scholarly journals The chronic kidney disease perception scale (CKDPS): development and construct validation

2020 ◽  
Vol 21 (1) ◽  
Author(s):  
Haryati Anuar ◽  
Shamsul Azhar Shah ◽  
Abdul Halim Abdul Gafor ◽  
Mohd Ihsani Mahmood
Keyword(s):  
Social Psychology ◽  
Chronic Kidney Disease ◽  
Kidney Disease ◽  
Goodness Of Fit ◽  
Factor Loading ◽  
Diabetic Patients ◽  
Cross Sectional ◽  
Major Health Problem ◽  
Fit Index ◽  
Disease Perception

Abstract Background Chronic kidney disease has become a major health problem around the world. It displays no symptoms until the later stages. Therefore, its early detection is crucial, and a suitable intervention is necessary to halt its development. The aim of this study was to develop and validate a recently formulated Chronic Kidney Disease Perception Scale (CKDPS) for diabetic patients based on Social Psychology, and their perceptions based on the Health Belief Model (HBM). Methods The newly developed CKDPS instrument was tested on 300 patients with diabetes mellitus in a cross-sectional study. The number of domains, model-fit index, construct validity, and internal consistency of this instrument were determined using exploratory (EFA) and confirmatory factor analysis (CFA). Results The EFA yielded nine domains: illness identity, timeline motivation, medical practice and co-operation for Social Psychology, and perceived benefit, perceived barriers, perceived susceptibility, perceived severity, and perceived cue to action for HBM. Four items with low factor loading were removed. CFA yielded the following fit indices for Social Psychology: the goodness of fit index (GFI) = 0.889, comparative fit index (CFI) = 0.934, root mean square error of approximation (RMSEA) = 0.053, normed chi-square (NC) = 1.831; and the following for HBM: GFI = 0.834, CFI = 0.957, RMSEA = 0.053, NC = 1.830. Values of Cronbach’s α ranged between 0.760 and 0.909. Conclusions The CKDPS includes 61 questions across nine domains, divided under two categories of Social Psychology and HBM. It is also a valid and reliable tool for measuring diabetic patients’ perception of CKD prevention that can be used in larger studies.

scholarly journals Association of Retinopathy with Chronic Kidney Disease in Diabetes Mellitus

2018 ◽  
Vol 8 (3) ◽  
pp. 210-214
Author(s):  
Rushda Sharmin Binte Rouf ◽  
SM Ashrafuzzaman ◽  
Zafar Ahmed Latif
Keyword(s):  
Diabetes Mellitus ◽  
Chronic Kidney Disease ◽  
Diabetic Retinopathy ◽  
Kidney Disease ◽  
Strong Association ◽  
Albumin Excretion Rate ◽  
Cross Sectional Study ◽  
Fundus Photography ◽  
Diabetic Patients ◽  
Cross Sectional

Background: Diabetic retinopathy (DR) and nephropathy are two major complications of diabetes mellitus carrying significant morbidity and mortality. In this study DR was investigated in different stages of chronic kidney disease (CKD) to find out possible association of these two devastating complications.Methods: This cross-sectional study was conducted in 150 diabetic patients having CKD in BIRDEM. CKD was defined as estimated glomerular filtration rate (eGFR) of <60ml/min/1.73m2and/or urinary albumin excretion rate (UAER) >30 mg/day in at least two occasions in 3 months apart. Retinopathy was assessed by direct fundoscopic examination and confirmed by color fundus photography. Severe DR (SDR) included proliferative diabetic retinopathy, severe non-proliferative DR and maculopathy; whereas microaneurysm regarded as non-severe retinopathy.Results: Majority (68%) of the respondents had some form of retinopathy (38.35% SDR and 29.65% nonsevere). There was strong association between different levels of albuminuria (UAER) and DR (p<0.0001). On the contrary DR did not correspond with stages of CKD (P=0.349). Hypertension (79.5%) and dyslipidaemia (59%) were common co-morbidities.Conclusion: This study concluded that DR prevalence was more in nephropathy along with significant association with UAER. Whereas different stages of CKD was not associated with stages of DR . This finding focused the necessity of regular retinal examination irrespective of the stage of renal involvement.Birdem Med J 2018; 8(3): 210-214

scholarly journals The Effect of Renal Dysfunction on Circulating Sclerostin Level in Patients with Type 2 Diabetes

2014 ◽  
Vol 2014 ◽  
pp. 1-5 ◽  
Author(s):  
Se Hwa Kim ◽  
Soo Young Yoon ◽  
Sung-Kil Lim ◽  
Yumie Rhee
Keyword(s):  
Type 2 Diabetes ◽  
Chronic Kidney Disease ◽  
Renal Function ◽  
Kidney Disease ◽  
Renal Dysfunction ◽  
Diabetic Patients ◽  
Type 2 Diabetic Patients ◽  
Cross Sectional ◽  
Sclerostin Level

Objective. Sclerostin is a Wnt inhibitor produced specifically by osteocytes. However, it is not currently clear whether renal dysfunction has an effect on circulating sclerostin level in patients with type 2 diabetes. The aim of the study was to evaluate this relationship. Design and Patients. We conducted a cross-sectional observational study of 302 type 2 diabetic patients with or without chronic kidney disease. Serum sclerostin level was analyzed by ELISA, and renal function was assessed by estimated glomerular filtration rate (eGFR) using chronic kidney disease epidemiology collaboration (CKD-EPI) equation. Results. There was a strong correlation between sclerostin level with renal function presented as serum creatinine (r=0.745, P<0.001) and eGFR (r=-0.590, P<0.001). Serum sclerostin level was significantly higher in patients with CKD-G3 stage than those with CKD-G1/2 stages after adjusting for age, sex, and BMI (P=0.011). Patients with CKD-G4/5 stages had dramatically increased level of circulating sclerostin. Multiple regression analyses found that age, sex, and eGFR were independent determining factors for circulating sclerostin level. Conclusion. Our data showed that serum sclerostin levels start to increase in diabetic patients with CKD-G3 stage. Further studies are needed to establish the potential role of elevated sclerostin in diabetic patients with CKD.

scholarly journals Glucose Lowering Therapeutic Strategies for Type 2 Diabetic Patients with Chronic Kidney Disease in Primary Care Setting in France: A Cross-Sectional Study

2013 ◽  
Vol 2013 ◽  
pp. 1-6 ◽  
Author(s):  
N. Grandfils ◽  
B. Detournay ◽  
C. Attali ◽  
D. Joly ◽  
D. Simon ◽  
...  
Keyword(s):  
Chronic Kidney Disease ◽  
Kidney Disease ◽  
Cross Sectional Study ◽  
Therapeutic Strategies ◽  
Diabetic Patients ◽  
Sectional Study ◽  
Cross Sectional ◽  
Glucose Lowering ◽  
Patient Profile

Aim. To understand glucose lowering therapeutic strategies of French general practitioners (GPs) in the management of type 2 diabetes mellitus (T2DM) patients with chronic kidney disease (CKD).Methods. A multicenter cross-sectional study was conducted from March to June 2011 among a sample of French GPs who contribute to the IMS Lifelink Disease Analyzer database. Eligible patients were those with T2DM and moderate-to-severe CKD who visited their GPs at least once during the study period. Data were collected through electronic medical records and an additional questionnaire.Results. 116 GPs included 297 patients: 86 with stage 3a (Group 1, GFR = 45–60 mL/min/1.73 m2) and 211 with stages 3b, 4, or 5 (Group 2, GFR < 45 mL/min/1.73 m2). Patients’ mean age was approximately 75 years. Insulin was used in 19% of patients, and was predominant in those with severe CKD. More than two-thirds of patients were treated with glucose lowering agents which were either contraindicated or not recommended for CKD. Conclusion Physicians most commonly considered the severity of diabetes and not CKD in their therapeutic decision making, exposing patients to potential iatrogenic risks. The recent patient oriented approach and individualization of glycemic objectives according to patient profile rather than standard HbA1c would improve this situation.

scholarly journals Prevalence of Potential Drug–Drug Interaction Risk among Chronic Kidney Disease Patients in a Spanish Hospital

Pharmaceutics ◽  
2020 ◽  
Vol 12 (8) ◽  
pp. 713
Author(s):  
Gracia Santos-Díaz ◽  
Ana María Pérez-Pico ◽  
Miguel Ángel Suárez-Santisteban ◽  
Vanesa García-Bernalt ◽  
Raquel Mayordomo ◽  
...  
Keyword(s):  
Chronic Kidney Disease ◽  
Kidney Disease ◽  
Drug Interactions ◽  
Cross Sectional Study ◽  
Potential Drug ◽  
Cross Sectional ◽  
Major Health Problem ◽  
Major Health ◽  
Spanish Hospital

Chronic kidney disease (CKD) is a major health problem worldwide and, in Spain, it is present in 15.1% of individuals. CKD is frequently associated with some comorbidities and patients need to be prescribed multiple medications. Polypharmacy increases the risk of adverse drug reactions (ADRs). There are no published studies evaluating the prevalence of potential drug–drug interactions (pDDIs) among CKD patients in any European country. This study was aimed to determine the prevalence, pattern, and factors associated with pDDIs among CKD patients using a drug interactions program. An observational cross-sectional study was carried out at Plasencia Hospital, located in Spain. Data were collected among patients with CKD diagnoses and pDDIs were assessed by the Lexicomp® Drug Interactions platform. Data were obtained from 112 CKD patients. A total number of 957 prescribed medications were acknowledged, and 928 pDDIs were identified in 91% of patients. Age and concomitant drugs were significantly associated with the number of pDDIs (p < 0.05). According to the results, the use of programs for the determination of pDDIs (such as Lexicomp®) is recommended in the clinical practice of CKD patients in order to avoid serious adverse effects, as is paying attention to contraindicated drug combinations.

scholarly journals Knowledge attitude and practices towards chronic kidney disease among type-2 diabetic patients in Bangladesh

2021 ◽  
Vol 5 (1) ◽  
Author(s):  
Rajib Mondal ◽  
Rani Baroi Ritu ◽  
Md. Shamsur Rahman ◽  
Rajib Chandra Sarker ◽  
Palash Chandra Banik
Keyword(s):  
Chronic Kidney Disease ◽  
Kidney Disease ◽  
Cross Sectional Study ◽  
Average Level ◽  
Diabetic Patients ◽  
Type 2 Diabetic Patients ◽  
Cross Sectional ◽  
Level Of Knowledge ◽  
Knowledge And Attitude

INTRODUCTION: Having proper knowledge, attitude, and practices (KAP) towards chronic kidney disease (CKD) among type-2 diabetes mellitus (T2DM) patients is very important to reduce the disease burden. However, the information about KAP towards CKD among Bangladeshi T2DM patients is unknown, based on the available literatures till the date. OBJECTIVES: We aimed to assess the KAP towards CKD among T2DM patients attended a selected hospital in Dhaka city. METHODS AND MATERIALS: In this cross-sectional study, we conveniently selected Aalok hospital and also its 224 T2DM patients who attended the outdoor. We excluded the already developed CKD patients and aged over 70 years. We adopted a questionnaire from a validated instrument consisted of a 10 itemed knowledge, 8 itemed attitude, and 7 itemed practice domains towards CKD (total 25 items). Data were collected by face-to-face interviews. Both descriptive and comparative (Independent Sample t-tests and One-way ANOVA tests) statistics were used for data analysis where appropriates. RESULTS: Women respondents were higher (69.6%). The mean age of the respondents was 49.8±11.3 years. Most of them had average level of knowledge (69.6%) and attitude (60.7%). Majority also reported a good hypothetical practices in general if they would find out to have CKD. Knowledge was significantly associated (p<0.05) with sex, level of education, occupation, and income, whereas attitude was with sex, occupation, and income. CONCLUSION: T2DM patients of our study reported mostly average level of knowledge and attitude, and a good hypothetical practices in general towards CKD. Proper health awareness programs are needed to increase the KAP towards CKD among T2DM patients in Bangladesh.

scholarly journals Study of clinical profile of chronic kidney disease in non-diabetic patients

2021 ◽  
Author(s):  
Ravi Kumar U. ◽  
Shashank J. ◽  
Narayana Swamy
Keyword(s):  
Diabetes Mellitus ◽  
Cardiovascular Disease ◽  
Chronic Kidney Disease ◽  
Kidney Disease ◽  
Clinical Signs ◽  
Signs And Symptoms ◽  
Diabetic Patients ◽  
Hypertensive Nephropathy ◽  
Major Health Problem ◽  
Clinical Signs And Symptoms

Background: Chronic kidney disease (CKD) encompasses a spectrum of different pathophysiological processes associated with abnormal kidney function and a progressive decline in glomerular filtration rate. Cardiovascular disease is one of the major cause of morbidity and mortality in patients at every stage of CKD. Diabetes mellitus and hypertension together being major cause for CKD. Hypertension is a common cause for CKD and an independent risk factor for cardiovascular disease. This study mainly focused on the causes of CKD other than diabetes mellitus. An early detection and appropriate intervention of these patients will possibly help prevent progression of renal disease.Methods:We assessed 55 non diabetic CKD patients who presented to the OPD/IPD in Victoria hospital, Bowring and Lady Curzon hospital and other hospitals affiliated to Bangalore medical college and research institute during period June 2018 to December 2019. A detailed history and clinical examination was performed and patients were subjected to necessary investigations.Results: The commonest etiology for CKD was found to be hypertensive nephropathy followed by glomerulonephritis. Common symptoms were generalized weakness, lower limb swelling. Commonest signs are pallor, pedal edema and hypertension.Conclusions:CKD is a major health problem. Diabetic nephropathy is the commonest cause for CKD followed by hypertensive nephropathy and glomerulonephritis. Anaemia, pedal oedema, oliguria and generalised weakness were the major presenting clinical signs and symptoms in CKD. This condition when detected in early stages and managed can slow down the progression of CKDs and delay the need of renal replacement therapy.  

scholarly journals Peripheral insulin resistance is associated with copeptin in patients with chronic kidney disease

Kidney360 ◽  
2021 ◽  
pp. 10.34067/KID.0002622021
Author(s):  
Juan Pablo Arroyo ◽  
Elvis A. Akwo ◽  
Andrew S. Terker ◽  
Aseel Alsouqi ◽  
Gautam Bhave ◽  
...  
Keyword(s):  
Insulin Resistance ◽  
Chronic Kidney Disease ◽  
Kidney Disease ◽  
Disease Risk ◽  
Cardiovascular Disease Risk ◽  
Hepatic Insulin Resistance ◽  
Diabetic Patients ◽  
Cross Sectional ◽  
Peripheral Insulin Resistance ◽  
The Relationship

Background - Insulin resistance is associated to cardiovascular disease risk and worsened kidney function. Patients with CKD have higher levels of insulin resistance. Elevated levels of copeptin (a surrogate for vasopressin levels), has been associated to increased incidence and progression of CKD as well as incident diabetes mellitus. The purpose of our study was to study the relationship between insulin resistance, copeptin, and CKD. Methods - We performed a cross-sectional study to investigate if insulin resistance was associated with higher copeptin levels in non-diabetic patients with stage 3-4 CKD vs controls. We measured plasma copeptin levels and utilized data from 52 patients with stage 3-4 CKD and 85 controls (eGFR ≥ 60mL/min/1.73m2) enrolled in The Insulin Resistance in Chronic Kidney Disease (IRCKD) study. We then used a multivariable linear regression model to assess the independent relationship between peripheral or hepatic insulin resistance and copeptin across levels of eGFR. Results - We found that in patients with CKD (eGFR 30-60 mL/min/1.73m2), but not in controls, peripheral insulin resistance was significantly correlated with higher levels of log copeptin (r = -0.21, p = 0.04). In patients with CKD when adjusted for age, sex, BMI, serum osmolality, log IL6, and log leptin-adiponectin ratio, each 1 SD decrease in insulin sensitivity was associated to a 38.9% increase in serum copeptin levels. The relationship between hepatic insulin resistance, copeptin, and eGFR is similar between controls and patients with reduced eGFR. Conclusion -Peripheral insulin resistance is associated with elevated copeptin levels in non-diabetic patients with stage 3-4 CKD. Further research into how the interaction between peripheral insulin resistance and elevated vasopressin impacts CKD progression could be of interest.

scholarly journals Prevalence and determinants of chronic kidney disease in urban adults’ populations of northern Cameroon: a cross-sectional study

2019 ◽  
Author(s):  
Francois Folefack Kaze ◽  
Mahamat Maimouna ◽  
Augustin Fanday Beybey ◽  
Eric Walter Pefura-Yone ◽  
Adamou Dodo Balkissou ◽  
...  
Keyword(s):  
Risk Factors ◽  
Chronic Kidney Disease ◽  
Kidney Disease ◽  
Herbal Medicines ◽  
Sub Saharan Africa ◽  
Cluster Sampling ◽  
Cross Sectional Survey ◽  
Cross Sectional ◽  
Major Health Problem ◽  
Chronic Nephropathy

Abstract Background: Chronic kidney disease (CKD) is a major health problem with growing prevalence in sub-Saharan Africa. We present the prevalence and determinants of CKD in Garoua and Figuil cities of the North region of Cameroon. Methods: A cross-sectional survey was conducted from January to June 2018 in the two cities, using a multi-level cluster sampling. All adults with low estimated glomerular filtration rate (eGFR) (< 60 ml/min/1.73 m2) by Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI) equation and/or albuminuria (≥ 30 mg/g) were reviewed three months later. Logistic regression models (accounting for the sampling strategy) were used to investigate the predictors of the outcomes. Results: A total of 433 participants were included, with a mean age (95%CI) of 45.0 (43.4-46.6) years, 212 (48.7%) men, 294 (67.9%) from Garoua and 218 (45.6%) with no formal education. Risk factors for chronic nephropathy were highly prevalent including longstanding use of street medications (52.8%), herbal medicines (50.2%) and non-steroidal anti-inflammatory drugs (50%), alcohol consumption (34.4%), hypertension (33.9%), overweight/obesity (33.6%), hyperuricemia (16.8%), smoking (11.3%) and hyperglycemia (6.5%). The prevalence of CKD was 11.7% overall, 10.7% in Garoua and 13% in Figuil participants. Equivalents figures for CKD G3-5 and albuminuria were 2.8%, 2.0% and 4.5%; and 9.1%, 9.3% and 8.5% respectively. History of diabetes, increase systolic blood pressure, hyperglycemia and hyperuricemia were predictors of CKD. Conclusion: The prevalence of CKD is as high in these northern cities as previously reported in southern cities of Cameroon, driven mostly by known modifiable risk factors of chronic nephropathy.

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