scholarly journals Malaria outbreak investigation in Tanquae Abergelle district, Tigray region of Ethiopia: a case–control study

2019 ◽  
Vol 12 (1) ◽  
Author(s):  
Kissanet Tesfay ◽  
Belete Assefa ◽  
Alefech Addisu
Keyword(s):  
Case Control Study ◽  
Case Fatality ◽  
Case Control ◽  
P Value ◽  
Breeding Sites ◽  
Tigray Region ◽  
Mosquito Breeding ◽  
Associated Risk Factors ◽  
Malaria Outbreak ◽  
Control Study

Abstract Objective We investigated this outbreak to describe the magnitude and associated risk factors due to the malaria outbreak in Tanquae Abergelle district, Tigray, Ethiopia, in 2017. Result Case fatality rate of this study was zero. Among the 62 cases and 124 controls, the presence of mosquito breeding sites [OR = 6.56 CI (2.09–20.58) P value = 0.001], sleeping outside a home [OR = 5.06 CI (1.75–14.61) P-value = 0.003] and having unscreened window [OR = 14.89 CI (1.87–118.25) P-value = 0.011] were associated with illness in multivariate analysis.

Risk Factors Associated With Dengue Fever Outbreak in Taiz Governorate, Yemen, 2018: Case-control Study

2021 ◽  
Author(s):  
Abdulkareem Ali Hussein Nassar ◽  
Amr Abdulaziz Torbosh ◽  
Yassin Abdulmalik Mahyoub ◽  
Mohammed Abdullah Al Amad
Keyword(s):  
Risk Factors ◽  
Dengue Fever ◽  
Case Control Study ◽  
Significant Risk ◽  
Case Fatality ◽  
Case Control ◽  
Case Definition ◽  
P Value ◽  
Factors Associated ◽  
Control Study

Abstract Background: Dengue Fever (DF) is a significant health problem in Yemen especially in the coastal areas. On November 6, 2018, Taiz governorates surveillance officer notified the Ministry of Public Health and Population on an increase in the number of suspected DF in Al Qahirah and Al Mudhaffar districts, Taiz governorate. On November 7, 2018, Field Epidemiology Training Program sent a team to perform an investigation. The aims were to confirm and describe the outbreak by person, place and time in Taiz governorate, and identify its risk factors.Methodology: Descriptive and case-control study (1:2 ratio) were conducted. WHO case definition was used to identify cases in Al Qahirah or Al Mudhaffar districts during August-November 2018. Control was selected from the same districts who did not suffer from DF. Predesigned questionnaire was used to collect data related to sociodemographic, behavioral and environmental characteristics. Bivariate and multivariate backward stepwise analyses were used. The adjusted odds ratios (aOR) and 95% confidence intervals (95%CI) were calculated. A P value < 0.05 was considered as the cut point for statistically significant. Epi info version 7.2 was used.Results: A total of 50 DF cases were found. Almost 52% were males and 76% were <30 years of age. The overall attack rate was 1/10,000 of the population. Case fatality rate was 4%. In multivariate analysis, not working (aOR = 26.6, 95% CI: 6.8–104.7), not using mosquito repellent (aOR = 13.9, 95% CI:1.4–136.8), wearing short sleeves/pants (aOR = 27.3, 95% CI: 4.8–156.8), poor sanitation (aOR = 5.4, 95% CI: 1.4–20.3), presence of outdoor trees (aOR = 13.2, 95% CI: 2.8–63.0) and houses without window nets (aOR = 15.7, 95% CI: 3.9–63.4) were statistically significant risk factors associated with DF outbreak. Eleven 11 (58%) of blood samples were positive for DF IgM.Conclusions: DF outbreak in Al Qahirah and Al Mudhaffar districts, Taiz governorate was confirmed. This study provides evidence-based information regarding the identified risk factors that contributed to the occurrence of this outbreak. Raising community awareness on the importance of personal protection measures and improving the sanitation services are strongly recommended.

scholarly journals Malaria Outbreak Facilitated by Appearance of Vector-Breeding Sites after Heavy Rainfall and Inadequate Preventive Measures: Nwoya District, Northern Uganda, February–May 2018

2020 ◽  
Vol 2020 ◽  
pp. 1-10
Author(s):  
Godfrey Nsereko ◽  
Daniel Kadobera ◽  
Denis Okethwangu ◽  
Joyce Nguna ◽  
Damian Rutazaana ◽  
...  
Keyword(s):  
Heavy Rainfall ◽  
Case Control Study ◽  
Preventive Measures ◽  
Case Fatality ◽  
Case Control ◽  
Control Measures ◽  
Northern Uganda ◽  
Entire Study ◽  
Breeding Sites ◽  
Control Study

Background. Malaria is a leading cause of morbidity and mortality in Uganda. In April 2018, malaria cases surged in Nwoya District, Northern Uganda, exceeding expected limits and thereby requiring epidemic response. We investigated this outbreak to estimate its magnitude, identify exposure factors for transmission, and recommend evidence-based control measures. Methods. We defined a malaria case as onset of fever in a resident of Anaka subcounty, Koch Goma subcounty, and Nwoya Town Council, Nwoya District, with a positive rapid diagnostic test or microscopy for malaria from 1 February to 25 May 2018. We reviewed medical records in all health facilities of affected subcounties to find cases. In a case-control study, we compared exposure factors between case-persons and asymptomatic controls matched by age and village. We also conducted entomological assessments on vector density and behavior. Results. We identified 3,879 case-persons (attack rate [AR] = 6.5%) and two deaths (case-fatality rate = 5.2/10,000). Females (AR = 8.1%) were more affected than males (AR = 4.7%) (p<0.0001). Of all age groups, 5–18 years (AR = 8.4%) were most affected. Heavy rain started in early March 2018, and a propagated outbreak followed in the first week of April 2018. In the case-control study, 55% (59/107) of case-persons and 18% (19/107) of controls had stagnant water around households for several days following rainfall (ORM-H = 5.6, 95% CI = 3.0–11); 25% (27/107) of case-persons and 51% (55/107) of controls wore full extremity covering clothes during evening hours (ORM-H = 0.30, 95% CI = 0.20–0.60); 71% (76/107) of case-persons and 85% (91/107) of controls slept under a long-lasting insecticide-treated net (LLIN) 14 days before symptom onset (ORM-H = 0.43, 95% CI = 0.22–0.85); 37% (40/107) of case-persons and 52% (56/107) of controls had access to at least one LLIN per 2 household members (ORM-H = 0.54, 95% CI = 0.30–0.97). Entomological assessment indicated active breeding sites in the entire study area; Anopheles gambiae sensu lato species were the predominant vector. Conclusion. Increased vector-breeding sites after heavy rainfall and inadequate malaria preventive measures were found to have contributed to this outbreak. We recommended increasing coverage for LLINs and larviciding breeding sites in the area.

scholarly journals Factors Associated with a Malaria Outbreak at Tongogara Refugee Camp in Chipinge District, Zimbabwe, 2021: A Case-Control Study

2021 ◽  
Author(s):  
Kudzai Patience Takarinda ◽  
Simon Nyadundu ◽  
Emmanuel Govha ◽  
Addmore Chadambuka ◽  
Notion Tafara Gombe ◽  
...  
Keyword(s):  
Case Control Study ◽  
Refugee Camp ◽  
Case Control ◽  
Habitat Modification ◽  
Whole Body ◽  
Disease Notification ◽  
Breeding Sites ◽  
Factors Associated ◽  
Malaria Outbreak ◽  
Control Study

Abstract Background: Malaria is a leading cause of morbidity and mortality among forcibly displaced populations including refugees, approximately two-thirds of whom reside in malaria endemic regions. Data from the rapid disease notification system (RDNS) reports for Manicaland Province in Zimbabwe showed that despite implementation of malaria control initiatives, there was an increase in number of malaria cases above action thresholds at Tongogara Refugee Camp in Chipinge District during weeks 12-14. We investigated the malaria outbreak describing the outbreak by person, place and time, assessing malaria emergency preparedness and response and appropriateness of case management. We also determined the factors associated with contracting malaria to enable the formulation of appropriate interventions, establish control and prevent future malaria outbreaks among this vulnerable population.Methods: We conducted a 1:1 unmatched case control study involving 80 cases and 80 controls using interviewer-administered questionnaires at household level. Data was entered using Epi Data version 3.1 and analyzed using Epi InfoTM version 7.2.4 to generate medians, proportions, odds ratios and their 95% confidence intervals.Results: Malaria cases were distributed throughout the 10 residential sections within Tongogara Refugee Camp, the majority being from section 7, 28/80 (35%). Despite constituting 11% of the total population, Mozambican nationals accounted for 36/80 (45%) cases. Males constituted 47/80 (59%) among cases versus controls 43/80 (54%), p=0.524. Median age for cases was also lower compared to controls; 15 years [Interquartile range (IQR), 9-26] versus 17 years (IQR, 10-30). Several natural and manmade potential vector breeding sites were observed around the camp. Risk factors associated with contracting malaria were engaging in outdoor activities at night [AOR 4.26 (95% CI, 1.43-12.68)], wearing clothes that do not cover the whole body [AOR=2.74 (95% CI 1.04-7.22) while sleeping in a refugee housing unit reduced the risk of contracting malaria [AOR=0.18 (CI, 0.06-0.55)]. Conclusions: The malaria outbreak at Tongogara Refugee Camp reemphasizes the role of behavioral factors in malaria transmission. We recommend intensified health education to address human behaviors that expose residents to malaria and habitat modification with larviciding to eliminate mosquito breeding sites.

scholarly journals Factors associated with a malaria outbreak at Tongogara Refugee Camp in Chipinge District, Zimbabwe, 2021: A case-control study

2021 ◽  
Author(s):  
Kudzai Patience Takarinda ◽  
Simon Nyadundu ◽  
Emmanuel Govha ◽  
Addmore Chadambuka ◽  
Notion Tafara Gombe ◽  
...  
Keyword(s):  
Case Control Study ◽  
Refugee Camp ◽  
Case Control ◽  
Habitat Modification ◽  
Whole Body ◽  
Disease Notification ◽  
Breeding Sites ◽  
Factors Associated ◽  
Malaria Outbreak ◽  
Control Study

Abstract BackgroundMalaria is a leading cause of morbidity and mortality among forcibly displaced populations including refugees, approximately two-thirds of whom reside in malaria endemic regions. Data from the rapid disease notification system (RDNS) reports for Manicaland Province in Zimbabwe showed that despite implementation of malaria control initiatives, there was an increase in number of malaria cases above action thresholds at Tongogara Refugee Camp in Chipinge District during weeks 12-14. We investigated the malaria outbreak describing the outbreak by person, place and time, assessing malaria emergency preparedness and response and appropriateness of case management. We also determined the factors associated with contracting malaria to enable the formulation of appropriate interventions, establish control and prevent future malaria outbreaks among this vulnerable population.MethodsWe conducted a 1:1 unmatched case control study involving 80 cases and 80 controls using interviewer-administered questionnaires at household level. Data was entered using Epi Data version 3.1 and analyzed using Epi InfoTM version 7.2.4 to generate medians, proportions, odds ratios and their 95% confidence intervals.ResultsMalaria cases were distributed throughout the 10 residential sections within Tongogara Refugee Camp, the majority being from section 7, 28/80 (35%). Despite constituting 11% of the total population, Mozambican nationals accounted for 36/80 (45%) cases. Males constituted 47/80 (59%) among cases versus controls 43/80 (54%), p=0.524. Median age for cases was also lower compared to controls; 15 years [Interquartile range (IQR), 9-26] versus 17 years (IQR, 10-30). Several natural and manmade potential vector breeding sites were observed around the camp. Risk factors associated with contracting malaria were engaging in outdoor activities at night [AOR 4.26 (95% CI, 1.43-12.68)], wearing clothes that do not cover the whole body [AOR=2.74 (95% CI 1.04-7.22) while sleeping in a refugee housing unit reduced the risk of contracting malaria [AOR=0.18 (CI, 0.06-0.55)]. ConclusionsThe malaria outbreak at Tongogara Refugee Camp reemphasizes the role of behavioral factors in malaria transmission. We recommend intensified health education to address human behaviors that expose residents to malaria and habitat modification with larviciding to eliminate mosquito breeding sites.

scholarly journals Malaria Outbreak Facilitated by Increased Human Activities around Swamps: Kisoro District, Uganda, December 2017-March 2018

2019 ◽  
Author(s):  
Joyce Nguna ◽  
Dennis Okethwangu ◽  
Daniel Kadobera
Keyword(s):  
Malaria Elimination ◽  
Human Activities ◽  
Case Control Study ◽  
Case Control ◽  
Bed Net ◽  
Sudden Increase ◽  
Breeding Sites ◽  
Late Night ◽  
Malaria Outbreak ◽  
Control Study

Abstract Background: Malaria elimination is increasingly becoming a global priority. On 19 December 2018, a district in southwestern Uganda known to have achieved pre-elimination levels of malaria (<30 cases per month) reported a sudden increase in cases to the Ministry of Health. We investigated to determine the magnitude and scope of the outbreak and identify exposures associated with transmission. Methods:We reviewed medical records in all health facilities in the affected Kanaba and Murora sub-counties to find cases. We calculated attack rates (AR) by age, sex, and village using the projected 2016 population. In a case-control study, we compared potential exposures between case-patients, selected randomly from the line-list, and neighborhood- and age-matched asymptomatic controls. We conducted an entomological and environmental assessment of randomly-selected households and potential breeding sites of the affected sub-counties. Results: We found 3,130 malaria cases (compared with 879 cases during the same period the previous year). Persons in the age groups 10-19 (AR=14/1,000) and 20-29 (AR=12/1,000) years were the most affected. Villages closest to the swamp had the highest attack rate. In the case-control study, 89% (129/145) of case-patients and 73% (106/145) of controls reported frequent late-night mosquito bites (ORCLR=3.9; 95%CI: 1.8-8.4); 70% (102/145) of case-patients and 59% (86/145) of controls had a household size >5 (ORCLR=1.8; 95%CI: 1.04-3.1); 78% (113/145) of case-patients and 86% (125/145) of controls usually slept under a bednet (ORCLR=0.56; 95%CI: 0.29-1.1). Anopheles gambiae sensu lato was identified in breeding places around Sereri and Mpundu swamps. In total, 64% (23/36) of female adult Anopheles captured in case-patients’ households by pyrethrum spray catches were fed, suggesting low bed-net usage the previous night in the surveyed households. Conclusion: This malaria outbreak was likely propagated by favorable breeding conditions, including recent heavy rainfall, and exacerbated by new human activities around two swamps. To achieve malaria elimination, low-endemic areas should be particularly aware of activities that can lead to resurgences in malaria, such as night-time exposures, lack of bed-net usage, and human activities focused around breeding sites. We recommended increased awareness about bed-net usage and use of larvicides in the residential area and swamps to break the breeding cycle.

SERUM PROLACTINE LEVEL IN PATIENTS OF PSORIASIS VULGARIS AND ITS CORRELATION WITH DISEASE SEVERITY: A CASE-CONTROL STUDY

2019 ◽  
Vol 3 (6) ◽  
Author(s):  
Pawan Kumar Saini ◽  
Devendra Yadav ◽  
Rozy Badyal ◽  
Suresh Jain ◽  
Arti Singh ◽  
...  
Keyword(s):  
Disease Severity ◽  
Prolactin Level ◽  
Case Control Study ◽  
Statistical Significance ◽  
Case Control ◽  
Serum Prolactin ◽  
P Value ◽  
Serum Prolactin Level ◽  
R Value ◽  
Control Study

Background: Psoriasis is an autoimmune chronic inflammatory disorder affecting the skin mediated by T-lymphocytes resulting in production of cytokines which cause hyperproliferation of keratinocytes.  Several factors and hormones like Prolactin have an action similar to these cytokines in promoting the multiplication of keratinocytes and other cells like lymphocytes and epithelial cells may have a role on the etiopathogenesis of psoriasis. Aim:-The aim of study is to compare the serum Prolactin levels in patients of psoriasis with a control group. Setting and study design: This is a case-control study conducted in the department of Dermatology, Venereology and Leprosy GMC, Kota over a period of 1year from July 2017 to June 2018 Material and method: The study included 100 cases of psoriasis (60 males and 40 females) and 100 controls similar for age and sex. Serum Prolactin levels were measured by ECLIA and results were obtained. Statistical analysis: Mean and standard deviation were calculated for each variable. Statistical significance of the results was analyzed using correlation analysis (Pearson correlation coefficient) and independent samples t-test. Statistical significance was assumed at p value<0.05. Result: Serum Prolactin level was significantly higher in cases of psoriasis compared to controls (p-value <0.001). PASI score and serum Prolactin levels were found to have a positive correlation (r value = 0.337; p-value: 0.001). No significant  correlation was found between serum levels of Prolactin and duration of disease r value= -0.034, P value =0.733). Serum Prolactin level was higher in male patients compared to females patients. Conclusion:- High serum Prolactin may be a biological marker of disease severity in psoriasis and may have a role in the pathogenesis of psoriasis. Further studies with large sample size are required to confirm this hypothesis.

scholarly journals 530. COVID-19 in kidney transplant recipients: Single-center experience and case-control study

2020 ◽  
Vol 7 (Supplement_1) ◽  
pp. S332-S332
Author(s):  
Anna Hardesty ◽  
Aakriti Pandita ◽  
Yiyun Shi ◽  
Kendra Vieira ◽  
Ralph Rogers ◽  
...  
Keyword(s):  
Kidney Transplant ◽  
Case Control Study ◽  
Clinical Course ◽  
Case Series ◽  
Case Fatality ◽  
Case Control ◽  
Transplant Recipients ◽  
Kidney Transplant Recipients ◽  
Transplant Patients ◽  
Control Study

Abstract Background Organ transplant recipients (OTR) are considered high-risk for morbidity and mortality from COVID-19. Case-fatality rates (CFR) vary significantly in different case series, and some patients were still hospitalized at the time of analyses. To our knowledge, no case-control study of COVID-19 in OTR has been published to-date. Methods We captured kidney transplant recipients (KTR) diagnosed with COVID-19 between 3/1 and 5/18/2020. After exclusion of KTR on hemodialysis and off immunosuppression (IS), we compared the clinical course of COVID-19 between hospitalized KTR and non-transplant patients, matched by sex and age (controls). All patients were discharged from the hospital or died. Results 16 KTR had COVID-19. All 3 KTR off IS, who were excluded from further analyses, survived. Median age was 54 (range: 34–65) years; 5/13 KTR (38.4%) were men. Median time from transplant was 41 (range: 1–203) months. Two KTR, both transplanted &gt;10 years ago, were managed as outpatients. IS was reduced in 12/13 (92.3%), most often by discontinuation of the antimetabolite. IL6 levels were &gt;1,000 (normal: &lt; 5) pg/mL in 3 KTR. Tacrolimus or sirolimus levels were &gt;10 ng/mL in 6/9 KTR (67%) (Table 1). Eleven KTR were hospitalized (84.6%) and matched with 44 controls. One KTR, the only one treated with hydroxychloroquine, died (CFR 5.8%; 7.6% in KTR on IS; 9% in hospitalized KTR on IS). Four controls died (CFR: 9%; state CFR: 5.2%; inpatient CFR: 16.6%). There were no significant differences in length of stay or worst oxygenation status between hospitalized KTR and controls. Four KTR (30.7%), received remdesivir, 4 convalescent plasma, 3 (23%) tocilizumab. KTR received more often broad-spectrum antibiotics, convalescent plasma or tocilizumab, compared to controls (Table 2). Table 1 Table 2 Conclusion Unlike early reports from the pandemic epicenters, the clinical course and outcomes of KTR with COVID-19 in our small case series were comparable to those of non-transplant patients. Calcineurin or mTOR inhibitor levels were high, likely due to diarrhea and COVID-19-related hepatic dysfunction. Extremely high IL6 levels were common. The role of IS and potential benefits from investigational treatments remain to be elucidated. A larger multi-institutional study is underway. Disclosures All Authors: No reported disclosures

ANALISIS FAKTOR RISIKO YANG BERHUBUNGAN DENGAN KEJADIAN PNEUMONIA BALITA DI WILAYAH KERJA UPTD PUSKESMAS BANDA RAYA KOTA BANDA ACEH TAHUN 2019

2020 ◽  
Vol 6 (1) ◽  
pp. 20-28
Author(s):  
Miftahul Jannah ◽  
Asnawi Abdullah ◽  
Melania Hidayat ◽  
Qatratul Asrar
Keyword(s):  
Retrospective Study ◽  
Case Control Study ◽  
Case Control ◽  
P Value ◽  
Chi Square ◽  
Control Study ◽  
Banda Aceh

Latar Belakang: Pneumonia merupakan pembunuh utama balita di seluruh dunia. Berdasarkan Laporan Dinas Kesehatan Banda Aceh tahun 2018, jumlah balita penderita Pneumonia meningkat setiap tahunnya. Kasus Pneumonia balita yang paling banyak terdapat di UPTD Puskesmas Banda Raya. Penelitian ini bertujuan untuk mengetahui faktor risiko yang berhubungan dengan kejadian Pneumonia pada Balita di wilayah kerja UPTD Puskesmas Banda Raya Kota Banda Aceh tahun 2019. Metode: Penelitian ini menggunakan desain Case Control Study atau Retrospective Study. Penelitian ini menggunakan total populasi dengan jumlah sampel adalah 142 anak balita berusia 12–59 bulan. Data dianalisis secara Univariat dan Bivariat. Analisis Bivariat menggunakan Uji Chi-Square dengan derajat kepercayaan 95% (p value0.05). Hasil: Hasil penelitian menunjukkan bahwa faktor risiko yang berhubungan dengan kejadian pneumonia adalah luas ventilasi rumah (OR=15.81; CI 95%=4.70-53.12; p value=0.0001); sedangkan umur balita (OR=1.15; CI 95%=0.54-2.43; p value=0.705); jenis kelamin (OR=1.11; CI 95%=0.57-2.16; p value=0.737); pengetahuan ibu (OR=0.38; CI 95%=0.12-1.24; p value=0.112); dan kepadatan hunian (OR=1.80; CI 95%=0.78-4.13; p value=0.163), tidak terbukti secara signifikan sebagai faktor risiko pneumonia balita di UPTD Puskesmas Banda Raya Kota Banda Aceh. Kesimpulan: Faktor risiko yang berhubungan dengan kejadian Pneumonia balita adalah luas ventilasi rumah. Oleh karena itu diperlukannya sanitasi lingkungan yang sehat sebagai upaya preventif terhadap kejadian Pneumonia, serta memperbaiki pola perilaku hidup bersih dan sehat.

Antioxidant potential of diet: Association between dietary antioxidant index and odds of coronary heart disease: A case-control study

2021 ◽  
pp. 1-13
Author(s):  
Farhad Vahid ◽  
Zahra Nasiri ◽  
Amir Abbasnezhad ◽  
Ezatollah Fazeli Moghadam
Keyword(s):  
Coronary Heart Disease ◽  
Heart Disease ◽  
Antioxidant Capacity ◽  
Case Control Study ◽  
Case Control ◽  
P Value ◽  
Dietary Antioxidants ◽  
Dietary Antioxidant ◽  
The Relationship ◽  
Control Study

BACKGROUND: Oxidative stress and chronic inflammation are among the leading causes of coronary heart disease (CHD). Studies investigated the relationship between dietary antioxidants and the risk/odds of CHD, and contradictory results have been reported. Dietary antioxidant index (DAI) is a novel and reliable nutritional tool that examines the diet’s overall antioxidant capacity. Its validity was examined using serum total antioxidant capacity and malondialdehyde. OBJECTIVE: This study aimed to investigate the relationship between DAI score and odds of CHD. METHODS: In this incidence case-control study, 320 individuals with a definitive diagnosis of CHD and 320 participants without CHD or related risk factors attending the same hospitals/polyclinics were selected as the case and control groups. We estimated the DAI by summing up six standardized intakes of major dietary antioxidants, including manganese, vitamin E, A, C, selenium, and zinc. RESULTS: Modeling DAI categorized according to the median (–0.38), in multi-adjusted model showed a significant protective association with the odd of CHD (OR = 0.72; 95%CI:0.51–0.99, p-value = 0.05). Also, modeling DAI as a continuous variable in multi-adjusted models (OR = 0.94;95%CI:0.90–0.95; p-value = 0.01) showed significant results. CONCLUSION: Using the DAI to investigate the relationship between dietary antioxidants and CHD can show more realistic results than a single study of antioxidants.

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