scholarly journals Evaluation of optical quality in pterygium patients with a new modified sutureless and glue-free method

2021 ◽  
Vol 21 (1) ◽  
Author(s):  
Li Peng ◽  
Shu Zhou ◽  
Bin Yan ◽  
Baihua Chen
Keyword(s):  
Anterior Segment ◽  
Surgical Excision ◽  
Perioperative Period ◽  
Postoperative Recovery ◽  
Optical Quality ◽  
Quality Analysis ◽  
Modulation Transfer ◽  
Ocular Surface Disease Index ◽  
Group 2 ◽  
Group 1

Abstract Background Modified sutureless and glue-free method is an effective and novel surgical approach for pterygium. We aim to evaluate optical quality in pterygium treated with the new method and investigate the clinical application of the Optical Quality Analysis System (OQAS) and Anterior segment optical coherence tomography (AS-OCT) to evaluate the pterygium surgery. Methods A total of 52 eyes of 52 patients with pterygium were randomly divided into 2 groups. After surgical excision, the bare sclera was placed with a tight fit limbal conjunctival autograft fixed via the modified sutureless and glue-free method in group 1 (26 eyes) and conventional sutures in group 2 (26 eyes). Objective scattering index (OSI), modulation transfer function (MTF) and Strehl ratio (SR) were measured using OQAS in both groups during the perioperative period. Pterygium diameter was measured on AS-OCT. Ocular surface disease index (OSDI) questionnaire also was used. Results The group 1 had significantly lower mean OSI, higher mean MTF, and higher mean SR at 1 month and 3 months after surgery (p < 0.05). The group 1 had significantly lower mean OSDI at 1 month (p < 0.05), while was similar to group 2 at 3 months (p > 0.05). Pterygium diameter positively correlated with OSI (r = 0.528, p < 0.001), while it negatively correlated with MTF (r = − 0.501, p < 0.001) and SR (r = − 0.174, p = 0.217) before operation. Conclusions The modified sutureless and glue-free method might be more advantageous in improving the optical quality during early postoperative recovery times and pterygium diameter affected optical quality. OQAS can be reliably used to evaluate postoperative outcomes.

scholarly journals Comparison of the visual performance of iris-fixated phakic lens and implantable collamer lens to correct high myopia

2021 ◽  
Vol 21 (1) ◽  
Author(s):  
Xiao-ling Jiao ◽  
Jun Li ◽  
Zhe Yu ◽  
Ping-hui Wei ◽  
Hui Song
Keyword(s):  
Visual Acuity ◽  
High Myopia ◽  
Optical Quality ◽  
Visual Performance ◽  
Quality Analysis ◽  
Modulation Transfer ◽  
Implantable Collamer Lens ◽  
Good Visual Acuity ◽  
Significant Difference ◽  
Group 6

Abstract Background To compare visual performance between the iris-fixated phakic intraocular len (pIOL) and implantable collamer len (ICL) to correct high myopia. Methods Twenty-four eyes underwent iris-fixated pIOL implantation and 24 eyes underwent ICL implantation. At the 6-month follow-up, the best-corrected visual acuity (BCVA) and uncorrected distance visual acuity (UDVA) were compared between the iris-fixated pIOL and ICL groups. The objective scatter index (OSI), modulation transfer function (MTF) cutoff, and ocular aberrations were performed to evaluate postoperative visual quality between the two groups. Results No significant difference was found in UDVA, BCVA, and spherical equivalent between the iris-fixated pIOL and ICL groups (P > 0.05). Six months after surgery, the following values were significantly higher in the ICL group than in the iris-fixated pIOL group: MTF cutoff, strehl ratio and optical quality analysis system values at contrasts of 9 %, 20 %, and 100 % (P < 0.01). The OSI in the iris-fixated pIOL group was higher than in the ICL group 6 months after surgery (P < 0.01). All high-order aberrations were slightly more severe in the iris-fixated pIOL group than in the ICL group 6 months after surgery, although only trefoil (P = 0.023) differed significantly in this regard. Conclusions Both iris-fixated lenses and ICLs can provide good visual acuity. ICLs confer better visual performance in MTF-associated parameters and induce less intraocular light scattering than iris-fixated pIOLs.

scholarly journals Predictors of the recurrence of surgically removed previous caesarean skin scars at caesarean section: A retrospective cohort study

2021 ◽  
Vol 7 ◽  
pp. 205951312110233 ◽  
Author(s):  
İhsan Bağlı ◽  
Rei Ogawa ◽  
Sait Bakır ◽  
Cuma Taşın ◽  
Ayhan Yıldırım ◽  
...  
Keyword(s):  
Risk Factor ◽  
Cohort Study ◽  
Caesarean Section ◽  
Retrospective Cohort ◽  
Treatment Strategies ◽  
Surgical Excision ◽  
Hypertrophic Scars ◽  
Group 2 ◽  
Risk Factor For Recurrence ◽  
Group 1

Background: Caesarean skin scars (CSS; hypertrophic scars and keloids) are very stressful for women and treatment strategies vary. However, there is a lack of knowledge about the outcome of surgical excision of CSS during caesarean section (CS). The study aims to determine the rate of recurrence and risk factors of recurrence for surgically removed CSS. Method: This is a retrospective cohort study that used STROBE guidelines. Pfannenstiel incisions of 145 patients were evaluated. Patients were divided into two groups: recurred (group 1, n = 19) and non-recurred group (group 2, n = 126). The groups were compared. Results: The rate of recurrence of CSS was 13% in the total cohort (19/145), one of the main outcomes of the study. While emergency CS was performed for 12 patients in group 1 (63%), CS was carried out in 25 patients in group 2 (20%); this difference was significant ( P = 0.001). Before surgery, white blood cell and neutrophil counts were significantly higher in group 1 ( P = 0.014 and P = 0.023, respectively). There were 11 dark-skinned women (26%; Fitzpatrick type 4) in group 1 and 31 (74%) in group 2. This difference was statistically significant ( P = 0.031). As the other main outcome, emergency CS could be accepted as a risk factor for recurrence in the multivariate regression analysis ( P = 0.060; odds ratio = 5.07; 95% confidence interval = 0.93–17.51). Conclusion: The rate of recurrence of surgically removed previous CSS at CS is promising without adjunct therapy. Emergency CS was found to be a risk factor for recurrence. Lay Summary Background Caesarean skin scars (CSS; hypertrophic scars and keloids) are very stressful and are generally itchy and painful for women. Treatment strategies vary. However, there is a lack of knowledge about the outcome of only surgical excision of CSS scars during caesarean section (CS). The issue being explored There are few data in the literature for CSS in the lower abdomen. These scars can be removed during the second or third CS, but the results are not known exactly. How was the work conducted? In our clinic, 145 patients with CSS were given a CS and their scars were removed at the same time. While most of these scars were reported as hypertrophic by pathological examination, some were reported as keloid. At the earliest, one year after surgery, the rate of recurrence was found to be 13%. What we learned from the study Asymptomatic patients who are planning another pregnancy and do not want to receive any other radiotherapy or steroid injection therapy can wait to remove their CSS at the next CS, especially elective CS with or without adjunct therapy. Emergency CS was found to be a risk factor for the recurrence of these scars.

A Comparative Study Between Preoperative Subconjunctival Bevacizumab Injection And Postoperative Topical Application In Prevention Of Recurrence After Excision Of Primary Pterygium In Egyptian Patients

QJM ◽  
2021 ◽  
Vol 114 (Supplement_1) ◽  
Author(s):  
Basma Helal Mohamed ◽  
Othman Ali Othman Ziko ◽  
Hisham M Khairy Abd El Dayem ◽  
Nancy Ezzelregal Khamis Ahmed
Keyword(s):  
Corneal Thickness ◽  
Anterior Segment ◽  
P Value ◽  
Eye Drops ◽  
Subconjunctival Injection ◽  
Fibrovascular Tissue ◽  
Significant Difference ◽  
Group 2 ◽  
Group 1 ◽  
Primary Pterygium

Abstract Purpose to compare between recurrence incidence after primary pterygium excision when using preoperative subconjunctival injection of Bevacizumab (Avastin) and using it as a postoperative eye drops. Methods thirty two eyes of thirty patients (two patients had bilateral pterygium) with primary pterygia were clinically examined, classified into 3 groups and operated by simple excision with bare sclera technique. Group 1 included 10 patients received Bevacizumab (Avastin) in the form of eye drops (10 mg/ml) 3 times daily for 6 days postoperative. Group 2 included 10 patients received preoperative Bevacizumab in the form of subconjunctival injection (1.25 mg/0.05ml) single dose 1 week preoperative. Group 3 included 10 patients (12 eyes) 2 patients with bilateral Pterygium didn’t receive any form of Bevacizumab. Postoperative follow up was done clinically and by serial photography at 1 week, 1 month, 3 months and 6 months searching for signs of recurrence and/or complications. Results The results showed different grades of recurrence in 18 eyes of 32.True recurrence was seen in 7 patients of 18 (1 patient in group 1, 2 in group 2 and 4 in group3).Recurrence grades in group 1and 2 who used the Bevacizumab (20%grade II, 50% grade III, and 30% grade IV). Recurrence could be predicted by 100% depending on fibrovascular tissue appearing in the surgical bed at 3 months postoperative (P value 0.038).Preoperative fleshy pterygium has high statistical significance in realation to recurrence(P value = 0.006).Patient’s sex, residence and occupation had no statistically significant value in the process of recurrence (P value &gt; 0.05). Patients with recurrent Pterygia (in group 1&2) had statistically significant changes in the corneal K- readings at 3 months and 6 months.No significant difference in the limbal or central corneal thickness in the operated eye and the other eye (Pvalue &gt; 0.05). Conclusion Bevacizumab (Avastin) is a well tolerated drug with multiple drug delivery methods.The eye drops give better results than the subconjunctival injection.Appearance of fibrovascular tissue in the surgical bed at 3 months predict the recurrence by 100%. Preoperative fleshy pterygia will mostly recur again whatever Bevacizumab form was used .The corneal thickness by anterior segment OCT has no role in prediction or detection of early pterygium recurrence.

Ovarian Reserve Reduction With Surgery Is Not Correlated With the Amount of Ovarian Tissue Inadvertently Excised at Laparoscopic Surgery for Endometriomas

2019 ◽  
Vol 26 (11) ◽  
pp. 1493-1498 ◽  
Author(s):  
Ludovico Muzii ◽  
Chiara Di Tucci ◽  
Mara Di Feliciantonio ◽  
Giulia Galati ◽  
Irene Pecorella ◽  
...  
Keyword(s):  
Ovarian Reserve ◽  
Ovarian Tissue ◽  
Reduction Rate ◽  
Surgical Excision ◽  
Significant Difference ◽  
Laparoscopic Cystectomy ◽  
Group 2 ◽  
Ovarian Endometriomas ◽  
Serial Measurements ◽  
Group 1

The aim of the present study was to evaluate the effect of laparoscopic cystectomy on ovarian reserve by means of anti-Müllerian hormone (AMH) serial measurements and to compare AMH values with the number of inadvertently removed follicles in histological specimens. Fifty-two women were enrolled: 34 patients with endometriomas (group 1) and 18 patients with other benign ovarian cysts (group 2). All patients underwent laparoscopic cystectomy performed by a single experienced surgeon. The AMH was measured before, and 1, 3, and 6 months after cystectomy in group 1, and before and 6 months after surgery in group 2. Preoperative AMH levels (mean [standard deviation, SD]) in group 1 (3.39 [2.43] ng/mL) were not significantly different from group 2 (3.74 [2.57] ng/mL; P = .68). In group 1, a significant decrease in AMH levels of 43.4% was observed at 1 month (1.93 [1.36]; P = .003), and of 63.1% at 3 months (1.25 [1.00]; P = .007) postoperatively. The AMH increased not significantly between the third and sixth months in group 1 (+9.4%). Six months after surgery, AMH was reduced by 59.3% compared to baseline values in group 1 ( P = .012), and by 29.5% in group 2 ( P = .200). A significant difference in the AMH decrease was present between bilateral and monolateral endometriomas ( P = .006). There was no correlation between the reduction rate of AMH and the number of follicles inadvertently removed in patients with endometriomas ( P = .669). In conclusion, AMH decreases significantly after surgical excision of ovarian endometriomas. The postoperative decrease does not appear to correlate with the amount of ovarian tissue inadvertently excised with the endometrioma wall.

Assessment of myocardial remodeling in the perioperative period of coronary artery bypass grafting: effects of prehabilitation

2020 ◽  
Vol 41 (Supplement_2) ◽  
Author(s):  
Y Argunova ◽  
A Korotkevich ◽  
E Moskin ◽  
S Pomeshkina ◽  
O Barbarash
Keyword(s):  
Coronary Artery ◽  
Myocardial Perfusion ◽  
Postoperative Period ◽  
Artery Bypass ◽  
Perioperative Period ◽  
Control Group ◽  
Bypass Grafting ◽  
Myocardial Remodeling ◽  
Group 2 ◽  
Group 1

Abstract Purpose To assess serial changes in the morphological and functional parameters, and indicators of myocardial perfusion in the perioperative period of coronary artery bypass grafting (CABG), depending on the preoperative management strategy. Methods 60 male patients with stable coronary artery disease (CAD) were randomized into two groups before on-pump CABG. Group 1 patients (n=30, aged of 61.5 [56; 63] years) underwent treadmill training at 80% of VO2max for a 7-day period. Group 2 patients (n=30, aged of 62.0 [56; 64] years) underwent routine management without prehabilitation. Cardiac morphological and functional parameters were evaluated using echocardiography in the preoperative period and 5–7 days after CABG. Adenosine loading single-photon emission computed tomography (SPECT) was used to measure the parameters of myocardial perfusion before and after the indexed CABG. Data were processed using the QPS program (Cedars Sinai Medical Center (USA)) and the 17-segment polar mapping. Statistical analysis was performed using commercially available Statistica 10.0 software package (Statsoft, USA). Results Both groups demonstrated a decrease in LVEF in the postoperative period. However, an LVEF decline in Group 1 patients was less significant (p=0.00015) than in the control group (p=0.000003). LV end-systolic dimension increased by 8.5% and LV end-systolic volume by 18% in patients who underwent prehabilitation as compared to the baseline, whereas these changes were more pronounced in the control group (17% (p=0.00029) and 41% (p=0.00028), respectively). Group 1 patients demonstrated better myocardial perfusion parameters in the postoperative period. Patients in the prehabilitation group reported higher accumulation levels of radiopharmaceuticals in the basal (75.0 [72.5; 80] and 72.0 [70; 75]%, p=0.036), middle (87.0 [83; 91] and 81.0 [77; 84]%, p=0.012) and apical (86.0 [82; 89] and 82.0 [78; 86]%, p=0.037) myocardium as compared with those in the control group. The stress-induced ischemia (SDS) was less pronounced in Group 1 compared to Group 2 (p=0.025). Conclusion Optimized myocardial remodeling parameters and improved myocardial perfusion in the postoperative period have proved the effectiveness of high intensity physical trainings introduced in the prehabilitation program for CABG. Funding Acknowledgement Type of funding source: None

scholarly journals Effect of Autologous Serum Eyedrops on Ocular Surface Disease Caused by Preserved Glaucoma Eyedrops

2020 ◽  
Vol 9 (12) ◽  
pp. 3904
Author(s):  
Ha-Rim So ◽  
Hae Young Lopilly Park ◽  
So-Hyang Chung ◽  
Hyun-Seung Kim ◽  
Yong-Soo Byun
Keyword(s):  
Ocular Surface ◽  
Ocular Surface Disease ◽  
Autologous Serum ◽  
Ocular Surface Disease Index ◽  
Ocular Surface Diseases ◽  
Group 3 ◽  
Baseline Values ◽  
Group 2 ◽  
Group 1

Autologous serum eyedrops (ASE) are effective in treating various ocular surface diseases, including damages induced by long-term use of preserved glaucoma eyedrops. However, there has been no study on whether ASE is effective without stopping the causative eyedrops. This retrospective observational study included 55 patients with ocular-surface diseases caused by long-term use of preserved glaucoma eyedrops: 18 patients who used ASEs for 2 months without discontinuing the use of glaucoma eyedrops (Group 1), 22 patients who used ASEs for 2 months, discontinuing the use of glaucoma eyedrops for the first month (Group 2) and 15 patients who used non-preservative artificial tears for 2 months, discontinuing the use of glaucoma eyedrops for the first month (Group 3). There were no intergroup differences in the baseline values of the Schirmer I test results, tear breakup time (TBUT), ocular surface staining (OSS) score, loss of the meibomian gland, meibum quality and ocular-surface disease index (OSDI). Group 1 showed significant differences in TBUT, OSS score and OSDI at 2 months when compared to the baseline values before treatment, while Group 2 showed significant differences in those values at both 1 and 2 months. There were no differences in any of the parameters at baseline, 1 month or 2 months in Group 3. Our result suggested that ASE is effective for treating ocular surface diseases caused by glaucoma eyedrops containing preservatives and its effects can be expected without interruption of glaucoma eyedrop treatment.

scholarly journals Evaluation of the Perioperative Period After Off-Pump Coronary Artery Bypass Grafting in Patients with the History of COVID-19

2021 ◽  
pp. 80-85
Author(s):  
Artur V. Gabriyelyan ◽  
Olexander V. Cheveliuk ◽  
Svitlana V. Romanova ◽  
Irina V. Kudlai ◽  
Marchelina S. Gergi ◽  
...  
Keyword(s):  
Coronary Artery ◽  
Coronary Artery Bypass Grafting ◽  
Coronary Artery Bypass ◽  
Artery Bypass ◽  
Perioperative Period ◽  
Bypass Grafting ◽  
Artery Bypass Grafting ◽  
History Of ◽  
Group 2 ◽  
Group 1

Previous COVID-19 is known to have negative impact on postoperative course of coronary artery bypass grafting. According to a number of foreign sources, mortality after coronary artery bypass grafting is increased in patients with previous COVID-19, and the perioperative period is accompanied by complications such as myocardial infarction, acute renal failure, acute cerebrovascular accident, sternal infection. The aim. To evaluate the features of the perioperative period after coronary artery bypass grafting in patients with the history of COVID-19. Materials and methods. The research is based on the analysis of data from patients who were operated at the Department of Transplantation and Heart Surgery of Shalimov National Institute of Surgery and Transplantation for the last 2 years. The article presents a comparative analysis of the perioperative period after coronary artery bypass grafting on a beating heart in patients with and without the history of COVID-19. Both groups of patients were basically equivalent in demographics, incidence of comorbidities, NYHA functional class, ejection fraction, and the difference between them was insignificant. Severe course of previous COVID-19 was noted only in 2 (10%) patients, moderate in 6 (30%), mild in 12 (60%). The most common finding was 11% to 30% damage of the lung tissue which was observed in 10 (50%) patients. Residual effects of spiral computed tomography immediately before surgery were detected in 6 (30%) cases. Results and discussion. In the early postoperative period there were such complications as: acute myocardial infarc-tion, acute renal failure, acute cerebrovascular accident, sternal infection. In the early postoperative period, patients in both groups developed complications: 14 (70%) patients in group 1 vs. 7 (35%) patients in group 2. Acute renal failure (ARF) was verified by a 1.5–1.9-fold increase in creatinine levels compared to baseline, or ≥0.3 mg/dL (≥26.5 mmol/l), and was significantly more common in the group of patients after COVID-19 (6 [30%]) than in the group of patients with-out the history of COVID-19 (2 [10%]). The incidence of myocardial infarction confirmed by high levels of highly specific troponin T and changes in electrocardiography also prevailed in group 1 with 4 (20%) patients vs. 2 (10%) patients in group 2 (P <0.001). In patients with a history of COVID-19, the duration of ventilation and the need for additional oxygen-ation was higher compared to those who did not have COVID-19. We found that patients with the history of COVID-19 had more abundant exudates in the first 24 hours: 113 ± 36.4 ml in group 1 vs. 78 ± 26.8 ml in group 2 without COVID-19. The length of stay of the patients in the ICU differs in both groups: 78.4 ± 14.1 hours in group 1 and 52.8 ± 12.1 hours in group 2 (P <0.01), and is observed as a consequence of the above-mentioned complications accompanying early postoperative period. Conclusions. Analysis of the results of coronary artery bypass graft surgery in patients with a history of COVID-19 showed that the postoperative course in them is more severe compared with patients who did not have COVID-19. The patients with the history of COVID-19 who are candidates for coronary artery bypass grafting are more likely to devel-op acute myocardial infarction and acute renal failure manifested by increased creatinine in the postoperative period.

scholarly journals Intense pulsed light plus meibomian gland expression versus intense pulsed light alone for meibomian gland dysfunction: A randomized crossover study

PLoS ONE ◽  
2021 ◽  
Vol 16 (3) ◽  
pp. e0246245
Author(s):  
Kyoung Yoon Shin ◽  
Dong Hui Lim ◽  
Chan Hee Moon ◽  
Byung Jin Kim ◽  
Tae-Young Chung
Keyword(s):  
Meibomian Gland ◽  
Treatment Session ◽  
Intense Pulsed Light ◽  
Meibomian Gland Dysfunction ◽  
P Value ◽  
Pulsed Light ◽  
Ocular Surface Disease Index ◽  
P Values ◽  
Group 2 ◽  
Group 1

Purpose To investigate the comparative efficacy of intense pulsed light (IPL) therapy alone with that of IPL plus meibomian gland expression (MGX) for meibomian gland dysfunction (MGD). Methods This is a prospective randomized crossover clinical trial. Sixty patients were enrolled and randomly assigned to two groups. All of patients underwent four treatment sessions in total, which were two weeks apart. Group 1 underwent two sessions of IPL therapy with MGX, as well as two sessions of IPL alone. Group 2 received two sessions of IPL therapy alone, and two sessions of IPL therapy with MGX. The following parameters were measured at baseline (BL), 2 weeks after the second treatment session (FU1), and 2 weeks after the fourth treatment session (FU2): tearfilm break-up time (BUT), Oxford grade for corneal staining, meibomian gland expressibility (MGE), meibum quality (MQ), and ocular surface disease index (OSDI). The separate effect of MGX on improvement of MGD parameters was evaluated using generalized estimating equation (GEE). Results The mean age of the participants was 57.52 ± 10.50 years. The BUT, Oxford grade, MGE, MQ, and OSDI of both groups improved significantly (from baseline) by the end of four treatment sessions (FU2 compared to BL; all p-values <0.05). The MGE and MQ significantly improved after the first and second treatment sessions (FU1 compare to BL; all p-values < 0.001). However, the improvement was not statistically significant after the third and fourth treatment sessions (FU2 compared to FU1; p-value of 0.388 for MGE and 0.645 for MQ in group 1, 0.333 for MGE and 0.333 for MQ in group 2). The IPL plus MGX therapy produced greater improvements in the BUT scores than did IPL therapy alone (p = 0.003 by GEE). In contrast, the Oxford grade, MGE, MQ, and OSDI were not influenced by the addition of MGX to IPL (p = 0.642, 0.663, 0.731, and 0.840, respectively by GEE). Conclusion IPL therapy effectively improves the subjective symptoms and objective ocular findings of MGD. MGX enhanced the improvement of BUT driven by IPL therapy. The meibomian gland function (MGE and MQ) recovers faster in response to IPL therapy than did the other parameters.

scholarly journals Comparison of Objective and Subjective Visual Quality Following LASEK, FS-LASIK and SMILE for Different Myopic Corrections: A Prospective Study

2021 ◽  
Author(s):  
Gang Liang ◽  
Miao Zhou ◽  
Chen-Wei Pan
Keyword(s):  
Prospective Study ◽  
High Myopia ◽  
Cutoff Frequency ◽  
Visual Quality ◽  
Optical Quality ◽  
Quality Analysis ◽  
Laser In Situ Keratomileusis ◽  
Modulation Transfer ◽  
Significant Difference ◽  
A Prospective Study

Abstract Background: To investigate the differences in visual quality after laser epithelial keratomileusis (LASEK), femtosecond laser in situ keratomileusis (FS-LASIK) and small-incision lenticule extraction (SMILE) in different degrees of myopia.Methods: This prospective study incorporated 200 consecutive myopic subjects (200 eyes). Myopia was subdivided into 3 levels based on the preoperative spherical equivalent (SE) value: low myopia (SE ≥ -3.0 D), moderate myopia (−3.0 D > SE ≥ −6.0 D), and high myopia (SE < −6.0 D). Visual quality was recorded and analyzed both objectively using the Optical Quality Analysis System II (OQAS II), and subjectively with uncorrected distance visual acuity (UDVA) and a questionnaire, preoperatively, 1 month and 6 months postoperatively. Results: Six months after LASEK, FS-LASIK and SMILE in myopia, the logarithm of the minimum angle of resolution (LogMAR) UDVA statistically decreased compared with preoperative values (all P < 0.001). While preoperatively, in three surgical procedure groups, objective visual quality parameters demonstrated no significant difference among three degrees of myopia (all P > 0.05), at 6 months postoperatively, after FS-LASIK and SMILE, the modulation transfer function (MTF) cutoff frequency in low myopia was significantly higher than that in high myopia (both P < 0.05). Moreover, intergroup differences in LASEK, FS-LASIK and SMILE groups were not statistically significant, before and 6 months after surgery (all P > 0.05), except that FS-LASIK provided a significantly higher preoperative LogMAR UDVA than SMILE in high myopia (P < 0.05).Conclusion: LASEK, FS-LASIK and SMILE could achieve similar improvement in visual quality to each other after myopia correction. Low myopic patients may achieve better postoperative visual quality after FS-LASIK and SMILE than high myopic patients.Trial registration: This is a prospective study. The study followed the Declaration of Helsinki and was approved by the Institutional Review Board of the Second People’s Hospital of Yunnan Province.

scholarly journals In Vivo Confocal Microscopy of the Corneal Sub-Basal Nerve plexus in Medically Controlled Glaucoma

2022 ◽  
pp. 1-8
Author(s):  
Luca Agnifili ◽  
Lorenza Brescia ◽  
Edoardo Villani ◽  
Giada D'Onofrio ◽  
Michele Figus ◽  
...  
Keyword(s):  
Confocal Microscopy ◽  
Nerve Fibers ◽  
Nerve Plexus ◽  
Ocular Surface Disease Index ◽  
Corneal Nerves ◽  
Group 3 ◽  
Group 2 ◽  
Group 1

The present study investigated the corneal sub-basal nerve plexus (SNP) modifications in glaucoma. Ninety-five glaucomatous patients were enrolled and divided into Group 1 and 2, preserved and preservative-free mono-therapy (30 and 28 patients), and Group 3, multi-therapy (37). Thirty patients with dry eye disease (DED) and 32 healthy subjects (HC) served as controls. In vivo confocal microscopy evaluated the nerve fibers density (CNFD), length (CNFL), thickness (CNFT), branching density (CNBD), and dendritic cell density (DCD). CNFD, CNFL, and CNBD were reduced in Group 3 and DED compared to HC (p < 0.05). CNFL was reduced in Group 3 compared to Group 2 (p < 0.05), and in Group 1 compared to HC (p < 0.001). CNFD, CNBD, and CNFT did not differ between glaucomatous groups. DCD was higher in Group 3 and DED compared to HC and Group 2 (p < 0.01). Group 3 showed worse ocular surface disease index (OSDI) scores compared to Group 1, 2, and HC (p < 0.05). CNFL and DCD correlated with OSDI score in Group 3 (r = −0.658, p < 0.001; r = 0.699, p = 0.002). Medical therapy for glaucoma harms the corneal nerves, especially in multi-therapy regimens. Given the relations with the OSDI score, SNP changes seem features of glaucoma therapy-related OSD and negatively affects the patient's quality of life.

Sign in / Sign up

Export Citation Format

Share Document