scholarly journals Clinical characteristics, imaging phenotypes and events free survival in Takayasu arteritis patients with hypertension

2021 ◽  
Vol 23 (1) ◽  
Author(s):  
Sun Ying ◽  
Wu Sifan ◽  
Wang Yujiao ◽  
Chen Rongyi ◽  
Huang Qingrong ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Blood Pressure Control ◽  
Takayasu Arteritis ◽  
Clinical Characteristics ◽  
Cox Regression ◽  
Pressure Control ◽  
Free Survival ◽  
Uncontrolled Blood Pressure ◽  
Kaplan Meier ◽  
Cluster 2

Abstract Background Hypertension occurred in 30–80% of Takayasu arteritis (TAK) patients around the world and the occurrence of hypertension might worsen the disease prognosis. This study aimed to investigate the clinical characteristics and imaging phenotypes, as well as their associations with events free survival (EFS) in Chinese TAK patients with hypertension. Methods This current research was based on a prospectively ongoing observational cohort-the East China Takayasu Arteritis (ECTA) cohort, centered in Zhongshan Hospital, Fudan University. Totally, 204 TAK patients with hypertension were enrolled between January 2013 and December 2019. Clinical characteristics and imaging phenotypes of each case were evaluated and their associations with the EFS by the end of August 30, 2020, were analyzed. Results Severe hypertension accounted for 46.1% of the entire population. Three specific imaging phenotypes were identified: Cluster 1: involvement of the abdominal aorta and/or renal artery (27.5%); Cluster 2: involvement of the ascending aorta, thoracic aorta, the aortic arch, and/or its branches (18.6%); and Cluster 3: combined involvement of Cluster 1 and 2 (53.9%). Clinical characteristics, especially hypertensive severity, differed greatly among the three imaging clusters. In all, 187 patients were followed up for a median of 46 (9–102) months; 72 events were observed in 60 patients (1–3 per person). The overall blood pressure control rate was 50.8%, and the EFS was 67.9% by the end of the follow-up. Multivariate Cox regression indicated that controlled blood pressure (HR = 2.13, 95% CI 1.32–3.74), Cluster 1 (HR = 0.69, 95% CI 0.48–0.92) and Cluster 3 (HR = 0.72, 95% CI 0.43–0.94) imaging phenotype was associated with the EFS. Kaplan–Meier curves showed that patients with controlled blood pressure showed better EFS (p = 0.043). Furthermore, using cases with Cluster 1 imaging phenotype and controlled blood pressure as reference, better EFS was observed in patients with Cluster 2 phenotype and controlled blood pressure (HR = 2.21, 95%CI 1.47–4.32), while the case with Cluster 1 phenotype plus uncontrolled blood pressure (HR = 0.64, 95%CI 0.52–0.89) and those with Cluster 3 phenotype and uncontrolled blood pressure (HR = 0.83, 95%CI 0.76–0.92) suffered worse EFS. Conclusion Blood pressure control status and imaging phenotypes showed significant effects on the EFS for TAK patients with hypertension.

scholarly journals Clinical characteristics, imaging phenotypes and events free survival in hypertensive Takayasu arteritis population

2021 ◽  
Author(s):  
Ying Sun ◽  
Sifan Wu ◽  
Yujiao Wang ◽  
Rongyi Chen ◽  
Qingrong Huang ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Blood Pressure Control ◽  
Takayasu Arteritis ◽  
Clinical Characteristics ◽  
Cox Regression ◽  
Pressure Control ◽  
Free Survival ◽  
Uncontrolled Blood Pressure ◽  
Kaplan Meier ◽  
Cluster 2

Abstract Background Hypertension occurred in 30–80% of Takayasu arteritis (TAK) patients around the world and the occurrence of hypertension might worsen the disease prognosis. This study aimed to investigate the clinical characteristics and imaging phenotypes, as well as their associations with events free survival (EFS) in hypertensive TAK population. Methods This current research was based on a prospectively on-going observational cohort-the East China Takayasu Arteritis (ECTA) cohort, centered in Zhongshan Hospital, Fudan University. Totally, 204 hypertensive TAK patients were enrolled between January 2013 and December 2019. Clinical characteristics and imaging phenotypes of each case were evaluated and their associations with the EFS by the end of August 30, 2020 were analyzed. Results Severe hypertension accounted for 46.1% of the entire population. Three specific imaging phenotypes were identified: Cluster 1: involvement of the abdominal aorta and/or renal artery (27.5%); Cluster 2: involvement of the ascending aorta, thoracic aorta, and the aortic arch and/or its branches (18.6%); and Cluster 3: combined involvement of Cluster 1 and 2 (53.9%). Clinical characteristics, especially hypertensive severity, differed greatly among three imaging clusters. In all, 187 patients were followed-up for a median of 46 (9-102) months; 127 (67.9%) cases did not experience any events, while 72 events were observed in 60 patients. The overall blood pressure control rate was 50.8%, and the EFS was 67.9% by the end of the follow-up. Multivariate Cox regression indicated that controlled blood pressure (HR = 2.13, 95% CI 1.32–3.74), Cluster 1 (HR = 0.69, 95% CI 0.48–0.92) and Cluster 3 (HR = 0.72, 95% CI 0.43–0.94) imaging phenotype was associated with the EFS. Kaplan–Meier curves showed that patients with controlled blood pressure showed better EFS (p = 0.043). Furthermore, patients had controlled blood pressure and Cluster 1 phenotype was set as reference, better EFS was observed in patients with controlled blood pressure and Cluster 2 phenotype (HR = 2.21, 95%CI 1.47–4.32), while those had uncontrolled blood pressure and Cluster 1 phenotype (HR = 0.64, 95%CI: 0.52–0.89) and those had uncontrolled blood pressure and Cluster 3 phenotype (HR = 0.83, 95%CI: 0.76–0.92) suffered worse EFS. Conclusion Blood pressure control status and imaging phenotypes showed significant effects on the EFS for hypertensive TAK.

scholarly journals POS0815 CLINICAL CHARACTERISTICS, IMAGING PHENOTYPE, AND LONG-TERM OUTCOMES OF TAKAYASU ARTERITIS PATIENTS WITH HYPERTENSION

2021 ◽  
Vol 80 (Suppl 1) ◽  
pp. 661.1-661
Author(s):  
Y. Sun ◽  
L. Ma ◽  
H. Chen ◽  
C. Rongyi ◽  
L. Jiang
Keyword(s):  
Blood Pressure ◽  
Adverse Events ◽  
Clinical Features ◽  
Takayasu Arteritis ◽  
Pressure Control ◽  
Free Survival ◽  
The World ◽  
Cluster 2

Background:Hypertension occurred in 30-80% of TAK patients around the world. The occurrence of hypertension might severely worsen TAK prognosis. Nevertheless, data describing the specific imaging features in hypertensive TAK patients and the associations between hypertensive severity, blood pressure control status and long-term outcome were still lacking.Objectives:To investigate the characteristics and associations of hypertensive characteristics with adverse events-free survival in Takayasu arteritis (TAK) patients with hypertension.Methods:This research was based on a prospectively on-going observational cohort-East China Takayasu Arteritis (ECTA) cohort. In all, 618 TAK patients, who registered in the ECTA cohort up to December 2019, were enrolled. The main outcome was the adverse-events-free survival among hypertensive TAK patients during the follow-up ended on August 2020.Results:Totally, 204 (33.0%) patients suffered from hypertension, with 48 (23.5%), 62 (30.4%), and 94 (46.1%) mild, moderate, and severe hypertension, respectively. Cluster analysis indicated three imaging phenotypes for hypertensive TAK patients: Cluster 1: involvement of the abdominal aorta and/or renal artery (n=56, 27.5%); Cluster 2: involvement of the ascending aorta, thoracic aorta, and the aortic arch and its branches (n=38, 18.6%); Cluster 3: combined involvement of Cluster 1 and Cluster 2 (n=111, 54.4%). By the end of the follow-up, the blood pressure control rate was 50.8%, while the adverse-events-free survival was 67.9% in the entire hypertensive population. Multivariate Cox regression analysis indicated that well-controlled blood pressure (HR=2.13, 95%CI 1.32–3.78, p=0.047), co-existence of severe aortic valve regurgitation (HR=0.87, 95%CI 0.64–0.95, p=0.043), Cluster 1 (HR=0.69, 95%CI 0.48–0.92, p=0.017) and Cluster 3 (HR=0.72, 95%CI 0.43–0.94, p=0.048) imaging phenotype was associated with the adverse-events-free survival.Conclusion:Patients with controlled hypertension showed better adverse-events-free survival, while those with the Cluster 1 imaging phenotype were more likely to suffer from worse adverse-events-free survival. Hypertension occurred in 30-80% of TAK patients around the world. The occurrence of hypertension might severely worsen TAK prognosis.References:[1]Johnston SL, Lock RJ, Gompels MM. Takayasu arteritis: a review. J Clin Pathol 2002; 55:481–6.[2]Watanabe Y, Miyata T, Tanemoto K. Current clinical features of new patients with Takayasu arteritis observed from a cross-country research in Japan: age and sex specificity. Circulation 2015; 132:1701–9.[3]Yilmaz N, Can M, Oner FA, et al. Impaired quality of life, disability and mental health in Takayasu’s arteritis. Rheumatol. (Oxford) 2013; 52:1898–904.[4]Laurent A, Julien H, Nicolas L, et al. Takayasu arteritis in France: a single-center retrospective study of 82 cases comparing white, North African, and black patients. Medicine 2010; 89:1–17.[5]Mwipatayi BP, Jeffery PC, Beningfield SJ, et al. Takayasu arteritis: clinical features and management: report of 272 cases. ANZ J Surg 2005; 75:110–7.Disclosure of Interests:None declared

scholarly journals Socio-demographic, Clinical Characteristics and Status of Hypertension Control among Rural Hypertensive Patients

1970 ◽  
Vol 6 (1) ◽  
pp. 5-9
Author(s):  
NU Ahmed ◽  
M Rahman ◽  
MDU Islam ◽  
SY Ali ◽  
AM Hossain ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Blood Pressure Control ◽  
Clinical Characteristics ◽  
Pressure Control ◽  
Cross Sectional Study ◽  
Hypertension Control ◽  
Cross Sectional ◽  
Hypertensive Patients ◽  
Education And Awareness ◽  
Males And Females

Hypertension is an important independent predictor of cardiovascular disease, cerebrovascular accidents and death. The prevalence of cardiovascular diseases and hypertension is rapidly increasing in developing countries. A cross sectional study was conducted among 103 hypertensive patients during December 2009 to June 2010 in Goshair Hat Upazilla of Shariatpur District to determine the socio-demographic, clinical characteristics and status of control of hypertension in rural population. Respondents were distributed more or less equally among males and females. The mean ± SD and median age of the respondents were calculated as 59.97 ± 11.12 years, with 64% of them were included in the age group of 51 to 70 years. More than half of the respondents were housewives (51.5%), which were followed by businessmen (21.4%). Every three of five patients were over weight, while 22.3% respondents were obese. One third of the respondents were also diabetic (33%). None of the 103 patients had achieved the target for SBP (Systolic blood pressure) control (<140mm of Hg) and only 21.4% of the patients had achieved the target for DBP (Diastolic blood pressure) control (<90 mm of Hg). Again none of the diabetic hypertensive patients had achieved the target for SBP control (<130mm of Hg) and only one patient had achieved the target for DBP control (<80 mm of Hg). Overall five patients were found to have uncontrolled and severe hypertension (BP >180/110 mm of Hg), all of whom were female. From this study control of hypertension was found poor among rural hypertensive population. For effectively combating the burden of hypertension in this population, education and awareness about hypertension needs to be given priority. Key words: Hypertension; socio-demographic characteristics; rural area; control of blood pressure DOI: 10.3329/fmcj.v6i1.7402 Faridpur Med. Coll. J. 2011;6(1): 05-09

scholarly journals Influence of dietary and lifestyle factors on blood pressure control among adult hypertensive patients under care in Uganda

2021 ◽  
Author(s):  
Patience Annet Nakalega ◽  
Levicatus Mugenyi ◽  
Lilian Nuwabaine ◽  
Mathius Amperiize ◽  
Barbara Kirunda Tabusibwa
Keyword(s):  
Blood Pressure ◽  
Blood Pressure Control ◽  
Pressure Control ◽  
Lifestyle Factors ◽  
Dietary Factors ◽  
Poor Adherence ◽  
Uncontrolled Blood Pressure ◽  
Hypertensive Patients ◽  
Factors Associated ◽  
Study Participants

Abstract Background Hypertension is an important worldwide public-health challenge because of its high prevalence and for being a risk factor for cerebrovascular, cardiovascular and chronic renal disease. Despite these risk factors, blood pressure control among hypertensive patients is still poor. Objectives To assess dietary and lifestyle factors associated with uncontrolled blood pressure control among a series of Ugandan hypertensive patients under care at a Kiruddu hospital.Methods A cross sectional study involving 271 adult hypertensive patients attending general outpatient hypertensive clinic were enrolled. We collected data on dietary and lifestyle factors, social demographics, BMI, comorbidities, and adherence to hypertensive medication. Dietary factors were based on recommended DASH diet including nine food items salt; grains; fruits; vegetables; nut/seeds, and legumes; dairy; meat; fat; and sweets. Questionnaires on alcohol intake, smoking status and level of physical activity were also administered. An average of the previous two Blood pressure readings were recorded while weight and height were measured for each subject at enrolment. Factors associated with uncontrolled blood pressure (>140/90mmHg) were assessed using a multivariate logistic regression model.Results The mean age of study participants was 57 years (SD ± 0.76 years), with female dominance (77.9%). Among the study participants, 121 (44.7%) had uncontrolled BP. Dietary factors that remained significantly associated with uncontrolled blood pressure with adjusted OR (95%CI) included consumption of raw salt: 4.18 (1.32-13.24) and inadequate fruit consumption (less than 7days/week): 2.18 (1.26-3.75) while clinical factors included being overweight: 2.51 (1.27-4.95) and poor adherence to antihypertensive medications prescribed: 1.82 (1.03-3.21).Conclusion The proportion of hypertensive patients with uncontrolled BP was high (44.7%). Consumption of raw salt, inadequate fruit consumption being overweight and poor adherence to antihypertensive medication were significantly associated with uncontrolled BP. From these findings, many of the factors that impact on the control of blood pressure are fortunately modifiable.

scholarly journals ASSOCIATION OF DIETARY AND LIFESTYLE FACTORS ON BLOOD PRESSURE CONTROL AMONG ADULT HYPERTENSIVE PATIENTS ATTENDING A UGANDAN TERTIARY HOSPITAL

2021 ◽  
Vol 2 (2) ◽  
pp. 103-114
Author(s):  
A. P. Nakalega ◽  
L. Mugenyi ◽  
L. Nuwabaine ◽  
M. Amperiize ◽  
K. B. Tabusibwa
Keyword(s):  
Blood Pressure ◽  
Blood Pressure Control ◽  
Pressure Control ◽  
Lifestyle Factors ◽  
Poor Adherence ◽  
Fruit Consumption ◽  
Uncontrolled Blood Pressure ◽  
Hypertensive Patients ◽  
Factors Associated ◽  
Study Participants

Hypertension is an important worldwide public-health challenge due to its high prevalence and being a risk factor for cerebrovascular, cardiovascular, and chronic renal diseases. Despite these risk factors, blood pressure control among hypertensive patients is still poor.  The main objective was to assess dietary and lifestyle factors associated with uncontrolled blood pressure control among Ugandan hypertensive patients at Kiruddu hospital. Materials and methods: A cross-sectional study involving 271 adult hypertensive patients attending the outpatient hypertensive clinic was enrolled. Data were obtained on dietary, lifestyle factors (alcohol intake, smoking status, and level of physical activity), social demographics, Body Mass Index (BMI), comorbidities, and adherence to hypertensive medication. An average of the current and previous two Blood pressure readings was recorded. Factors associated with uncontrolled blood pressure were assessed using a multivariate logistic regression model. Results: The mean age of study participants was 57 ± 0.76 years, with female dominance (77.9%). Among the study participants, 121 (44.7%) had uncontrolled BP. Dietary factors that were associated with uncontrolled blood pressure with adjusted OR (95%CI) included consumption of raw salt: 4.18 (1.32-13.24) and inadequate fruit consumption: 2.18 (1.26-3.75) while clinical factors included being overweight: 2.51 (1.27-4.95) and poor adherence to antihypertensive medications prescribed: 1.82 (1.03-3.21). Conclusion: The proportion of hypertensive patients with uncontrolled Blood Pressure was high (44.7%). Consumption of raw salt, inadequate fruit consumption, being overweight and poor adherence to antihypertensive medication were significantly associated with uncontrolled BP. From these findings, factors that were associated with the control of blood pressure are modifiable.

scholarly journals Thyroid Complications Negatively Affect Therapeutic Response and Survival in Waldenstrom Macroglobulinaemia/ Lymphoplasmacytoid Lymphoma

Blood ◽  
2021 ◽  
Vol 138 (Supplement 1) ◽  
pp. 4513-4513
Author(s):  
Xinting Hu ◽  
Hua Wang ◽  
Hongzhi Xu ◽  
Xin Liu ◽  
Ying Li ◽  
...  
Keyword(s):  
Gene Expression ◽  
Clinical Characteristics ◽  
Cox Regression ◽  
Statistical Significance ◽  
Progression Free Survival ◽  
Chi Square ◽  
Free Survival ◽  
Kaplan Meier ◽  
Chi Square Test

Abstract Introduction: Waldenström macroglobulinaemia/ Lymphoplasmacytoid lymphoma (WM/LPL) is a rare lymphoproliferative neoplasm characterized by small B lymphocytes proliferation. Abnormalities of thyroid hormones are common in clinical courses. Yet, the role of thyroid complications has not been explored in WM/LPL. Hence, the aim of this study was to investigate the clinical significance of thyroid complications in WM/LPL. Methods: 105 clinically diagnostic WM/LPL patients from Shandong Provincial Hospital were enrolled with informed consents. Baseline and clinical data concerning sex, age, International Staging System Waldenstrom Macroglobulinemia (ISSWM) score et al were collected. Chi-square test was used for comparison of clinical characteristics. The Kaplan-Meier method was used for analysis of survival outcomes. Cox regression analyses were utilized to identify prognostic-related key factors associated with overall survival (OS) and progression-free survival (PFS) in WM/LPL patients. Microarray datasets GSE6691 were obtained from Gene Expression Omnibus. Results: Over the 105 WM/LPL patients, the median overall survival (OS) was not reached and median progression-free survival (PFS) was 96 months (Figure 1A, 1B). Patients classified as complete response (CR)/ partial response (PR)/ stable disease (SD), showed better OS and PFS than patients with progression disease (PD) (Figure 1C, D). There were 13.3% of enrolled patients with mixed thyroid complications. The results of Chi-square test showed that thyroid complications were significantly associated with reduced IgM level (p=0.036) and elevated β2-macroglobulin (p=0.032). Moreover, patients without thyroid comorbidities were more likely to get overall response (CR+PR) to the first-line treatment (p=0.004). Kaplan-Meier curves showed patients with thyroid complications had significantly shorter OS (p=0.02) and PFS (p&lt;0.001) versus those without thyroid complications (Figure 1E, F). In the univariate Cox regression model, age (p=0.022), ISSWM score (p=0.014) and thyroid complications (p&lt;0.001) were significantly associated with an increased risk of progression developed. Subsequent multivariate analysis showed the presence of thyroid complications was an independent prognostic indicator for PFS in WM/LPL patients (p=0.03). However, there was no statistical significance of thyroid complications in OS. Microarray dataset analysis was conducted to further investigate the role of thyroid-related genes in WM/LPL patients. A network of interactions among thyroid-related genes and critical factors in WM/LPL, including MYD88 and CXCR4, was shown in Figure 1G. Correlations were statistically significant between SLC5A5 (p&lt;0.05), TG (p&lt;0.01), TPO (p&lt;0.01) and CXCR4 by Spearman correlation analysis (Figure 1H, I). In addition, differential gene expression analysis between the WM and normal lymphocytes was assessed (Figure 1J). Thyroid-related genes with statistical significance were annotated in the volcano plots (Figure 1K). Enrichment analysis indicated that differential genes were involving in PI3K-Akt signaling pathway and response to peptide hormone (Figure 1L). Moreover, five of them reached statistical significance, illuminating the potential importance of thyroid-related genes in WM/LPL (Figure 1M). Conclusion: Taken together, the present study was the first investigation on the role of thyroid complications in WM/LPL. Patients with thyroid complications showed worse clinical characteristics and conferred independent prognostic significance. The primary strength of this study is that it provides robust real-world evidence on the prognostic role of thyroid complications, highlighting the need to monitor and appropriately manage WM/LPL patients with thyroid complications in medical admissions. Figure 1 Figure 1. Disclosures No relevant conflicts of interest to declare.

Abstract MP73: Systolic Blood Pressure Control among Hypertensives and Incident Heart Failure: The Atherosclerosis Risk in Communities Study

Circulation ◽  
2013 ◽  
Vol 127 (suppl_12) ◽  
Author(s):  
Carlos J Rodriguez ◽  
Katrina Swett ◽  
Sunil K Agarwal ◽  
Aaron R Folsom ◽  
Laura R Loehr ◽  
...  
Keyword(s):  
Heart Failure ◽  
Blood Pressure ◽  
Systolic Blood Pressure ◽  
Cox Regression ◽  
Disease Risk ◽  
Pressure Control ◽  
Progressive Increase ◽  
Population Based ◽  
Free Survival ◽  
Intensive Group

Background: Studies document a progressive increase in heart disease risk as systolic blood pressure (SBP) rises above 115mmHg, suggesting a benefit of treatment to a SBP <120mmHg. Hypertension is a major risk factor for heart failure (HF) but whether an SBP <120mmHg lowers HF risk is unknown. Methods: Hypertensive participants at baseline (SBP/DBP >140/90mmHg, report of hypertension or taking BP medication) from ARIC, a prospective population-based study of black and white men and women from 4 US communities, were included. SBP measured at baseline and at three triennial visits was treated as a time-dependent variable and categorized as: Elevated (SBP >140), Standard (SBP 120-139) and Intensive (SBP <120). Prevalent HF at baseline was excluded. Incident HF was defined from HF hospitalization or a death certificate with an ICD-9 or ICD-10 codes. Multivariable Cox regression models included baseline age, sex, diabetes, BMI, high cholesterol, smoking and alcohol intake. Results: After median follow-up of 20.8 years, a total of 1,111 incident HF events occurred in 4,802 hypertensives. Participants with elevated SBP had less HF-free survival compared to those with intensive group (log-rank p<0.001). However, there was no difference in incident HF-free survival among those with standard vs. intensive group (log-rank p=0.08). In adjusted analysis, findings remained similar for elevated SBP (HR: 1.2; 95% CI 1.0-1.5, intensive group as referent); and for standard SBP (HR: 0.9; 95% CI 0.8-1.1, intensive group as referent). There were no differences by race and sex (p for interaction >0.05). Further adjustment for BP medication use at baseline did not significantly affect the results. Conclusion: Hypertension control is necessary to prevent HF. Our results suggest that among hypertensives, having elevated SBP carries the highest risk for HF but in this categorical analysis we observed no risk difference between the standard and intensive SBP groups.

scholarly journals Rate of blood pressure control and its determinants among adult hypertensive patients at Jimma University Medical Center, Ethiopia: Prospective cohort study

2021 ◽  
Vol 9 ◽  
pp. 205031212110060
Author(s):  
Bekalu Kebede ◽  
Legese Chelkeba ◽  
Bekalu Dessie
Keyword(s):  
Blood Pressure ◽  
Cohort Study ◽  
Data Collection ◽  
Confidence Interval ◽  
Blood Pressure Control ◽  
Medical Center ◽  
Pressure Control ◽  
Uncontrolled Blood Pressure ◽  
Hypertensive Patients ◽  
Jimma University

Introduction: Despite the fact that the goals for the management of hypertension are well-defined and effective therapies are available, control of hypertension remains poor in countries with low resources including Ethiopia. This study aimed to determine blood pressure control rate and its determinants among ambulatory adult hypertensive patients at Jimma University Medical Center. Methods: A general prospective cohort study was conducted among adult hypertensive patients who had regular follow-up at Jimma University Cardiac Clinic from 20 March to 20 June 2018. Hypertensive patients who fulfilled the inclusion criteria were selected in the first month of the data collection period. Then, only those patients who visited the clinic at the first month were consequently followed-up for the next 3 months. The Eighth Joint National Committee guideline was used to categorize controlled and uncontrolled blood pressures. Patients’ specific data were collected using a structured data collection tool. Data were analyzed using the statistical software package SPSS version 21.0. Bivariate and multivariable logistic regression analysis was used to identify independent variables influencing blood pressure control. p-values of less than 0.05 were considered statistically significant. Results: From a total of 416 patients, 237 (57.0%) were male with a mean age of 56.50 ± 11.96 years. Two hundred and fifty eight (62.0%) participants had comorbid conditions and 275 (66.1%) were on combination therapy. The rate of blood pressure control was 42.8%. Age ⩾60 years was negatively associated with uncontrolled blood pressure (adjusted odd ratio = 0.52, confidence interval = 0.31–0.88, p = 0.015). Medication non-adherence (adjusted odd ratio = 1.64, confidence interval = 1.04–2.58, p = 0.034) and non-adherence to international guidelines (adjusted odd ratio = 2.33, confidence interval = 1.49–3.64, p < 0001) were positively associated with uncontrolled blood pressure. Conclusion: The rate of blood pressure control among hypertensive patients was suboptimal. Age, clinicians’ non-adherence to international guidelines, and patients’ non-adherence to medications were independent predictors of blood pressure control. Physicians and clinical pharmacists should adhere to guidelines for better treatment and care of hypertensive patients.

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