The relationship of plasma Trans fatty acids with dietary inflammatory index among US adults

Using cultured human umbilical vein endothelial cells, in which phosphatidylcholine (PC) is equally pulse-labelled by various eicosanoid precursor fatty acids (EPFAs), we have studied the remodelling of EPFAs among the phospholipid classes and subclasses with and without activation, and the relationship of this remodelling process to the selective release of arachidonic acid (AA) by phospholipase A2-mediated cell stimulation. When endothelial cells are pulse-incubated with radiolabelled EPFA for 15 min, greater than 80% of cell-associated radioactivity is present in phospholipids, among which greater than 60% is found in 1,2-diacyl-sn-glycero-3-phosphocholine (diacyl PC). After removing unincorporated radioactivity, reincubation of the pulse-labelled cells for up to 6 h results in progressive decrease in EPFA-labelled diacyl PC, increase in AA- or eicosapentaenoic acid (EPA)-labelled 1-O-alk-1-enyl-2-acyl-sn-glycero-3-phosphoethanolamine (plasmalogen PE) and increase only in AA-labelled 1-O-alkyl-2-acyl-sn-glycero-3-phosphocholine (alkyl PC). This redistribution of radiolabelled phospholipids is not altered by the presence of excess non-radiolabelled EPFAs. When aspirin-treated EPFA-labelled endothelial cells are stimulated with ionophore A23187, a very selective release of AA is noted in comparison with eicosatrienoate (ETA) or EPA, accompanied by an equivalent decrease in AA-labelled diacyl PC and specific increase in AA-labelled plasmalogen PE and alkyl PC. These selective changes in AA radioactivity induced by A23187 are enhanced 2-fold by pretreating the AA-labelled cells with phorbol 12-myristate 13-acetate, which by itself induces no changes. The changes in radioactivity induced by A23187 without and with phorbol ester among the released AA, the diacyl PC and the plasmalogen PE are significantly correlated with each other. These results indicate that human endothelial cells incorporate EPFAs (AA, ETA, EPA) equally into diacyl PC but selectively release AA esterified into diacyl PC with specific remodelling into plasmalogen PE and alkyl PC.

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Association between dietary inflammatory index and prostate cancer among Italian men

British Journal Of Nutrition ◽

10.1017/s0007114514003572 ◽

2014 ◽

Vol 113 (2) ◽

pp. 278-283 ◽

Cited By ~ 92

Author(s):

Nitin Shivappa ◽

Cristina Bosetti ◽

Antonella Zucchetto ◽

Maurizio Montella ◽

Diego Serraino ◽

...

Keyword(s):

Prostate Cancer ◽

Cancer Risk ◽

Smoking Status ◽

Wide Spectrum ◽

Prostate Cancer Risk ◽

Dietary Inflammatory Index ◽

Logistic Regression Models ◽

Inflammatory Index ◽

History Of ◽

Relationship Of

Previous studies have shown that various dietary components may be implicated in the aetiology of prostate cancer, although the results remain equivocal. The possible relationship of inflammation derived from dietary exposures with prostate cancer risk has not been investigated. We examined the ability of a newly developed dietary inflammatory index (DII) to predict prostate cancer risk in a case–control study conducted in Italy between 1991 and 2002. A total of 1294 patients aged < 75 years with incident, histologically confirmed carcinoma of the prostate served as cases. A total of 1451 subjects aged < 75 years who were admitted to the same hospitals as cases for a wide spectrum of acute, non-neoplastic conditions served as controls. The DII was computed based on dietary intake assessed using a previously validated seventy-eight-item FFQ. Logistic regression models were used to estimate multivariable OR adjusted for age, study centre, years of education, social class, BMI, smoking status, family history of prostate cancer and total energy intake. Men with higher DII scores had a higher risk of prostate cancer when analysed using the DII as both continuous (OR 1·06, 95 % CI 1·00, 1·13) and categorical, i.e. compared with men in the lowest quartile of the DII, men in the third and fourth quartiles were at elevated risk (ORQuartile 3 v. 1 1·32, 95 % CI 1·03, 1·69 and ORQuartile 4 v. 1 1·33, 95 % CI 1·01, 1·76; Ptrend= 0·04). These data suggest that a pro-inflammatory diet, as indicated by the increasing DII score, is a risk factor of prostate cancer in Italian men.

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Dietary inflammatory index and mental health: A cross-sectional analysis of the relationship with depressive symptoms, anxiety and well-being in adults

Clinical Nutrition ◽

10.1016/j.clnu.2017.08.029 ◽

2018 ◽

Vol 37 (5) ◽

pp. 1485-1491 ◽

Cited By ~ 28

Author(s):

Catherine M. Phillips ◽

Nitin Shivappa ◽

James R. Hébert ◽

Ivan J. Perry

Keyword(s):

Mental Health ◽

Depressive Symptoms ◽

Well Being ◽

Dietary Inflammatory Index ◽

Cross Sectional ◽

Inflammatory Index ◽

Cross Sectional Analysis ◽

Sectional Analysis ◽

The Relationship

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The Relationship Between Dietary Inflammatory Index of Women Receiving Infertility Treatment and Nutritional Status and Embryo Quality: Systematic Review

Turkiye Klinikleri Journal of Health Sciences ◽

10.5336/healthsci.2020-77334 ◽

2021 ◽

Vol 6 (3) ◽

pp. 401-408

Author(s):

Beyza Nur BİŞKİN ◽

Mendane SAKA ◽

Murat SÖNMEZER

Keyword(s):

Systematic Review ◽

Nutritional Status ◽

Embryo Quality ◽

Infertility Treatment ◽

Dietary Inflammatory Index ◽

Inflammatory Index ◽

The Relationship

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Systematic Literature Review and Meta-Analysis of the Relationship Between Polyunsaturated and Trans Fatty Acids During Pregnancy and Offspring Weight Development

Frontiers in Nutrition ◽

10.3389/fnut.2021.625596 ◽

2021 ◽

Vol 8 ◽

Author(s):

Xuan Ren ◽

Birgitta Lind Vilhjálmsdóttir ◽

Jeanett Friis Rohde ◽

Karen Christina Walker ◽

Suzanne Elizabeth Runstedt ◽

...

Keyword(s):

Fatty Acids ◽

Birth Weight ◽

Observational Studies ◽

Trans Fatty Acids ◽

Meta Analysis ◽

Randomized Controlled ◽

Neonatal Blood ◽

The Relationship ◽

Long Term Studies

Eicosapentaenoic acid (EPA), docosahexaenoic acid (DHA), and trans fatty acids (TFAs) may have an impact on offspring weight development. We conducted a systematic review and meta-analysis according to PRISMA guidelines to evaluate whether levels of these fatty acids during pregnancy influenced offspring weight development. Randomized controlled trials (RCTs) with DHA and/or EPA supplementation or cohort studies, which examined levels of DHA, EPA, or TFAs in maternal or neonatal blood samples and recorded offspring weight, were included. Overall, 27 RCTs and 14 observational studies were identified. The results showed that DHA and/or EPA supplementation doses >650 mg/day resulted in slightly higher birth weight (MD 87.5 g, 95% CI 52.3–122.6, n = 3,831) and combined BMI and BMI z score at 5–10 years (SMD 0.11, 95% CI 0.04–0.18, n = 3,220). These results were rated as moderate quality. Results from the observational studies were generally inconsistent. High TFA levels during pregnancy seemed to be associated with lower birth weight. Finally, this review and meta-analysis supports a relationship between high maternal or neonatal DHA and/or EPA levels and higher offspring birth weight and weight in childhood. More high-quality long-term studies are still needed.

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Association Between Dietary Inflammatory Index and Biomarkers of Inflammation, DNA/RNA Oxidative Stress, Glycemic Control, and Blood Pressure in Adults with Type 2 Diabetes (P19-001-19)

Current Developments in Nutrition ◽

10.1093/cdn/nzz049.p19-001-19 ◽

2019 ◽

Vol 3 (Supplement_1) ◽

Author(s):

Sahar Ajabshir ◽

Tan Li ◽

Fatma Huffman

Keyword(s):

Oxidative Stress ◽

Blood Pressure ◽

Type 2 Diabetes ◽

Glycemic Control ◽

Hypovitaminosis D ◽

Inverse Association ◽

Dietary Inflammatory Index ◽

Inflammatory Index ◽

The Relationship

Abstract Objectives Nutrition plays a critical role in systemic inflammation regulation and the risk of developing inflammatory diseases such as type 2 diabetes (T2D). The Dietary Inflammatory Index (DII) is a non-invasive comprehensive literature-derived tool that evaluates the inflammatory potential of each individual's diet. The aim of this study was to assess the relationship between DII and biomarker of inflammation (CRP), DNA/RNA oxidative stress (8OHdG), glycemic control [HbA1c, glycated albumin (GA) and insulin], and blood pressure (BP) among individuals with T2D and hypovitaminosis D. Methods Sixty-eight participants were recruited by community outreach. DII for each individual was calculated based on the values obtained from the Willett food frequency questionnaire. DII score was categorized into quartiles (Q1-Q4) ranged from −5.214 (maximally anti-inflammatory) to +3.999 (maximally pro-inflammatory). CRP, 8OHdG, HbA1c and GA were measured by enzymatic assays. Linear regression analysis was performed to test for the linear trend between DII and CRP, 8-OHdG, HbA1c, GA, insulin, and BP. Results Mean age was 54.94 ± 7.93 with 60.3% of participants being female. Participants in the DII Q4 were less likely to be female and had higher 8OHdG, HbA1c and GA levels. A significant inverse association was observed between DII Q3-Q4 and insulin level (P = 0.006 and P = 0.030, respectively). After adjusting for covariates, the model remained significant for both Q3 and Q4 (P = 0.040 and P = 0.049, respectively). There was a significant association between systolic BP and DII in Q4 (P = 0.029). However, after adjusting the model for the covariates the model lost significance. There was no statistically significant relationship between the overall DII, CRP, 8OHdG, HbA1c and GA. Conclusions A pro-inflammatory diet may be associated with increased risk of hypo-insulinemia and incidence of higher systolic BP among individuals with T2D and vitamin D deficiency/insufficiency. To our knowledge, this was the first study assessing the relationship between DII, 8-OHdG, HbA1c, GA, insulin, and SBP among individuals with type 2 diabetes and hypovitaminosis D. The results of this study may serve as a basis for future nutrition interventions to improve health status of individuals with type 2 diabetes. Funding Sources Funding for this research was provided through an NIH/NIDDK sponsored grant.

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