scholarly journals Hepatitis C virus DNA vaccines: a systematic review

2021 ◽  
Vol 18 (1) ◽  
Author(s):  
Ali Shayeghpour ◽  
Roya Kianfar ◽  
Parastoo Hosseini ◽  
Mehdi Ajorloo ◽  
Sepehr Aghajanian ◽  
...  
Keyword(s):  
Systematic Review ◽  
Information Science ◽  
Vaccine Development ◽  
Dna Vaccines ◽  
Therapeutic Potential ◽  
Scientific Information ◽  
Hcv Rna ◽  
Effective Measure ◽  
Public Health Burden ◽  
Persian Language

Abstract Background Vaccination against HCV is an effective measure in reduction of virus-related public health burden and mortality. However, no prophylactic vaccine is available as of yet. DNA-based immunization is a promising modality to generate cellular and humoral immune responses. The objective of this study is to provide a systematic review of HCV DNA vaccines and investigate and discuss the strategies employed to optimize their efficacies. Methods MEDLINE (PubMed), Web of Science, Scopus, ScienceDirect, and databases in persian language including the Regional Information Centre for Science & Technology (RICeST), the Scientific Information Database and the Iranian Research Institute for Information Science and Technology (IranDoc) were examined to identify studies pertaining to HCV nucleic acid vaccine development from 2000 to 2020. Results Twenty-seven articles were included. Studies related to HCV RNA vaccines were yet to be published. A variety of strategies were identified with the potential to optimize HCV DNA vaccines such as incorporating multiple viral proteins and molecular tags such as HBsAg and Immunoglobulin Fc, multi-epitope expression, co-expression plasmid utilization, recombinant subunit immunogens, heterologous prime-boosting, incorporating NS3 mutants in DNA vaccines, utilization of adjuvants, employment of less explored methods such as Gene Electro Transfer, construction of multi- CTL epitopes, utilizing co/post translational modifications and polycistronic genes, among others. The effectiveness of the aforementioned strategies in boosting immune response and improving vaccine potency was assessed. Conclusions The recent progress on HCV vaccine development was examined in this systematic review to identify candidates with most promising prophylactic and therapeutic potential.

Protective efficacy of liver fluke DNA vaccines: A systematic review and meta-analysis: Guiding novel vaccine development

2019 ◽  
Vol 267 ◽  
pp. 90-98 ◽  
Author(s):  
Rama Jayaraj ◽  
Chellan Kumarasamy ◽  
Luke Norbury ◽  
David Piedrafita ◽  
Peter Smooker
Keyword(s):  
Systematic Review ◽  
Liver Fluke ◽  
Vaccine Development ◽  
Dna Vaccines ◽  
Protective Efficacy ◽  
Meta Analysis

scholarly journals Exploring the challenges and features of implementing performance-based payment plan in hospitals: a protocol for a systematic review

2021 ◽  
Vol 10 (1) ◽  
Author(s):  
Asieh Mousaloo ◽  
Mehrdad Amir-Behghadami ◽  
Ali Janati ◽  
Masoumeh Gholizadeh
Keyword(s):  
Systematic Review ◽  
Data Extraction ◽  
Grey Literature ◽  
Scientific Information ◽  
Knowledge Network ◽  
Cochrane Library ◽  
Hand Search ◽  
Persian Language ◽  
Data Extraction Form ◽  
Barriers And Challenges

Abstract Background Implementing performance-based payment (PBP) plan has led to developing a number of significant potentialities such as performance improvement and effectiveness, quality improvement of provided services, and decline in health system expenditure in hospitals. Despite the fact that PBP plan has a variety of potential advantages, its implementation still may face some challenges. Hence, it seems crucial to identify these barriers and challenges in order to devise some strategies and interventions to pave the way for better implementation of PBP in hospitals. The aim of this proposed protocol is to identify, summarize, and synthesize the existing evidence by undertaking a systematic review to explore the challenges, barriers, and features of implementing PBP in hospitals. Methods and analysis An inclusive search of the literature will be conducted in seven international and national databases including PubMed/MEDLINE, Scopus, Cochrane Library and Web of Science, Magiran, Scientific Information Database (SID), and Barakat knowledge network system (BKNS). The search will be limited to the studies published in English or Persian language. Database search will be supplemented by hand-search of citation, reference lists, and grey literature sources. Based on the pre-established criteria in all steps of the review, two researchers will independently screen all of the retrieved studies. Any discrepancies will be resolved through a discussion between two researchers. In cases where consensus is not reached, it will be referred to a third researcher. The methodological quality of all the included studies will be appraised using the Mixed Methods Appraisal Tool (MMAT). The data will be extracted by means of using a data extraction form, which will be developed and piloted by the research team. The findings will be synthesized through directed content analysis method. Discussion With the growth and development of payment systems all over the world, it is expected that recognizing the challenges of implementing a PBP plan in hospitals will be useful in developing and designing strategies to better implement this plan. Systematic review registration PROSPERO registration number CRD42020152569

scholarly journals Radiotherapy of oligometastatic prostate cancer: a systematic review

2021 ◽  
Vol 16 (1) ◽  
Author(s):  
Paul Rogowski ◽  
Mack Roach ◽  
Nina-Sophie Schmidt-Hegemann ◽  
Christian Trapp ◽  
Rieke von Bestenbostel ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Systematic Review ◽  
Predictive Factors ◽  
Therapeutic Potential ◽  
Case Series ◽  
Current Evidence ◽  
Oligometastatic Disease ◽  
Psma Pet ◽  
Oligometastatic Prostate Cancer ◽  
Prognostic And Predictive Factors

Abstract Background Due to improved imaging sensitivity, the term “oligometastatic” prostate cancer disease is diagnosed more often, leading to an increasing interest in metastasis-directed therapy (MDT). There are two types of radiation based MDT applied when treating oligometastatic disease: (1) stereotactic body radiation therapy (SBRT) generally used for bone metastases; or (2) SBRT for isolated nodal oligometastases combined with prophylactic elective nodal radiotherapy. This review aims to summarize current evidence data, which may shed light on the optimal management of this heterogeneous group of patients. Methods A systematic review of the Medline database through PubMed was performed according to PRISMA guidelines. All relevant studies published up to November 2020 were identified and screened. Fifty-six titles were included. Besides outcome parameters, different prognostic and predictive factors were assessed, including site of metastases, time between primary treatment and MDT, use of systemic therapies, hormone sensitivity, as well as pattern of recurrence. Findings Evidence consists largely of retrospective case series and no consistent precise definition of oligometastasis exists, however, most investigators seem to acknowledge the need to distinguish between patients presenting with what is frequently called “synchronous” versus “metachronous” oligometastatic disease. Available data on radiotherapy as MDT demonstrate high local control rates and a small but relevant proportion of patients without progressive disease after 2 years. This holds true for both hormone sensitive and castration resistant prostate cancer diseases. The use of 68Ga-PSMA PET/CT for staging increased dramatically. Radiation doses and field sizes varied considerably among the studies. The search for relevant prognostic and predictive factors is ongoing. Conclusions To our best knowledge this review on oligometastatic prostate cancer included the largest number of original articles. It demonstrates the therapeutic potential and challenges of MDT for oligometastatic prostate cancer. Prospective studies are under way and will provide further high-level evidence.

scholarly journals Systematic Review of Human Poisoning and Toxic Exposures in Myanmar

2021 ◽  
Vol 18 (7) ◽  
pp. 3576
Author(s):  
Meghan A. Cook ◽  
Pardeep S. Jagpal ◽  
Khin Hnin Pwint ◽  
Lai Lai San ◽  
Saint Saint Kyaw Thein ◽  
...  
Keyword(s):  
Public Health ◽  
Systematic Review ◽  
Drugs Of Abuse ◽  
International Health ◽  
Petroleum Products ◽  
Treatment Unit ◽  
Middle Income ◽  
Public Health Burden ◽  
Toxic Exposures ◽  
Human Poisoning

The International Health Regulations (2005) promote national capacity in core institutions so that countries can better detect, respond to and recover from public health emergencies. In accordance with the ‘all hazards’ approach to public health risk, this systematic review examines poisoning and toxic exposures in Myanmar. A systematic literature search was undertaken to find articles pertaining to poisoning in Myanmar published between 1998 and 2020. A number of poisoning risks are identified in this review, including snakebites, heavy metals, drugs of abuse, agrochemicals and traditional medicine. Patterns of poisoning presented in the literature diverge from poisoning priorities reported in other lower-middle income countries in the region. The experience of professionals working in a Yangon-based poison treatment unit also indicate that frequently observed poisoning as a result of pharmaceuticals, methanol, and petroleum products was absent from the literature. Other notable gaps in the available research include assessments of the public health burden of poisoning through self-harm, household exposures to chemicals, paediatric risk and women’s occupational risk of poisoning. There is a limited amount of research available on poisoning outcomes and routes of exposure in Myanmar. Further investigation and research are warranted to provide a more complete assessment of poisoning risk and incidence.

Pharmacological activities and Therapeutic potential of kaempferitrin in medicine for the treatment of human disorders: A review of medicinal importance and health benefits

2021 ◽  
Vol 21 ◽  
Author(s):  
Dinesh Kumar Patel
Keyword(s):  
Broiler Chickens ◽  
Therapeutic Potential ◽  
Scientific Information ◽  
Aloe Vera ◽  
Crocus Sativus ◽  
Related Complication ◽  
Food Material ◽  
Biological Potential ◽  
Anti Oxidant ◽  
Anti Inflammatory

Background: Herbal drugs and their derived phytochemicals are valuable for human being as a source of vital component of food material and drugs. Flavonoids are naturally occurring phytochemical produced in plants through metabolisms and they are having anti-hyperlipidemia, anti-inflammatory, anti-oxidant and anti-apoptotic activity. Flavonoids have been identified in the fruits, nuts, vegetables, seeds, stem, flowers and tea. Kaempferol is a natural flavonoidal compound present in edible plants such as apples, broccoli, strawberries, beans, grapefruit, propolis and medicinal plants such as Aloe vera, Ginkgo biloba, Rosmarinus officinalis, Crocus sativus L., Hypericum perforatum L. Kaempferol have anti-oxidant, anti-inflammatory, anti-apoptotic, pro-apoptotic, cardio-protective and anti-cancer activities. Methods: Glycosides of kaempferol such as kaempferitrin also called kaempferol 3,7-dirhamnoside are known to be more abundant than their flavonoid monomers in plants. Various literature databases have been searched to collect all the scientific information of kaempferitrin in the present investigation and analyzed in order to know the therapeutic benefit and biological potential of kaempferitrin. Moreover all the information has been presented here in two broad sections i.e. pharmacological and analytical. Results: From the analysis of all the collected and presented information, it was found that kaempferitrin has potent insulin-mimetic potential and could be used for the treatment of diabetes and related complication. However, it has also shown anti-oxidant, anti-inflammatory, anti-convulsant, anti-osteoporotic, anti-depressant, anthelmintic, immunostimulatory and natriuretic properties and inhibits cell proliferation and apoptosis. Kaempferitrin also improves meat quality of broiler chickens. Conclusions: The presented information in this work will be valuable to justify the biological importance and therapeutic potential of kaempferitrin in the scientific field.

scholarly journals The Internationalization of the Academic Library: A Systematic Review of 25 Years of Literature on International Students

2017 ◽  
Vol 78 (3) ◽  
pp. 328 ◽  
Author(s):  
Amanda B. Click ◽  
Claire Walker Wiley ◽  
Meggan Houlihan
Keyword(s):  
Systematic Review ◽  
International Students ◽  
Academic Libraries ◽  
Information Science ◽  
Academic Library ◽  
The United States ◽  
Library And Information Science ◽  
Original Research ◽  
Journal Articles ◽  
Conference Papers

This study is a systematic review of the library and information science (LIS) literature related to international students and academic libraries. A systematic review involves the methodical collection and analysis of a body of literature and is growing in popularity in the LIS field. Three well-known LIS databases were systematically searched for articles related to the topic, and manual bibliography searches were conducted to find additional publications. Journal articles, book chapters, and conference papers were included or excluded based on established criteria. Findings show that articles published about international students and academic libraries have increased steadily between 1990 and 2014. The majority of authors are affiliated with universities and institutions in the United States, although an increase in represented countries is apparent. Fewer than half of the articles can be considered original research, and surveys are the most popular method for data collection. The LIS field—and international students—would benefit from further exploration of this topic, particularly from original research with practical implications.

scholarly journals Systematic Review of Human Poisoning and Toxic Exposures in Myanmar

2021 ◽  
Author(s):  
Meghan A Cook ◽  
Pardeep Jagpal ◽  
Khin Hnin Pwint ◽  
Lai Lai San ◽  
Saint Saint Kyaw Thein ◽  
...  
Keyword(s):  
Public Health ◽  
Systematic Review ◽  
Drugs Of Abuse ◽  
International Health ◽  
Petroleum Products ◽  
Treatment Unit ◽  
Middle Income ◽  
Public Health Burden ◽  
Toxic Exposures ◽  
Human Poisoning

The International Health Regulations (2005) promote national capacity in core institutions so countries can better detect, respond to and recover from public health emergencies. In accordance with the ‘all hazards’ approach to public health risk, this systematic review examines poisoning and toxic exposures in Myanmar. A systematic literature search was undertaken to find articles pertaining to poisoning in Myanmar published between 1998 and 2020. A number of poisoning risks are identified in this review including snakebites, heavy metals, drugs of abuse, agro-chemicals and traditional medicine. Patterns of poisoning presented in the literature diverge from poisoning priorities reported in other lower-middle income countries in the region. The expe-rience of professionals working in a Yangon-based poison treatment unit indicates that frequently observed poisoning as a result of substances including pharmaceuticals, methanol, and petroleum products were absent from the literature. Other notable gaps in the available research include assessments of the public health burden of poisoning through self-harm, household exposures to chemicals, paediatric risk and women’s occupational risk of poisoning. There is a limited amount of research available on poisoning outcomes and routes of exposure in Myanmar. Further inves-tigation and research is warranted to provide a more complete assessment of poisoning risk and incidence.

scholarly journals Safety and Efficacy of Therapeutic Taping in Primary Dysmenorrhea: a Systematic Review and Meta-analysis

2021 ◽  
Author(s):  
Bandara EMIA ◽  
Kularathne WNI ◽  
K Brain ◽  
Weerasekara I
Keyword(s):  
Systematic Review ◽  
Meta Analysis ◽  
Cochrane Library ◽  
Adult Women ◽  
Primary Dysmenorrhea ◽  
Level Of Evidence ◽  
Effective Measure ◽  
Safety And Efficacy ◽  
Pain Anxiety

Abstract Primary dysmenorrhea (PD) is a common gynecological complaint among adolescents and adult women. Various pharmacological and alternative therapies such as therapeutic taping have been used as a treatment of PD. Although several studies have been conducted to evaluate the safety and efficacy of therapeutic taping in PD, these studies have not provided adequate level of evidence related to the safety and efficacy of therapeutic taping in PD. Hence, a systematic review and meta-analysis was performed to evaluate the safety and efficacy of therapeutic taping in PD. The following databases; Medline, Cochrane Library, Embase, PEDro, CINAHL and any other gray literature sources were searched for randomized controlled trials (RCTs) that used therapeutic taping to treat PD from inception to June 2021 with the language restricted to English. Independently screened articles by two reviewers were extracted according to the study objectives. A total of nine studies were included in the systematic review, involving 577 participants. Three studies were eligible for meta-analysis to find the pooled effect of taping on pain intensity. The review indicates that therapeutic taping is an effective measure in improving pain, anxiety and quality of life of women with PD. Meta-analysis conducted to compare the effect of elastic therapeutic taping (ETT) to sham taping showed that the ETT is an effective measure in improving pain among women with PD (MD = -3.12 (95% CI -5.64, -0.60); p=0.02; I2=95 %). The quality of the studies was assessed using the PEDro scale and the included RCTs indicated a fair to good level of quality. Our systematic review and meta-analysis demonstrated that therapeutic taping is an effective intervention for PD. However, RCTs with higher quality and larger sample sizes are necessary to verify the current results of the review.

scholarly journals Parental Factors Affecting the Incidence of Infantile Colic: A Systematic Review

2021 ◽  
Vol 9 (2) ◽  
pp. 105-114
Author(s):  
Mahbobeh Firooz ◽  
◽  
Fereshteh Eidy ◽  
Zohreh Abbasi ◽  
Seyed Javad Hosseini ◽  
...  
Keyword(s):  
Risk Factors ◽  
Systematic Review ◽  
Socioeconomic Status ◽  
Observational Studies ◽  
Data Extraction ◽  
Scientific Information ◽  
Physical Factors ◽  
Infantile Colic ◽  
Parental Factors ◽  
Factors Affecting

Context: Infantile Colic (IC) is an essential problem in infancy that is influenced by factors related to infants and parents. The parental factors associated with colic have not been comprehensively assessed. Objectives: The present systematic review was conducted to investigate the parental factors affecting the incidence of IC. Data Sources: Databases, including PubMed, Web of Science, Scopus, Science Direct, Google scholar, as well as Scientific Information Database (SID), and Magiran (Iranian websites) were searched to identify all eligible papers concerning parental factors affecting infantile CI. The registration number of this study was CRD42020163518 in the PROSPERO database. Study Selection: A total of 423 relevant articles published up to the end of December 2019 were assessed. The selected articles were screened based on duplicated, eligibility criteria, and quality appraisal. The main inclusion criteria were observational studies and articles in Persian and English languages. Data Extraction: The Mesh keywords and Boolean operators included (“risk factors” OR “causality”) AND (“parents” OR “fathers” OR “mothers”) AND (“infant”) AND (“colic”). Consequently, 18 papers were thoroughly studied and the related data were extracted. Two researchers independently performed the data extraction and quality assessment based on the STROBE checklist from the observational studies. The information of selected studies was recorded in a table, i.e. consisted of authors’ names, purpose, design, population, and main results. Results: Final articles consisted of 10 prospective, 6 cross-sectional, and 2 case-control studies. Eventually, the effective factors were placed in 6 categories, as follows: psychological factors, physical factors, taking medications, perinatal factors, family’s socioeconomic status, and maternal diet. The most important characteristics predisposing to IC were parental depression, anxiety, smoking, maternal history of migraine, young age, primiparity, low family support, high socioeconomic status, high-risk pregnancies, and delivery, taking antibiotics, as well as the consumption of celery, onions, and bananas. Conclusions: Various parental factors affect the incidence of colic. Identifying these risk factors and accurate planning can be beneficial in the prevention and treatment of IC.

scholarly journals Psychological factors contributing to parenting styles: A systematic review

F1000Research ◽  
2019 ◽  
Vol 7 ◽  
pp. 906
Author(s):  
Zahra Vafaeenejad ◽  
Fourozan Elyasi ◽  
Mahmood Moosazadeh ◽  
Zohreh Shahhosseini
Keyword(s):  
Systematic Review ◽  
Attachment Style ◽  
Parenting Style ◽  
Parenting Styles ◽  
Psychological Factors ◽  
Scientific Information ◽  
Personal Characteristics ◽  
Psychological Status ◽  
Factors Affecting ◽  
Socio Economic Variables

Background: The set of strategies used by parents to put their children’s behaviors under control are called parenting styles, which can be influenced by numerous factors including socio-economic variables, cultural differences, personal characteristics, and psychological factors. These factors can differently contribute to parenting style. The purpose of this systematic review was to examine psychological factors affecting parenting style. Methods: This study was a comprehensive literature review using the keywords of parenting styles, psychological factors, and parenting to search the databases of Google Scholar, PubMed, Scopus, Web of , and Scientific Information Database. In this respect, 416 articles were extracted. 368 articles were removed after reviewing their abstracts and full text and eventually 48 articles were selected to elicit the required data. Results: Our findings were classified under two categories: factors related to parents (mental status, self-efficacy, parenting stress, perfectionism, personality traits, childhood trauma, marital satisfaction, parents’ attachment style, perceived parenting style, and substance abuse); and those related to children (child developmental and mental disability, child temperament, and anxiety). Conclusions: Considering the multiple psychological factors that affect parenting style, it is recommended to include an assessment of parent-child psychological status in family programs in order to identify the needs for -oriented care and take steps towards the development of parenting skills.

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