scholarly journals Spectral, thermal, antimicrobial studies for silver(I) complexes of pyrazolone derivatives

BMC Chemistry ◽  
2020 ◽  
Vol 14 (1) ◽  
Author(s):  
Soha F. Mohamed ◽  
Wesam S. Shehab ◽  
Aboubakr M. Abdullah ◽  
Mostafa H. Sliem ◽  
Walaa H. El-Shwiniy
Keyword(s):  
Thermal Analysis ◽  
Knoevenagel Condensation ◽  
Aromatic Aldehydes ◽  
Biological Properties ◽  
Spectroscopic Methods ◽  
Pharmacological Activities ◽  
Antimicrobial Studies ◽  
Pyrazolone Derivatives ◽  
Antibacterial And Antifungal ◽  
Antifungal Efficacy

Abstract Background Synthesize new complexes of Ag(I) to enhance efficacy or stability and also, pharmacological activities on the operation of pyrazolone's biological properties. Results Efficient and high yielding pathways starting from the versatile and readily available 3-methyl-1-phenyl-5-pyrazolone by Knoevenagel condensation of a sequence of 4-arylidene-3-methyl-1-phenyl-5-pyrazolone derivatives (2a-c) have been formed by the reaction of various substituted aromatic aldehydes Used as ligands to synthesize Ag(I) chelates. Synthesized compounds and their complexes have been characterized by elemental analysis, magnetic and spectroscopic methods (IR, 13C, 1HNMR, mass) and thermal analysis. The spectrophotometric determinations suggest distorted octaedral geometry for all complexes. Both ligands and their metal complexes have also been tested for their antibacterial and antifungal efficacy. Conclusions Newly synthesized compounds have shown potent antimicrobial activity. The results showed that the complex 's high activity was higher than its free ligands, and that Ag(I)-L3 had the highest activity.

scholarly journals ANTIMICROBIAL STUDIES OF DIFFERENT EXTRACTS OF HOLOPTELEA INTEGRIFOLIA (ROXB.) LEAVES

2020 ◽  
pp. 191-193
Author(s):  
REKHA TRIPATHI
Keyword(s):  
Aqueous Extract ◽  
Methanolic Extract ◽  
Diffusion Method ◽  
Antibacterial And Antifungal Activity ◽  
Disk Diffusion Method ◽  
Rhizoctonia Bataticola ◽  
Antimicrobial Studies ◽  
Almost All ◽  
Antibacterial And Antifungal ◽  
Antifungal Efficacy

Objective: The aim of this study was to examine various extracts of leaves of Holoptelea integrifolia against some test bacteria and test fungi. Methods: Disk diffusion method was adopted for the assessment of antimicrobial activity. Amikacin and nystatin were used as standard drugs for antibacterial and antifungal activity, respectively. Results: The screening data indicated that all four extracts showed antibacterial activity against Staphylococcus aureus, but the growth of this bacteria was inhibited the most by the aqueous extract. In the case of antifungal efficacy, all the extracts inhibited the growth of almost all the test fungi. Petroleum ether and benzene extracts showed maximum efficacy against Aspergillus flavus, whereas methanolic extract and aqueous extract inhibited the growth of Rhizoctonia bataticola significantly. Conclusion: Different extracts of leaves of H. integrifolia were significantly active against selected test fungi and they can be a harmless alternative of expensive conventional medicines.

scholarly journals Synthesis, Spectral, and Biological Properties of Copper(II) Complexes of Thiosemicarbazones of Schiff Bases Derived from 4-Aminoantipyrine and Aromatic Aldehydes

2006 ◽  
Vol 2006 ◽  
pp. 1-10 ◽  
Author(s):  
Ram K. Agarwal ◽  
Lakshman Singh ◽  
Deepak Kumar Sharma
Keyword(s):  
Schiff Bases ◽  
Room Temperature ◽  
Electrical Conductance ◽  
Aromatic Aldehydes ◽  
Transition Metal Ions ◽  
Biological Properties ◽  
Thermal Stabilities ◽  
Potential Activity ◽  
Antibacterial And Antifungal ◽  
Solid Complexes

We have synthesized a novel series of Schiff bases by condensation of 4-aminoantipyrine and various aromatic aldehydes followed by reaction with thiosemicarbazide. These thiosemicarbazones are potential ligands toward transition metal ions. The reaction of copper(II) salts with 4[N-(benzalidene)amino]antipyrinethiosemicarbazone (BAAPTS), 4[N-(4′-methoxybenzalidene) amino] antipyrinethiosemicarbozone (MBAAPTS), 4[N-(4′-dimethylamino benzalidene) amino] antipyrinethiosemicarbazone (DABAAPTS), and 4[N-(cinnamalidene) amino] antipyrinethiosemicarbazone (CAAPTS) resulted in the formation of solid complexes with the general compositionCuX2⋅(H2O)(L)(X = Cl, Br,NO3, NCS, orCH3COO; L = BAAPTS, MBAAPTS, DABAAPTS, or CAAPTS). These complexes were characterized through elemental analysis, molecular weight, electrical conductance, infrared, electronic spectra, and magnetic susceptibilities at room temperature. Copper(II) complexes with BAAPTS and MBAAPTS were screened for antibacterial and antifungal properties and have exhibited potential activity. Thermal stabilities of two representative complexes were also investigated.

scholarly journals Antibacterial and Antifungal Capacity of Three Commercially Available Mouthwashes with Different Concentrations of Chlorhexidine

2021 ◽  
pp. 380-391
Author(s):  
Daniel Chavarría-Bolaños ◽  
Vicente Esparza-Villalpando ◽  
Karol Ramírez
Keyword(s):  
Escherichia Coli ◽  
Dental Plaque ◽  
Inhibitory Effect ◽  
Low Doses ◽  
Antifungal Effect ◽  
Antibacterial And Antifungal ◽  
Antiseptic Solutions ◽  
Antifungal Efficacy ◽  
Support Evidence

Chlorhexidine was introduced almost seven decades ago and has a myriad of applications in dentistry. Few studies have evaluated the antimicrobial and antifungal capacity of different concentrations of chlorhexidine mouthwashes. Therefore, the aim of this study, was to evaluate in vitro, the antibacterial and antifungal capacity of three commercially available mouthwashes in Costa Rica, with different concentrations of chlorhexidine, 0.12%, 0.06%, and 0.03%. The experimental method selected was the Kirby-Bauer method to evaluate the antibacterial and antifungal effect of each compound by measuring the inhibitory effect on Staphylococcus aureus, Enterococcus faecalis, Escherichia coli, and Candida albicans strains, exposed to the antiseptic solutions. All samples showed some degree of antibacterial and antifungal effect. Even though we provide in vitro results, our findings are of relevance since all the species used in our experiment are microorganisms that may be present in dental plaque. Our results further support evidence that oral hygiene regimens may include mouthwashes with low doses of chlorhexidine and maintain reasonable antibacterial and antifungal efficacy.

Approaches for the synthesis, chemical modification and biological properties of N-acylphenothiazines

2021 ◽  
Vol 10 (4) ◽  
pp. 377-392 ◽  
Author(s):  
Iryna Myrko ◽  
Taras Chaban ◽  
Yulia Matiichuk ◽  
Mohammad Arshad ◽  
Vasyl Matiychuk
Keyword(s):  
Experimental Data ◽  
Chemical Modification ◽  
Medicinal Chemistry ◽  
Biological Properties ◽  
Chemotherapeutic Agents ◽  
Present Review ◽  
The Novel ◽  
Pharmacological Activities ◽  
The Past ◽  
Biological Potential

In this review we systematized the theoretical and experimental data concerning the versatile approaches for the synthesis of N-acylphenothiazines. The aim of the study was to compile the literature reported worldwide in the past 20 years. This article also reviewed the analysis of pharmacological activities of these heterocycles as one of the promising chemotherapeutic objects for the modern bioorganic and medicinal chemistry. It has been hypothesized that the enormous biological potential of these moieties is due to the radical nature in the acyl moiety. Therefore, the present review will be a good contribution to the literature and will provide the platform for the medicinal chemistry researchers to carry out more studies aiming the N-acylphenothiazine moieties as the novel chemotherapeutic agents.

(–)-Agelasidine A from Agelas clathrodes

2006 ◽  
Vol 61 (7-8) ◽  
pp. 472-476 ◽  
Author(s):  
Maria Augusta Medeiros ◽  
Ana Lourenço ◽  
Maria Regina Tavares ◽  
Maria João Marcelo Curto ◽  
Sónia Savluchinske Feio ◽  
...  
Keyword(s):  
Staphylococcus Aureus ◽  
Marine Sponge ◽  
Methanol Extract ◽  
Spectroscopic Methods ◽  
Antifungal Activities ◽  
Antibacterial And Antifungal Activities ◽  
Bacteriostatic Agent ◽  
Antibacterial And Antifungal ◽  
First Time

(-)-Agelasidine A was identified from the methanol extract of the marine sponge Agelas clathrodes for the first time together with zooanemonin, 1-carboxymethylnicotinic acid, hymenidin, mukanadins A and C, monobromodispacamide, agelasidine D, 2-amide-4-bromopyrrole, O-methyltryptophan and an agelasines mixture. The structures were characterized by spectroscopic methods. (-)-Agelasidine A was tested for antibacterial and antifungal activities and shown to act as a bacteriostatic agent as it inhibited the growth of Staphylococcus aureus and partially the growth of other bacteria.

Biological Properties of Chitosan/Collagen Composites

2013 ◽  
Vol 587 ◽  
pp. 205-210 ◽  
Author(s):  
Alina Sionkowska ◽  
Beata Kaczmarek ◽  
J. Stalinska ◽  
A.M. Osyczka
Keyword(s):  
Mechanical Properties ◽  
Thermal Analysis ◽  
Alkaline Phosphatase ◽  
Human Mesenchymal Stem Cells ◽  
Biological Properties ◽  
Cellular Activity ◽  
New Materials ◽  
Sem Images ◽  
Biological Compatibility ◽  
Chitosan Films

The properties of new materials based on the blends of collagen and chitosan were studied along with their biological compatibility. Mechanical properties, thermal analysis, FTIR spectra and SEM images were obtained for different blends of chitosan/collagen in weight ratios 75/25, 50/50, 25/75. The materials in the form of 2D sheets were then subjected to cultures of human mesenchymal stem cells (hMSC) directed toward osteogenesis with ascorbate-2-phosphate and dexamethasone. The results showed that specified amounts of components influence the mechanical properties of obtained materials. Proliferation of hMSC decreased with increasing amounts of chitosan in collagen/chitosan films. However, the cellular activity of alkaline phosphatase (ALP), a marker of preosteoblasts and active osteoblasts, for plain collagen films ALP was the highest, whereas different ratios of collagen in chitosan/collagen composites had no effect on overall good ALP activity of hMSC. Based on the presented data, we believe the obtained materials are suitable for bone tissue engineering strategies.

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