The impact of severe osteogenesis imperfecta on the lives of young patients and their parents – a qualitative analysis

ObjectivePrevious studies that evaluated cardiovascular risk factors considered age as a potential confounder. We aimed to investigate the impact of cardiovascular disease (CVD) and its risk factors on fatal outcomes according to age in patients with COVID-19.MethodsA systematic literature review and meta-analysis was performed on data collected from PubMed and Embase databases up to 11 June 2020. All observational studies (case series or cohort studies) that assessed in-hospital patients were included, except those involving the paediatric population. Prevalence rates of comorbid diseases and clinical outcomes were stratified by mean patient age in each study (ranges: <50 years, 50–60 years and ≥60 years). The primary outcome measure was a composite fatal outcome of severe COVID-19 or death.ResultsWe included 51 studies with a total of 48 317 patients with confirmed COVID-19 infection. Overall, the relative risk of developing severe COVID-19 or death was significantly higher in patients with risk factors for CVD (hypertension: OR 2.50, 95% CI 2.15 to 2.90; diabetes: 2.25, 95% CI 1.89 to 2.69) and CVD (3.11, 95% 2.55 to 3.79). Younger patients had a lower prevalence of hypertension, diabetes and CVD compared with older patients; however, the relative risk of fatal outcomes was higher among the former.ConclusionsThe results of the meta-analysis suggest that CVD and its risk factors (hypertension and diabetes) were closely related to fatal outcomes in COVID-19 for patients across all ages. Although young patients had lower prevalence rates of cardiovascular comorbidities than elderly patients, relative risk of fatal outcome in young patients with hypertension, diabetes and CVD was higher than in elderly patients.Prospero registration numberCRD42020198152.

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POS1012 HOW IMPORTANT WOULD BE THE IMPACT OF SPONDYLOARTHRITIS ON MILITARY POPULATION’S WORKING LIFE?

Annals of the Rheumatic Diseases ◽

10.1136/annrheumdis-2021-eular.3740 ◽

2021 ◽

Vol 80 (Suppl 1) ◽

pp. 774.2-774

Author(s):

T. Mehmli ◽

R. Dhahri ◽

M. Slouma ◽

E. Hannech ◽

B. Louzir ◽

...

Keyword(s):

Ankylosing Spondylitis ◽

Disease Activity ◽

Activity Index ◽

Productivity Loss ◽

Young Patients ◽

Work Productivity ◽

C Reactive Protein ◽

Reactive Protein ◽

Military Patients ◽

The Impact

Background:Spondyloarthritis is a group of chronic inflammatory diseases involving axial and peripheral joints. It mainly affects young patients typically of working age. Therefore, its impact on work outcomes may be considerable particularly in military patients.Objectives:The aim of this study was to evaluate the impact of spondyloarthritis on work ability and productivity in military patients, and to assess relationship between work productivity loss and disease activity.Methods:Thirty Three patients diagnosed with spondyloarthritis in the militay hospital of Tunis were included in the study. Age, gender and C-reactive protein were recorded. Data related to duration of the disease, Ankylosing Spondylitis Disease Activity Score (ASDAS) and Bath Ankylosing Spondylitis Disease Activity Index (BASDAI) were also recorded. Employed patients completed Work Productivity and Activity Impairment (WPAI) questionnaire witch assesses four subscales: presenteism, absenteism, overall work impairemend and daily activity impairement in the 7 past days.Results:Among the thirty three patients, 63 % were men and 37% were women. The average age was 43,7 ± 13,5. The average duration of disease was 8,5 ± 7,75 years. Mean C-Reactive protein was 27,5 ± 39,3. Mean ASDAS and BASDAI were 3,12 ± 1,39 and 4,26 ± 1,78 respectively. 22 patients (66%) had an active disease and 11 (33%)were in remission. 48,4% of patients were using NSAIDs, 48,4% were under DMARDs and 42% were under biologics (12 patients using TNF-alpha blockers and 2 patients were given IL-17 inhibitors). Among this patients, 27 were employed. Three patients (11%) had a total work disability and were retired from work and two have been outplaced.Employed patients worked an average of 35,6 ± 10,3 hours per week and missed an average of 3,48 ± 6,49 hours per week. The mean rates of absenteeism, presenteeism and work productivity loss were 8,8 ± 16,9 %, 48,4 ± 19,9 % and 48,6 ± 19,7 %.There was a statistically significant correlation between BASDAI and work missed hours (p<0,05, r=0,48), absenteeism (p<0,05, r=0,48), presenteeism (p<0,01, r=0,669), work impairement (p<0,01, r=0,669), activity impairement (p<0,05, r=0,475) and work productivity loss (p<0,05, r=0,475), as well as between ASDAS CRP and presenteeism (p<0,05, r= 0,593), work impairement (p<0,05, r=0,593), activity impairement(p<0,05, r=0,460) and work productivity loss (p<0,05, r=0,460). No relation was found between WPAI indexes and C-reactive protein.Conclusion:This study demonstrates that spondyloarthritis has a major impact on military patients’ work productivity with a significant correlation between WAPI indexes and disease activity scores (ASDAS CRP and BASDAI). No relation was found with C-reactive protein.Disclosure of Interests:None declared.

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Neurospect Findings in Patients Exposed to Neurotoxic Chemicals

Toxicology and Industrial Health ◽

10.1177/074823379401000525 ◽

1994 ◽

Vol 10 (4-5) ◽

pp. 561-571

Author(s):

Gunnar Heuser ◽

Ismael Mena ◽

Francisca Alamos

Keyword(s):

Elderly Patients ◽

Qualitative Analysis ◽

Right Hemisphere ◽

Young Patients ◽

Chronic Fatigue ◽

Psychiatric Symptomatology ◽

Elderly Individuals ◽

Parietal Lobes ◽

The Right ◽

The Brain

Exposures to neurotoxic chemicals such as pesticides, glues, solvents, etc. are known to induce neurologic and psychiatric symptomatology. We report on 41 patients 16 young patients (6 males, 10 females, age 34 8 yrs.) and 25 elderly patients (9 males, 16 females, age 55 7 yrs). Fifteen of them were exposed to pesticides, and 29 to solvents. They were studied with quantitative and qualitative analysis of regional cerebral bood flow (rCBF), performed with 30 mCi of Xe-133 by inhalation, followed by 30 mCi of Tc-HMPAO given intravenously. Imaging was performed with a brain dedicated system, distribution of rCBF was assessed with automatic ROI definition, and HMPAO was normalized to maximal pixel activity in the brain. Results of Xe rCBF are expressed as mean and S.D. in ml/min/100g, and HMPAO as mean and S.D. uptake per ROI, and compared with age-matched controls 10 young and 20 elderly individuals. Neurotoxics HMPAO Uptake Young Elderly R. Orbital frontal R. Dorsal frontal .70 .66 p < 0.05 R. Temporal .64 p < 0.001 R. Parietal .66 .66 We conclude that patients exposed to chemicals present with diminished CBF, worse in the right hemisphere, with random presentation of areas of hypoperfusion, more prevalent in the dorsal frontal and parietal lobes. These findings are significantly different from observations in patients with chronic fatigue and depression, suggesting primary cortical effect, possibly due to a vasculitis process.

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Heart-related mortality after postoperative breast irradiation in patients with ductal carcinoma in situ in the contemporary radiotherapy era

Scientific Reports ◽

10.1038/s41598-021-82263-8 ◽

2021 ◽

Vol 11 (1) ◽

Author(s):

Yu Jin Lim ◽

Jaemoon Koh

Keyword(s):

Competing Risks ◽

Ductal Carcinoma In Situ ◽

Carcinoma In Situ ◽

Ductal Carcinoma ◽

Statistical Significance ◽

Young Patients ◽

Subdistribution Hazard ◽

The Impact ◽

Related Mortality

AbstractAlthough radiation-induced cardiotoxicity has been addressed, its prognostic relevance to modern radiotherapy (RT) techniques is unclear. This study assessed the impact of adjuvant RT on heart-related deaths in patients with ductal carcinoma in situ. Patients who underwent adjuvant RT after breast-conserving surgery between 1988 and 2008 were identified from the Surveillance, Epidemiology, and End Results database. Kaplan‒Meier and competing risks analyses were conducted after propensity score-matching according to tumor laterality. A total of 41,526 propensity-matched patients were identified (n = 20,763 for either left- or right-sided tumor). In the analysis of the cumulative incidence of heart-related mortality events, there was a greater risk increment in the left-sided group over the first to second decades after RT in patients aged ≤ 50 years (P = 0.048). Competing risks analysis of the young patients showed that left-sided RT was associated with higher heart-related mortality rates (Grey’s test, P = 0.049). The statistical significance remained after adjusting for other covariates (subdistribution hazard ratio 2.35; 95% confidence interval 1.09‒5.10). Regarding the intrinsic effect of modern RT techniques, further strategies to reduce heart-related risks are needed for young patients. Close surveillance within an earlier follow-up period should be considered for these patients in clinics.

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On the impact of velocity on the train-to-earth MIMO propagation channel: Statistical observations and qualitative analysis

2017 IEEE International Symposium on Antennas and Propagation & USNC/URSI National Radio Science Meeting ◽

10.1109/apusncursinrsm.2017.8072975 ◽

2017 ◽

Cited By ~ 2

Author(s):

Claes Beckman ◽

Johan Garcia ◽

Stefan Alfredsson ◽

Anna Brunstrom

Keyword(s):

Qualitative Analysis ◽

Propagation Channel ◽

The Impact

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First year medical students’ perceptions of the impact of wearing scrubs on professional identity: a narrative analysis in the United Arab Emirates

BMJ Open ◽

10.1136/bmjopen-2020-039357 ◽

2020 ◽

Vol 10 (11) ◽

pp. e039357

Author(s):

Sara Sorrell ◽

Halah Ibrahim

Keyword(s):

Medical Students ◽

Qualitative Analysis ◽

Medical School ◽

Professional Identity ◽

United Arab Emirates ◽

Medical Curriculum ◽

First Year ◽

Written Narratives ◽

First Year Medical Students ◽

The Impact

ObjectivesMedical school serves as a critical developmental period for future physicians, during which students begin to form a professional identity. Just as personal appearance, particularly clothing, is an important external expression of one’s personal identity, ‘uniforms’ in healthcare, including white coats and scrubs, symbolise status and a group identity. There are, however, limited studies on the impact of physician attire on medical students’ formation of professional identity. Accordingly, through qualitative analysis of written narratives, we sought to analyse medical students’ experiences of wearing professional physician attire, namely scrubs, and how the uniform impacted their confidence level, performance and behaviours, as well as their identity as future physicians.DesignQualitative analysis of medical student’s written narratives.SettingKhalifa University College of Medicine and Health Sciences (KU CMHS) is a new medical school in the United Arab Emirates, with an inaugural class of 30 students admitted in August 2019. It is the only medical school in the city of Abu Dhabi, and the only school in the country that follows a postgraduate medical curriculum.ParticipantsAll first year medical students at KU CMHS were purposively sampled.MethodsStudents completed a voluntary online anonymous questionnaire. We employed a social identity approach to data analysis. Thematic content analysis was conducted on their narratives to identify themes.ResultsWe identified three major themes, namely (1) emotions, (2) logistics and (3) interpersonal relationships.ConclusionsMedical students form early perceptions regarding physician attire and its impact on their professional identity. Engaging in conversations regarding professional attire with educators or mentors could provide an important opportunity for students to discuss and explore professional identity early in training.

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Augmented Rehabilitation Program for Young Patients Following Total Hip Arthroplasty

10.21203/rs.3.rs-138081/v1 ◽

2021 ◽

Author(s):

Ahmed Negm ◽

Milad Yavarai ◽

Gian Jhangri ◽

Robert Haennel ◽

Allyson Jones

Keyword(s):

Physical Activity ◽

Total Hip Arthroplasty ◽

Hip Arthroplasty ◽

Intervention Group ◽

Young Patients ◽

Rehabilitation Program ◽

Control Group ◽

Total Hip ◽

The Impact

Abstract BackgroundThe increase rate seen in Total Hip Arthroplasty (THA) for younger patients has implications for future rehabilitation demands for primary and revision THA surgery. This study aims to determine the impact of a 6-week post-operative rehabilitation program designed for THA patients ≤ 60 years on physical activity (PA) and function compared to age- and a sex-matched control group received usual postoperative care at 12-week post-THA. MethodsIn this quasi-experimental study, a cohort of THA candidates was recruited during their 6-week postoperative visit to their surgeons. The out-patient rehabilitation program consisted of 12 structured exercise classes (2 hrs/class) over 6 weeks. Physical activity was assessed using Sense Wear Pro ArmbandTM [SWA]. Participants completed the Hip Osteoarthritis Outcome Score (HOOS), and THA satisfaction questionnaire before and immediately after the intervention. ResultsThe intervention group took significantly more steps/day at the follow-up compared to baseline. The intervention group had a higher mean change in the number of weekly PA bouts than the control group. Within the intervention groups, all HOOS subscales were significantly higher at the follow-up compared to baseline. ConclusionThe augmented rehabilitation program may have immediate effects on pain relief and symptom reduction for patients (≤60 years) following THA.

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A Clinical Study of the Impact of Soft Contact Lenses on the Progression of Myopia in Young Patients

Clinical Ophthalmology ◽

10.2147/opth.s338199 ◽

2022 ◽

Vol Volume 16 ◽

pp. 51-62

Author(s):

Andrzej Malinowski ◽

Małgorzata Mrugacz ◽

Marcin Stopa ◽

Erita Filipek ◽

Anna Moniuszko-Malinowska ◽

...

Keyword(s):

Clinical Study ◽

Contact Lenses ◽

Young Patients ◽

Soft Contact ◽

Soft Contact Lenses ◽

The Impact

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Evaluación cualitativa de un programa de intervención psicológica con hombres violentos dentro de la pareja

Acciones e Investigaciones Sociales ◽

10.26754/ojs_ais/ais.201028484 ◽

2011 ◽

pp. 135

Author(s):

Santiago Boira Sarto ◽

Yolanda López del Hoyo ◽

Lucía Tomás Aragonés ◽

Ana Rosa Gaspar

Keyword(s):

Domestic Violence ◽

Qualitative Analysis ◽

Therapeutic Alliance ◽

Discussion Groups ◽

Prison Sentence ◽

Key Aspects ◽

Assessment Strategies ◽

The Impact

La tardía implantación en España de programas de intervención con hombres maltratadores enfatiza la necesidad de desarrollar investigaciones que maximicen la eficacia de los tratamientos. Hasta el momento, han sido escasos los estudios publicados que evalúen las variables relacionadas con la permanencia o el abandono del tratamiento y su eficacia, y todavía más escasos los que han estudiado este tema desde un punto de vista cualitativo. El objetivo del estudio es identificar aspectos clave en los programas de intervención que puedan mejorar la eficacia de los tratamientos para hombres condenados por un delito de violencia de género a los que se les ha suspendido o sustituido la ejecución de la pena de prisión por la realización del programa terapéutico. Para ello se ha analizado cualitativamente la información obtenida en dos grupos de discusión formados por los psicólogos que aplicaron el programa y distribuidos según el tipo de terapia, individual o grupal.Los resultados reflejan la conveniencia de considerar la especificidad de este contexto de intervención en el diseño de los programas y en la evaluación. Deberán mejorarse las estrategias que aumenten la motivación, la alianza terapéutica y la adherencia de los hombres al tratamiento. Además habrá que ampliar las estrategias de evaluación para que ofrezcan una información cualitativamente diferente y permitan una valoración global del impacto del tratamiento y el riesgo para la víctima.The late implementation in Spain of intervention programmes for male abusers stresses the need to carry out research that can maximise the effectiveness of such treatment. Up till now, very few studies have been published that assess the variables relating to the continuation or abandonment of the treatment and its efficiency, and there are even fewer studies that examine this subject from a qualitative standpoint. The object of the study is to identify key aspects in the intervention programmes that can enhance the efficiency of the treatment offered to men that have been convicted for a crime involving domestic violence, and who have had their prison sentence suspended or commuted to a programme entailing therapy. With this aim in mind, a qualitative analysis is conducted of the data obtained in two discussion groups formed by psychologists who applied the programme and who are distributed in accordance with the type of therapy �individual or group-oriented� they administered.The findings reflect the convenience of considering the specifics of this context of intervention in the design of such programmes, along with their assessment. Strategies should be improved to enhance motivation, and also to strengthen the therapeutic alliance and ensure that the men stick to the treatment. We will also have to broaden our assessment strategies so that they offer data that is qualitatively different and can enable an overall assessment to be made of the impact of the treatment and the risk to the victim.

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