scholarly journals Association of reduced retinal arteriolar tortuosity with depression in older participants from the Northern Ireland Cohort for the Longitudinal Study of Ageing

2021 ◽  
Vol 21 (1) ◽  
Author(s):  
R. A. O’Neill ◽  
A. P. Maxwell ◽  
F. Kee ◽  
I. Young ◽  
R. E. Hogg ◽  
...  
Keyword(s):  
Longitudinal Study ◽  
Northern Ireland ◽  
Depression Scale ◽  
Epidemiologic Studies ◽  
Regression Analyses ◽  
Retinal Microvasculature ◽  
Before And After ◽  
Automated Software ◽  
The Brain ◽  
Retinal Arteriolar

Abstract Introduction The retina shares similar anatomical and physiological features with the brain and subtle variations in retinal microvascular parameters (RMPs) may reflect similar vascular variation in the brain. The aim of this study was to assess associations between RMPs and measures of depression in the Northern Ireland Cohort for the Longitudinal Study of Ageing. Methods RMPs (arteriolar and venular caliber, fractal dimension and tortuosity) were measured from optic disc centred fundus images using semi-automated software. Depression was characterised by the Centre for Epidemiologic Studies Depression Scale (CES-D) in the absence of mild cognitive impairment or use of anti-depressive medications. Associations between depression and RMPs were assessed by regression analyses with adjustment for potential confounders. Results Data were available for 1376 participants of which 113 (8.2%) and 1263 (91.8%) were classified with and without depression. Participants had a mean age of 62.0 ± 8.4 yrs., 52% were female, and 8% were smokers. Individuals with depression had a higher CES-D score than those without (22.0 ± 6.2 versus 4.4 ± 3.9). Lower values of arteriolar tortuosity were significantly associated with depression, before and after adjustment for potential confounders (odds ratio = 0.79; 95% confidence intervals: 0.65, 0.96; P = 0.02). Conclusion Decreased retinal arteriolar tortuosity, a measure of the complexity of the retinal microvasculature was associated with depression in older adults independent of potential confounding factors. Retinal measures may offer opportunistic assessment of microvascular health associated with outcomes of depression.

scholarly journals Retinal microvascular parameters are not associated with diabetes in the Northern Ireland Cohort for the Longitudinal Study of Ageing

2021 ◽  
Author(s):  
Rachael Ann O’Neill ◽  
Alexander Peter Maxwell ◽  
Frank Kee ◽  
Ian Young ◽  
Bernadette McGuinness ◽  
...  
Keyword(s):  
Longitudinal Study ◽  
Northern Ireland ◽  
Glycated Haemoglobin ◽  
Haemoglobin A1c ◽  
Cross Sectional ◽  
Non Invasive ◽  
Retinal Microvasculature ◽  
Diabetes Status ◽  
Automated Software ◽  
Sectional Analysis

Abstract Background The retinal microvasculature offers unique non-invasive evaluation of systemic microvascular abnormalities. Previous studies reported associations between retinal microvascular parameters (RMPs) and diabetes. The aim of this study was to assess associations between RMPs and diabetes in a cross-sectional analysis of older persons from the Northern Ireland Cohort for the Longitudinal Study of Ageing (NICOLA). Methods RMPs (central retinal arteriolar/venular equivalents, arteriolar to venular ratio, fractal dimension, and tortuosity) were measured from optic disc-centred fundus images using semi-automated software. Associations were assessed between RMPs and diabetes status with adjustment for potential confounders. Results Data were included for 1762 participants with 209 classified as having diabetes. Participants had a mean age of 62.1 ± 8.5 years, and 54% were female. As expected, participants with diabetes had significantly higher mean glycated haemoglobin A1c compared to participants without diabetes (57.4 ± 17.6 mmol/mol versus 37.0 ± 4.2 mmol/mol, respectively). In unadjusted and minimally adjusted regression, arteriolar to venular ratio, arteriolar tortuosity and venular tortuosity were significantly associated with diabetes (minimally adjusted odds ratio [OR] = 0.85; 95% confidence intervals [CIs] 0.73, 0.99; P = 0.04, OR = 1.18; 95% CI 1.02, 1.37; P = 0.03 and OR = 1.20; 95% CI 1.04, 1.38; P = 0.01, respectively), although all failed to remain significant following adjustment for potential confounders. No additional associations between other RMPs and diabetes were detected. Conclusion Despite previously reported associations between diabetes and RMPs, our study failed to corroborate these associations in an older community-based cohort.

scholarly journals Retinal microvasculature: population epidemiology and concordance in Australian children aged 11–12 years and their parents

BMJ Open ◽  
2019 ◽  
Vol 9 (Suppl 3) ◽  
pp. 44-52 ◽  
Author(s):  
Julian Dascalu ◽  
Mengjiao Liu ◽  
Kate Lycett ◽  
Anneke C Grobler ◽  
Mingguang He ◽  
...  
Keyword(s):  
Correlation Coefficients ◽  
Population Based ◽  
Linear Regression Models ◽  
Cross Sectional ◽  
Complex Sampling ◽  
Retinal Microvasculature ◽  
Automated Software ◽  
Retinal Photographs ◽  
Retinal Arteriolar ◽  
Parent Child

ObjectivesTo describe distributions and concordance of retinal microvasculature measurements in a population-based sample of Australian parent–child dyads at child age 11–12 years.DesignCross-sectional Child Health CheckPoint study, between waves 6 and 7 of the national population-based Longitudinal Study of Australian Children (LSAC).SettingAssessment centres in seven Australian cities, February 2015–March 2016.ParticipantsOf the 1874 participating families, 1288 children (51% girls) and 1264 parents (87% mothers, mean age 43.7) were analysed. Diabetic participants and non-biological pairs were excluded from concordance analyses.Outcome measuresRetinal photographs were taken by non-mydriatic fundus camera. Trained graders scored vascular calibre using semi-automated software, yielding estimates of central retinal arteriolar equivalent (CRAE) and central retinal venular equivalent (CRVE) and arteriolar–venular ratio (AVR). Pearson’s correlation coefficients and multivariable linear regression models assessed parent–child concordance. Survey weights and methods accounted for LSAC’s complex sampling, stratification and clustering within postcodes.ResultsMean (SD) of CRAE and CRVE were larger in children (159.5 (11.8) and 231.1 (16.5) μm, respectively) than parents (151.5 (14.0) and 220.6 (19.0) μm), yielding similar AVR (children 0.69 (0.05), parents 0.69 (0.06)). Correlation coefficients for parent–child pairs were 0.22 (95% CI 0.16 to 0.27) for CRAE, 0.23 (95% CI 0.17 to 0.28) for CRVE and 0.18 (95% CI 0.13 to 0.24) for AVR. Mother–child and father–child values were similar (0.20 and 0.32 for CRAE, 0.22 and 0.29 for CRVE, respectively). Relationships attenuated slightly on adjustment for age, sex, blood pressure, diabetes and body mass index. Percentiles and concordance are presented for the whole sample and by sex.ConclusionsArteriolar and venular calibre were similar to previously documented measures in midlife adult and late childhood populations. Population parent–child concordance values align with moderate polygenic heritability reported in smaller studies.

scholarly journals Duration of depressive symptoms and mortality risk: The English Longitudinal Study of Ageing (ELSA)

2016 ◽  
Vol 208 (4) ◽  
pp. 337-342 ◽  
Author(s):  
James White ◽  
Paola Zaninotto ◽  
Kate Walters ◽  
Mika Kivimäki ◽  
Panayotes Demakakos ◽  
...  
Keyword(s):  
Depressive Symptoms ◽  
Longitudinal Study ◽  
Mortality Risk ◽  
Depression Scale ◽  
Epidemiologic Studies ◽  
Symptom Duration ◽  
Functional Impairments ◽  
Hazard Ratios ◽  
And Gender ◽  
English Longitudinal Study

BackgroundThe relationship between the duration of depressive symptoms and mortality remains poorly understood.AimsTo examine whether the duration of depressive symptoms is associated with mortality risk.MethodData (n = 9560) came from the English Longitudinal Study of Ageing (ELSA). We assessed depressive symptom duration as the sum of examinations with an eight-item Center for Epidemiologic Studies Depression Scale score of ⩾3; we ascertained mortality from linking our data to a national register.ResultsRelative to those participants who never reported symptoms, the age- and gender-adjusted hazard ratios for elevated depressive symptoms over 1, 2, 3 and 4 examinations were 1.41 (95% CI 1.15–1.74), 1.80 (95% CI 1.44–2.26), 1.97 (95% CI 1.57–2.47) and 2.48 (95% CI 1.90–3.23), respectively (P for trend <0.001). This graded association can be explained largely by differences in physical activity, cognitive function, functional impairments and physical illness.ConclusionsIn this cohort of older adults, the duration of depressive symptoms was associated with mortality in a dose–response manner.

A Study Evaluating Mindfulness and Naikan-Based Therapy: AEON-HO for Attachment Style, Self-Actualization, and Depression

2018 ◽  
Vol 123 (2) ◽  
pp. 239-251
Author(s):  
Chieko Fujisaki
Keyword(s):  
Attachment Style ◽  
Attachment Styles ◽  
Depression Scale ◽  
Epidemiologic Studies ◽  
Attachment Anxiety ◽  
Depressive State ◽  
Attachment Avoidance ◽  
High Affinity ◽  
Before And After ◽  
Self Actualization

AEON-HO (Altering emotional organization-holistic operation) contains methods of Naikan therapy and mindfulness. Naikan and mindfulness are originally from Buddhism tradition, and they have a high affinity. AEON-HO was conceptualized to improve attachment issues and the growth of self-actualization, because Naikan and mindfulness are known to be effective for attachment issues but partially if they are used independently. Naikan can approach to attachment avoidance, while mindfulness can approach to attachment anxiety. The primary purpose of this study was to assess the effectiveness of AEON-HO on attachment styles, self-actualization, and depression by using “attachment style scale the Experiences in Close Relationships inventory–the generalized–other–version (ECR-GO),” “self-actualization scale” translated to Japanese, and “center for epidemiologic studies for depression scale.” Participants have taken these three psychological questionnaires before and after the eight-week program of AEON-HO, and the results of scales were compared. Participants were 36 adults with a mean age of 49 years ( SD = 3.9). Changes in two attachment styles, anxiety and avoidance and depressive state, were observed between pre- and posttest, while there were no significant changes in self-actualization. However, attachment anxiety and self-actualization were correlated negatively in pre- and posttest, while attachment avoidance and self-actualization were correlated negatively only in pretest.

scholarly journals Antidepressant use and depressive symptomatology among older people from the Australian Longitudinal Study of Ageing

2010 ◽  
Vol 22 (3) ◽  
pp. 437-444 ◽  
Author(s):  
Ying Zhang ◽  
Veronica Chow ◽  
Agnes I. Vitry ◽  
Philip Ryan ◽  
Elizabeth E. Roughead ◽  
...  
Keyword(s):  
Depressive Symptoms ◽  
Longitudinal Study ◽  
Health Status ◽  
Depressive Symptomatology ◽  
Depression Scale ◽  
Epidemiologic Studies ◽  
Self Report ◽  
Perceived Health Status ◽  
Australian Longitudinal Study ◽  
Antidepressant Use

ABSTRACTBackground:Depression is one of the leading contributors to the burden of non-fatal diseases in Australia. Although there is an overall increasing trend in antidepressant use, the relationship between use of antidepressants and depressive symptomatology is not clear, particularly in the older population.Methods:Data for this study were obtained from the Australian Longitudinal Study of Ageing (ALSA), a cohort of 2087 people aged over 65 years at baseline. Four waves of home interviews were conducted between 1992 and 2004 to collect information on sociodemographic and health status. Depressive symptoms were measured by the Center for Epidemiologic Studies – Depression Scale. Use of antidepressants was based on self-report, with the interviewer able to check packaging details if available. Longitudinal analysis was performed using logistic generalized estimating equations to detect if there was any trend in the use of antidepressants, adjusting for potential confounding factors.Results:The prevalence of depressive symptoms was 15.2% in 1992 and 15.8% in 2004 (p> 0.05). The prevalence of antidepressant users increased from 6.5% to 10.9% (p< 0.01) over this period. Among people with depressive symptoms, less than 20% were taking antidepressants at any wave. Among people without depressive symptoms, the prevalence of antidepressant use was 5.2% in 1992 and 12.0% in 2004 (p< 0.01). Being female (OR = 1.67, 95%CI: 1.25–2.24), having poor self-perceived health status (OR = 1.17, 95%CI: 1.04–1.32), having physical impairment (OR = 1.48, 95%CI: 1.14–1.91) and having depressive symptoms (OR = 1.62, 95%CI: 1.24–2.13) significantly increased the use of antidepressants, while living in community (OR = 0.51, 95%CI: 0.37–0.71) reduced the risk of antidepressant use.Conclusions:Use of antidepressants increased, while depressive symptoms remained stable, in the ALSA over a 12-year period. Use of antidepressants was low for people with depressive symptoms.

scholarly journals The Impact of Transitions in Caregiving Status on Depressive Symptoms among Older Family Caregivers: Findings from the Korean Longitudinal Study of Aging

2020 ◽  
Vol 18 (1) ◽  
pp. 42
Author(s):  
Kyungduk Hurh ◽  
Hin Moi Youn ◽  
Yoon Sik Park ◽  
Eun-Cheol Park ◽  
Sung-In Jang
Keyword(s):  
Older Adults ◽  
Depressive Symptoms ◽  
Longitudinal Study ◽  
Family Caregivers ◽  
Depression Scale ◽  
Estimating Equation ◽  
Epidemiologic Studies ◽  
Equation Model ◽  
Significant Difference ◽  
The Impact

This study identifies the effects of transitions in caregiving status on depressive symptoms among middle-aged or older adults who care for family members with limitations in activities of daily living (ADL). Data were collected from the 2006–2018 Korean Longitudinal Study of Aging. A total of 7817 subjects were included. On the basis of their caregiving status transition, participants were categorized into four groups: started caregiving, continued caregiving, stopped caregiving, and noncaregivers. Depressive symptoms were measured using the 10 item Center for Epidemiologic Studies Depression Scale. Analysis using a generalized estimating equation model and subgroup analyses were conducted. Compared to noncaregivers, women who started caregiving showed more depressive symptoms in the following year (β 0.761, p < 0.0001). Regardless of sex, older adults who continued caregiving had more depressive symptoms than noncaregivers did (β 0.616, p < 0.0277 in men, and β 1.091, p < 0.0001 in women). After relinquishing caregiving responsibilities to other caregivers, participants’ depressive symptoms in the following year showed no statistically significant difference from that of noncaregivers. Thus, starting or continuing caregiving was associated with increased depressive symptoms, and those symptoms could be normalized by stopping caregiving. Intervention strategies to reduce family caregivers’ depressive symptoms are needed.

scholarly journals Antidepressants strongly influence the relationship between depression and heart rate variability: findings from The Irish Longitudinal Study on Ageing (TILDA)

2014 ◽  
Vol 45 (3) ◽  
pp. 623-636 ◽  
Author(s):  
C. O'Regan ◽  
R. A. Kenny ◽  
H. Cronin ◽  
C. Finucane ◽  
P. M. Kearney
Keyword(s):  
Heart Rate ◽  
Heart Rate Variability ◽  
Longitudinal Study ◽  
Selective Serotonin Reuptake Inhibitors ◽  
Linear Regression Analysis ◽  
Depression Scale ◽  
Low Frequency ◽  
Antidepressant Medication ◽  
Epidemiologic Studies ◽  
Self Report

BackgroundHeart rate variability (HRV) is known to be reduced in depression; however, is unclear whether this is a consequence of the disorder or due to antidepressant medication.MethodsWe analysed data on 4750 participants from the first wave of The Irish Longitudinal Study on Ageing (TILDA). Time [standard deviation of normal to normal intervals (SDNN ms2)] and frequency domain [low frequency (LF) and high frequency (HF)] measures of HRV were derived from 3-lead surface electrocardiogram records obtained during 10 min of supine rest. Depression was assessed using the Center for Epidemiologic Studies – Depression scale.ResultsParticipants on antidepressants [with (n = 80) or without depression (n = 185)] differed significantly from controls (not depressed and not taking antidepressants n = 4107) on all measures of HRV. Depressed participants not taking antidepressants (n = 317) did not differ from controls on any measures of HRV. In linear regression analysis adjusted for relevant factors all antidepressants were associated with lower measures HRV. Participants on selective serotonin reuptake inhibitors (SSRIs) had higher measures of HRV relative to participants on tricyclic antidepressants or serotonin–norepinephrine reuptake inhibitors respectively.ConclusionsOur results suggest that reductions in HRV observed among depressed older adults are driven by the effects of antidepressant medications. SSRIs have less impact on HRV than other antidepressants but they are still associated with lower measures of HRV. Study limitations include the use of a self-report measure of depression and floor effects of age on HRV could have limited our ability to detect an association between HRV and depression.

scholarly journals Effect of spousal loss on depression in older adults

2020 ◽  
Author(s):  
Yong-Hsin Chen ◽  
Meng-Chih Lee ◽  
Mei-Huey Shiau ◽  
Chih-Jung Yeh
Keyword(s):  
Older Adults ◽  
Health Status ◽  
Successful Aging ◽  
Smoking Status ◽  
Family Members ◽  
Depression Scale ◽  
Epidemiologic Studies ◽  
Factors Affecting ◽  
Self Rated Health ◽  
Before And After

Abstract Background: In addition to increasing the mortality among older adults, spousal death (SD) increases their risk of depression. This study explored the factors affecting depression among widowed older adults to provide health care strategies for successful aging. Methods: A total of 710 adults older than 60 years completed a questionnaire before and after their spouses’ deaths. The survey data included age, sex, ethnic group, education level, financial station socioeconomic status, SD (including time point), smoking status, alcohol consumption, self-rated health status, Center for Epidemiologic Studies Depression Scale score, mobility, and degree of support from relatives and friends. Results: The proportion of participants with depression after SD was 1.7 times that of before SD (P < 0.0001). Worsened mobility (odds ratio [OR] = 1.3, P < 0.01), low self-rated health status (OR = 0.5, P < 0.01), and a high degree of support from relatives and friends (OR = 1.5, P < 0.01) had a significant positive correlation with depression after SD. The proportion of depression that occurred within 6 months after SD was 6.0 times higher than that of depression before SD. Participants who lived alone after losing their spouses who were healthy before their deaths exhibited a significantly increased proportion of depression after their spouses’ deaths. Conclusion: Male sex, spouse’s health, and the period of 6 months after SD are risk factors for depression in older adults. The maintenance of mobility, positive self-rated health status, and a shorter period of depression after a spouse’s death result in more favorable adaptability among women. Social workers or family members should focus on older adults whose spouses died unexpectedly or within the last 6 months. Living with family members after SD can alleviate depression in older adults.

scholarly journals Distribution of item responses and total item scores for the Center for Epidemiologic Studies Depression Scale (CES-D): Data from the Irish Longitudinal Study on Ageing (TILDA)

PLoS ONE ◽  
2018 ◽  
Vol 13 (8) ◽  
pp. e0202607 ◽  
Author(s):  
Shinichiro Tomitaka ◽  
Yohei Kawasaki ◽  
Kazuki Ide ◽  
Maiko Akutagawa ◽  
Yutaka Ono ◽  
...  
Keyword(s):  
Longitudinal Study ◽  
Depression Scale ◽  
Epidemiologic Studies ◽  
Item Responses ◽  
Item Scores ◽  
Total Item

Abortion and subsequent depressive symptoms: an analysis of the National Longitudinal Study of Adolescent Health

2017 ◽  
Vol 48 (2) ◽  
pp. 294-304 ◽  
Author(s):  
A. M. Gomez
Keyword(s):  
Depressive Symptoms ◽  
Longitudinal Study ◽  
Adolescent Health ◽  
Young Women ◽  
Depression Scale ◽  
Epidemiologic Studies ◽  
Traumatic Experiences ◽  
Linear Regression Models ◽  
National Longitudinal Study ◽  
Increased Risk

BackgroundTwenty states currently require that women seeking abortion be counseled on possible psychological responses, with six states stressing negative responses. The majority of research finds that women whose unwanted pregnancies end in abortion do not subsequently have adverse mental health outcomes; scant research examines this relationship for young women.MethodsFour waves of data from the National Longitudinal Study of Adolescent Health were analyzed. Population-averaged lagged logistic and linear regression models were employed to test the relationship between pregnancy resolution outcome and subsequent depressive symptoms, adjusting for prior depressive symptoms, history of traumatic experiences, and sociodemographic covariates. Depressive symptoms were measured using a nine-item version of the Center for Epidemiologic Studies Depression scale. Analyses were conducted among two subsamples of women whose unwanted first pregnancies were resolved in either abortion or live birth: (1) 856 women with an unwanted first pregnancy between Waves 2 and 3; and (2) 438 women with an unwanted first pregnancy between Waves 3 and 4 (unweighted n’s).ResultsIn unadjusted and adjusted linear and logistic regression analyses for both subsamples, there was no association between having an abortion after an unwanted first pregnancy and subsequent depressive symptoms. In fully adjusted models, the most recent measure of prior depressive symptoms was consistently associated with subsequent depressive symptoms.ConclusionsIn a nationally representative, longitudinal dataset, there was no evidence that young women who had abortions were at increased risk of subsequent depressive symptoms compared with those who give birth after an unwanted first pregnancy.

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