Anxiety and depression in adults with cystic fibrosis: a comparison between patients and the general population in Sweden and three other European countries

Cystic Fibrosis (CF) is the commonest inherited genetic disorder in Caucasians due to a mutation in the gene CFTR (Cystic Fibrosis Transmembrane Conductance Regulator), and it should be considered as an Inherited Colorectal Cancer (CRC) Syndrome. In the United States, physicians of CF Foundation established the “Developing Innovative Gastroenterology Speciality Training Program” to increase the research on CF in gastrointestinal and hepatobiliary diseases. The risk to develop a CRC is 5–10 times higher in CF patients than in the general population and even greater in CF patients receiving immunosuppressive therapy due to organ transplantation (30-fold increased risk relative to the general population). Colonoscopy should be considered the best screening for CRC in CF patients. The screening colonoscopy should be started at the age of 40 in CF patients and, if negative, a new colonoscopy should be performed every 5 years and every 3 years if adenomas are detected. For transplanted CF patients, the screening colonoscopy could be started at the age of 35, in transplanted patients at the age of 30 and, if before, at the age of 30. CF transplanted patients, between the age of 35 and 55, must repeat colonoscopy every 3 years. Our review draws attention towards the clinically relevant development of CRC in CF patients, and it may pave the way for further screenings and studies.

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Gerontologia (geragogika) specjalna – obszar koniecznych badań i refleksji pedagogiki specjalnej. Wybrane zagadnienia

Interdyscyplinarne Konteksty Pedagogiki Specjalnej ◽

10.14746/ikps.2017.17.07 ◽

2018 ◽

pp. 117-141

Author(s):

Iwona Chrzanowska

Keyword(s):

General Population ◽

Special Needs ◽

People With Disabilities ◽

European Countries ◽

Life Situation ◽

Scientific Merit ◽

The People ◽

Special Needs Education ◽

The World ◽

The Relationship

In the text, an attempt was made to analyse selected issues related to gerontology in the relationship to people with disabilities. The context of analyses is the tendency of social ageing tendencies, observed in Poland and in the world, especially in European countries. Selected areas of reflection are combined with the conviction that there is a need for research which would fill in the gap in the field of research carried out so far, focused on the issue of the broadly defined life situation of the people with disabilities in the senior years, which is in the scientific merit of Polish special needs education (pedagogics). There is a justified fear that these individuals are more likely to experience marginalisation and exclusion in many areas of life than people of similar age in the general population.

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Global Burden of Anxiety and Depression among Cystic Fibrosis Patient: Systematic Review and Meta-Analysis

International Journal of Chronic Diseases ◽

10.1155/2021/6708865 ◽

2021 ◽

Vol 2021 ◽

pp. 1-9

Author(s):

Mistire Teshome Guta ◽

Tiwabwork Tekalign ◽

Nefsu Awoke ◽

Robera Olana Fite ◽

Getahun Dendir ◽

...

Keyword(s):

Cystic Fibrosis ◽

North America ◽

Publication Bias ◽

Meta Analysis ◽

Systemic Review ◽

Anxiety And Depression ◽

Close Monitoring ◽

The World ◽

Trim And Fill ◽

Meta Analyses

Aims. This systemic review and meta-analysis were aimed at determining the level of anxiety and depression among cystic fibrosis patients in the world. Methods. We conducted a systematic search of published studies from PubMed, EMBASE, MEDLINE, Cochrane, Scopus, Web of Science, CINAHL, and manually on Google Scholar. This meta-analysis follows the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines. The quality of studies was assessed by the modified Newcastle-Ottawa Scale (NOS). Meta-analysis was carried out using a random-effects method using the STATA™ Version 14 software. Trim and fill analysis was done to correct the presence of significant publication bias. Result. From 419,820 obtained studies, 26 studies from 2 different parts of the world including 9766. The overall global pooled prevalence of anxiety and depression after correction for publication bias by trim and fill analysis was found to be 24.91(95% CI: 20.8-28.9) for anxiety. The subgroup analyses revealed with the lowest prevalence, 23.59%, (95% CI: 8.08, 39.09)) in North America and the highest, 26.77%, (95% CI: 22.5, 31.04) seen in Europe for anxiety and with the highest prevalence, 18.67%, (95% CI: 9.82, 27.5) in North America and the lowest, 13.27%, (95% CI: -10.05, 16.5) seen in Europe for depression. Conclusion. The global prevalence of anxiety and depression among cystic fibrosis patients is common. Therefore, close monitoring of the patient, regularly screening for anxiety and depression, and appropriate prevention techniques is recommended.

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319 Anxiety and depression symptoms in caregivers of children and adolescents with cystic fibrosis in Spain

Journal of Cystic Fibrosis ◽

10.1016/s1569-1993(13)60460-9 ◽

2013 ◽

Vol 12 ◽

pp. S130

Author(s):

M. Cebrián ◽

A. Solé ◽

C. Olveira ◽

A.L. Quittner

Keyword(s):

Cystic Fibrosis ◽

Children And Adolescents ◽

Anxiety And Depression ◽

Depression Symptoms

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Anxiety and depression in children and adolescents with obesity: a nationwide study in Sweden

BMC Medicine ◽

10.1186/s12916-020-1498-z ◽

2020 ◽

Vol 18 (1) ◽

Cited By ~ 9

Author(s):

Louise Lindberg ◽

Emilia Hagman ◽

Pernilla Danielsson ◽

Claude Marcus ◽

Martina Persson

Keyword(s):

Risk Factors ◽

Family History ◽

General Population ◽

Children And Adolescents ◽

Neuropsychiatric Disorders ◽

Obesity Treatment ◽

Sensitivity Analyses ◽

Anxiety And Depression ◽

History Of ◽

Anxiety Depression

Abstract Background Anxiety and depression are more common in children with obesity than in children of normal weight, but it is unclear whether this association is independent of other known risk factors. Interpretation of results from previous studies is hampered by methodological limitations, including self-reported assessment of anxiety, depression, and anthropometry. The aim of this study was to investigate whether obesity increases the risk of anxiety or depression independently of other risk factors in a large cohort of children and adolescents, using robust measures with regard to exposure and outcome. Methods Children aged 6–17 years in the Swedish Childhood Obesity Treatment Register (BORIS, 2005–2015) were included (n = 12,507) and compared with a matched group (sex, year of birth, and area of residence) from the general population (n = 60,063). The main outcome was a diagnosis of anxiety or depression identified through ICD codes or dispensed prescribed medication within 3 years after the end of obesity treatment. Hazard ratios (HRs) with 95% confidence intervals (CIs) from Cox proportional models were adjusted for several known confounders. Results Obesity remained a significant risk factor for anxiety and depression in children and adolescents after adjusting for Nordic background, neuropsychiatric disorders, family history of anxiety/depression, and socioeconomic status. Girls in the obesity cohort had a 43% higher risk of anxiety and depression compared to girls in the general population (adjusted HR 1.43, 95% CI 1.31–1.57; p < 0.0001). The risk in boys with obesity was similar (adjusted HR 1.33, 95% CI 1.20–1.48; p < 0.0001). In sensitivity analyses, excluding subjects with neuropsychiatric disorders and a family history of anxiety/depression, the estimated risks in individuals with obesity were even higher compared with results from the main analyses (adjusted HR [95% CI]: girls = 1.56 [1.31–1.87], boys = 2.04 [1.64–2.54]). Conclusions Results from this study support the hypothesis that obesity per se is associated with risk of both anxiety and depression in children and adolescents.

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