scholarly journals Development and validation of the comprehensive assessment scale for chemotherapy–induced peripheral neuropathy in survivors of cancer

BMC Cancer ◽  
2019 ◽  
Vol 19 (1) ◽  
Author(s):  
K. Kanda ◽  
K. Fujimoto ◽  
R. Mochizuki ◽  
K. Ishida ◽  
B. Lee
Keyword(s):  
Factor Analysis ◽  
Peripheral Neuropathy ◽  
Cancer Survivors ◽  
Cancer Patients ◽  
Internal Consistency ◽  
Reliability And Validity ◽  
Comprehensive Assessment ◽  
Assessment Scale ◽  
Fine Motor ◽  
Gynecologic Oncology Group

Abstract Background Appropriate assessment is essential for the management of chemotherapy-induced peripheral neuropathy (CIPN), an intractable symptom that cannot yet be palliated, which is high on the list of causes of distress for cancer patients. However, objective assessment by medical staff makes it easy to underestimate the symptoms and effects of CIPN in cancer survivors. As a result, divergence from subjective evaluation of cancer survivors is a significant problem. Therefore, there is an urgent need to develop a subjective scale with high accuracy and applicability that reflects the experiences of cancer patients. We developed a comprehensive assessment scale for CIPN in cancer survivors, named the Comprehensive Assessment Scale for Chemotherapy-Induced Peripheral Neuropathy in Survivors of Cancer (CAS-CIPN), and demonstrated its reliability and validity. Methods We developed a questionnaire based on qualitative studies of peripheral neuropathy in Japanese cancer patients and literature review. Twelve cancer experts confirmed the content validity of the questionnaire. A draft version comprising 40 items was finalized by a pilot test on 100 subjects. The participants in the present study were 327 Japanese cancer survivors. Construct validity was determined by factor analysis, and internal validity by confirmation factor analysis and Cronbach’s α. Results Factor analysis showed that the structure consisted of 15 items in four dimensions: “Threatened interference in daily life by negative feelings”, “Impaired hand fine motor skills”, “Confidence in choice of treatment/management,” and “Dysesthesia of the palms and soles.” The CAS-CIPN internal consistency reliability was 0.826, and the reliability coefficient calculated using the Spearman-Brown formula [q = 2r/(1 + r)] was 0.713, confirming high internal consistency and stability. Scores on this scale were strongly correlated with Gynecologic Oncology Group-Neurotoxicity scores (r = 0.714, p < 0.01), confirming its criterion-related validity. Conclusions The CAS-CIPN is an assessment tool with high reliability and validity for the comprehensive evaluation of CIPN in cancer survivors. The CAS-CIPN is simple to use, and can be used by medical professionals for appropriate situational assessment and intervention.

Validation of the chemotherapy-induced neuropathy assessment scale.

2012 ◽  
Vol 30 (15_suppl) ◽  
pp. 9140-9140
Author(s):  
Sheeba K. Thomas ◽  
Tito R. Mendoza ◽  
Elisabeth G. Vichaya ◽  
Xin Shelley Wang ◽  
Mary H Sailors ◽  
...  
Keyword(s):  
Factor Analysis ◽  
Peripheral Neuropathy ◽  
Reliability And Validity ◽  
Assessment Tools ◽  
Assessment Scale ◽  
Motor Deficits ◽  
Painful Neuropathy ◽  
Motor Functioning ◽  
Hematopoietic Stem ◽  
Sensory Motor

9140 Background: Many of the assessment tools used to assess peripheral neuropathy in clinical trials focus on painful neuropathy. However, some chemotherapy agents cause both painful and non-painful peripheral neuropathy. The Chemotherapy-Induced Neuropathy Assessment Scale (CINAS) was designed to evaluate the multi-dimensional nature of chemotherapy-induced neuropathy, including non-painful sensory and motor deficits. This study evaluated the psychometric properties of the CINAS in patients with multiple myeloma (MM) receiving induction chemotherapy and/or autologous hematopoietic stem cell transplantation. Methods: We collected demographic and clinical data and administered 2 items measuring pain and numbness/tingling at its worst (0-10 scale), and the CINAS. A total CINAS score was computed by summing all 11 CINAS items. For reliability and validity analyses, we used the highest total CINAS score for each patient. Validity was assessed by factor analysis and by correlating CINAS subscales with the pain and numbness/tingling items. Cronbach alpha reliability coefficients were computed. To test sensitivity, we compared change in total CINAS score during induction from baseline to last total CINAS score in a subset of patients (N=20) receiving bortezomib or thalidomide. We hypothesized that such patients would develop neuropathy. Results: Ninety patients were enrolled. Participants were primarily white (90%) and male (63%). Factor analysis revealed 3 underlying constructs for the CINAS - sensory, motor functioning, and allodynia - explaining 74% of the common variance. Cronbach alphas were 0.84, 0.85, and 0.83 for the sensory, motor functioning, and allodynia subscales, respectively, while subscale correlations with the numbness/tingling item were 0.74, 0.56, and 0.52, respectively. Pain was only modestly correlated with these subscales (0.21, 0.36, 0.29). Total CINAS scores of patients receiving bortezomib or thalidomide induction worsened significantly (from 3.4 to 11.9, effect size=0.55, p<.02). Conclusions: The CINAS demonstrated validity, reliability and sensitivity in patients with MM during and after chemotherapy and can be used to assess the multidimensional aspects of chemotherapy-induced neuropathy.

Developing the Reliability and Validity of an Urdu Version-Self-Efficacy Scale for Breast Cancer Patients in Pakistan

2021 ◽  
pp. JNM-D-19-00065
Author(s):  
Sehrish Sajjad ◽  
Raisa Gul ◽  
Sajida Chagani ◽  
Asho Ali ◽  
Ambreen Gowani
Keyword(s):  
Breast Cancer ◽  
Cancer Patients ◽  
Internal Consistency ◽  
Self Efficacy ◽  
Reliability And Validity ◽  
Principal Component ◽  
Breast Cancer Patients ◽  
Validity And Reliability ◽  
Pilot Studies ◽  
Post Hoc

Background and PurposeNo suitable scale was identified in literature that comprehensively measure self-efficacy of Pakistani breast cancer patients. The study aimed to develop a self-efficacy scale in Urdu language and determine its dimensions.MethodsThe scale was developed with input from experts and literature. It was administered, in crosssectional phase of two pilot studies, on breast cancer patients receiving chemotherapy. Post hoc internal consistency reliability was computed and principal component analysis (PCA) was performed.ResultsSES-U comprised 17 questions. PCA revealed a total of five factors explaining cumulative variance of 68.7%. These factors were self-confidence, faith, coping, optimism, and decision making. Post hoc internal consistency (Cronbach's alpha) value was high (∞ = 0.87).ConclusionsThe self-efficacy scale has acceptable validity and reliability and has potential to obtain information related to self-efficacy of cancer patients receiving chemotherapy.

An Instrument to Measure the Attentional Demands of Community-Dwelling Elders

1999 ◽  
Vol 7 (2) ◽  
pp. 197-214 ◽  
Author(s):  
Debra A. Jansen ◽  
Mary L. Keller
Keyword(s):  
Factor Analysis ◽  
Cognitive Functioning ◽  
Internal Consistency ◽  
Reliability And Validity ◽  
Theoretical Framework ◽  
Community Dwelling ◽  
Attentional Demands ◽  
Attentional Functioning ◽  
Attentional Fatigue ◽  
Test Retest Reliability

The capacity to direct attention (CDA) is a pivotal facet of cognitive functioning that allows people to focus on trains of thought, complex tasks, and the daily business of life. According to a theoretical framework of directed attentional fatigue (DAF) and restoration, excessive demand for attention depletes CDA, a condition called DAF. Attentional demands are factors such as feelings of loss and worries that require intense or prolonged use of CDA and thus can lead to DAF. The purposes of this study were to determine reliability and validity for an instrument to measure attentional demands, the Attentional Demands Survey (ADS). The ADS was administered to 197 (142 females, 50 males) community-dwelling elderly (ages 65-98 years, M = 77). A factor analysis revealed 4 factors/subscales consistent with theorized domains. Internal consistency for each subscale ranged from .87 to .90 and test-retest reliability was .91. The ADS can be used to explore the relationships among attentional demands, CDA, and interventions to support and restore attentional functioning for elders.

TJ-107 for the prevention of oxaliplatin-induced peripheral neuropathy: Results of a phase II randomized placebo-controlled clinical trial.

2012 ◽  
Vol 30 (4_suppl) ◽  
pp. 567-567
Author(s):  
Toru Kono ◽  
Taishi Hata ◽  
Yoshinori Munemoto ◽  
Takanori Matsui ◽  
Hiroshi Kojima ◽  
...  
Keyword(s):  
Clinical Trial ◽  
Peripheral Neuropathy ◽  
Cancer Patients ◽  
Phase Ii ◽  
Gynecologic Oncology ◽  
Phase Iii ◽  
Chemotherapy Response ◽  
Gynecologic Oncology Group ◽  
Response To Chemotherapy ◽  
Patient Reported

567 Background: Oxaliplatin-induced peripheral neuropathy (OPN) continues to be a substantial problem for many cancer patients. In light of the promising data on TJ-107 from a previous pilot study (ASCO-GI, 2009), the present clinical trial was conducted to evaluate its efficacy for the prevention of OPN. To determine whether TJ-107 given as an adjuvant therapy effectively prevents oxaliplatin-induced peripheral neuropathy Methods: A phase II, randomized, double-blind, placebo-controlled trial was conducted in colorectal cancer patients undergoing therapy with infusional fluorouracil, leucovorin, and oxaliplatin (FOLFOX). TJ-107 (7.5g) or matching placebo was orally administered three times daily. The primary endpoint was the incidence of grade 2 or greater OPN according to the National Cancer Institute Common Terminology Criteria for Adverse Events (NCI CTCAE; version 3) criteria after 8 cycles of chemotherapy. Patient-reported neurotoxicity symptoms were also assessed using the neurotoxicity subscale of the Functional Assessment of Cancer Therapy/Gynecologic Oncology Group–Neurotoxicity (FACT/GOG-Ntx, version 4). Secondary endpoints included the incidence of all grades of OPN after each cycle and chemotherapy response rates. Results: A total of 93 patients were enrolled from May 1, 2009 to March 31, 2010 at 37 participating GONE trial institutions in Japan. Eighty-nine evaluable patients were randomized to either the TJ-107 group (n = 44) or the placebo group (n = 45). Placebo patients showed a significantly higher rate of neurotoxicity than that of TJ-107 patients (p < 0.001), with the median difference in NTX-12 score of 3 and 3.5 at the 8th week and 26th week, respectively. There were no significant between-group differences in response to chemotherapy (55.5% in TJ-107, 39.1% in placebo). In addition, TJ-107 treatment was well tolerated overall. Conclusions: TJ-107 shows promise in reducing the incidence of OPN. Further investigation in a larger phase III trial is necessary before any conclusions can be drawn. [Table: see text]

scholarly journals Korean Version of the Stroke Rehabilitation Motivation Scale: Reliability and Validity Evaluation

2020 ◽  
Vol 44 (1) ◽  
pp. 11-19
Author(s):  
Mina Park ◽  
Ji-Yeong Lee ◽  
Yeajin Ham ◽  
Sang-Wook Oh ◽  
Joon-Ho Shin
Keyword(s):  
Factor Analysis ◽  
Exploratory Factor Analysis ◽  
Internal Consistency ◽  
Stroke Rehabilitation ◽  
Reliability And Validity ◽  
Stroke Patients ◽  
Good Reliability ◽  
Validity Test ◽  
Korean Version ◽  
Motivation Scale

Objective To translate the Stroke Rehabilitation Motivation Scale (SRMS), developed to evaluate the motivation level of stroke patients during rehabilitation, into the Korean language and to verify the reliability and validity of the Korean version of SRMS (K-SRMS).Methods The K-SRMS was developed following a structured process that included translation, verification, compromise assessment, reverse translation, feedback, and final correction. K-SRMS reliability was evaluated by performing internal consistency and test–retest analyses. The reliability test was conducted in 50 stroke patients. Its validity was assessed by comparing the K-SRMS with the scale and performing exploratory factor analysis. The validity test was conducted in 102 stroke patients.Results The test–retest analysis showed good reliability, and the internal consistency of the K-SRMS was similar to that of the original version for all, except 4, items. Thus, these 4 items were excluded, and then the validity test was conducted. Pearson correlation analysis demonstrated that the K-SRMS score was significantly correlated with the BAS total score (Pearson r=0.207, p<0.05). In the exploratory factor analysis, K-SRMS items were categorized into 7 groups (factors), and factors 1 and 4 showed mutual concordance with K-SRMS subscales, including intrinsic motivation factors and amotivation, respectively.Conclusion The newly developed K-SRMS showed good reliability and validity. It could also be used as a tool to objectify the degree of motivation for rehabilitation among stroke patients in clinical care and research.

Factor Structure, Reliability, and Validity of the Death Attitude Profile-Revised

2000 ◽  
Vol 40 (3) ◽  
pp. 453-463 ◽  
Author(s):  
Richard Clements ◽  
Linda A. Rooda
Keyword(s):  
Factor Analysis ◽  
Factor Structure ◽  
Internal Consistency ◽  
Principal Components ◽  
Concurrent Validity ◽  
Reliability And Validity ◽  
Fear Of Death ◽  
Hospice Nurses ◽  
Structure Reliability ◽  
Two Factors

The Present Study Examined The Factor Structure, reliability, and validity of the Death Attitude Profile-Revised (DAP-R; Wong, Reker, & Gesser, 1994) using a sample of 403 hospital and hospice nurses. A principal-components factor analysis of the DAP-R indicated that the DAP-R may consist of six factors instead of the five originally reported by Wong et al. The first four factors reported by Wong et al., which correspond to the subscales that they labeled Fear of Death, Death Avoidance, Approach Acceptance, and Escape Acceptance, were replicated in the present study, and these subscales were found to have acceptable levels of internal consistency and to possess some degree of concurrent validity. However, the items which loaded on the fifth factor in Wong et al.‘s study (their “Neutral Acceptance” subscale) were split across two factors in the present study, suggesting that this subscale may not be measuring a unitary construct.

HSR19-100: CancerSupportSource®-15: Development and Evaluation of a Short Form of a Distress Screening Program for Cancer Survivors

2019 ◽  
Vol 17 (3.5) ◽  
pp. HSR19-100
Author(s):  
Shauna McManus ◽  
Alexandra K. Zaleta ◽  
Melissa F. Miller ◽  
Joanne S. Buzaglo ◽  
Julie S. Olson ◽  
...  
Keyword(s):  
Factor Analysis ◽  
Confirmatory Factor Analysis ◽  
Cancer Survivors ◽  
Psychometric Properties ◽  
Internal Consistency ◽  
Short Form ◽  
Distress Screening ◽  
Cancer Support ◽  
Confirmatory Factor ◽  
Item Quality

Background: CancerSupportSource (CSS) is a 25-item distress screening tool implemented at community-based cancer support organizations and hospitals nationwide. CSS assesses distress over 5 domains: (1) emotional concerns (including depression and anxiety risk screening subscales), (2) symptom burden, (3) body and healthy lifestyle, (4) healthcare team communication, and (5) relationships. This study developed a short form of CSS and examined its psychometric properties. Methods: 2,379 cancer survivors enrolled in the Cancer Support Community’s Cancer Experience Registry. Participants provided demographic and clinical background and completed CSS-25 and PROMIS-29, a measure of health-related quality of life. Item reduction was conducted with a subsample of 1,435 survivors and included external item quality (correlations between items and PROMIS-29 scales), internal item quality (inter-item and inter-factor correlations, factor loadings and structure, and item communalities from an exploratory factor analysis of CSS-25), and professional judgement (ranking/prioritization of items by CSS-25 developers, accounting for theoretical and practical implications). Pearson correlations and confirmatory factor analysis were conducted on a separate subsample of 944 survivors to corroborate psychometric properties and dimensionality of the shortened scale. Results: Scale refinement resulted in a 15-item short form of CSS (CSS-15). At least 1 item from each of the 5 CSS-25 domains was retained to preserve multidimensionality, including anxiety and depression risk screening subscale items. Additionally, 1 item about tobacco/substance use was kept due to clinical significance for risk assessment. In confirmatory factor analysis, the model explained 59% of the variance and demonstrated good fit (RMSEA=0.068, 90% CI=0.061–0.075; SRMR=0.033; CFI=0.959; χ2(68)=334.75, P<.001). Correlation between CSS-15 and CSS-25 was 0.986, P<.001. Total distress was associated with PROMIS subscales (rs=−.65–.75, ps<.001); internal consistency reliability was excellent (α=.92). Conclusions: CSS-15 is a brief, reliable, and valid multidimensional measure of distress. The reduced measure retained excellent internal consistency and a stable factor structure, while correlating well with CSS-25 and PROMIS-29. CSS-15 can serve as a practical tool to efficiently screen for distress among cancer patients and survivors.

scholarly journals Reliability and Validity of the Korean-Parental Self-Efficacy with Eczema Care Index

2016 ◽  
Vol 8 (10) ◽  
pp. 57 ◽  
Author(s):  
Hyejung Lee ◽  
Hae Kyoung Son ◽  
Ji Su Kim ◽  
Man Yong Han ◽  
Geunwoong Noh
Keyword(s):  
Factor Analysis ◽  
Atopic Dermatitis ◽  
Internal Consistency ◽  
Self Efficacy ◽  
Reliability And Validity ◽  
Psychometric Testing ◽  
Language Version ◽  
Tertiary Hospitals ◽  
Positive Treatment ◽  
Care Index

<p><strong>Background: </strong>Atopic dermatitis is a global problem affecting children, and its prevalence in Korea is steadily increasing. Since it is a chronically relapsing inflammatory skin disease, caregiver management of young children's atopic dermatitis is crucial for positive treatment outcomes. A factor that contributes to adherence to recommended prescriptions is parents’ self-efficacy. However, accurate measurements of parental self-efficacy in relation to disease-specific task management are scarce.</p><p><strong>Objecti</strong><strong>ves</strong><strong>:</strong> This study<strong> </strong>examined the psychometric properties of the Korean language version of the Parental Self-Efficacy with Eczema Care Index (K-PASECI).</p><p><strong>Methods: </strong>One hundred twenty five mothers of children younger than 13 years old who had atopic dermatitis were recruited from three tertiary hospitals across Korea. The K-PASECI was developed in accordance with the published guidelines. Psychometric testing included factor analysis, internal consistency testing, and concurrent validity analysis by comparing K-PASECI domains with parenting self-efficacy subscales.</p><p><strong>Results: </strong>Factor analysis revealed a four-factor structure that explained 69.4% of the variance. The four factors were as follows; managing a child’s symptoms and behaviour, communicating with medical staff, managing medication, and using moisturizer as part of routine management. The findings showed acceptable internal consistency (<em>α</em>=.94) and a moderate positive correlation with parenting self-efficacy (r=.48, <em>p&lt;</em>.001).</p><p><strong>Conclusion: </strong>The K-PASECI, a reliable and valid scale for measuring self-efficacy in parents caring for children with atopic dermatitis, may be used in clinical and research settings to measure parents’ self-efficacy in Korea, as well as in other English-speaking countries. </p>

Structural validity and reliability of the return to work assessment scale among post stroke survivors

Work ◽  
2021 ◽  
pp. 1-11
Author(s):  
Peter. O. Ibikunle ◽  
Anthea Rhoda ◽  
Mario Smith
Keyword(s):  
Factor Analysis ◽  
Return To Work ◽  
Internal Consistency ◽  
Assessment Scale ◽  
Stroke Survivors ◽  
Validity And Reliability ◽  
Structural Validity ◽  
Bartlett’S Test ◽  
Work Assessment ◽  
Domain 3

BACKGROUND: Return to work (RTW) after injury or illness is a behavior influenced by physical, psychological and social factors. This study aims to determine the structural validity and reliability of a return to work assessment scale using internal consistency and factor analysis. METHOD: A cross sectional survey research design was adopted for this study involving 101 Post stroke survivors. The return to work assessment scale, which was developed by Ibikunle et al. in 2019, was subjected to structural validity and reliability. RESULT: The results reveal that 58 (57.4%) were males and 43 (42.2%) females with mean ages of 53.88±10.68 years. Internal consistency was high with a Cronbach’s alpha coefficient of 0.81 for Domain 1, 0.93 for Domain 2 and 0.76 for Domain 3.Test-retest reliability analysis gave an ICC of 0.85(p = 0.001) for Domain 1, Domain 2 an ICC of 0.91 (p = 0.001) and Domain 3 an ICC of 0.99 (p = 0.001). The Kaiser-Meyer-Olkin measure of sampling adequacy (KMO) value for Domain 1 was X2  = 0.63 and that of Bartlett’s test of sphericity value was significant (P = 0.000), Kaiser-Meyer-Olkin measure of sampling adequacy for Domain 2 was 0.84 and the Bartlett’s test of sphericity value was significant (P = 0.000), the Kaiser-Meyer-Olkin measure of sampling adequacy for Domain 3 was 0.66 while the Barlett’s test of sphericity was significant (p = 0.001). Therefore the factor analysis was appropriate. CONCLUSION: The return to work assessment scale is a good, internally consistent and reliable tool that has demonstrated good group and structural validity.

scholarly journals Factor Structure, Reliability and Validity of the Institutional Culture Assessment Scale (ICAS)

2020 ◽  
Author(s):  
Gabriela Massaro Carneiro Monteiro ◽  
Carolina Meira Moser ◽  
Luciana Terra de Oliveira ◽  
Glen Owens Gabbard ◽  
Pricilla Braga Laskoski ◽  
...  
Keyword(s):  
Factor Analysis ◽  
Confirmatory Factor Analysis ◽  
Factor Structure ◽  
Reliability And Validity ◽  
Institutional Culture ◽  
Well Being ◽  
Assessment Scale ◽  
Structure Reliability ◽  
Unidimensional Model ◽  
Confirmatory Factor

Introduction: Work environment can affect the employees, fostering well-being versus emotional burden. The aim of this study was to develop the Institutional Culture Assessment Scale (ICAS), and evaluate its Factor Structure, Reliability and Validity in a Brazilian sample of medical students and physicians in different settings and phases of the medical career. Method: 2537 individuals were evaluated by an online questionnaire. The sample was split in half for independent testing of Exploratory Factor Analysis and Confirmatory Factor Analysis. We then used Confirmatory Factor Analysis (CFA) to test the best solutions in the second half of the sample. Then, considering a unidimensional model solution, an item response theory (IRT) analysis was conducted. Simple linear regression analysis was performed to investigate associations between ICAS factor scores and internal validators (burnout scores), using again the second half of the sample. Result: Parallel analysis revealed two factors. The first factor encompassed items involving the institution and supervisors. The second factor encompassed items involving peers. We decided to performed the next analysis with a unidimensional construct based solely on institution/supervisor items. A unidimensional model including the remaining seven items from the ICAS instrument revealed an excellent fit with the data. All items loaded significantly on the unidimensional latent trait with factor loadings ranging from 0.583 to 0.869. McDonalds Omega was 0.89, showing a high internal consistency. Conclusion: This study presents a valid and reliable scale to assess aspects of institutional culture connected to the relationships with superiors/supervisors and to the relation to the institutions themselves.

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