Beneficial effects of curcumin nano-emulsion on spermatogenesis and reproductive performance in male rats under protein deficient diet model: enhancement of sperm motility, conservancy of testicular tissue integrity, cell energy and seminal plasma amino acids content

1. Newly weaned 21-d-old male rats were given isoenergetic diets containing 200, 100 and 50 g protein/kg for 7, 14, 28 or 70 d. The mid-jejunum was removed from the rats and a micrometric analysis of the mucosa was made. The following measurements were made: number of villi/mm2, vilius dimensions, villus surface area, crypt depth, crypt: villus, the number of cells/crypt in metaphase arrest per h.2. Comparisons were made between animals of the same age but on different diets, and animals on the same diet but of different ages. The latter comparison gave information on the effect of protein deficiency on the pattern of maturation of each feature of The villus or crypt studied.3. The effect of protein deficiency was not consistent at each stage of maturation. For instance villus height was decreased when compared with the controls following 28 d on a protein-deficient diet but not after 7 or 70 d.4. The only measurement to be unaffected by protein deficiency was the number of villi per unit area.5. In general the 50 g protein/kg diet had a more pronounced effect than the 100 g protein/kg diet. Protein deficiency delayed maturation by either slowing or inhibiting changes seen in normal maturation.6. In rats given 50 g protein/kg diet, although the villus surface area did not increase as the rats matured there were increases in epithelial cell production rate and number of crypts per villus.

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Effects of cobalt deficiency in the pregnant ewe on neonatal lamb survival

BSAP Occasional Publication ◽

10.1017/s0263967x00004201 ◽

1992 ◽

Vol 15 ◽

pp. 169-171 ◽

Cited By ~ 1

Author(s):

G. E. J. Fisher ◽

A. MacPherson

Keyword(s):

Reproductive Performance ◽

Dry Matter ◽

Methylmalonic Acid ◽

Milk Powder ◽

Vitamin B ◽

Deficient Diet ◽

Cobalt Deficiency ◽

Acid Status ◽

Pregnant Ewe ◽

Skimmed Milk Powder

It has been suggested (Mills, 1981) that there was a lack of research on the effects of cobalt (Co) deficiency on the reproductive performance of sheep. Duncan, Morrison and Garton (1981) reported that clinically Co-deficient ewes produced fewer lambs with a higher incidence of stillbirths and neonatal mortalities than Co-sufficient animals. Garton, Duncan and Fell (1981) related these findings to the vitamin B12 and methylmalonic acid status of dams. However, their investigations used few animals and were therefore inconclusive. The objectives of this work were to investigate the effects of subclinical Co deficiency in pregnant hill sheep on reproductive performance and neonatal lamb viability.Experiment 1 (1985/86) comprised 60 Scottish Blackface × Swaledale ewes, while experiment 2 (1986/87) included 30 of these animals plus 30 pure Scottish Blackface sheep. In both experiments the ewes were housed and bedded on sawdust and a Co-deficient diet of timothy hay, micronized maize, maize gluten, dibasic calcium phosphate and sodium chloride was offered. Skimmed milk powder was introduced to the diet during lactation. The Co content of the diet was 0.06 mg Co per kg dry matter.

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Beneficial effects on the reproductive performance of sows of administering prostaglandin analogues after farrowing

Veterinary Record ◽

10.1136/vr.164.26.807 ◽

2009 ◽

Vol 164 (26) ◽

pp. 807-809 ◽

Cited By ~ 1

Author(s):

J. V. Lopez ◽

M. Ptaszynska ◽

P. Gonzalez ◽

M. Jimenez ◽

M. R. T. M. Martens

Keyword(s):

Reproductive Performance ◽

Prostaglandin Analogues ◽

Beneficial Effects

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Veterinary needs of dogs in two resource-limited communities in the Gauteng and North West provinces of South Africa

Journal of the South African Veterinary Association ◽

10.4102/jsava.v72i4.654 ◽

2001 ◽

Vol 72 (4) ◽

Cited By ~ 1

Author(s):

W.N. Minnaar ◽

R.C. Krecek

Keyword(s):

South Africa ◽

Health Status ◽

Body Condition ◽

Veterinary Services ◽

Structured Interviews ◽

Deficient Diet ◽

North West ◽

The North ◽

Resource Limited ◽

Protein Deficient Diet

Information on the socioeconomic aspects and the health status of dogs in 2 resource-limited communities in the North West and Gauteng provinces of South Africa was gathered using semi-structured interviews and a standardised questionnaire. The dogs were examined clinically to determine their health status, and their body condition and age were scored. Most of the dogs (93 % in Jericho and 90 % in Zuurbekom) were infected with hookworm, which poses a threat to animal and human health in the 2 study areas. Many dogs were also being given a protein-deficient diet, which together with hookworm parasites would impact considerably on the dog's health. Dogs were mainly kept for security reasons. The need indicated to be most important by the residents of the 2 commnities was a lack of available and affordable veterinary services.

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Iberian pig adaptation to acorn consumption: I. Net portal appearance of metabolites

PeerJ ◽

10.7717/peerj.5861 ◽

2018 ◽

Vol 6 ◽

pp. e5861 ◽

Cited By ~ 2

Author(s):

Ignacio Fernández-Fígares ◽

Jose Miguel Rodríguez-López ◽

Lucrecia González-Valero ◽

Manuel Lachica

Keyword(s):

Sampling Period ◽

Metabolic Energy ◽

Blood Collection ◽

Standard Diet ◽

Deficient Diet ◽

Protein Energy ◽

Sampling Session ◽

Protein Deficient Diet ◽

Portal Plasma ◽

Set Up

Most valuable cured products from Iberian pigs come from pure bred animals raised for a final grazing-fattening period where pigs eat mainly acorns, a low protein energy rich fruit. This is a nutritional challenge for animals fed equilibrated diets from weaning. The aim of the study was to determine net portal appearance (NPA) of metabolites in gilts fed acorns and evaluate adaptational changes after one week of feeding. Two sampling periods were carried out (after one day and after one week of acorn feeding) with six gilts (34 kg average BW) set up with three catheters: in carotid artery and portal vein for blood sampling, and ileal vein for para-aminohippuric acid (PAH) infusion to measure portal plasma flow (PPF). Pigs were fed at 2.5 × ME for maintenance a standard diet in two portions, at 09:00 (0.25) and 15:00 h (the remaining 0.75). On the day prior to the first sampling period, pigs were fed 2.4 kg of oak acorns. After feeding 0.25 of ration a 6 h serial blood collection was initiated. Following an identical protocol, a second sampling session was performed 1 week later. Adaptation to acorn consumption decreased NPA of ammonia (47%,P < 0.001). Although there was a transfer of urea from the gastrointestinal tract to the circulation in both sampling periods, no differences in NPA of urea was found (P > 0.05). NPA of glucose was not influenced by sampling period (P > 0.05), but NPA of lactate was greatly increased (231%,P < 0.001). There was a negative NPA of albumin although adaptation to acorn feeding did not alter it. Although NPA of triglycerides and cholesterol were unchanged, a subtle increase in arterial and portal cholesterol was noticed (9.6%,P < 0.01). Pigs fed a protein deficient diet for one week adapted decreasing NPA of ammonia for saving metabolic energy as less ammonia would become available for conversion to urea.

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The effects of a tryptophan- and protein-deficient diet upon growth in rats

Bulletin of the Psychonomic Society ◽

10.3758/bf03334623 ◽

1989 ◽

Vol 27 (4) ◽

pp. 345-347 ◽

Cited By ~ 2

Author(s):

Angela H. Becker ◽

Stephen F. Davis ◽

Cathy A. Grover ◽

Cynthia A. Erickson

Keyword(s):

Deficient Diet ◽

Protein Deficient Diet

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Curcumin Along With Fe3O4 Nanoparticles Improved Sperm Parameters In Rats With Testicular Ischemia

Galen Medical Journal ◽

10.31661/gmj.v10i0.2034 ◽

2021 ◽

Vol 10 ◽

pp. e2034

Author(s):

Shabnam Zarei Moradi ◽

Seyed Abdolhamid Angaji ◽

Mitra Salehi ◽

Mehrdad Hashemi

Keyword(s):

Fe3o4 Nanoparticles ◽

Sperm Concentration ◽

Concomitant Administration ◽

Testicular Tissue ◽

Sperm Parameters ◽

Male Rats ◽

Semen Parameters ◽

Control Group ◽

Fe3o4 Nps ◽

Testicular Ischemia

Background: Ischemic/reperfusion (I/R) in testicular tissue is one reason for the worldwide increase in male infertility. In the present study, we assessed the effects of curcumin and Fe3O4 nanoparticles (NPs) on sperm parameters in rats with I/R damage. Materials and Methods: Forty-eight adult male rats were divided into two groups (n=24 per group): control and torsion/detorsion. The control and torsion/detorsion groups were divided into four subgroups include sham, Fe3O4 NPs, curcumin, and Fe3O4 NPs+curcumin. After the rats were sacrificed, semen was collected from their epididymal tissues to assess sperm viability, motility, concentration, and morphology. Results: Curcumin significantly improved viability, motility, and normal sperm morphology in rats with I/R damage compared to the control group; however, it did not have a significant effect on sperm concentration (P<0.001). Fe3O4 NPs alone decreased all sperm parameters in the control and I/R rats (P<0.001). However, concomitant administration of Fe3O4 nanoparticles with curcumin significantly improved sperm parameters in rats with I/R damage (P<0.001). Conclusion: The increase in all semen parameters in the experimental groups with concomitant use of Fe3O4 NPs plus curcumin indicated that green synthesis of NPs could be recommended for future clinical studies.

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On the local damaging effect of biogenic degradation products of the BAK-1000 silicate matrix after implantation (experimental morphological study)

Nauchno-prakticheskii zhurnal «Patogenez» ◽

10.25557/2310-0435.2018.03.44-49 ◽

2018 ◽

pp. 44-49

Author(s):

А.Ф. Фидаров ◽

А.С. Григорьян ◽

Т.Д. Колокольцова ◽

А.А. Орлов ◽

Е.Е. Устинова ◽

...

Keyword(s):

Bone Tissue ◽

Morphological Study ◽

Degradation Products ◽

Healing Process ◽

Male Rats ◽

Tissue Integrity ◽

And Function ◽

Tissue Trauma ◽

Tissue Restoration ◽

Late Stages

Актуальность. Травматизм костных тканей остается одной из серьезных проблем современности. Восстановление структуры и функциональности костной ткани больных с посттравматическими поражениями подчеркивает высокую значимость и актуальность проведения исследований по поиску новых методов и материалов для восстановления целостности и оптимизации процессов заживления костной ткани. Целью исследования было экспериментально-морфологическое изучение эффективности применения остеокондуктивного апатитосиликатного композита БАК-1000 в качестве имплантационного материала для восстановления обширного дефекта костной ткани. Методика. Исследования проведены на крысах линии CD, самцах массой 600 ± 10 г (n = 12). После остеотомии с удалением фрагмента кости размером 0,3 х 0,5 см дефект заполняли стерильным имплантационным материалом БАК-1000 в виде цилиндрических блоков того же размера. Контроль восстановления костной ткани проводили гистологическим методом. Результаты показали, что БАК-1000 обладает выраженным местным побочным эффектом, приводящим к возникновению очагов патологического процесса на поздних сроках заживления. Заключение. Данные экспериментально-морфологического исследования подтверждают необходимость проведения более тщательных исследований предлагаемых для использования в клинической практике материалов или композитов на поздних сроках после применения. Background. Bone tissue trauma remains one of serious current challenges. Restoration of the bone tissue structure and function in posttraumatic lesions emphasizes a high relevance of searching for new methods and materials to restore the bone tissue integrity and optimize the healing process. The aim of this experimental morphological study was to evaluate the effectiveness of an osteoconductive apatite-silicate composite BAK-1000 as an implant material for restoration of large defects in bone tissue. Methods. The study was performed on male rats (CD strain) weighing 600 ± 10 g (n = 12). After osteotomy with removal of a 0.3 х 0.5 cm bone fragment, the defect was filled with sterile BAK-1000 implantation material in the form of cylindrical blocks of the same size. The bone tissue restoration process was monitored histologically. The results showed that BAC-1000 had a pronounced local side effect, leading to the emergence of pathological foci at late stages of healing. Conclusion. This experimental morphological study confirmed the need to study more thoroughly the materials or composites proposed for use in clinical practice at late terms following application.

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The protective effect of curcumin against aluminum chloride-induced oxidative stress and hepatotoxicity in rats

Pharmaceutical and Biomedical Research ◽

10.18502/pbr.v5i1.761 ◽

2019 ◽

Cited By ~ 3

Author(s):

Ebrahim Cheraghi ◽

Kambiz Roshanaei

Keyword(s):

Aluminum Chloride ◽

Liver Homogenate ◽

Male Rats ◽

Health Concern ◽

Distilled Water ◽

Histopathological Changes ◽

Public Health Concern ◽

Treatment Control ◽

Beneficial Effects ◽

Peroxidation Index

Aluminum is recognized as a public health concern because of its potential toxic effects on human health. Therefore, the present experiment was undertaken to determine the effectiveness of curcumin (CUR) in reducing the hepatotoxicity induced by aluminum chloride (AlCl3) in animals. In this experimental study, forty male rats were allocated to five groups (N = 8), viz. no treatment (control), solvent (DMSO or distilled water), CUR (10 mg/kg B.W.), AlCl3 (10 mg/kg B.W.), and CUR+AlCl3 (each with 10 mg/kg B.W.). Treatments were performed by intra-peritoneal injections for 28 days. On the final day, animals were sacrificed, and liver function markers in blood plasma, hepatic antioxidants, and lipid peroxidation index in liver homogenate were estimated. AlCl3 treatment resulted in a significant increase in plasma AST, ALT, ALP and LDH activities with decreased total protein compared to control. AlCl3 significantly reduced superoxide dismutase (SOD), catalase (CAT) and glutathione (GSH) levels but increased malondialdehyde (MDA) level in the liver compared to control. AlCl3 also caused various histopathological changes in the livers of rats. Curcumin could normalize nearly all these parameters. CUR improved levels of changes in different parameters when was combined with AlCl3. It is concluded that CUR has beneficial effects being able to antagonize AlCl3 toxicity.

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