the WONDERFUL Randomized Controlled Trial

Nutrients ◽  
2021 ◽  
Vol 13 (12) ◽  
pp. 4407
Author(s):  
Benjamin D. Horne ◽  
Joseph B. Muhlestein ◽  
Heidi T. May ◽  
Viet T. Le ◽  
Tami L. Bair ◽  
...  
Keyword(s):  
Metabolic Syndrome ◽  
Controlled Trial ◽  
Low Density Lipoprotein ◽  
Secondary Analysis ◽  
Density Lipoprotein ◽  
Red Cell Distribution Width ◽  
Intermittent Fasting ◽  
Red Cell ◽  
Cell Distribution ◽  
Distribution Width

Red cell distribution width (RDW) predicts cardiovascular outcomes, but it is unstudied with regard to intermittent fasting. In WONDERFUL trial subjects, the effect of the interaction between baseline RDW and intermittent fasting on changes in insulin and other cardiometabolic endpoints and the effect of fasting on changes in RDW were evaluated. The subjects enrolled were aged 21–70 years and were free of statins, anti-diabetes medications, and chronic diseases, and had ≥1 metabolic syndrome feature, as well as elevated low-density lipoprotein cholesterol. Subjects were randomized to 24-h, water-only fasting (twice per week for 4 weeks, once per week for 22 weeks) or 26 weeks of ad libitum eating. Subjects (N = 71; n = 38 intermittent fasting, n = 33 controls) had more substantial changes in insulin in intermittent fasting vs. controls (−3.45 ± 2.27 vs. 0.48 ± 3.55 mIU/L) when baseline RDW size distribution (RDW-SD) was ≥median (42.6 fL) than <median (−1.99 ± 2.80 vs. −1.08 ± 3.40 mIU/L) (p-interaction = 0.039). Results were similar but weaker for glucose, HOMA-IR, and metabolic syndrome score. RDW-SD (intermittent fasting: 1.27 ± 9.6 fL vs. control: −0.37 ± 1.76 fL, p = 0.34) was unchanged by fasting at 26 weeks. Intermittent fasting decreased insulin more in subjects with higher baseline RDW. RDW may identify individuals who derive the most health benefits from intermittent fasting and who have the most cause to adhere to a fasting regimen.

scholarly journals Manganese Inhibits Indomethacin-Induced Hepatorenal Oxidative Stress in Wistar Rats

2020 ◽  
pp. 79-90
Author(s):  
Tijani Stephanie Abiola ◽  
Olori Ogaraya David ◽  
Farombi Ebenezer Olatunde
Keyword(s):  
Oxidative Stress ◽  
Density Lipoprotein ◽  
Treated Group ◽  
Control Group ◽  
Gamma Glutamyl Transferase ◽  
Cellular Processes ◽  
Concomitant Reduction ◽  
Liver And Kidney ◽  
Glutamyl Transferase ◽  
And Oxidative Stress

Aim: Manganese (Mn) is an essential trace element in many cellular processes. However, there is dearth of literature on its influence on indomethacin-induced hepatorenal damage. Therefore, this study was conducted to investigate the effect of manganese on indomethacin-induced hepatorenal damage in rats. Methods: Rats were divided into four groups of eight rats consisting of control group, indomethacin (IND) alone (20 mg/kg), Mn alone (10 mg/kg) and co-treated group that were treated orally for 14 consecutive days. Twenty four hours after treatment, under pentobarbital anesthesia, blood was collected and liver was excised to prepare homogenate and histology staining. Liver and kidney function tests aspartate aminotransferase (AST), alanine aminotransferase (ALT), alkaline phosphatase (ALP), gamma glutamyl transferase (GGT), lactate dehydrogenase (LDH), malate dehydrogenase (MDH), glutamine dehydrogenase (GLDH), sorbitol dehydrogenase (SDH), glucose-6-phosphate dehydrogenase (G6PD), bilirubin (BIL), urea, creatinine, cholesterol (CHOL), triglycerides (TG), low and high density lipoprotein (LDL and HDL), electrolytes and oxidative stress superoxide dismutase (SOD), catalase (CAT), glutathione (GSH) and lipid peroxidation (LPO) biomarkers were assessed. Results: The results showed that indomethacin caused hepatorenal damage in rats manifested with increase in serum hepatic and renal function biomarkers. But co-administration of IND with Mn significantly (p < 0.05) decreased the level of hepatorenal biomarkers. Additionally, co-administration of IND with Mn improved the antioxidant status with concomitant reduction of LPO and restored the integrity of the liver and kidney histologically. Conclusion: The results of this study emphasize that co-administration of IND with Mn to rats alleviated IND-induced hepatorenal toxicities and oxidative stress in rats.

Sign in / Sign up

Export Citation Format

Share Document