Interleukin-10(IL-10)1082-A and Tumor Necrosis Factor(TNF)-Alpha 238/308A Genotypes Are Associated with Earlier (Younger Than 55) Onset of Multiple Myeloma.

Blood ◽  
2004 ◽  
Vol 104 (11) ◽  
pp. 4869-4869
Author(s):  
Meral Beksac ◽  
Merih Kizil ◽  
Ender A. Soydan ◽  
Esin Serbest ◽  
Klara Dalva
Keyword(s):  
Age Of Onset ◽  
Interleukin 10 ◽  
Tnf Alpha ◽  
Nucleotide Polymorphisms ◽  
Promoter Gene ◽  
Age Of Diagnosis ◽  
Definition Of ◽  
The Individual ◽  
The Impact ◽  
Secretory Pattern

Abstract The individual differences among the polymorphic regions of the cytokine genes involved in the pathogenesis of myeloma have been investigated by various groups: Neben et al have found the TNF238 A allel to be associated with a higher serum level of TNF-alpha and with better response to Thalidomide. The IL 10-1082 G promoter gene genotype have been found to be associated with high secretory pattern and in increased frequency among myeloma patients compared to normal controls by Zheng et al. Van Ness et al have reported the IL-10-G genotype to be associated with shorter survival compared to IL-10-A allele carriers None of these groups have analyzed the impact of these genotypes on age of onset. With an aim to analyze the association between the frequencies of the cytokines known to be important in the pathogenesis of Myeloma, TNF-alpha, IL-6, IL-10 and the age of diagnosis, we have isolated DNA from peripheral blood of 59 patients. Patients with a median age of 56(28–83)M/F:35/24 diagnosed and treated in our center between 2002–2004 were analyzed. To determine the TNF 238 and 308(G/A), IL-6 174(G/C), IL-10 1082(G/A),819(T/C) and 592(A/C) bp polymorphic allele frequencies Cytokine Genotyping Kit (Pel-Freeze) and/or Cytgen (OneLambda) Genotyping Trays have been used. Evaluation of results were done as described in the worksheets. Interpretation and definition of phenotypes(low and high secretory patterns) were based on the previously published reports. 30 patients(50,8%) were younger than 56 (median=the cutoff:56). TNF-A homozygous alelle couldnot be observed among all patients. The frequencies of all alleles were: TNF-alfa308A, TNF-alfa238A, IL-10 1082 G 20%, 20%, 12% respectively. IL-6 -GG/GC alleles which have been linked with high secretory pattern constituted the majority of the patients(58/59). When TNFalfa-A were detected based on the 238 bp reactivity the association of low phenotype with elder age was remarkable(p=0.019). This finding wasnot valid for the 308 bp location. IL-10 phenotypes were more complicated with an accumulation in the intermediate level of secretion. The impact of TNF was varified with the separate evaluation of this group, based on their TNF-238/308 genotype, p=0.031). Conclusion: There is a trend towards younger age of onset in Myeloma. Genetic factors for susceptibility have not been defined yet. The new tools for detection of single nucleotide polymorphisms have a promising role in this field. In our prospective study we have found a predominance of low IL-10 secretory A genotype and the high secretory TNF-A genotype among patients younger than 56. To our knowledge this is the first report on such an association. Investigation of other genes in linkeage with TNF on the neighboring MHC region may be necessary for understanding myeloma pathogenesis. Age TNF 238 H/L TNF 308 H/L TNF 238,308 H/L IL-10 H/I/L IL-10 I,TNF H(238 or 308)/ IL-10 I,TNF L(238 or308) L:Low, H: High,I:Intermediate secretory, TNF238A:H, TNF238G:L, TNF308A:H, TNF308G:L, IL-10G: H ≤55 5 / 7 6 / 24 7 / 5 1 /16 / 13 5 / 2 >55 1 / 16 6 / 23 4 / 13 6 /13 / 8 1 / 6 N=29, p=0.019 N=59, p=0.948 N=29, p=0.057 N=57, p=0.085 N=14, p=0.031

MOBILE APPLICATION REMOVES SOCIETAL BARRIERS TO P4 MEDICINE

2017 ◽  
pp. 1-3
Author(s):  
J.-P. Michel
Keyword(s):  
Cognitive Abilities ◽  
Mobile Application ◽  
New Technologies ◽  
Global Evaluation ◽  
P4 Medicine ◽  
Fertile Ground ◽  
Definition Of ◽  
The Individual ◽  
The Impact

The overlap between one innovative paradigm (P4 medicine: predictive, personalized, participatory and preventive) and another (a new definition of “Healthy ageing”) is fertile ground for new technologies; a new mobile application (app) that could broaden our scientific knowledge of the ageing process and help us to better analyse the impact of possible interventions in slowing the ageing decline. A novel mobile application is here presented as a game including questions and tests will allow in 10 minutes the assessment of the following domains: robustness, flexibility (lower muscle strength), balance, mental and memory complaints, semantic memory and visual retention. This game is completed by specific measurements, which could allow establishing precise information on functional and cognitive abilities. A global evaluation precedes advice and different types of exercises. The repetition of the tests and measures will allow a long follow up of the individual performances which could be shared (on specific request) with family members and general practitioners.

scholarly journals Association of CD58 polymorphism and multiple sclerosis in Malaysia: a pilot study

2019 ◽  
Vol 10 (1) ◽  
Author(s):  
Yee Ming Ching ◽  
Shanthi Viswanathan ◽  
Nurhanani Mohamed Nor ◽  
Shuwahida Shuib ◽  
Balqis Kamarudin ◽  
...  
Keyword(s):  
Multiple Sclerosis ◽  
Pilot Study ◽  
Gene Polymorphism ◽  
Age Of Onset ◽  
Nucleotide Polymorphisms ◽  
Healthy Individuals ◽  
Disease Manifestation ◽  
Southeast Asians ◽  
Multiple Sclerosis Patients ◽  
The Impact

Abstract Background Multiple sclerosis is an immune mediated disease targeting the central nervous system. Association of non-human leukocyte antigen gene, CD58, with multiple sclerosis has been reported in several populations but is unclear among Southeast Asians. This pilot study was conducted to explore the association between CD58 polymorphism and multiple sclerosis among the Malay population in Malaysia. Methods Blood samples were collected from 27 multiple sclerosis patients, and compared with 58 age- and gender matched healthy individuals. All patients were tested negative for anti-aquaporin 4. DNA was extracted from the blood and genotyped for 3 single nucleotide polymorphisms rs12044852, rs2300747 and rs1335532 of gene CD58 by real-time PCR. Results The majority of multiple sclerosis patients were female (85.2%). The general mean age of onset was 30.5 years. Genotyping results showed that frequencies of the alleles were between 40 and 50% for MS patients and healthy individuals. Association (allelic model) between multiple sclerosis and CD58 gene polymorphism alleles rs12044852 (p = 0.410), rs2300747 (p = 0.881) and rs1335532 (p = 0.407) were indistinct. Conclusions The impact of the CD58 gene polymorphism was not prominent in this pilot study, implying that genetic composition contributing to multiple sclerosis may be different between different populations, thus results in a heterogeneity of disease manifestation and distribution.

scholarly journals Społeczeństwo i kultura jako definicyjny kontekst badań nad wpływem technologii na ponowoczesnego człowieka

2021 ◽  
Vol 65 (1) ◽  
pp. 197-211
Author(s):  
Paweł Piotr Nowak ◽  
Keyword(s):  
Social Relations ◽  
Service Sector ◽  
Social Inequalities ◽  
New Technology ◽  
Digital Transformation ◽  
Negative Consequences ◽  
Philosophy Of Dialogue ◽  
Definition Of ◽  
The Individual ◽  
The Impact

Based on an analysis of selected definitions of the terms used for society and culture, the author creates the sociological theoretical framework for the article. In conjunction with the characterized phenomenon of digital transformation, extensive and far-reaching conclusions are formulated on the impact of new technology for postmodernity. In relation to the scientific achievements of Buber and Tischner, the author deeply analyzes the assumptions of philosophy of dialogue. This allows the observation of a wide dimension in the relationship between the relational nature of social relations, the condition of the individual, the durability of the systems humans create, the technocratic direction of civilizational development and the consumerist attitude to reality in contemporary society of the 21st century. The author describes technological worship and presents the negative consequences of digital transformation processes. On the example of the service sector, the transition is presented as symbolic culture based on the relations and dialogue with technical and functional culture. The research method used in the article is a review of the scientific literature. In the study, the author set the goal of determining the impact of digital transformation on humans in the context of the definition of culture and society. As a result of the research, the author states that technological insight (i.e. looking at technology as a way of resolving all contemporary problems) has the danger of successively weakening man, and could lead to a deepening of social inequalities. The author also emphasizes the need to deepen research on the consequences of the digital transformation on society and culture and to develop models that can reduce the negative consequences of the change process.

scholarly journals TYPES OF INDIVIDUAL WOMEN EROTIC CODE

2018 ◽  
Keyword(s):  
Life Experience ◽  
Married Couples ◽  
Professional Activity ◽  
Self Reflection ◽  
Early Life Experience ◽  
New Material ◽  
Definition Of ◽  
The Individual ◽  
The Impact ◽  
First Time

The article is devoted to the current issue of sexuality. Significant expansion and development of psychologists’ professional activity necessitate creating of generalized classification of individuals and married couples’ behavioral erotic types. The destruction of self-reflection, self-perception and the difficulty of interpersonal understanding are due to the substitution of concepts. The study of sexual-psychological characteristics of behavioral patterns of women in erotic relationships is very important in this regard. The new material on the topic under study is generalized. Erotic imagination functions and erotic images impact on the process of forming a fixed erotic Image of a sexual partner in women are determined. The impact of early life experience (imprinting) influenced on the individual erotic code formation is determined. Several motivational schemes of sexual behavior are described. Authors submit the definition of «individual erotic code» for the first time. «Individual erotic code» is found out as the unified recording system of the individual model erotic behavior and her «ideal partner» reactions on this behavior. The types of women individual erotic code, based on the concept of archetypes (K.G. Jung, D. S. Bolen) study are defined. Types of individual erotic code were named after the ancient Greek goddesses: Artemis, Athena, Hestia, Hera, Demeter, Persephone, Aphrodite. The attention is focused on the deep analysis of individual women erotic code stages realization, such as, the genesis of erotic impulse, the tempting process, the sexual act behavior, the pregnancy, the caring of posterity. Materials of research can be used in the practical work of psychologists and psychotherapists which working both with married couples, as well as in individual work with the client.

scholarly journals Criteria for Housing Design with Emphasis on Comparison between Traditional and Today Contemporary Iranian Architecture

2016 ◽  
Vol 9 (6) ◽  
pp. 182
Author(s):  
Tahereh Nasr
Keyword(s):  
Design Pattern ◽  
Field Method ◽  
Traditional Architecture ◽  
Housing Design ◽  
Residential Architecture ◽  
Definition Of ◽  
The Individual ◽  
The Right ◽  
House Design ◽  
The Impact

<p>Settling in the cities and the numerous efforts being made for massive supply of houses in a short time period, makes difficult the access to a pattern as appropriate for family life with increase in concentration in building construction, the individual and family borders, too, are neglected.</p><p>Though due to the extensiveness and complexity of the concept of housing, one cannot give a comprehensive, unique definition of it, but the housing, as a shelter, is regarded as the primary and basic needs of the family.</p><p>House as a place for relaxation and comfort and a shelter for removing tiredness has been a peace and security locality from a long time ago. House demand is one of the most essential human`s demands. According to Article 31 of fundamental law of Islamic Republic of Iran also, possessing a suitable house is considered as the right for every person and every Iranian family. House not only as a shelter, but also as a place for humans raise, has a great importance in the initial and most fundamental society union, namely family.</p><p>Identifying the identity and investigating the residential complexes in regard to the aesthetics implies the precise and conscious observing and noticing their beauties and or ugliness.</p><p>Main Questions in this paper are:</p><ul><li>What are the consequences of disregarding the identity of today's housing architecture, especially the architecture of the ancient towns?</li><li>Can the components of Iranian traditional architecture be applied in today contemporary residential architecture and be effective to create a sense of place?</li></ul><p>So the main purpose of this article is Pathology of Today Contemporary Iranian housing Architecture and Comparison with traditional Iranian architecture.</p><p>The method explored is a descriptive-analytical and field method to gather information and documents are available. The impact of known factors and variables in Iranian contemporary and traditional residential architecture has been evaluated and compared.</p><p>Accordingly, having some criteria for achieving a suitable house design pattern is essential in a way that makes it possible to understand all its visual embodiments and identify its identity.</p>This research also state the reasons for disability of today`s architecture and urban development against house problem and recommend some criteria for achieving a house design pattern after an overview of the definition of housing and examination of Iranian housing.

Frequency of Severe Attacks in Migraine Sufferers of the Gazel Cohort

Cephalalgia ◽  
1997 ◽  
Vol 17 (8) ◽  
pp. 863-866 ◽  
Author(s):  
P Michel ◽  
B Dubroca ◽  
JF Dartigues ◽  
A El Hasnaoui ◽  
Henry
Keyword(s):  
Treatment Strategies ◽  
Individual Variability ◽  
Measurement Tool ◽  
Severe Attack ◽  
Migraine Sufferer ◽  
Definition Of ◽  
The Individual ◽  
The Impact ◽  
Severe Migraine ◽  
Very High

The concept of severe migraine was raised to define migraineurs most in need of care and for use in clinical practice. We aimed to measure the frequency of severe attacks in a working sample of 276 migraine sufferers using a diary over a 3-month period. Migraine sufferers recorded each attack's clinical features, the degree of their disability, their use of drugs and the effectiveness of the drugs. Since the definition of severe attack is not standardized, we studied the impact of different definitions on the frequency. The frequency of severe attacks was 0.9% and appeared to be very sensitive to the definitions, ranging between 0.4 and 13%. In France, the extrapolated number of severe attacks is nearly one million out of a total of 115 million. In the migraineurs who had had at least one severe attack, the individual variability of intensity, duration or disability was very high, so the proportion of severe attacks in a given sufferer was low—between 15% and 50%. We conclude that the global concept of severe migraine is not relevant and should be split into two componentssevere attack and severe migraine sufferer. The goals are different, too. Regarding treatment, for example, the severe attack concept is more valid for acute treatment strategies, whereas the severe migraine sufferer concept should be preferred to determine the need for prophylactic treatment. Since much work is being done nowadays to define a rate treatment strategies, definition of the criteria of severe attack and validation of a measurement tool should be a priority.

Age at Onset in Schizophrenia and Risk of Illness in Relatives

1996 ◽  
Vol 169 (2) ◽  
pp. 213-218 ◽  
Author(s):  
Kenneth S. Kendler ◽  
Laura Karkowski-Shuman ◽  
Dermot Walsh
Keyword(s):  
Family Study ◽  
Age Of Onset ◽  
Age At Onset ◽  
Proportional Hazard ◽  
Common Sense Model ◽  
Cox Proportional Hazard ◽  
Developmental Effects ◽  
Cox Proportional Hazard Models ◽  
Definition Of ◽  
The Individual

BackgroundFor many common medical and neuropsychiatric disorders, early age at onset reflects high familial liability to illness. However, for schizophrenia, most studies do not find such a relationship.MethodUsing Cox proportional hazard models, we investigate this question in the epidemiologically-based Roscommon family study.ResultsNo relationship was found between age at onset in schizophrenic probands and the hazard rate for schizophrenia in their relatives. Similar results were obtained when the definition of illness was expanded to include schizoaffective disorder and other non-affective psychoses.ConclusionsFor schizophrenia, a ‘common-sense’ model for age of onset (i.e. those with highest familial liability to illness succumb first while those with lower liability survive longer before falling ill) does not seem to apply. Our results are more consistent with a model in which variation in age at onset of schizophrenia is due to random developmental effects or to environmental experiences unique to the individual.

scholarly journals How accurately can we measure the baryon acoustic oscillation feature?

2020 ◽  
Vol 498 (3) ◽  
pp. 3744-3757
Author(s):  
Rossana Ruggeri ◽  
Chris Blake
Keyword(s):  
Asymptotic Variance ◽  
Confidence Region ◽  
Acoustic Oscillation ◽  
Acoustic Oscillations ◽  
Noise Component ◽  
Posterior Probability Distribution ◽  
The Difference ◽  
Definition Of ◽  
The Individual ◽  
The Impact

ABSTRACT Baryon acoustic oscillations (BAOs) represent one of the cleanest probes of dark energy, allowing for tests of the cosmological model through the measurement of distance and expansion rate from a 3D galaxy distribution. The signal appears at large scales in the correlation function where linear theory applies, allowing for the construction of accurate models. However, due to the lower number of modes available at these scales, sample variance has a significant impact on the signal, and may sharpen or widen the underlying peak. Therefore, equivalent mock realizations of a galaxy survey present different errors in the position of the peak when uncertainties are estimated from the posterior probability distribution corresponding to the individual mocks. Hence, the posterior width, often quoted as the error in BAO survey measurements, is subject to sample noise. A different definition of the error is provided by the asymptotic variance of the maximum likelihood estimator, which involves the average over multiple realizations, and is not subject to sample noise. In this work, we reanalyse the main galaxy survey data available for BAO measurements and quantify the impact of the noise component on the error quoted for BAO measurements. We quantify the difference between three definitions of the error: the confidence region computed from a single posterior, the average of the variances of many realizations, and the Fisher matrix prediction assuming a Gaussian likelihood. We also explore the impact of a ‘detectability prior’ based on the significance of the BAO detection.

scholarly journals THE ASSISTED LIVING SETTING: CLINICAL CARE AND OUTCOMES

2019 ◽  
Vol 3 (Supplement_1) ◽  
pp. S235-S236
Author(s):  
Barbara Resnick
Keyword(s):  
Life Satisfaction ◽  
Assisted Living ◽  
Clinical Care ◽  
High Rate ◽  
Supportive Services ◽  
Skilled Nursing ◽  
Facility Level ◽  
Definition Of ◽  
The Individual ◽  
The Impact

Abstract Although the description of assisted living (AL) varies by state this term generally refers to residences that provide housing and supportive services, 24-hour supervision, and at least two meals a day to meet the individual needs of residents. Approximately 37% of residents in AL need help with three or more activities of daily living (ADLs), 42% have some cognitive impairment and 39% need skilled nursing services. Approximately 15 to 50% of older adults living in AL communities experience a fall over a 6 to 24 month period. The cause of these falls involves multiple factors at the resident and facility level. In addition to a high rate of falls there is a high rate of polypharmacy, using the polypharmacy definition of taking five or more medications daily. Polypharmacy results in negative outcomes such as falls and hospitalizations among AL residents. Along with high rates of falls and polypharmacy there is also a high incidence of pain among AL residents and concerns that some pain goes unreported and untreated. Pain, polypharmacy and falls can all influence life satisfaction along with other factors such as the environment itself. The purpose of this symposium is to describe the incidence and factors that influence falls, polypharmacy, pain and pain management and the impact of these care concerns, among others, on life satisfaction drawn from 508 residents from 54 nursing homes participating in the first two cohorts of the study testing the implementation of Function Focused Care for Assisted Living (FFC-AL-EIT).

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