scholarly journals The Connection Between Triglycerides and Ectopic Fat Obesity: An Inverted U-Shaped Curve

2020 ◽  
Author(s):  
Yang Zou ◽  
Meng Yu ◽  
Guotai Sheng ◽  
Guobo Xie
Keyword(s):  
Inflection Point ◽  
Additive Model ◽  
Smooth Curve ◽  
Cross Sectional Study ◽  
Ectopic Fat ◽  
Cross Sectional ◽  
Adult Participants ◽  
Study Population ◽  
The Right ◽  
The Relationship

Abstract Background: Ectopic fat obesity and Triglycerides are risk factors for diabetes and multiple cardiovascular diseases, but the data on the relationship between Triglycerides and the risk of ectopic fat obesity are limited. The purpose of this study is to explore the connection between Triglycerides and ectopic fat obesity.Methods: This is a cross-sectional study, we retrospectively analyzed 15464 adult participants recruited by Murakami Memorial Hospital from 2004-2015(8430 men and 7034 women, average age 43.71±8.9), to performed the relationship between Triglycerides and ectopic fat obesity, we divided all patients into 4 groups according to the quartile of Triglycerides. Logistic regression model was used to analyze the relationship between Triglycerides and the risk of ectopic fat obesity, and the generalized additive model was used to identify the nonlinear relationship.Results: In the study population, the prevalence of ectopic fat obesity was 17.73%, and gradually increased in the quartile of Triglycerides (2.86,7.89,18.25 and 41.22% respectively, P < 0.001).After adjusting other covariables, Triglycerides was positively correlated with the risk of ectopic fat obesity (OR:1.55,95%CI:1.41-1.69, p<0.00001). Then we carried out smooth curve fitting and found that there was an inverted U-shaped curve relationship between Triglycerides and ectopic fat obesity, even if those adjusted covariables were removed from the model, the result remained unchanged, and the inflection point of the curve was 3.98. On the left side of the inflection point, Triglycerides was positively correlated with the risk of ectopic fat obesity(OR:1.784,95%CI:1.611-1.975,p<0.0001), while on the right side of the inflection point, there was a negative correlation (OR:0.519,95%CI:0.333-0.810,p=0.0039).Conclusions: Our research shows that there is a significant correlation between Triglycerides and ectopic fat obesity, this relation is not a simple linear relationship, but it was an inverted U-shaped curve relationship.

scholarly journals The association between triglycerides and ectopic fat obesity: An inverted U-shaped curve

PLoS ONE ◽  
2020 ◽  
Vol 15 (11) ◽  
pp. e0243068
Author(s):  
Yang Zou ◽  
Guotai Sheng ◽  
Meng Yu ◽  
Guobo Xie
Keyword(s):  
Inflection Point ◽  
Generalized Additive Model ◽  
Additive Model ◽  
Smooth Curve ◽  
Cross Sectional Study ◽  
Ectopic Fat ◽  
Sectional Study ◽  
Cross Sectional ◽  
Adult Participants ◽  
Study Population

Background Ectopic fat obesity and triglycerides are risk factors for diabetes and multiple cardiovascular diseases. However, there have been limited studies on the association between triglycerides and ectopic fat obesity. The purpose of this study was to explore the association between triglycerides and ectopic fat obesity. Methods and results In this cross-sectional study, we retrospectively analyzed 15464 adult participants recruited by Murakami Memorial Hospital (8430 men and 7034 women, average age of 43.71 ± 8.90). All patients were divided into two groups according to the threshold used to diagnose hypertriglyceridemia. The logistic regression model was used to analyze the association between triglycerides and the risk of ectopic fat obesity, and the generalized additive model was used to identify the nonlinear association. In this study population, the prevalence of ectopic fat obesity was 17.73%. After adjusting other covariables, triglycerides were positively correlated with the risk of ectopic fat obesity (OR: 1.54, 95% CI:1.41–1.69, P<0.0001). Through smooth curve fitting, we found that there was an inverted U-shaped curve association between triglycerides and ectopic fat obesity. This association remained unchanged even if the adjusted covariables were removed from the model, and the inflection point of the curve was 3.98. When triglyceride levels were ≤3.98, triglycerides were positively correlated with the risk of ectopic fat obesity (OR:1.784, 95% CI:1.611–1.975, P<0.0001). When triglyceride levels were >3.98 (right side of the inflection point), there was a negative correlation (OR:0.519, 95% CI:0.333–0.810, P = 0.0039). Conclusions Our research showed that there is a significant association between triglycerides and ectopic fat obesity. This relation is not a simple linear relationship but instead an inverted U-shaped curve association.

scholarly journals Serum 25-hydroxyvitamin D is negatively associated with severe periodontitis: a cross-sectional study

2021 ◽  
Vol 21 (1) ◽  
Author(s):  
Fangjing Zhou ◽  
Ning Ma ◽  
Ruiting Su ◽  
Xiaoyu He ◽  
Xiaona Wang ◽  
...  
Keyword(s):  
Effect Size ◽  
Inflection Point ◽  
Cross Sectional Study ◽  
Cross Sectional ◽  
Negatively Associated ◽  
Hydroxyvitamin D ◽  
Severe Periodontitis ◽  
25 Hydroxyvitamin D ◽  
The Right ◽  
The Relationship

Abstract Background Periodontitis can lead to the destruction of periodontium and adversely influence the overall health, wellbeing, and quality of life. However, studies on the relationship between severe periodontitis and serum 25-hydroxyvitamin D [25(OH)D] are limited. This study is designed to explore the relationship between 25(OH)D and severe periodontitis. Methods A cross-section study of 2928 participants enrolled from the National Health and Nutrition Examination Survey (NHANES) from 2013 to 2014 was conducted. The periodontal examination was performed using a total oral periodontal examination program, and probe measurements were collected at six sites per tooth in NHANES. Severe periodontitis was characterized as: ≥ 2 interproximal sites with attachment loss (AL) ≥ 6 mm (not on the same tooth) and ≥ 1 interproximal site with probing depth (PD) ≥ 5 mm. Severe periodontitis and serum 25(OH)D were the dependent and independent variables, respectively. Univariate, multivariate, and subgroup analyses were performed to explore the relationship between severe periodontitis and serum 25(OH)D. Results Among the 2928 participants, the average age of the population was 50 ± 13.71 years old, with 1425 (48.67%) males, 316 (10.79%) exhibited severe periodontitis. Serum 25(OH)D showed a significantly negative association with severe periodontitis after adjusting all variables (OR 0.75, 95% CI 0.63–0.89). In addition, severe periodontitis has a nonlinear relationship with serum 25(OH)D, whoes inflection point was 102 (nmol/L). On the left side of the inflection point (25(OH)D ≤ 102 nmol/L), the effect size was 0.98 and 95%CI was 0.98–0.99 (25(OH)D per 1 nmol/L increments). On the right side of the inflection point (25(OH)D > 102 nmol/L), the effect size was 0.99 and 95% CI was 0.98–1.01. The subgroup analysis showed pronounced changes in non-Hispanic white, alcohol consumption, diabetes, and health insurance. Conclusion Serum 25 (OH) D in relation to severe periodontitis is nonlinear in our study.When serum 25 (OH) D is less than 102 nmol/L, serum 25 (OH) D is negatively associated with severe periodontitis.

scholarly journals The Knowledge, Attitude, and Behavior of Hospitalized Patients' Families in the Effort to Prevent COVID-19

2021 ◽  
Author(s):  
Anies Dewi Wirati Indraswari ◽  
Abdul Aziz ◽  
Meircurius Dwi Condro Surboyo
Keyword(s):  
Strong Relationship ◽  
Cross Sectional Study ◽  
Hospitalized Patients ◽  
Chi Square ◽  
Cross Sectional ◽  
Chi Square Test ◽  
Knowledge And Attitude ◽  
The Right ◽  
And Behavior ◽  
The Relationship

Abstract Introduction The coronavirus disease-2019 (COVID-19) pandemic has also hit Indonesia. Until September 2020, cases continued to increase with the highest number in Jakarta. The right behavior needs to be followed to prevent COVID-19; this aspect has a strong relationship with knowledge and attitude. This study aimed to analyze the relationship between the knowledge, attitudes, and behavior of hospitalized patients' families in Fatmawati Hospital, Jakarta, in an effort to prevent COVID-19. Materials and Methods A cross-sectional study was conducted on 300 respondents using a self-administered questionnaire to assess their knowledge, attitude, and behavior about COVID-19. The relationship between knowledge, attitude, and behavior was analyzed using the chi-square test with p < 0.05. Results Most of the participants responded to the questionnaire showing a good knowledge, attitude, and behavior related to the efforts to prevent COVID-19. No relationship was present between knowledge, attitude, and behavior in an effort to prevent COVID-19 (p = 0.414 and p = 0.165). Conclusion The hospitalized patients' families exhibited an adequate level of knowledge, attitude, and preventive behaviors toward COVID-19.

Development and Psychometric Relationship between Occupational Prestige and Social Health of Nursing Staff: A Cross-Sectional Study

2016 ◽  
Vol 9 (3) ◽  
pp. 251
Author(s):  
Shahin Tohidi ◽  
Maryam Shoorvasi ◽  
Arezoo Shayan ◽  
Hassan Ahmadinia ◽  
Sedigheh Furohari
Keyword(s):  
Cross Sectional Study ◽  
Staff Nurses ◽  
Social Health ◽  
Occupational Prestige ◽  
Cross Sectional ◽  
Significant Difference ◽  
Study Population ◽  
Convenience Sampling ◽  
Promotion Strategies ◽  
The Relationship

<p><strong>BACKGROUND: </strong>One of the features that any profession possesses is that it occupies a social status relative to other professions. The present paper contributes to the discussion on the relationship between nursing occupational prestige and social health.</p><p><strong>METHOD:</strong> This study was a cross-sectional research that was conducted in 2015. The study population consisted of 200 staff nurses working in all hospitals located in Hamedan, Iran. A convenience sampling was employed to select 200 nurses who were asked respond to the 25item Keyes’s Social Health Questionnaire and the16-item Nursing Occupational Prestige Questionnaire. Higher score reflected better social health and occupational prestige. The quantitative analysis of this study was carried out using the Statistical Package for Social Science (SPSS).</p><p><strong>RESULTS:</strong> The results showed that the nurses’ mean score of social health and nursing occupational prestige were respectively 43.88±9.18 and occupational prestige44.83±25.14. Social health was significantly related to occupational prestige in the nurses (r=0.15, P=0.04). 66.5% of the nurses were reported to have average occupational prestige and 75.5% of them were believed to have average social health. There was a statistically significant difference in scores of the occupational prestige among the nursing post (P=0.01), job satisfaction (P&lt;0.001) and job interest (P=0.007).</p><p><strong>CONCLUSION:</strong> Nurses’ social health deserves special attention. Effective social health promotion strategies should be considered for promoting their social health particularly in occupational prestige.</p>

Prevalence and Predictors of Need for Seating Intervention and Mobility for Persons in Long-Term Care

2007 ◽  
Vol 26 (3) ◽  
pp. 195-204 ◽  
Author(s):  
Melissa C. Bourbonniere ◽  
Laura M. Fawcett ◽  
William C. Miller ◽  
Jennifer Garden ◽  
William B. Mortenson
Keyword(s):  
Long Term Care ◽  
Cross Sectional Study ◽  
Independent Mobility ◽  
Cross Sectional ◽  
Term Care ◽  
Home Life ◽  
Study Population ◽  
Wheel Chair ◽  
The Relationship

ABSTRACTA descriptive cross-sectional study was conducted to (a) determine the prevalence of need for wheel-chair seating intervention in two long-term care facilities in Vancouver, BC, (b) determine the extent of the residents' independent mobility within these facilities, and (c) explore the relationship between proper wheel-chair seating and positioning and independent mobility. The study population comprised 99 wheel-chair-using older adults. Four trained raters assessed need for seating intervention, using the Seating Identification Tool, and quantified extent and frequency of wheel-chair mobility, using the Nursing Home Life-Space Diameter. Results indicated that (a) there was a low need (overall 22%) for wheel-chair seating intervention in the two facilities, (b) half of the residents were independently mobile in their own rooms and on their units, but independent mobility decreased when greater distances needed to be travelled, and (c) the need for wheel-chair seating intervention was the only significant predictor of extent of independent mobility. These findings suggest that, where there are dedicated staff and equipment resources, the need for wheel-chair seating intervention can be minimized and independent mobility for long-term care residents maximized.

Is there a relationship between dietary sodium and potassium intake and clinical findings of a migraine headache?

2021 ◽  
pp. 1-28
Author(s):  
Arman Arab ◽  
Fariborz Khorvash ◽  
Zahra Heidari ◽  
Gholamreza Askari
Keyword(s):  
Migraine Headache ◽  
Linear Regression Analysis ◽  
Multiple Linear Regression Analysis ◽  
Cross Sectional Study ◽  
Clinical Findings ◽  
Dietary Sodium ◽  
Cross Sectional ◽  
Migraine Headaches ◽  
Study Population ◽  
The Relationship

Abstract Aim: Few studies have assessed the association between sodium (Na) and potassium (K) and migraine headaches. In this study, we aimed to examine the relationship between 24-hour urine Na and K intakes and clinical findings of migraine in an Iranian sample. Methods: In this cross-sectional study, 262 participants, aged 20-50 years, were included with a body mass index (BMI) of 18.5-30 kg/m2 and a diagnosis of migraine. One 24-hour urine sample was collected from each subject to estimate the Na and K intakes. The clinical features of migraine, including frequency, duration, severity, Migraine Headache Index Score (MHIS), and Headache Impact Test (HIT) score, were assessed. Besides, a multiple linear regression analysis was performed, and beta estimates and the corresponding 95% confidence intervals (CIs) were reported. Results: Overall, 224 women and 38 men, with a mean age of 36.10 years and BMI of 25.55 kg/m2 comprised our study population. After controlling for potential confounders, the 24-hour urine Na was positively associated with a longer headache duration (β=0.29; 95% CI: 0.06, 0.53) in the group with the highest urine Na levels as compared to the group with the lowest levels. After adjustments for potential confounders, an increase of 13.05 in the MHIS was observed when the 24-hour urine Na level increased from the first to the third tertile (β=13.05; 95% CI: 1.70, 24.41). Conclusion: Our findings suggested that a higher 24-hour urine Na level was positively associated with a longer duration of migraine headaches and a higher MHIS.

U-shaped association between serum bilirubin levels and peripheral arterial disease in Chinese males with hypertension

2020 ◽  
Author(s):  
Yumeng Shi ◽  
Lihua Hu ◽  
Minghui Li ◽  
Xiao Huang ◽  
Congcong Ding ◽  
...  
Keyword(s):  
Peripheral Arterial Disease ◽  
Inflection Point ◽  
Total Bilirubin ◽  
Arterial Disease ◽  
Cross Sectional Study ◽  
Serum Total Bilirubin ◽  
Cross Sectional ◽  
Artery Disease ◽  
Peripheral Arterial ◽  
The Right

Abstract Background: Previous studies have indicated that serum total bilirubin might play an important role in peripheral artery disease (PAD). However, the effects of different levels of serum total bilirubin (TBiL) on PAD development remain uncertain, and there are limited data in male participants. We aimed to examine the prevalence of PAD and TBiL among Chinese male adults with hypertension.Methods: A total of 5129 hypertensive male subjects aged 27-93 years were included in the current study. The outcome was peripheral arterial disease (PAD), defined as present when the ABI of either side was ≤ 0.90.Results: Of 5129 hypertensive male participants, 194 (3.78%) had PAD, and the mean serum total bilirubin was 15.67 (7.76) μmol/L. Compared to participants in Q2-Q3 of LgTBiL, there was a significantly increased prevalence of PAD for participants in both Q1 (OR, 1.49; 95% CI: 1.04-2.14) and Q4 (OR, 1.70; 95% CI: 1.16-2.48). After adjusting for potential confounders, a nonlinear U-shaped relationship was detected between TBiL and the prevalence of PAD, and the inflection point was calculated to be 1.08 (LgTBiL = 1.08, TBiL = 12.02 μmol/L). The ORs (95% CIs) were 0.11 (0.02, 0.83) on the left side of the inflection point and 5.26 (1.59, 17.38) on the right side of the inflection point. Similar results were found in various subgroups.Conclusions: This cross-sectional study showed that there was a U-shaped curve for the prevalence of PAD with TBiL concentration in Chinese males with hypertension, with a turning point at 12.02 μmol/L.

scholarly journals C1q/TNF-Related Protein5 (CTRP5) as a Biomarker to Predict Metabolic Syndrome and Each of Its Components

2018 ◽  
Vol 2018 ◽  
pp. 1-8 ◽  
Author(s):  
Feiyu Jiang ◽  
Min Yang ◽  
Xili Zhao ◽  
Rui Liu ◽  
Gangyi Yang ◽  
...  
Keyword(s):  
Insulin Resistance ◽  
Metabolic Syndrome ◽  
Binary Logistic Regression ◽  
Cross Sectional Study ◽  
Sectional Study ◽  
Cross Sectional ◽  
Multiple Stepwise Regression Analysis ◽  
Glucose And Lipid Metabolism ◽  
Study Population ◽  
The Relationship

Objective. C1q/TNF-related protein5 (CTRP5) is a member of the C1q/tumor necrosis factor α- (TNF-α-) related protein family and has been reported to be associated with the regulation of glucose and lipid metabolism. However, the clinical association between CTRP5 and metabolic syndrome (MetS) has not been reported. The aim of the current study is to investigate the association between CTRP5 and MetS by a cross-sectional study. Methods. We performed a cross-sectional study in a Chinese population including 89 controls and 88 MetS individuals. Serum CTRP5 concentrations were determined by ELISA. The relationship between circulating CTRP5 and MetS and insulin resistance (IR) was assessed by Spearman’s correlation and multiple stepwise regression analysis. Results. Circulating CTRP5 concentrations were markedly decreased in MetS individuals relative to normal adults. Overweight/obese individuals (BMI ≥ 25 kg/m2) showed a lower serum CTRP5 level than lean subjects (BMI < 25 kg/m2) in the study population (124.1 (99.12–147.37) vs. 103.9 (79.15–124.25) μg/L; P<0.01). Circulating CTRP5 was found to be correlated negatively with BMI, FAT%, FBG, WHR, SBP, HbA1c, TG, 2-hour blood glucose after glucose overload (2-hOGTT), FIns, and HOMA-IR and positively with HDL-C (P<0.05 or P<0.01). Binary logistic regression revealed that serum CTRP5 levels were associated with MetS. In addition, serum CTRP5 levels gradually decreased with the increase in MetS components. Conclusions. Circulating CTRP5 is relative to the elevated risk of MetS in humans and may be in part through the effect of insulin resistance. This trial is registered with ChiCTR-OCS-13003185.

scholarly journals COVID-19 Hospitalization in Adults with Type 1 Diabetes: Results from the T1D Exchange Multicenter Surveillance Study

2020 ◽  
Author(s):  
Grenye O’Malley ◽  
Osagie Ebekozien ◽  
Marisa Desimone ◽  
Catherina T Pinnaro ◽  
Alissa Roberts ◽  
...  
Keyword(s):  
Type 1 Diabetes ◽  
Glucose Monitoring ◽  
Cross Sectional Study ◽  
Care Providers ◽  
Cross Sectional ◽  
Logistic Regression Models ◽  
Study Population ◽  
Few Data ◽  
The Relationship

Abstract Context Diabetes mellitus is associated with increased COVID-19 morbidity and mortality, but there are few data focusing on outcomes in people with type 1 diabetes. Objective The objective of this study was to analyze characteristics of adults with type 1 diabetes for associations with COVID-19 hospitalization. Design An observational multisite cross-sectional study was performed. Diabetes care providers answered a 33-item questionnaire regarding demographics, symptoms, and diabetes- and COVID-19-related care and outcomes. Descriptive statistics were used to describe the study population, and multivariate logistic regression models were used to analyze the relationship between glycated hemoglobin (HbA1c), age, and comorbidities and hospitalization. Setting Cases were submitted from 52 US sites between March and August 2020. Patients or Other Participants Adults over the age of 19 with type 1 diabetes and confirmed COVID-19 infection were included. Interventions None. Main Outcome Measures Hospitalization for COVID-19 infection. Results A total of 113 cases were analyzed. Fifty-eight patients were hospitalized, and 5 patients died. Patients who were hospitalized were more likely to be older, to identify as non-Hispanic Black, to use public insurance, or to have hypertension, and less likely to use continuous glucose monitoring or insulin pumps. Median HbA1c was 8.6% (70 mmol/mol) and was positively associated with hospitalization (odds ratio 1.42, 95% confidence interval 1.18-1.76), which persisted after adjustment for age, sex, race, and obesity. Conclusions Baseline glycemic control and access to care are important modifiable risk factors which need to be addressed to optimize care of people with type 1 diabetes during the worldwide COVID-19 pandemic.

scholarly journals The Association of PTSD Symptom Severity With Localized Hippocampus and Amygdala Abnormalities

2017 ◽  
Vol 1 ◽  
pp. 247054701772406 ◽  
Author(s):  
Teddy J. Akiki ◽  
Christopher L. Averill ◽  
Kristen M. Wrocklage ◽  
Brian Schweinsburg ◽  
J. Cobb Scott ◽  
...  
Keyword(s):  
Ptsd Symptom ◽  
Cross Sectional Study ◽  
Ptsd Symptoms ◽  
Structural Shape ◽  
Cross Sectional ◽  
Fine Grained ◽  
The Right ◽  
Post Hoc ◽  
The Relationship ◽  
Shape Analyses

Background The hippocampus and amygdala have been repeatedly implicated in the psychopathology of posttraumatic stress disorder (PTSD). While numerous structural neuroimaging studies examined these two structures in PTSD, these analyses have largely been limited to volumetric measures. Recent advances in vertex-based neuroimaging methods have made it possible to identify specific locations of subtle morphometric changes within a structure of interest. Methods In this cross-sectional study, we used high-resolution magnetic resonance imaging to examine the relationship between PTSD symptomatology, as measured using the Clinician Administered PTSD Scale for the DSM-IV, and structural shape of the hippocampus and amygdala using vertex-wise shape analyses in a group of combat-exposed U.S. Veterans (N = 69). Results Following correction for multiple comparisons and controlling for age and cranial volume, we found that participants with more severe PTSD symptoms showed an indentation in the anterior half of the right hippocampus and an indentation in the dorsal region of the right amygdala (corresponding to the centromedial amygdala). Post hoc analysis using stepwise regression suggest that among PTSD symptom clusters, arousal symptoms explain most of the variance in the hippocampal abnormality, whereas reexperiencing symptoms explain most of the variance in the amygdala abnormality. Conclusion The results provide evidence of localized abnormalities in the anterior hippocampus and centromedial amygdala in combat-exposed U.S. Veterans suffering from PTSD symptoms. This novel finding provides a more fine-grained analysis of structural abnormalities in PTSD and may be informative for understanding the neurobiology of the disorder.

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