scholarly journals The relationship between SARS-COV-2 RNA positive duration and the risk of recurrent positive

2021 ◽  
Vol 10 (1) ◽  
Author(s):  
Hong Zhao ◽  
Chi Zhang ◽  
Xian-Xiang Chen ◽  
Qi Zhu ◽  
Wen-Xiang Huang ◽  
...  
Keyword(s):  
Curve Fitting ◽  
Additive Model ◽  
Smooth Curve ◽  
Fold Increase ◽  
Monocyte Count ◽  
Increased Risk ◽  
Adjusted Logistic Regression ◽  
Multi Center Study ◽  
Adjusted Model ◽  
The Relationship

Abstract Background The management of discharge COVID-19 patients with recurrent positive SARS-CoV-2 RNA is challenging. However, there are fewer scientific dissertations about the risk of recurrent positive. The aim of this study was to explore the relationship between SARS-COV-2 RNA positive duration (SPD) and the risk of recurrent positive. Methods This case–control multi-center study enrolled participants from 8 Chinese hospital including 411 participants (recurrent positive 241). Using unadjusted and multivariate-adjusted logistic regression analyses, generalized additive model with a smooth curve fitting, we evaluated the associations between SPD and risk of recurrent positive. Besides, subgroup analyses were performed to explore the potential interactions. Results Among recurrent positive patients, there were 121 females (50.2%), median age was 50 years old [interquartile range (IQR): 38–63]. In non-adjusted model and adjusted model, SPD was associated with an increased risk of recurrent positive (fully-adjusted model: OR = 1.05, 95% CI: 1.02–1.08, P = 0.001); the curve fitting was not significant (P = 0.286). Comparing with SPD < 14 days, the risk of recurrent positive in SPD > 28 days was risen substantially (OR = 3.09, 95% CI: 1.44–6.63, P = 0.004). Interaction and stratified analyses showed greater effect estimates of SPD and risk of recurrent positive in the hypertension, low monocyte count and percentage patients (P for interaction = 0.008, 0.002, 0.036, respectively). Conclusion SPD was associated with a higher risk of recurrent positive and especially SPD > 28 day had a two-fold increase in the relative risk of re-positive as compared with SPD < 14 day. What’s more, the risk may be higher among those with hypertension and lower monocyte count or percentage.

scholarly journals Using the General Social Survey – National Death Index cohort to study the relationship between neighbourhood fear and mortality in the USA

BMJ Open ◽  
2019 ◽  
Vol 9 (11) ◽  
pp. e030330
Author(s):  
Erin Grinshteyn ◽  
Peter Muennig ◽  
Roman Pabayo
Keyword(s):  
Fear Of Crime ◽  
General Social Survey ◽  
National Death Index ◽  
Social Survey ◽  
Time To Death ◽  
Risk Of Death ◽  
Increased Risk ◽  
Adjusted Model ◽  
The Relationship

ObjectivesFear of crime is associated with adverse mental health outcomes and reduced social interaction independent of crime. Because mental health and social interactions are associated with poor physical health, fear of crime may also be associated with death. The main objective is to determine whether neighbourhood fear is associated with time to death.Setting and participantsData from the 1978–2008 General Social Survey were linked to mortality data using the National Death Index (GSS-NDI) (n=20 297).MethodsGSS-NDI data were analysed to assess the relationship between fear of crime at baseline and time to death among adults after removing violent deaths. Fear was measured by asking respondents if they were afraid to walk alone at night within a mile of their home. Crude and adjusted HRs were calculated using survival analysis to calculate time to death. Analyses were stratified by sex.ResultsAmong those who responded that they were fearful of walking in their neighbourhood at night, there was a 6% increased risk of death during follow-up in the adjusted model though this was not significant (HR=1.06, 95% CI 0.99 to 1.13). In the fully adjusted models examining risk of mortality stratified by sex, findings were significant among men but not women. Among men, in the adjusted model, there was an 8% increased risk of death during follow-up among those who experienced fear at baseline in comparison with those who did not experience fear (HR=1.08, 95% CI 1.02 to 1.14).ConclusionsResearch has recently begun examining fear as a public health issue. With an identified relationship with mortality among men, this is a potential public health problem that must be examined more fully.

scholarly journals The Relationship between Insufficient Sleep and Self-Rated Health in a Nationally Representative Sample

2012 ◽  
Vol 2012 ◽  
pp. 1-8 ◽  
Author(s):  
Sarah Dee Geiger ◽  
Charumathi Sabanayagam ◽  
Anoop Shankar
Keyword(s):  
Representative Sample ◽  
Positive Association ◽  
Cross Sectional Survey ◽  
Cross Sectional ◽  
Insufficient Sleep ◽  
Self Rated Health ◽  
Increased Risk ◽  
Nationally Representative ◽  
Adjusted Model ◽  
The Relationship

Reduced sleep has been found to be associated with increased risk of diabetes mellitus, hypertension, cardiovascular disease (CVD), and mortality. Self-rated health (SRH) has been shown to be a predictor of CVD and mortality. However, study of the association between insufficient sleep and SRH is limited. We examined participants >18 years of age (n=377, 160) from a representative, cross-sectional survey (2008 BRFSS). Self-reported insufficient sleep in the previous 30 days was categorized into six groups. The outcome was poor SRH. We calculated odds ratios ((OR) (95% confidence interval (CI)) of increasing categories of insufficient rest/sleep, taking zero days of insufficient sleep as the referent category. We found a positive association between increasing categories of insufficient sleep and poor SRH, independent of relevant covariates. In the multivariable-adjusted model, compared to 0 days insufficient sleep, the OR (95% CI) of poor SRH was 1.03 (0.97–1.10) for 1–6 days, 1.45 (1.34–1.57) for 7–13 days, 2.12 (1.97–2.27) for 14–20 days, 2.32 (2.09–2.58) for 21–29 days, and and 2.71 (2.53–2.90) for 30 days of insufficient sleep in the prior 30 days (P-trend <0.0001). In a nationally representative sample, increasing categories of insufficient sleep were associated with poor SRH.

scholarly journals The Impact of Gravidity, Symptomatology and Timing of Infection on Placental Malaria

2020 ◽  
Author(s):  
Erin E Tran ◽  
Morgan Cheeks ◽  
Abel Kakuru ◽  
Mary K Muhindo ◽  
Paul Natureeba ◽  
...  
Keyword(s):  
Plasmodium Falciparum ◽  
Blood Smear ◽  
Placental Malaria ◽  
Fold Increase ◽  
Preventive Therapy ◽  
Malaria Parasites ◽  
Increased Risk ◽  
Placental Blood ◽  
The Impact ◽  
The Relationship

Abstract Background : Placental malaria is associated with increased risk of adverse perinatal outcomes. While primigravidity has been reported as a risk factor for placental malaria, little is known regarding the relationship between gravidity, symptomatology and timing of Plasmodium falciparum infection and the development of placental malaria. Methods : Our aim was to investigate the relationship between the development of placental malaria and gravidity, timing of infection, and presence of symptoms. This is a secondary analysis of data from a double-blind randomized control trial of intermittent preventive therapy during pregnancy in Uganda. Women were enrolled from 12 to 20 weeks gestation and followed through delivery. Exposure to malaria parasites was defined as symptomatic (fever with positive blood smear) or asymptomatic (based on molecular detection of parasitemia done routinely every 4 weeks). The primary outcome was placental malaria diagnosed by histopathology, placental blood smear, and/or placental blood loop-mediated isothermal amplification. We performed subgroup analysis based on the presence of symptomatic malaria, gravidity, and timing of infection. Results : Of the 228 patients with documented maternal infection with malaria parasites during pregnancy, 101 (44.3%) had placental malaria. Primigravidity was strongly associated with placental malaria (aOR 8.90, 95% CI 4.34-18.2, p<0.001), and each episode of malaria was associated with over a 2-fold increase in placental malaria (aOR 2.35, 95% CI 1.69-3.26, p<0.001). Among multigravid women, the odds of placental malaria increased by 14% with each advancing week of gestation at first documented infection (aOR 1.14, 95% CI 1.02-1.27, p=0.02). When stratified by the presence of symptoms, primigravidity was only associated with placental malaria in asymptomatic women, who had a 12-fold increase in the odds of placental malaria (aOR 12.19, 95% CI 5.23-28.43, p<0.001). Conclusions : Total number of Plasmodium falciparum infections in pregnancy is a significant predictor of placental malaria. The importance of timing of infection on the development of placental malaria varies based on gravidity. In primigravidas, earlier asymptomatic infections were associated with placental malaria, whereas in multigravidas, parasitemias detected later in gestation were associated with placental malaria. Earlier initiation of an effective intermittent preventive therapy may help to prevent placental malaria and improve birth outcomes, particularly in primigravid women.

scholarly journals Risk factors for systemic thromboembolism after left chamber cardiac thrombi --- A retrospective multi-center study

2019 ◽  
Author(s):  
wei zhou ◽  
Shun-yi Shi ◽  
Yuan Ji ◽  
Xin Chen ◽  
Jun Huang ◽  
...  
Keyword(s):  
Medical Records ◽  
Heart Function ◽  
Multivariate Logistic Regression ◽  
Increased Risk ◽  
All Cause Mortality ◽  
History Of ◽  
Multi Center Study ◽  
Relationship Of ◽  
The Relationship

Abstract Background : We aimed to characterize the independent predictors of systemic thromboembolism (ST) after left chamber thrombi. Methods: A retrospective analysis on the medical records of 175 patients diagnosed with left chamber thrombi by transthoracic echocardiography (TTE) at three centers were carried out. Multivariate logistic regression was performed to determine the relationship of each characteristic with ST. Multivariate Cox proportional survival analysis was conducted, with covariate adjustments, to identify predictors of all-cause mortality. Results: During a median 42 months of follow-up (25th–75th percentile: 20–62 months), 24 (13.7%) patients had ST, and 62 (35.4%) died. History of diabetes and thrombus mobility were independent predictors of ST (P = 0.003, P = 0.02, respectively). There was a significant association between abnormal ejection fraction (EF) and all-cause mortality (P = 0.003). Conclusions: The morbidity associated with ST and the increased risk for mortality associated with left chamber cardiac thrombi relates to medical history, thrombus state, and diminished heart function.

scholarly journals The Connection Between Triglycerides and Ectopic Fat Obesity: An Inverted U-Shaped Curve

2020 ◽  
Author(s):  
Yang Zou ◽  
Meng Yu ◽  
Guotai Sheng ◽  
Guobo Xie
Keyword(s):  
Inflection Point ◽  
Additive Model ◽  
Smooth Curve ◽  
Cross Sectional Study ◽  
Ectopic Fat ◽  
Cross Sectional ◽  
Adult Participants ◽  
Study Population ◽  
The Right ◽  
The Relationship

Abstract Background: Ectopic fat obesity and Triglycerides are risk factors for diabetes and multiple cardiovascular diseases, but the data on the relationship between Triglycerides and the risk of ectopic fat obesity are limited. The purpose of this study is to explore the connection between Triglycerides and ectopic fat obesity.Methods: This is a cross-sectional study, we retrospectively analyzed 15464 adult participants recruited by Murakami Memorial Hospital from 2004-2015(8430 men and 7034 women, average age 43.71±8.9), to performed the relationship between Triglycerides and ectopic fat obesity, we divided all patients into 4 groups according to the quartile of Triglycerides. Logistic regression model was used to analyze the relationship between Triglycerides and the risk of ectopic fat obesity, and the generalized additive model was used to identify the nonlinear relationship.Results: In the study population, the prevalence of ectopic fat obesity was 17.73%, and gradually increased in the quartile of Triglycerides (2.86,7.89,18.25 and 41.22% respectively, P < 0.001).After adjusting other covariables, Triglycerides was positively correlated with the risk of ectopic fat obesity (OR:1.55,95%CI:1.41-1.69, p<0.00001). Then we carried out smooth curve fitting and found that there was an inverted U-shaped curve relationship between Triglycerides and ectopic fat obesity, even if those adjusted covariables were removed from the model, the result remained unchanged, and the inflection point of the curve was 3.98. On the left side of the inflection point, Triglycerides was positively correlated with the risk of ectopic fat obesity(OR:1.784,95%CI:1.611-1.975,p<0.0001), while on the right side of the inflection point, there was a negative correlation (OR:0.519,95%CI:0.333-0.810,p=0.0039).Conclusions: Our research shows that there is a significant correlation between Triglycerides and ectopic fat obesity, this relation is not a simple linear relationship, but it was an inverted U-shaped curve relationship.

scholarly journals Association Between Different Lipid Ratios and Diabetes in Chinese Adults With H-type Hypertension

2020 ◽  
Author(s):  
yu tao ◽  
Yu Yu ◽  
Huihui Bao ◽  
Xiaoshu Cheng
Keyword(s):  
Characteristic Curve ◽  
Low Density Lipoprotein ◽  
Density Lipoprotein ◽  
Smooth Curve ◽  
Lipoprotein Cholesterol ◽  
Atherogenic Index ◽  
Chinese Adults ◽  
Lipid Ratios ◽  
Adjusted Model ◽  
The Relationship

Abstract Background: Previous studies have shown that lipid ratios [total cholesterol (TC)/high-density lipoprotein cholesterol (HDL-C), atherogenic index of plasma (AIP, lg [triglyceride (TG)/HDL-C]), low-density lipoprotein cholesterol (LDL-C)/HDLC, non-HDL-C/HDL-C] were associated with the risk of diabetes in non-hypertension population. However, the relationship between different lipid ratios and diabetes is unclear in the H-type hypertension population. The purpose of this study is to investigate the relationship between lipid ratios and diabetes in Chinese adults with H- type hypertension.Methods: The current study included 13,581 H-type hypertension participants from the China hypertension registry study. Logistic regression analysis and smooth curve fitting were used to assess the association between different lipid ratios and diabetes.Results: Prevalence of diabetes was 17.8%. All lipid ratios (TC/HDL-C, AIP, LDL-C/HDL-C, and non-HDL-C/HDL-C) were positively and independently associated with diabetes. In the fully adjusted model, AIP manifested the largest ORs of diabetes (OR:2.84, 95%CI:2.37-3.41). However, the fully adjusted ORs (95%CI) of TC/HDL-C, LDL-C/HDL-C and non-HDL-C/HDL-C ratio was only 1.34 (1.27, 1.43), 1.40 (1.29, 1.51), 1.42 (1.35, 1.50), respectively. Comparing the area under receiver-operating characteristic curve (AUC), we found that AIP had the stronger ability to identify diabetes.Conclusions: all lipid ratios (TC/HDL-C, AIP, LDL-C/HDL-C, and non-HDL-C/HDL-C) were independently and positively correlated with the risk of diabetes in the Chinese population with H-type hypertension. Compared with other lipid ratios (TC/HDL-C, LDL-C/HDL-C, and non-HDL-C/HDL-C), AIP was superior in discriminating diabetes.

scholarly journals The impact of gravidity, symptomatology and timing of infection on placental malaria

2020 ◽  
Author(s):  
Erin E Tran ◽  
Morgan Cheeks ◽  
Abel Kakuru ◽  
Mary K Muhindo ◽  
Paul Natureeba ◽  
...  
Keyword(s):  
Plasmodium Falciparum ◽  
Blood Smear ◽  
Placental Malaria ◽  
Fold Increase ◽  
Preventive Therapy ◽  
Malaria Parasites ◽  
Increased Risk ◽  
Placental Blood ◽  
The Impact ◽  
The Relationship

Abstract Background Placental malaria is associated with increased risk of adverse perinatal outcomes. While primigravidity has been reported as a risk factor for placental malaria, little is known regarding the relationship between gravidity, symptomatology and timing of Plasmodium falciparum infection and the development of placental malaria. Methods The aim of this study was to investigate the relationship between the development of placental malaria and gravidity, timing of infection, and presence of symptoms. This is a secondary analysis of data from a double-blind randomized control trial of intermittent preventive therapy during pregnancy in Uganda. Women were enrolled from 12 to 20 weeks gestation and followed through delivery. Exposure to malaria parasites was defined as symptomatic (fever with positive blood smear) or asymptomatic (based on molecular detection of parasitemia done routinely every 4 weeks). The primary outcome was placental malaria diagnosed by histopathology, placental blood smear, and/or placental blood loop-mediated isothermal amplification. Multivariate analyses were performed using logistic regression models. Subgroup analysis was performed based on the presence of symptomatic malaria, gravidity, and timing of infection. Results Of the 228 patients with documented maternal infection with malaria parasites during pregnancy, 101 (44.3%) had placental malaria. Primigravidity was strongly associated with placental malaria (aOR 8.90, 95% CI 4.34-18.2, p<0.001), and each episode of malaria was associated with over a 2-fold increase in placental malaria (aOR 2.35, 95% CI 1.69-3.26, p<0.001). Among multigravid women, the odds of placental malaria increased by 14% with each advancing week of gestation at first documented infection (aOR 1.14, 95% CI 1.02-1.27, p=0.02). When stratified by the presence of symptoms, primigravidity was only associated with placental malaria in asymptomatic women, who had a 12-fold increase in the odds of placental malaria (aOR 12.19, 95% CI 5.23-28.43, p<0.001). Conclusions Total number of Plasmodium falciparum infections in pregnancy is a significant predictor of placental malaria. The importance of timing of infection on the development of placental malaria varies based on gravidity. In primigravidas, earlier asymptomatic infections were more frequently identified in those with placental malaria, whereas in multigravidas, parasitemias detected later in gestation were associated with placental malaria. Earlier initiation of an effective intermittent preventive therapy may help to prevent placental malaria and improve birth outcomes, particularly in primigravid women.

scholarly journals Association Between Different Lipid Ratios and Diabetes in Chinese Adults With H-type Hypertension

2020 ◽  
Author(s):  
yu tao ◽  
yu jiang ◽  
yu yu ◽  
huihui bao
Keyword(s):  
Characteristic Curve ◽  
Low Density Lipoprotein ◽  
Density Lipoprotein ◽  
Smooth Curve ◽  
Atherogenic Index ◽  
Chinese Adults ◽  
Atherogenic Index Of Plasma ◽  
Lipid Ratios ◽  
Adjusted Model ◽  
The Relationship

Abstract Background: Previous studies have shown that lipid ratios [total cholesterol (TC)/high-densitylipoprotein cholesterol (HDL-C), atherogenic index of plasma (AIP, lg [triglyceride (TG)/HDL-C]), low-density lipoprotein cholesterol (LDL-C)/HDLC, non-HDL-C/HDL-C] were associated with the risk of diabetes in non-hypertension population. However, the relationship between different lipid ratios and diabetes is unclear in the H-type hypertension population. The purpose of this study is to investigate the relationship between lipid ratios and diabetes in Chinese adults with H- type hypertension.Methods: The current study included 13,581 H-type hypertension participants from the China hypertension registry study. Logistic regression analysis and smooth curve fitting were used to assess the association between different lipid ratios and diabetes.Results: Prevalence of diabetes was 17.8%. All lipid ratios (TC/HDL-C, AIP, LDL-C/HDL-C, and non-HDL-C/HDL-C) were positively and independently associated with diabetes. In the fully adjusted model, AIP manifested the largest ORs of diabetes (OR:2.84, 95%CI:2.37-3.41). However, the fully adjusted ORs (95%CI) of TC/HDL-C, LDL-C/HDL-C and non-HDL-C/HDL-C ratio was only 1.34 (1.27, 1.43), 1.40 (1.29, 1.51), 1.42 (1.35, 1.50), respectively. Comparing the area under receiver-operating characteristic curve (AUC), we found that AIP had the stronger ability to identify diabetes.Conclusions: all lipid ratios (TC/HDL-C, AIP, LDL-C/HDL-C, and non-HDL-C/HDL-C) were independently and positively correlated with the risk of diabetes in the Chinese population with H-type hypertension. Compared with other lipid ratios (TC/HDL-C, LDL-C/HDL-C, and non-HDL-C/HDL-C), AIP was superior in discriminating diabetes.

Variation in fibrinogen FGG and FGA genes and risk of stroke

2008 ◽  
Vol 100 (08) ◽  
pp. 308-313 ◽  
Author(s):  
Elim Y. L. Cheung ◽  
Michiel J. Bos ◽  
Frank W. G. Leebeek ◽  
Peter J. Koudstaal ◽  
Albert Hofman ◽  
...  
Keyword(s):  
Ischemic Stroke ◽  
Haemorrhagic Stroke ◽  
Population Based ◽  
Nucleotide Polymorphisms ◽  
Single Nucleotide ◽  
Increased Risk ◽  
Fibrin Network ◽  
Adjusted Logistic Regression ◽  
The Relationship

SummaryHaplotypes of the fibrinogen gamma and alpha (FGG and FGA) genes are associated with the structure of the fibrin network and may therefore influence the risk of stroke. We investigated the relationship between common variation in these genes with ischemic and haemorrhagic stroke. The study was based on 6,275 participants of the prospective population-based Rotterdam Study who at baseline (1990 – 1993) were aged 55 years or over, free from stroke, and had successful assessment of at least one FGG or FGA single nucleotide polymorphisms (SNP). Common haplotypes were estimated using seven tagging SNPs across a 30 kb region containing the FGG and FGA genes. Follow-up for incident stroke was complete until January 1,2005. Associations between constructed haplotypes and risk of stroke were estimated with an age- and sex-adjusted logistic regression model. We observed 668 strokes, of which 393 were ischemic and 62 haemorrhagic, during a median follow-up time of 10.1 years. FGG+FGA haplotype 3 (H3) was associated with an increased risk of ischemic stroke (odds ratio [OR] 1.36, 95% confidence interval [CI] 1.09–1.69) and the risk estimate for hemorrhagic stroke was 0.71 (95% CI 0.46–1.09) compared to the most frequent H1. The FGG and FGA genes were not associated with stroke or its subtypes when analyzed separately. In conclusion, risk of ischemic stroke was higher in FGG+FGA H3 than in H1. The results suggested that an opposite association may exist for haemorrhagic stroke.

Abstract P294: Circulating Soluble ICAM-1 is Associated with Aorto-Iliac and Coronary Artery Calcified Plaque 10 years Later in Young Adults: The Coronary Artery Risk Development in Young Adults (CARDIA) Study

Circulation ◽  
2012 ◽  
Vol 125 (suppl_10) ◽  
Author(s):  
Myron D Gross ◽  
Jose R Suarez-Lopez ◽  
Alex P Reiner ◽  
Bharat Thyagarajan ◽  
J. J Carr ◽  
...  
Keyword(s):  
Cardiovascular Disease ◽  
Young Adults ◽  
Coronary Artery ◽  
Subclinical Atherosclerosis ◽  
Elevated Serum ◽  
Intercellular Adhesion Molecule ◽  
Increased Risk ◽  
Calcified Plaque ◽  
Adjusted Model ◽  
The Relationship

Background: Elevated serum soluble intercellular adhesion molecule-1 (sICAM-1) concentration has been associated with cardiovascular disease in older adults. Soluble ICAM-1may have a central role in the development of atherosclerosis, but few studies have investigated the relationship in young adults or evaluated prospective relationships. Objective/Hypothesis: To investigate the relationship between sICAM-1 and subclinical atherosclerosis measured 10 years later in young adults. sICAM-1 will have positive association with the presence of subclinical atherosclerosis. Methods: Soluble ICAM-1 concentrations were assayed in black and white men and women at average age 40 (range 32–47 years). Two markers of subclinical atherosclerosis, namely aorto-iliac calcified plaque (AoIC, n=1621, 55% with AoIC) and coronary artery calcium (CAC, n=1656, 30% with CAC), were measured 10 years later. Associations were evaluated by logistic regression methods. Results: Mean (standard deviation (SD)) of sICAM-1 was 155.1 (45.8) ng/ml. In a minimally adjusted (age, race, sex, clinic) model, sICAM-1 was associated with an increased risk of AoIC (OR=1.56 per SD, CI=1.37–1.78, p<0.0001,). This association remained highly significant (OR=1.22 per SD, CI=1.06–1.40, p<0.006) in a model fully-adjusted (adding education, body mass index, waist, blood lipids, cholesterol-lowering medication, smoking, blood pressure, antihypertensive medication, and exercise). CAC was associated with sICAM-1 (OR=1.41 per SD, CI=1.24–1.59, p<0.0001) in the minimally adjusted model as well as the fully-adjusted model (OR=1.18 per SD, CI=1.04–1.34, p<.01). Conclusion: Elevated concentrations of sICAM-1 were associated with subclinical atherosclerotic calcification, which in turn is known to be highly predictive of future cardiovascular disease. Soluble ICAM-1 assessed at average age 40 predicts the early development of advanced atherosclerosis, only partly mediated by effects of elevations of known risk factors.

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