scholarly journals Early anterior cingulate involvement is seen in presymptomatic MAPT P301L mutation carriers

2021 ◽  
Vol 13 (1) ◽  
Author(s):  
Mica T. M. Clarke ◽  
Frédéric St-Onge ◽  
Jean-Mathieu Beauregard ◽  
Martina Bocchetta ◽  
Emily Todd ◽  
...  
Keyword(s):  
Standard Deviation ◽  
Mutation Carrier ◽  
Anterior Cingulate ◽  
Grey Matter Volume ◽  
Specific Marker ◽  
Brain Scans ◽  
Mutation Carriers ◽  
P301l Mutation ◽  
Negative Controls ◽  
And Control

Abstract Background PET imaging of glucose metabolism has revealed presymptomatic abnormalities in genetic FTD but has not been explored in MAPT P301L mutation carriers. This study aimed to explore the patterns of presymptomatic hypometabolism and atrophy in MAPT P301L mutation carriers. Methods Eighteen asymptomatic members from five families with a P301L MAPT mutation were recruited to the study, six mutation carriers, and twelve mutation-negative controls. All participants underwent standard behavioural and cognitive assessment as well as [18F]FDG-PET and 3D T1-weighted MRI brain scans. Regional standardised uptake value ratios (SUVR) for the PET scan and volumes calculated from an automated segmentation for the MRI were obtained and compared between the mutation carrier and control groups. Results The mean (standard deviation) estimated years from symptom onset was 12.5 (3.6) in the mutation carrier group with a range of 7 to 18 years. No differences in cognition were seen between the groups, and all mutation carriers had a global CDR plus NACC FTLD of 0. Significant reduction in [18F] FDG uptake in the anterior cingulate was seen in mutation carriers (mean 1.25 [standard deviation 0.07]) compared to controls (1.36 [0.09]). A similar significant reduction was also seen in grey matter volume in the anterior cingulate in mutation carriers (0.60% [0.06%]) compared to controls (0.68% [0.08%]). No other group differences were seen in other regions. Conclusions Anterior cingulate hypometabolism and atrophy are both apparent presymptomatically in a cohort of P301L MAPT mutation carriers. Such a specific marker may prove to be helpful in stratification of presymptomatic mutation carriers in future trials.

Distinct Hemostatic Profile of Leukocytes in Essential Thrombocythemia (ET) Carrying the JAK2 V617F Mutation.

Blood ◽  
2005 ◽  
Vol 106 (11) ◽  
pp. 378-378 ◽  
Author(s):  
Anna Falanga ◽  
Marina Marchetti ◽  
Donatella Balducci ◽  
Alfonso Vignoli ◽  
Laura Russo ◽  
...  
Keyword(s):  
Jak2 V617f ◽  
Myeloproliferative Disorders ◽  
Specific Marker ◽  
Control Groups ◽  
Jak2 Mutation ◽  
Mutation Carriers ◽  
Mixed Aggregates ◽  
Platelet Aggregates ◽  
And Control

Abstract The pathogenesis of the thrombotic diathesis of patients with ET is not completely clarified. Activation of polymorphonuclear leukocyte (PMN) occurs in these patients and is associated with a hypercoagulable state and increased number of circulating platelet/PMN aggregates. Further, increased procoagulant Tissue Factor (TF) expression in ET PMN is also reported. Recently, a gain-of-function JAK2 mutation (V617F) has been described in a high proportion of bcr/abl-negative myeloproliferative disorders. Specifically, in subjects with ET the mutation is present in about 50% of cases and retrospective data suggest an association with a higher rate of complications, including thrombosis. Aim of this study was to evaluate whether ET patients carrying the JAK2 mutation possess PMN with different hemostatic characteristics compared to ET subjects without JAK2 mutation and healthy controls. Twenty ET patients, 10 with and 10 without JAK2 mutation (median age: 50 years, range 32–61; platelet count: median 782 x 109/L, range 474–1,565 x 109/L), not receiving cytoreductive therapy (classified as low risk group), were included in the study; 16 age matched healthy subjects acted as controls. Expression of CD11b, TF and fibrinogen on PMN surface as well as PMN-platelet mixed aggregates (defined as the percentage of CD11b-positive PMN co-expressing a platelet-specific marker, i.e. CD42b or CD62P) were evaluated by whole blood flow-cytometry in both basal condition and after in vitro PMN stimulation by f-MLP. In washed isolated PMN samples the level of TF-mRNA was determined by RT-PCR. In basal conditions, significantly (p<0.01) increased levels of PMN/platelet aggregates (both CD42 and CD62P pos. PMN) compared to controls were found, independently from JAK2 mutation. Differently, PMN from JAK2 mutation carriers expressed significantly higher surface TF (18.2±9 %pos. cells) and fibrinogen (12.3±7 %pos. cells) antigens compared to non-carrier (TF: 11.6±5 %; fibrinogen: 7.2±2 %pos. cells) and control subjects (TF: 11.1±3 %; fibrinogen: 7.1±3 %pos. cells). In vitro stimulation with f-MLP increased the proportion of platelet/PMN aggregates (CD11b/CD42 and CD11b/CD62P) in all ET patients and controls. However, in JAK2 mutation carriers the levels of both CD62P and CD42b positive PMN were significantly greater than those of non-carrier ET patients and controls (p<0.05). Similarly, TF and fibrinogen levels on stimulated PMN surface were more elevated in the JAK2 mutation positive group compared to both the mutation negative and control groups. The analysis of PMN TF-mRNA showed a significantly higher expression in the whole ET patient group compared to controls, independently from the presence of JAK2 mutation. In conclusions, these data indicate that the expression of JAK2 mutation in ET patients may confer to PMN a different hemostatic phenotype in terms of increased interaction with platelets and increased expression of surface TF and fibrinogen, suggesting a new link of this mutation with a prothrombotic status.

scholarly journals [18F]Flortaucipir PET Across Various MAPT Mutations in Presymptomatic and Symptomatic Carriers

Neurology ◽  
2021 ◽  
pp. 10.1212/WNL.0000000000012448
Author(s):  
Emma E. Wolters ◽  
Janne M. Papma ◽  
Sander C.J. Verfaillie ◽  
Denise Visser ◽  
Emma Weltings ◽  
...  
Keyword(s):  
Frontal Lobe ◽  
Mutation Carrier ◽  
Medial Temporal Lobe ◽  
Anterior Cingulate ◽  
Binding Potential ◽  
Cognitively Normal ◽  
Control Range ◽  
Mutation Carriers ◽  
Early Biomarker ◽  
Normal Controls

Objective:To assess the [18F]flortaucipir binding distribution across MAPT mutations in presymptomatic and symptomatic carriers.Methods:We compared regional [18F]flortaucipir binding potential(BPND) derived from a 130-minute dynamic [18F]flortaucipir PET scan, in nine (pre)symptomatic MAPT mutation carriers(4 with P301L[1 symptomatic], 2 with R406W[1 symptomatic]; 1 presymptomatic L315R, 1 presymptomatic S320F and 1 symptomatic G272V carrier) with 30 cognitively normal controls and 52 Alzheimer’s disease patients.Results:[18F]flortaucipir BPND images showed overall highest binding in the symptomatic carriers. This was most pronounced in the symptomatic R406W carrier in whom tau binding exceeded the normal control range in the anterior cingulate cortex, insula, amygdala, temporal, parietal and frontal lobe. Elevated medial temporal lobe BPND was observed in a presymptomatic R406W carrier. The single symptomatic and one of the three presymptomatic P301L carriers showed elevated [18F]flortaucipir BPND in the insula, parietal and frontal lobe compared to controls. The symptomatic G272V carrier exhibited a widespread elevated cortical BPND, with at neuropathological examination a combination of 3R pathology and encephalitis. The L315R presymptomatic mutation carrier showed higher frontal BPND compared to controls. The BPND values of the S320F presymptomatic mutation carrier fell within the range of controls.Conclusion:Presymptomatic MAPT mutation carriers already showed subtle elevated tau binding, whereas symptomatic MAPT mutation carriers showed a more marked increase in [18F]flortaucipir BPND. Tau deposition was most pronounced in R406W MAPT (pre)symptomatic mutation carriers, which is associated with both 3R and 4R tau accumulation. Thus, [18F]flortaucipir may serve as an early biomarker for MAPT mutation carriers in mutations that cause 3R/4R tauopathies.

scholarly journals Modelling the cascade of biomarker changes in GRN-related frontotemporal dementia

2021 ◽  
pp. jnnp-2020-323541
Author(s):  
Jessica L Panman ◽  
Vikram Venkatraghavan ◽  
Emma L van der Ende ◽  
Rebecca M E Steketee ◽  
Lize C Jiskoot ◽  
...  
Keyword(s):  
White Matter ◽  
Frontotemporal Dementia ◽  
Disease Severity ◽  
Grey Matter ◽  
Clinical Stage ◽  
Data Driven ◽  
Grey Matter Volume ◽  
Matter Volume ◽  
Mutation Carriers ◽  
Individual Disease

ObjectiveProgranulin-related frontotemporal dementia (FTD-GRN) is a fast progressive disease. Modelling the cascade of multimodal biomarker changes aids in understanding the aetiology of this disease and enables monitoring of individual mutation carriers. In this cross-sectional study, we estimated the temporal cascade of biomarker changes for FTD-GRN, in a data-driven way.MethodsWe included 56 presymptomatic and 35 symptomatic GRN mutation carriers, and 35 healthy non-carriers. Selected biomarkers were neurofilament light chain (NfL), grey matter volume, white matter microstructure and cognitive domains. We used discriminative event-based modelling to infer the cascade of biomarker changes in FTD-GRN and estimated individual disease severity through cross-validation. We derived the biomarker cascades in non-fluent variant primary progressive aphasia (nfvPPA) and behavioural variant FTD (bvFTD) to understand the differences between these phenotypes.ResultsLanguage functioning and NfL were the earliest abnormal biomarkers in FTD-GRN. White matter tracts were affected before grey matter volume, and the left hemisphere degenerated before the right. Based on individual disease severities, presymptomatic carriers could be delineated from symptomatic carriers with a sensitivity of 100% and specificity of 96.1%. The estimated disease severity strongly correlated with functional severity in nfvPPA, but not in bvFTD. In addition, the biomarker cascade in bvFTD showed more uncertainty than nfvPPA.ConclusionDegeneration of axons and language deficits are indicated to be the earliest biomarkers in FTD-GRN, with bvFTD being more heterogeneous in disease progression than nfvPPA. Our data-driven model could help identify presymptomatic GRN mutation carriers at risk of conversion to the clinical stage.

Porphyrin-lipid nanovesicles (Porphysomes) are effective photosensitizers for photodynamic therapy

Nanophotonics ◽  
2021 ◽  
Vol 0 (0) ◽  
Author(s):  
Keegan Guidolin ◽  
Lili Ding ◽  
Juan Chen ◽  
Brian C. Wilson ◽  
Gang Zheng
Keyword(s):  
Photodynamic Therapy ◽  
Tumor Growth ◽  
Intrinsic Structure ◽  
Therapeutic Applications ◽  
Positron Emission ◽  
Theranostic Agents ◽  
Negative Controls ◽  
And Control ◽  
Complete Tumor

Abstract Porphysomes (PS) are liposome-like nanoparticles comprising pyropheophorbide-conjugated phospholipids that have demonstrated potential as multimodal theranostic agents for applications that include phototherapies, targeted drug delivery and in vivo fluorescence, photoacoustic, magnetic resonance or positron emission imaging. Previous therapeutic applications focused primarily on photothermal therapy (PTT) and suggested that PSs require target-triggered activation for use as photodynamic therapy (PDT) sensitizers. Here, athymic nude mice bearing subcutaneous A549 human lung tumors were randomized into treatment and control groups: PS-PDT at various doses, PS-only and no treatment negative controls, as well as positive controls using the clinical photosensitizer Photofrin. Animals were followed for 30 days post-treatment. PS-PDT at all doses demonstrated a significant tumor ablative effect, with the greatest effect seen with 10 mg/kg PS at a drug-light interval of 24 h. By comparison, negative controls (PS-only, Photofrin-only, and no treatment) showed uncontrolled tumor growth. PDT with Photofrin at 5 mg/kg and PS at 10 mg/kg demonstrated similar tumor growth suppression and complete tumor response rates (15 vs. 25%, p = 0.52). Hence, porphysome nanoparticles are an effective PDT agent and have the additional advantages of multimodal diagnostic and therapeutic applications arising from their intrinsic structure. Porphysomes may also be the first single all-organic agent capable of concurrent PDT and PTT.

scholarly journals Voxel-wise meta-analysis of grey matter changes in obsessive–compulsive disorder

2009 ◽  
Vol 195 (5) ◽  
pp. 393-402 ◽  
Author(s):  
Joaquim Radua ◽  
David Mataix-Cols
Keyword(s):  
Obsessive Compulsive Disorder ◽  
Grey Matter ◽  
Antidepressant Treatment ◽  
Meta Analysis ◽  
Anterior Cingulate ◽  
Control Group ◽  
Grey Matter Volume ◽  
Obsessive Compulsive ◽  
Caudate Nuclei ◽  
Compulsive Disorder

BackgroundSpecific cortico-striato-thalamic circuits are hypothesised to mediate the symptoms of obsessive–compulsive disorder (OCD), but structural neuroimaging studies have been inconsistent.AimsTo conduct a meta-analysis of published and unpublished voxel-based morphometry studies in OCD.MethodTwelve data-sets comprising 401 people with OCD and 376 healthy controls met inclusion criteria. A new improved voxel-based meta-analytic method, signed differential mapping (SDM), was developed to examine regions of increased and decreased grey matter volume in the OCD group v. control group.ResultsNo between-group differences were found in global grey matter volumes. People with OCD had increased regional grey matter volumes in bilateral lenticular nuclei, extending to the caudate nuclei, as well as decreased volumes in bilateral dorsal medial frontal/anterior cingulate gyri. A descriptive analysis of quartiles, a sensitivity analysis as well as analyses of subgroups further confirmed these findings. Meta-regression analyses showed that studies that included individuals with more severe OCD were significantly more likely to report increased grey matter volumes in the basal ganglia. No effect of current antidepressant treatment was observed.ConclusionsThe results support a dorsal prefrontal–striatal model of the disorder and raise the question of whether functional alterations in other brain regions commonly associated with OCD, such as the orbitofrontal cortex, may reflect secondary compensatory strategies. Whether the reported differences between participants with OCD and controls precede the onset of the symptoms and whether they are specific to OCD remains to be established.

scholarly journals PENGARUH MODEL PEMBELAJARAN KOOPERATIF TIPE TEAMS GAMES AND TOURNAMENT (TGT) TERHADAP HASIL BELAJAR DASARLISTRIK DAN ELEKTRONIKA

2021 ◽  
Vol 1 (2) ◽  
pp. 123
Author(s):  
Dyan Novi Rezki Situmorang ◽  
Wanapri Pangaribuan
Keyword(s):  
Standard Deviation ◽  
Cooperative Learning ◽  
Learning Outcomes ◽  
Learning Model ◽  
Average Score ◽  
Homogeneous Distribution ◽  
Electrical Measurements ◽  
Model Type ◽  
Team Game ◽  
And Control

AbstrakJenis penelitian ini adalah penelitian quasi eksperimen. Populasi dalam penelitian ini adalah seluruh siswa kelas X semester genap SMK Swasta Imelda Medan Tahun Ajaran 2019/2020. Pengambilan sampel dilakukan dengan mengambil 2 kelas, yaitu kelas X TITL 1 sebagai kelas eksperimen dan kelas X TITL 2 sebagai kelas kontrol, yang masing-masing kelas berjumlah 28 orang siswa. Instrument yang digunakan untuk mengetahui hasil belajar siswa adalah tes hasil belajar dalam bentuk pilihan berganda dengan jumlah soal 30 butir. Hasil pengujian pretest sebelum diberi perlakuan yang berbeda, yaitu skor rata-rata di kelas eksperimen  (47) dengan standar deviasi 8,50 dan skor rata-rata di kelas kontrol (44,45) dengan standar deviasi 7,75. Pada pengujian data pretest kedua kelas diperoleh bahwa data kedua kelas berdistribusi normal dan homogen yang berarti memiliki kemampuan awal yang sama. Kemudian diberi perlakuan yaitu kelas eksperimen diajarkan dengan pembelajaran menggunakan model kooperatif tipe Team Game Tournament (TGT) dan kelas kontrol diajar dengan pembelajaran menggunakan model ekspositori. Setelah pembelajaran selesai diberikan posttest, diperoleh nilai posttest dengan hasil rata-rata kelas eksperimen (88,78) dengan standar deviasi 4,06 dan kelas kontrol (81,55) dengan standar deviasi 4,17. Dari hasil pengolahan data posttest diperoleh bahwa thitung=  6,40 dan ttabel = 1,67. Sehingga thitung > ttabel.Sehingga Ha diterima yaitu Model Pembelajaran Kooperatif Tipe Team Game Tournament (TGT)memberikan hasil belajar pada pelajaran dasar dan pengukuran listrik yang lebih tinggi daripada pembelajaran menggunakan model ekspositori pada siswa kelas X TITL SMK Swasta Imelda Medan.Kata Kunci: Pembelajaran Tipe Team Game Tournament, Model Pembelajaran Kooperatif AbstractEnglish translation. This type of research is quasi experimental research. The population in this study is all students of class X even semester of Imelda Medan Private Vocational School Year 2019/2020. Sampling is done by taking 2 classes, namely class X TITL 1 as an experimental class and class X TITL 2 as a control class, each of which totals 28 students. The instrument used to find out student learning outcomes is a test of learning results in the form of multiple choices with the number of questions 30 points. Pretest test results before being given different treatments, namely the average score in the experimental class (47) with a standard deviation of 8.50 and the average score in the control class (44.45) with a standard deviation of 7.75. In the pretest data test both classes it was obtained that the data of both classes are normal and homogeneous distribution which means it has the same initial capabilities. Then given the treatment that experimental classes are taught by learning using a cooperative model type Team Game Tournament (TGT) and control classes are taught by learning using an expository model. After the learning was completed, posttest scores were obtained with the average results of experimental classes (88.78) with a standard deviation of 4.06 and control classes (81.55) with a standard deviation of 4.17. From the results of posttest data processing obtained that thitung = 6.40 and ttabel = 1.67. So thitung > ttabel. So ha accepted, namely the Cooperative Learning Model Type Team Game Tournament (TGT) provides learning outcomes on basic lessons and higher electrical measurements than learning using the expository model in students of class X TITL SMK Swasta Imelda Medan.  Keywords: Team Game Tournament Type Learning, Cooperative Learning Model

scholarly journals Sensory perception in autism: an fMRI ALE meta-analysis

2020 ◽  
Author(s):  
Nazia Jassim ◽  
Simon Baron-Cohen ◽  
John Suckling
Keyword(s):  
Meta Analysis ◽  
Likelihood Estimation ◽  
Sensory Perception ◽  
Superior Temporal Gyrus ◽  
Occipital Cortex ◽  
Anterior Cingulate ◽  
Future Research ◽  
Precentral Gyrus ◽  
And Control ◽  
Lateral Occipital Cortex

Sensory sensitivities occur in up to 90% of autistic individuals. With the recent inclusion of sensory symptoms in the diagnostic criteria for autism, there is a current need to develop neural hypotheses related to autistic sensory perception. Using activation likelihood estimation (ALE), we meta-analysed 52 task-based fMRI studies investigating differences between autistic (n=891) and control (n=967) participants during non-social sensory perception. During complex perception, autistic groups showed more activity in the secondary somatosensory and occipital cortices, insula, caudate, superior temporal gyrus, and inferior parietal lobule, while control groups showed more activity in the frontal and parietal regions. During basic sensory processing, autistic groups showed hyperactivity in the lateral occipital cortex, primary somatosensory and motor cortices, insula, caudate, and thalamus, while controls showed heightened activity in the precentral gyrus, middle frontal gyrus, precuneus, and anterior cingulate cortex. We conclude that autistic individuals, on average, show distinct engagement of sensory-related brain networks during sensory perception. These findings may help guide future research to focus on relevant neurobiological mechanisms underpinning the autistic experience.

scholarly journals Effectiveness of the Group Play Therapy on the Insecure Attachment and Social Skills of Orphans in Ahvaz City

2016 ◽  
Vol 9 (9) ◽  
pp. 42
Author(s):  
Bahareh Mousavi ◽  
Sahar Safarzadeh
Keyword(s):  
Social Skills ◽  
Standard Deviation ◽  
Treatment Group ◽  
Play Therapy ◽  
Insecure Attachment ◽  
Control Group ◽  
Group Play Therapy ◽  
Group Play ◽  
And Control

<p class="apa">This study aimed to determine the effectiveness of the group play therapy on the insecure attachment and social skills of orphans in Ahvaz city. Statistical population included all orphans in Ahvaz city, of whom 30 students were selected whose scores in insecure attachment and in social skills were one standard deviation higher and one standard deviation lower than the mean, respectively and they were randomly divided into two treatment (15 persons) and control (15 persons) groups. The research tools included Randolph Attachment Disorder Questionnaire (2000) (RADQ) and Social Skills Rating System (SSRS) questionnaire (Gresham and Elliot, 1990). This is an experimental study with pretest, posttest, and follow-up by the control group. Firstly, pretest was implemented for both groups, and then experimental intervention (play therapy) was carried out for the treatment group during 10 sessions. After the therapeutic program, the posttest and two months later follow-up were implemented. The results obtained using the statistical method of multivariate covariance analysis showed that group play therapy reduces the insecure attachment and increases the social skills at P &lt; 0.001 during the stages of posttest and follow-up in the treatment group compared to the control group. Results also indicated that there is a significant difference between posttest and follow-up of the treatment and control group in terms of the components of social skills (collaboration, assertiveness, and self-control).</p>

scholarly journals Cerebral perfusion changes in presymptomatic genetic frontotemporal dementia: a GENFI study

Brain ◽  
2019 ◽  
Vol 142 (4) ◽  
pp. 1108-1120 ◽  
Author(s):  
Henri J M M Mutsaerts ◽  
Saira S Mirza ◽  
Jan Petr ◽  
David L Thomas ◽  
David M Cash ◽  
...  
Keyword(s):  
Blood Flow ◽  
Cerebral Blood Flow ◽  
Frontotemporal Dementia ◽  
Symptom Onset ◽  
Arterial Spin Labelling ◽  
Anterior Cingulate ◽  
Middle Temporal Gyrus ◽  
Inverse Association ◽  
Mutation Carriers ◽  
Spin Labelling

Abstract Genetic forms of frontotemporal dementia are most commonly due to mutations in three genes, C9orf72, GRN or MAPT, with presymptomatic carriers from families representing those at risk. While cerebral blood flow shows differences between frontotemporal dementia and other forms of dementia, there is limited evidence of its utility in presymptomatic stages of frontotemporal dementia. This study aimed to delineate the cerebral blood flow signature of presymptomatic, genetic frontotemporal dementia using a voxel-based approach. In the multicentre GENetic Frontotemporal dementia Initiative (GENFI) study, we investigated cross-sectional differences in arterial spin labelling MRI-based cerebral blood flow between presymptomatic C9orf72, GRN or MAPT mutation carriers (n = 107) and non-carriers (n = 113), using general linear mixed-effects models and voxel-based analyses. Cerebral blood flow within regions of interest derived from this model was then explored to identify differences between individual gene carrier groups and to estimate a timeframe for the expression of these differences. The voxel-based analysis revealed a significant inverse association between cerebral blood flow and the expected age of symptom onset in carriers, but not non-carriers. Regions included the bilateral insulae/orbitofrontal cortices, anterior cingulate/paracingulate gyri, and inferior parietal cortices, as well as the left middle temporal gyrus. For all bilateral regions, associations were greater on the right side. After correction for partial volume effects in a region of interest analysis, the results were found to be largely driven by the C9orf72 genetic subgroup. These cerebral blood flow differences first appeared approximately 12.5 years before the expected symptom onset determined on an individual basis. Cerebral blood flow was lower in presymptomatic mutation carriers closer to and beyond their expected age of symptom onset in key frontotemporal dementia signature regions. These results suggest that arterial spin labelling MRI may be a promising non-invasive imaging biomarker for the presymptomatic stages of genetic frontotemporal dementia.

scholarly journals Cortical thickness in obsessive–compulsive disorder: Multisite mega-analysis of 780 brain scans from six centres

2017 ◽  
Vol 210 (1) ◽  
pp. 67-74 ◽  
Author(s):  
Jean-Paul Fouche ◽  
Stefan du Plessis ◽  
Coenie Hattingh ◽  
Annerine Roos ◽  
Christine Lochner ◽  
...  
Keyword(s):  
Obsessive Compulsive Disorder ◽  
Cortical Thickness ◽  
Group Analysis ◽  
Analysis Of Covariance ◽  
Group Differences ◽  
Grey Matter Volume ◽  
Obsessive Compulsive ◽  
Brain Scans ◽  
Compulsive Disorder

BackgroundThere is accumulating evidence for the role of fronto-striatal and associated circuits in obsessive–compulsive disorder (OCD) but limited and conflicting data on alterations in cortical thickness.AimsTo investigate alterations in cortical thickness and subcortical volume in OCD.MethodIn total, 412 patients with OCD and 368 healthy adults underwent magnetic resonance imaging scans. Between-group analysis of covariance of cortical thickness and subcortical volumes was performed and regression analyses undertaken.ResultsSignificantly decreased cortical thickness was found in the OCD group compared with controls in the superior and inferior frontal, precentral, posterior cingulate, middle temporal, inferior parietal and precuneus gyri. There was also a group x age interaction in the parietal cortex, with increased thinning with age in the OCD group relative to controls.ConclusionsOur findings are partially consistent with earlier work, suggesting that group differences in grey matter volume and cortical thickness could relate to the same underlying pathology of OCD. They partially support a frontostriatal model of OCD, but also suggest that limbic, temporal and parietal regions play a role in the pathophysiology of the disorder. The group x age interaction effects may be the result of altered neuroplasticity.

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