scholarly journals Mycobacterium tuberculosis causing tuberculous lymphadenitis in Maputo, Mozambique

2015 ◽  
Vol 15 (1) ◽  
Author(s):  
Sofia Omar Viegas ◽  
Solomon Ghebremichael ◽  
Leguesse Massawo ◽  
Matos Alberto ◽  
Fabíola Couto Fernandes ◽  
...  
Keyword(s):  
Mycobacterium Tuberculosis ◽  
Tuberculous Lymphadenitis

scholarly journals Superficial tuberculous lymphadenitis in Merseyside: 1969–1984

1985 ◽  
Vol 95 (1) ◽  
pp. 115-122 ◽  
Author(s):  
E. G. L. Wilkins ◽  
C. Roberts
Keyword(s):  
Public Health ◽  
Mycobacterium Tuberculosis ◽  
Lymph Nodes ◽  
Clinical Presentation ◽  
The Elderly ◽  
Immigrant Population ◽  
Public Health Laboratory ◽  
Atypical Mycobacteria ◽  
Tuberculous Lymphadenitis ◽  
The Third

SUMMARYThe actiology, epidemiology and clinical presentation of 137 bacteriologically confirmed cases of superficial mycobacterial lymphadenitis identified at the Liverpool Public Health Laboratory between 1969 and 1984 were reviewed. Despite a fall in pulmonary and total extrapulmonary isolates, the annual recovery of mycobacteria from lymph nodes remained relatively constant. Mycobacterium tuberculosis was the cause of infection in 121 patients (88·3%), M. bovis in 6 and the remaining 10 isolates were atypical mycobacteria. In European patients (68·6%) the highest incidence was in the elderly, whereas in non-Europeans (31·4%) the disease almost exclusively occurred in the third and fourth decades. The proportion of isolates from non-Europeans reflected the size of the immigrant population and increased during the period of study.

scholarly journals The value of multimodal ultrasonography in differential diagnosis of tuberculous and non-tuberculous superficial lymphadenitis

BMC Surgery ◽  
2021 ◽  
Vol 21 (1) ◽  
Author(s):  
Jie Chu ◽  
Ying Zhang ◽  
Wenzhi Zhang ◽  
Dan Zhao ◽  
Jianping Xu ◽  
...  
Keyword(s):  
Differential Diagnosis ◽  
Mycobacterium Tuberculosis ◽  
Lymph Nodes ◽  
Color Doppler ◽  
Tuberculous Lymphadenitis ◽  
Contrast Enhanced Ultrasound ◽  
Doppler Examination ◽  
Contrast Enhanced ◽  
Sensitivity Specificity ◽  
Multimodal Method

Abstract Background To investigate the value of multimodal ultrasonography in differentiating tuberculosis from other lymphadenopathy. Methods Sixty consecutive patients with superficial lymphadenopathy treated at our hospital from January 2017 to December 2018 were categorized into four types based on the color Doppler ultrasound, five types based on contrast-enhanced ultrasound, and five types based on elastography. Sensitivity and specificity were calculated of all the three imaging, including color Doppler examination, contrast-enhanced ultrasound and one individual multimodal method, for detecting lymph nodes. Results A total of 60 patients were included in the final analysis. Of those, Mycobacterium tuberculosis was positive in 38 patients and negative in 22 patients. Among the 38 patients who were positive for Mycobacterium tuberculosis, of which 23 had a history of pulmonary tuberculosis, accounting for 60.53% of the positive cases, and the remaining patients did not combine lesions of other organs. Among the 60 superficial lymph nodes, 63.3% presented with tuberculous lymphadenitis. The sensitivity, specificity, and accuracy of the color Doppler examination were 73.68%, 68.18%, and 71.67%, respectively. The sensitivity, specificity and accuracy of contrast-enhanced ultrasound were 89.47%, 63.64% and 80.00%, respectively. The sensitivity, specificity and accuracy of the elastography were 63.16%, 63.64% and 63.33%, respectively. The sensitivity, specificity and accuracy of one individual multimodal method were 42.11%, 95.45% and 61.67%, respectively. The sensitivity, specificity and accuracy of all modes combined were 100.00%, 27.27% and 73.33%, respectively. Conclusion Multimodal ultrasonography has high predictive value for the differential diagnosis of superficial tuberculous lymphadenitis.

scholarly journals Comparison of different diagnostic modalities for isolation of Mycobacterium Tuberculosis among suspected tuberculous lymphadenitis patients

2023 ◽  
Vol 83 ◽  
Author(s):  
N. Sharif ◽  
D. Ahmed ◽  
R. T. Mahmood ◽  
Z. Qasim ◽  
S. N. Khan ◽  
...  
Keyword(s):  
Mycobacterium Tuberculosis ◽  
Communicable Disease ◽  
Multidrug Resistant ◽  
Drug Susceptibility Testing ◽  
Primary Objective ◽  
Diagnostic Methods ◽  
Smear Microscopy ◽  
High Morbidity ◽  
Tuberculous Lymphadenitis ◽  
Conventional Methods

Abstract Tuberculosis is a communicable disease with high morbidity and mortality rates in developing countries. The study's primary objective is to compare conventional methods such as acid-fast bacillus (AFB) culture and microscopy with rapid diagnostic methods. The secondary objective is to compare histopathological and microbiological findings in suspected patients with tubercular lymphadenitis. A total of 111 samples (August 2018 to September 2019) of lymph nodes were processed for AFB microscopy, AFB cultures, drug-susceptibility testing (DST), histopathology, and Xpert Mycobacterium Tuberculosis (MTB)/resistance to Rifampin (RIF) assays. Out of 111 lymph node samples, 6 (5.4%) were positive for AFB smear microscopy, 84 (75.6%) were positive for AFB culture, 80 (70.7%) were positive on Gene Xpert, and 102 (91.8%) were indicative of tuberculosis for histopathology studies. Mycobacteria growth indicator tube (MGIT) culture positivity was 84 (75.6%) higher than solid Lowenstein-Jensen (LJ) culture 74 (66.6%). Positive cultures underwent phenotypic DST. Two cases were Multidrug-resistant (MDR) on DST, while three cases were Rifampicin resistant on Gene Xpert. The sensitivity of Genexpert was (62%) against the conventional AFB culture method. The poor performance of conventional lymphadenitis diagnostic methods requires early and accurate diagnostic methodology. Xpert MTB/RIF test can help in the treatment of multidrug-resistant TB cases. Nonetheless, rapid and conventional methods should be used for complete isolation of Mycobacterium tuberculosis.

scholarly journals Immunocytochemical Study of Rabbit-Polyclonal to Mycobacterium Tuberculosis, AB905: Improving Diagnostic of Tuberculous Lymphadenitis

2021 ◽  
Vol 21 (2) ◽  
pp. 95-101
Author(s):  
Humairah Medina Liza Lubis ◽  
Emni Purwoningsih ◽  
Ance Roslina ◽  
Muhammad Al Anas
Keyword(s):  
Mycobacterium Tuberculosis ◽  
Predictive Value ◽  
Extrapulmonary Tuberculosis ◽  
Clinical History ◽  
Excisional Biopsy ◽  
Needle Aspiration ◽  
Cross Sectional Study ◽  
Tuberculous Lymphadenitis ◽  
Immunocytochemical Study ◽  
Cross Sectional

Tuberculous lymphadenitis (TBLN) is the most common form of extrapulmonary tuberculosis. However, the optimal diagnosis using Fine-Needle Aspiration Cytology (FNAC) or excisional biopsy is uncertain. This research aims to improve the diagnostic of TBLN with FNAC and immunocytochemistry (ICC) compared to the response to antituberculosis therapy. The cross-sectional study involved 43 patients with the criteria for TBLN diagnosis based on the appropriate clinical history of tuberculosis and indicative cytological results. Immunocytochemical examination employed rabbit-polyclonal to Mycobacterium tuberculosis (MTB) antibody (AB905). The MTB expression was found in 35 out of 43 cases (81%) that appropriate cytological features of the tuberculosis process. Meanwhile, eight out of 43 cases (19%) did not express MTB. Diagnostic tests for lesions with a positive cytologic appearance of TBLN and ICC were compared to the response to anti-tuberculosis therapy, revealing the sensitivity, specificity, positive predictive value, and negative predictive value of 95.2%, 75%, 95.2%, and 17%, respectively. Besides, Fisher's exact tests utilized to identify the relationship between two variables; p 0.05 was considered significant. This research found immunocytochemical study was a sensitive and specific tool for improving the diagnostic of TBLN.

scholarly journals Gene Xpert MTB / RIF – Diagnostic Role in Tuberculous Pleurisy

2016 ◽  
Vol 22 (1) ◽  
pp. 78
Author(s):  
Muhammad Khalid Ch ◽  
Muhammad Saqib Saeed ◽  
Rizwan Iqbal ◽  
Akhtar Ali
Keyword(s):  
Mycobacterium Tuberculosis ◽  
Tertiary Care ◽  
Cross Sectional Study ◽  
Tuberculous Lymphadenitis ◽  
Care Hospital ◽  
Cross Sectional ◽  
Diagnostic Role ◽  
Tuberculous Pleurisy ◽  
Medical University

<p><strong>Abstract</strong></p><p><strong>Background:  </strong>Tuberculous pleurisy is a common extrapulmonary manifestation and is second to tuberculous lymphadenitis. Due to its paucibacillary in origin, its diagnosis is a challenge. Furthermore, it is also complicated by the emergence of MDR. Gene Xpert MTB/RIF is a new rapid promising innovation for the detection of mycobacterium tuberculosis and its resistance to Rifampicin, giving result within two hours.</p><p><strong>Objective:  </strong>To evaluate the diagnostic role of Gene Xpert MTB/RIF in suspected cases of tuberculous pleurisy.</p><p><strong>Study Design:  </strong>Cross sectional study.</p><p><strong>Study Setting:  </strong>Institute of Chest Medicine Mayo Hospital – a Tertiary Care Hospital affiliated with King Edward Medical University, Lahore.</p><p><strong>Methodology:  </strong>The study group, one hundred (M-60 and F-40) cases having exudative, predominantly lymphocytic pleural effusion with strong suspicion of tuberculous in origin were enrolled randomly for Gene Xpert MTB / RIF.</p><p><strong>Results:  </strong>Among one hundred study cases, Gene Xpert detected mycobacterium tuberculosis in 12(12%) cases [M-8 (13.3%) and F-4 (10%)]. Resistance to Rifampacin was detected in 6 (6%) cases [M-2 (3.3%) and F-4 (10%)].</p><p><strong>Conclusion:  </strong>Gene Xpert MTB/RIF is a useful new rapid promising technique to diagnose tuberculous pleurisy. Although at present it has limited availability and utility.</p><p><strong>Key Words:  </strong>Gene Xpert. MTB – Mycobacterium tuberculosis. RIF – Rifampacin. TB – Tuberculosis. MDR – Multidrug resistance.</p>

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