Characteristics of human papillomaviruses distribution in Guizhou Province, China

Abstract Background Human papillomavirus (HPV) is one of the most common sexually transmitted viruses. Data about HPV infection in Guizhou is limited. Methods 56,768 cervical samples were collected and genotyped for 15 main high risk and 6 main low risk HPV types. Results 16.95% (9623/56768) of samples were HPV positive; 90.70% (8728/9623) of HPV positive women were infected by high risk HPV. High risk and high risk mix infection (1458; 70.85%) was the most common mix HPV infection type. The highest HPV detection rate was found in age group 41–45 years old (detection rate = 17.89%) (χ2 = 204.77; P < 0.001); the highest within-group HPV infection rates were found in the ≤20 (25.62%) and ≥ 61 (24.67%) years old age groups, the lowest within-group HPV infection rate was found in the 31–35 years old age group (15.02%). The highest mix infection proportions were found in the ≥61 (36.06%) and ≤ 20 (33.63%) years old age groups (χ2 = 111.21; P < 0.001), the lowest mix infection proportion was found in the 41–45 (17.42%) years old age group. The highest high risk infection proportions were found in the 26–30 (92.98%), ≥61 (92.68%), and 36–40 (92.16%) years old age groups (χ2 = 31.72; P < 0.001), the lowest high risk infection proportion was found in the ≤20 (84.96%) years old age group. HPV infection rates varied with seasons in Guizhou. Conclusions Characteristics of HPV distribution in Guizhou were identified. There were significant differences in HPV distribution among age groups, prevention strategies should be adjusted according to the characteristics.

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Epidemiological Characteristics and Genotypes of Human Papillomavirus Infection in Mianyang

Proceedings of Anticancer Research ◽

10.26689/par.v5i6.2808 ◽

2021 ◽

Vol 5 (6) ◽

pp. 61-67

Author(s):

Daping Song ◽

Min Min ◽

Pingjing Guo ◽

Xuemei Zhou

Keyword(s):

High Risk ◽

Infection Rate ◽

Age Groups ◽

Hpv Infection ◽

Low Risk ◽

Multiple Infection ◽

Infection Rates ◽

High Risk Hpv ◽

Epidemiological Characteristics ◽

Risk Infection

Objective: To investigate the epidemiological characteristics and genotypes of human papillomavirus (HPV) infection in Mianyang. Methods: The cervical samples of 27,040 patients, who visited the Department of Gynecology of The Third Hospital of Mianyang from January 2018 to January 2020, were collected. Results: The HPV-positive infection rate was 21.40% (5,787/27,040); the single HPV infection rate was 72.04% (4,169/5,787); the double HPV infection rate was 19.73% (1,142/5,787); the triple and above HPV infection rate was 8.22% (476/5,787); the top five high-risk HPV subtypes with the highest infection rates were HPV52, 16, 58, 53, and 51, while the top five low-risk HPV subtypes with the highest infection rates were HPV81, 42, 43, 6, and 11; there were significant differences in the HPV-positive infection rate, high-risk infection rate, low-risk infection rate, and multiple infection rate among different age groups (P < 0.05). Conclusion: The HPV infection rate in Mianyang was 21.4%, in which the majority of the cases were single infection; the high-risk HPV subtypes were HPV52, 16, 58, 53, and 51; the HPV-positive infection rate, high-risk infection rate, low-risk infection rate, and multiple infection rate were high in the middle but low at both ends in the context of age distribution; the top three age groups with the highest infection rates were 45-49, 40-44, and 30-34.

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Prevalence of high-risk human papillomavirus in uterine cervical lesions among older Japanese women.

Journal of Clinical Oncology ◽

10.1200/jco.2012.30.15_suppl.5084 ◽

2012 ◽

Vol 30 (15_suppl) ◽

pp. 5084-5084

Author(s):

Kazuhiro Takehara ◽

Hiroko Nakamura ◽

Osamu Samura ◽

Tomoya Mizunoe ◽

Akihisa Saito ◽

...

Keyword(s):

High Risk ◽

Age Groups ◽

Hpv Infection ◽

Japanese Women ◽

Older Age ◽

Age Group ◽

Hpv 16 ◽

Younger Age ◽

Hpv Genotypes ◽

High Risk Hpv

5084 Background: To estimate the prevalence and genotypes of high-risk human papillomavirus (HPV) among older Japanese women, using liquid-based cytology (LBC). Methods: ThinPrep LBC specimens were collected from 11,039 Japanese women (age range, 14-98 years). After classifying cytodiagnosis, specimens were analyzed for HPV DNA using the multiplex polymerase chain reaction method. Cervical smear specimens from 1,302 women showed positive results. To examine the prevalence of HPV in women defined as negative for intraepithelial lesion or malignancy (NILM), 2,563 samples were randomly selected from the remaining 9,737 women. Comparisons were made between women ≥50 years of age (older age group) and women <50 years of age (younger age group). Written informed consent was obtained from all patients. In this study, the high-risk HPV genotypes encountered were 16, 18, 31, 33, 35, 45, 52, and 58. Results: In the older age group with abnormal smear findings, HPV genotypes were detected in 49.7% (148/298), including high-risk HPV genotypes in 40.9% (122/298). In the younger age group with abnormal smear findings, HPV genotypes were detected in 71.7% (720/1004), including high-risk HPV genotypes in 58.1% (583/1,004). In NILM, HPV-positive rates were 4.5% (39/873) in the older age group and 11.8% (199/1,690) in the younger age group. In high-grade squamous intraepithelial lesion (HSIL) or more severe cytological findings, HPV genotypes of each group (older age group/younger age group) were detected in 61.7%/83.1%, and high-risk HPV genotypes were detected in 56.4%/74.7% of women. In positive cervical smears, HPV 16 was the most frequently detected (28.5%) in the younger age group, while HPV 52 (31.3%) and 58 (27.2%) were detected more frequently than HPV 16 (18.4%) in the older age group. Conclusions: In Japan, although HPV infection as a cause of abnormal cervical cytology is more frequent among younger age groups than in older age groups, high-risk HPV infection was more highly associated with older individuals (older age group/younger age group: abnormal smear findings, 82.4%/81.0%; HSIL or more severe cytological findings, 91.3%/89.9%). In older age groups, HPV 52 and 58 were more frequent than HPV 16.

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Retrospective Analysis of Prevalence of High-risk and Low-risk Human Papillomavirus (HPV) Genotypes in Iranian Women During 2013-2016

Asian Pacific Journal of Cancer Biology ◽

10.31557/apjcb.2017.2.4.85-90 ◽

2017 ◽

Vol 2 (4) ◽

pp. 85-90 ◽

Cited By ~ 1

Author(s):

Siavash Chalabiani ◽

Mina Khodadad Nazari ◽

Mahdi Shabani ◽

Neda Razavi Davoodi ◽

Abdolfattah Sarafnejad ◽

...

Keyword(s):

High Risk ◽

Age Groups ◽

Hpv Infection ◽

Low Risk ◽

Age Group ◽

Cancer Etiology ◽

Cross Sectional ◽

Hpv Dna ◽

Hpv Prevalence ◽

Hpv Genotypes

Background and objective: Considering the importance of HPV in cancer etiology, awareness of HPV prevalence and frequency of high-risk genotypes could help improve health care system management. We analyzed HPV prevalence in women forms different provinces of Iran that is the largest sample till now. Material and Methods: In this retrospective cross-sectional study, 2969 outpatient and suspicious women aged 17- 78 referred to Noor pathobiology laboratory from 24 provinces of Iran were studies. DNA extraction and PCR were performed on samples and then HPV genotypes were also determined using hybridization kit. Results: HPV DNA was detected in 29.3% of valid liquid-based samples. Among HPV positive cases, 67.2% and 52.0% accounted for high-risk and low-risk HPV subtypes, respectively. In patients with high-risk HPV types, HPV16 was confirmed as predominate type (30.5%) followed by HPV53 (17.3%) and HPV39 (13.3 %). HPV6 was found as the most common low-risk HPV type with 60.6% frequency rate followed by HPV11 (17.9%) and HPV81 (8.6%) in this age group. It was apparent that age group >25 years accounted the highest frequency of HPV positivity. The prevalence of HPV was significantly different among different age groups (p<0.0001). Conclusion: It can be concluded that HPV infection is currently at a considerable high level in Iran. Looking at the high risk and oncogenic HPV subtypes frequency especially in younger age groups, a concern could be noticed about HPV relevant cancers which can be prevented by commercial and approved HPV vaccines.

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Human papillomavirus infection and follow-up on positive results in 7222 female samples obtained from 2016 to 2019 in Hefei, China

PeerJ ◽

10.7717/peerj.10179 ◽

2020 ◽

Vol 8 ◽

pp. e10179

Author(s):

Liduo Peng ◽

Liping Yin ◽

Yaqian Dai ◽

Yuanjing Peng ◽

Yuanhong Xu ◽

...

Keyword(s):

Human Papillomavirus ◽

High Risk ◽

Age Groups ◽

Hpv Infection ◽

Single Infection ◽

Cervical Lesions ◽

Positive Rate ◽

Cervical Cells ◽

Risk Infection

Background Human papillomavirus (HPV) infection rates in women vary regionally. This study analyzed HPV infection in women of different age groups in Hefei, China, performed follow-up on positive cases, and discussed infection prognoses. Methods Samples (7,222) of exfoliated cervical cells were collected in Hefei and tested with an HPV assay kit against 27 HPV genotypes. Statistical software was used to analyze the data. Results The total positive rate of infection was 17.13% (1,068 women), and the 51–60-year age group had the highest HPV infection rate (19.82%). There were statistically significant differences between rates in the 21–30 and 31–40 (P = 0.002), 21–30 and 41–50 (P = 0.0003), 21–30 and 51–60 (P = 0.00003), and 51–60 and >60 age groups (P = 0.046). High-risk infection (15.67%) and single infection (13.01%) were the main types of HPV infection. The dominant genotypes of high-risk infection were HPV 52 (2.42%), HPV 16 (2.01%), HPV 53 (1.43%), HPV 58 (1.32%) and HPV 66 (1.01%). We conducted follow-up on cases in 69 of 94 women who had a history of 1–4 years of positive infection, and in 18 (seven treated, 11 untreated) patients, infection status turned negative (26.09%). Seventeen of the fifty-one women whose infections did not turn negative received treatment. Persistent infection was predominantly observed in high-risk genotypes (56 of 69). Conclusions The results recommend that women in Hefei improve health awareness and receive a 9-valent vaccine. Additionally, women with persistent infections should consult a gynecologist to prevent cervical lesions.

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Male papillomavirus infection and genotyping in the Qingyuan area

Virology Journal ◽

10.1186/s12985-020-01423-w ◽

2020 ◽

Vol 17 (1) ◽

Author(s):

Wei-Guo Yin ◽

Meng Yang ◽

Lei Peng ◽

Yan-Mei Liu ◽

Bin Cheng ◽

...

Keyword(s):

High Risk ◽

Infection Rate ◽

Detection Rate ◽

Blot Hybridization ◽

Hpv Infection ◽

Low Risk ◽

Single Infection ◽

Positive Detection Rate ◽

Infection Types ◽

Risk Infection

Abstract Background This study aims to screen the male human papillomavirus (HPV) infection status and genotyping in Qingcheng District, Qingyuan City, Guangdong Province, China to provide a reference basis for formulating prevention strategies for HPV infection. Methods The present study collected urethral epithelium or scraped penile epidermis from high-risk male patients in Qingyuan People's Hospital during the last five years, extracted DNA fragments using the boiling method, and detected 23 types of HPV genotypes by PCR-reverse blot hybridization. Results The positive detection rate was 54.31% of 1044 males with high risk of HPV (567/1044). Among these males, the positive detection rate of HPV was the highest in patients initially diagnosed with warts, and the rate was 66.47%. Five main HPV types are identified as follows: HPV6 18.87% (197/1044), HPV11 10.25% (107/1044), HPV52 8.81% (92/1044), HPV16 6.90% (72/1044), and HPV51 5.08% (53/1044). Among these HPV-infected patients, single infection mainly by low-risk HPV6 and HPV11 accounted for 56.61% (321/567); high- and low-risk combined HPV co-infections accounted for 29.10% (165/567). The HPV infected patients was mainly between 21 and 40 years old, and the HPV infection rate was higher with increased age. Conclusions The HPV infection rate in the Qingyuan area is higher than in other areas and the main infection is single infection. Furthermore, HPV52, HPV16, and HPV51 are the main high-risk infection types, while HPV6 and HPV11 are the main low-risk infection types.

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Genotype distribution characteristics of high-risk human papillomaviruses in women from Shanghai, China

Epidemiology and Infection ◽

10.1017/s0950268815002721 ◽

2015 ◽

Vol 144 (7) ◽

pp. 1482-1489 ◽

Cited By ~ 12

Author(s):

Y. GU ◽

M. YI ◽

Y. XU ◽

H. ZHAO ◽

F. FU ◽

...

Keyword(s):

High Risk ◽

Vaccination Strategy ◽

Hpv Infection ◽

Human Papillomaviruses ◽

Low Risk ◽

Multiple Infection ◽

Genotype Distribution ◽

Infection Rates ◽

Control And Prevention ◽

High Risk Hpv

SUMMARYHigh-risk human papillomaviruses (HPVs) are highly prevalent worldwide, and HPV genotype distribution varies regionally. Molecular surveys of HPVs are important for effective HPV control and prevention. Fifteen high-risk HPV strains (16, 18, 31, 33, 35, 39, 45, 51, 52, 53, 56, 58, 59, 66, 68) and six low-risk HPV strains (HPV6, 11, 42, 43, 44, CP8304) were detected by cervical cytology from 10 501 subjects. High-risk HPVs, low-risk HPVs, and both high- and low-risk HPVs were detected in 14·5%, 2·8%, and 2·4% of cases, respectively. Of 1782 subjects with high-risk HPV infection, 75·5%, 18·1%, and 6·4% were infected with one, two, and ⩾3 strains of high-risk HPVs, respectively. HPV52, HPV16, and HPV58 were the top three most dominant high-risk HPV genotypes in our population with positivity rates of 23·0%, 17·7% and 16·9%, respectively. Multiple infection was common, with significantly higher co-infection rates of HPV58/HPV33 (12·9%) and HPV58/HPV52 (11·3%). Further data comparisons showed that HPV genotype distribution varied markedly between domestic and international regions. In conclusion, a monolithic vaccination strategy is obviously impractical, and regional HPV surveillance is essential to optimize current HPV control and prevention.

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HPV and Other Microbiota; Who’s Good and Who’s Bad: Effects of the Microbial Environment on the Development of Cervical Cancer—A Non-Systematic Review

Cells ◽

10.3390/cells10030714 ◽

2021 ◽

Vol 10 (3) ◽

pp. 714

Author(s):

Matthias Läsche ◽

Horst Urban ◽

Julia Gallwas ◽

Carsten Gründker

Keyword(s):

Systematic Review ◽

Cervical Cancer ◽

High Risk ◽

Cervical Carcinoma ◽

Hpv Infection ◽

Human Papillomaviruses ◽

Inflammatory Reactions ◽

Metabolic Signalling ◽

Microbial Environment ◽

High Risk Hpv

Cervical cancer is responsible for around 5% of all human cancers worldwide. It develops almost exclusively from an unsolved, persistent infection of the squamocolumnar transformation zone between the endo- and ecto-cervix with various high-risk (HR) human papillomaviruses (HPVs). The decisive turning point on the way to persistent HPV infection and malignant transformation is an immune system weakened by pathobionts and oxidative stress and an injury to the cervical mucosa, often caused by sexual activities. Through these injury and healing processes, HPV viruses, hijacking activated keratinocytes, move into the basal layers of the cervical epithelium and then continue their development towards the distal prickle cell layer (Stratum spinosum). The microbial microenvironment of the cervical tissue determines the tissue homeostasis and the integrity of the protective mucous layer through the maintenance of a healthy immune and metabolic signalling. Pathological microorganisms and the resulting dysbiosis disturb this signalling. Thus, pathological inflammatory reactions occur, which manifest the HPV infection. About 90% of all women contract an HPV infection in the course of their lives. In about 10% of cases, the virus persists and cervical intra-epithelial neoplasia (CIN) develops. Approximately 1% of women with a high-risk HPV infection incur a cervical carcinoma after 10 to 20 years. In this non-systematic review article, we summarise how the sexually and microbial mediated pathogenesis of the cervix proceeds through aberrant immune and metabolism signalling via CIN to cervical carcinoma. We show how both the virus and the cancer benefit from the same changes in the immune and metabolic environment.

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Clinical and radiological imaging as prognostic predictors in COVID-19 patients

Egyptian Journal of Radiology and Nuclear Medicine ◽

10.1186/s43055-021-00470-9 ◽

2021 ◽

Vol 52 (1) ◽

Author(s):

Maha Ibrahim Metwally ◽

Mohammad Abd Alkhalik Basha ◽

Mohamed M. A. Zaitoun ◽

Housseini Mohamed Abdalla ◽

Hanaa Abu Elazayem Nofal ◽

...

Keyword(s):

Oxygen Saturation ◽

Old Age ◽

Fatal Outcome ◽

Age Groups ◽

Lower Lobe ◽

Chest Ct ◽

Imaging Features ◽

Age Group ◽

Significant Relation ◽

Ct Features

Abstract Background Since the announcement of COVID-19 as a pandemic infection, several studies have been performed to discuss the clinical picture, laboratory finding, and imaging features of this disease. The aim of this study is to demarcate the imaging features of novel coronavirus infected pneumonia (NCIP) in different age groups and outline the relation between radiological aspect, including CT severity, and clinical aspect, including age, oxygen saturation, and fatal outcome. We implemented a prospective observational study enrolled 299 laboratory-confirmed COVID-19 patients (169 males and 130 females; age range = 2–91 years; mean age = 38.4 ± 17.2). All patients were submitted to chest CT with multi-planar reconstruction. The imaging features of NCIP in different age groups were described. The relations between CT severity and age, oxygen saturation, and fatal outcome were evaluated. Results The most predominant CT features were bilateral (75.4%), posterior (66.3%), pleural-based (93.5%), lower lobe involvement (89.8%), and ground-glass opacity (94.7%). ROC curve analysis revealed that the optimal cutoff age that was highly exposed to moderate and severe stages of NCIP was 38 years old (AUC = 0.77, p < 0.001). NCIP was noted in 42.6% below 40-year-old age group compared to 84% above 40-year-old age group. The CT severity was significantly related to age and fatal outcome (p < 0.001). Anterior, centrilobular, hilar, apical, and middle lobe involvements had a significant relation to below 90% oxygen saturation. A significant negative correlation was found between CT severity and oxygen saturation (r = − 0.49, p < 0.001). Crazy-paving pattern, anterior aspect, hilar, centrilobular involvement, and moderate and severe stages had a statistically significant relation to higher mortality. Conclusion The current study confirmed the value of CT as a prognostic predictor in NCIP through demonstration of the strong relation between CT severity and age, oxygen saturation, and the fatal outcome. In the era of COVID-19 pandemic, this study is considered to be an extension to other studies discussing chest CT features of COVID-19 in different age groups with demarcation of the relation of chest CT severity to different pattern and distribution of NCIP, age, oxygen saturation, and mortality rate.

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Neuropsychological Differences Related to Age in Dementia with Lewy Bodies

Dementia and Geriatric Cognitive Disorders Extra ◽

10.1159/000477296 ◽

2017 ◽

Vol 7 (2) ◽

pp. 188-194 ◽

Cited By ~ 2

Author(s):

Yasuhiro Nagahama ◽

Tomoko Okina ◽

Norio Suzuki

Keyword(s):

Old Age ◽

Memory Impairment ◽

Dementia With Lewy Bodies ◽

Memory Performance ◽

Oldest Old ◽

Age Groups ◽

Lewy Bodies ◽

Age Group ◽

Recent Memory ◽

Better Than

Background/Aims: To examine the influence of age on neuropsychological performances in dementia with Lewy bodies (DLB) and Alzheimer disease (AD) patients. Methods: We examined memory, executive, and visuo-constructional performances in 202 DLB patients and 236 AD patients. We divided the subjects into three age groups (65–74, 75–84, and 85–95 years old), and evaluated the differences in neuropsychological performances. Results: Recent memory in the DLB group was significantly better than that in the age-matched AD group when comparing the age groups 65–74 years and 75–84 years; however, memory impairment in the DLB patients in the age group 85–95 years was comparable with that in the age-matched AD patients. In contrast to recent memory, the other assessed neuropsychological performances, such as visuospatial and executive functions, showed no significant change in differences between the DLB and AD groups with advancing age. Conclusion: Our study revealed that the nature of memory impairment in DLB patients changes according to age. DLB patients in the young-old and old-old age groups showed significantly better memory performance than the age-matched AD patients, whereas memory performance of the DLB patients in the oldest-old age group was similar to that of the age-matched AD patients. This may be associated with the increased rate of coexisting AD pathology in DLB patients with older age.

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Trends in Poliovirus Seroprevalence in Kano State, Northern Nigeria

Clinical Infectious Diseases ◽

10.1093/cid/ciy637 ◽

2018 ◽

Vol 67 (suppl_1) ◽

pp. S103-S109

Author(s):

Harish Verma ◽

Zubairu Iliyasu ◽

Kehinde T Craig ◽

Natalie A Molodecky ◽

Utibeabasi Urua ◽

...

Keyword(s):

Old Age ◽

Age Groups ◽

Significant Risk ◽

Immunization Coverage ◽

Neutralizing Antibody ◽

Age Group ◽

Parental Consent ◽

Population Immunity ◽

Antibody Titres ◽

The Impact

Abstract Background Kano state has been a protracted reservoir of poliovirus in Nigeria. Immunity trends have been monitored through seroprevalence surveys since 2011. The survey in 2015 was, in addition, intended to assess the impact of use of inactivated poliovirus vaccine (IPV). Methods It was a health facility based seroprevalence survey. Eligible children aged 6-9, 12-15 and 19-22 months of age brought to the paediatrics outpatient department of Murtala Mohammad Specialist Hospital between 19 October and 6 November 2015, were screened for eligibility. Eligible children were enrolled after parental consent, history taken, physical examination conducted, and a blood sample collected to test for neutralizing antibody titres against the three poliovirus serotypes. Results Overall, 365 results were available in the three age groups. In the 6-9-month-old age group, the seroprevalence was 73% (95% confidence interval [CI] 64-80%), 83% (95% CI 75-88%), and 66% (95% CI 57-73%) for serotypes 1, 2, and 3, respectively. In the 12-15- and 19-22-month-old age groups, seroprevalence was higher but still remained <90% across serotypes. Seroprevalence to serotypes 1 and 3 in 2015 was similar to 2014; however, for serotype 2 there was a significant improvement. IPV received in supplemental immunization activities was found to be a significant predictor of seropositivity among 6-9-month-old infants for serotypes 1 and 2. Conclusions Seroprevalence for serotypes 1 and 3 remains low (<80%) in 6-9-month-olds. This poses a significant risk for poliovirus spread if reintroduced into the population. Efforts to strengthen immunization coverage are imperative to secure and sustain high population immunity.

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