AST to ALT ratio and arterial stiffness in non-fatty liver Japanese population:a secondary analysis based on a cross-sectional study

Abstract Background The atherogenic index of plasma (AIP) always remains in a potential association with arterial stiffness, however, this association has not been fully discovered and needs to be studied in depth in large hypertensive patient populations. The present analysis thus sought to further explore the association that exists between AIP and arterial stiffness in Chinese patients diagnosed with arterial hypertension. Methods This cross-sectional study analyzed 4744 Chinese individuals with essential hypertension. AIP was defined as the base 10 logarithm of the ratio of plasma of triglycerides to high-density lipoprotein cholesterol levels indicated in molar concentrations. Measurement of arterial stiffness was carried out via brachial-ankle pulse wave velocity (baPWV). Results Data were adjusted for potential confounding variables, and multivariate linear regression analysis revealed AIP to be positively correlated with baPWV (β = 1.34, 95% CI: 0.96 to 1.72, P < 0.001). When AIP was instead treated as a categorical variable divided into quartiles, the same relationship was observed (P for trend < 0.001). We additionally found AIP and baPWV had a stronger positive association in individuals with a body mass index (BMI) < 24 kg/m2 (P for interaction < 0.05). Conclusion AIP and arterial stiffness were positively correlated in essential hypertension patients in China, especially in those with a BMI < 24 kg/m2. Clinical trial registration ChiCTR1800017274.

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Correlation Between Anthropometric Measurements and Non-alcoholic Fatty Liver Disease in Individuals With Obesity Undergoing Bariatric Surgery: Cross-Sectional Study

Obesity Surgery ◽

10.1007/s11695-021-05470-2 ◽

2021 ◽

Author(s):

Silênio Souza Reis ◽

Guilherme Hoverter Callejas ◽

Rodolfo Araújo Marques ◽

Martinho A. Gestic ◽

Murillo P. Utrini ◽

...

Keyword(s):

Bariatric Surgery ◽

Liver Disease ◽

Fatty Liver ◽

Fatty Liver Disease ◽

Cross Sectional Study ◽

Anthropometric Measurements ◽

Sectional Study ◽

Cross Sectional ◽

Alcoholic Fatty Liver ◽

Alcoholic Fatty Liver Disease

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Association of Serum Bilirubin Level with Metabolic Syndrome and Non-Alcoholic Fatty Liver Disease: A Cross-Sectional Study of 1672 Obese Children

Journal of Clinical Medicine ◽

10.3390/jcm10132812 ◽

2021 ◽

Vol 10 (13) ◽

pp. 2812

Author(s):

Cristina Bellarosa ◽

Giorgio Bedogni ◽

Annalisa Bianco ◽

Sabrina Cicolini ◽

Diana Caroli ◽

...

Keyword(s):

Metabolic Syndrome ◽

Fatty Liver ◽

Fatty Liver Disease ◽

Serum Bilirubin ◽

Cross Sectional Study ◽

Sectional Study ◽

Obese Children ◽

Cross Sectional ◽

Alcoholic Fatty Liver ◽

Alcoholic Fatty Liver Disease

As in adults, obesity also plays a central role in the development of metabolic syndrome (MS) in children. Non-alcoholic fatty liver disease (NAFLD) is considered a manifestation of MS. Not only MS but also NAFLD seem to be inversely associated with serum bilirubin concentrations, an important endogenous tissue protector when only mild elevated. The aim of the study was to evaluate the association between serum bilirubin levels and the prevalence of MS and NAFLD in Italian obese children and adolescents. A retrospective cross-sectional study was performed in 1672 patients aged from 5 to 18 years. Clinical and laboratory parameters were assessed. NAFLD was measured by liver ultrasonography. The study was approved by the Ethical Committee of the Istituto Auxologico Italiano (research project code 1C021_2020, acronym BILOB). MS was present in 24% and fatty liver (FL) in 38% of this population. Bilirubin was not associated with FL and MS as a whole, but it was inversely associated only with selected components of MS, i.e., large WC, high blood pressure and high triglycerides. Our data suggest that bilirubin is not protective against MS and NAFLD in the presence of severe obesity.

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Radiation effects on atherosclerosis in atomic bomb survivors: a cross‐sectional study using structural equation modeling

European Journal of Epidemiology ◽

10.1007/s10654-021-00731-x ◽

2021 ◽

Vol 36 (4) ◽

pp. 401-414

Author(s):

Tomoki Nakamizo ◽

John Cologne ◽

Kismet Cordova ◽

Michiko Yamada ◽

Tetsuya Takahashi ◽

...

Keyword(s):

Arterial Stiffness ◽

Radiation Exposure ◽

Structural Equation ◽

Atomic Bomb ◽

Cross Sectional Study ◽

Equation Modeling ◽

Study Cohort ◽

Sectional Study ◽

Cross Sectional ◽

Atomic Bomb Survivors

AbstractPast reports indicated that total-body irradiation at low to moderate doses could be responsible for cardiovascular disease risks, but the mechanism remains unclear. The purpose of this study was to investigate the association between radiation exposure and atherosclerosis, an underlying pathology of cardiovascular diseases, in the Japanese atomic bomb survivors. We performed a cross-sectional study measuring 14 clinical-physiological atherosclerosis indicators during clinical exams from 2010 to 2014 in 3274 participants of the Adult Health Study cohort. Multivariable analyses were performed by using a structural equation model with latent factors representing underlying atherosclerotic pathologies: (1) arterial stiffness, (2) calcification, and (3) plaque　as measured with indicators chosen a priori on the basis of clinical-physiological knowledge. Radiation was linearly associated with calcification (standardized coefficient per Gy 0.15, 95 % confidence interval: CI [0.070, 0.23]) and plaque (0.11, 95 % CI [0.029, 0.20]), small associations that were comparable to about 2 years of aging per Gy of radiation exposure, but not with arterial stiffness (0.036, 95 % CI [− 0.025, 0.095]). The model fitted better and had narrower confidence intervals than separate ordinary regression models explaining individual indicators independently. The associations were less evident when the dose range was restricted to a maximum of 2 or 1 Gy. By combining individual clinical-physiological indicators that are correlated because of common, underlying atherosclerotic pathologies, we found a small, but significant association of radiation with atherosclerosis.

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Association between soil heavy metals and fatty liver disease in men in Taiwan: a cross sectional study

BMJ Open ◽

10.1136/bmjopen-2016-014215 ◽

2017 ◽

Vol 7 (1) ◽

pp. e014215 ◽

Cited By ~ 12

Author(s):

Yen-Chih Lin ◽

Ie-Bin Lian ◽

Chew-Teng Kor ◽

Chia-Chu Chang ◽

Pei-Yuan Su ◽

...

Keyword(s):

Heavy Metals ◽

Liver Disease ◽

Fatty Liver ◽

Fatty Liver Disease ◽

Cross Sectional Study ◽

Sectional Study ◽

Cross Sectional ◽

Soil Heavy Metals

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Outcomes of Nonalcoholic Fatty Liver Disease In Covid Positive Diabetic Patients: Cross Sectional Study

10.53350/pjmhs2115123241 ◽

2021 ◽

Vol 15 (12) ◽

pp. 3241-3243

Author(s):

Azhar Hussain ◽

Mehwish Iftikhar ◽

Amna Rizvi ◽

Muhammad Latif ◽

Muhammad Javed Ahmed ◽

...

Keyword(s):

Liver Disease ◽

Fatty Liver ◽

Nonalcoholic Fatty Liver Disease ◽

Fatty Liver Disease ◽

Statistical Significance ◽

Cross Sectional Study ◽

Diabetic Patients ◽

Sectional Study ◽

Cross Sectional ◽

Nonalcoholic Fatty Liver

Background: SARS-CoV-2 principally invades the respiratory system. ACE receptor are also abundant throughout the hepatobiliary system and their increased expression on hepatocyte make patients with NAFLD more vulnerable. Aim: To see outcomes of COVID positive diabetic patients suffering from Nonalcoholic fatty liver disease (NAFLD). Study design: Cross Sectional Study. Methodology: 150 diabetic and COVID PCR positive were recruited from COVID ward of Services Hospital in Lahore. Clinical parameters like BMI, SpO2, Hepatomegaly and lab parameters like HbA1C, AST ALT were noted in spreadsheet. Statistical analysis was done using SPSS v.25. Statistical significance for difference in proportions is calculated using Pearson’s Chi-Squared test. P less than 0.05 was considered statistically significant. Results: Around 84(56%) were males and 66(44%) females, smoked were 27(18%), mean age (years) was 59.7333 ±11.35023, mean BMI (kg/m²) was 30.1425±7.30673, 87(58%) patients had NAFLD, who experienced sever disease (53.2%; x^2=0.010) and more mortalities (60.2%;x^2=0.453) as compared to those who do not had condition. Conclusion: We concluded that NAFLD makes COVID-19 infected patients more fragile. Such patients experienced sever disease and more mortalities however need of mechanical ventilation remains almost equal between those who has NAFLD and those who didn’t had. Keywords: Nonalcoholic fatty liver disease, COVID-19, Diabetes, Mortality and Severity.

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