Evaluation of modulatory effects of taurine in the aortic and myocardial tissue of nitroglycerin-induced tolerance Wistar rats

Nutrire ◽  
2021 ◽  
Vol 46 (2) ◽  
Author(s):  
Oluseye Odebiyi ◽  
Joseph Badejo ◽  
Babatunde Alabi ◽  
Abayomi Ajayi ◽  
Olugbenga Iwalewa ◽  
...  
Keyword(s):  
Wistar Rats ◽  
Myocardial Tissue ◽  
Induced Tolerance

Toxic effect of alpha cypermethrin, an environmental pollutant, on myocardial tissue in male wistar rats

2019 ◽  
Vol 27 (6) ◽  
pp. 5709-5717 ◽  
Author(s):  
Lakhdar Ghazouani ◽  
Anouar Feriani ◽  
Afoua Mufti ◽  
Meriam Tir ◽  
Intissar Baaziz ◽  
...  
Keyword(s):  
Toxic Effect ◽  
Wistar Rats ◽  
Environmental Pollutant ◽  
Myocardial Tissue ◽  
Male Wistar Rats

Cardiovascular and hormonal responses to swimming and running in the rat

1988 ◽  
Vol 65 (1) ◽  
pp. 116-123 ◽  
Author(s):  
D. Geenen ◽  
P. Buttrick ◽  
J. Scheuer
Keyword(s):  
Wistar Rats ◽  
Blood Gases ◽  
Myocardial Tissue ◽  
Base Line ◽  
Hormonal Responses ◽  
Arterial Lactate ◽  
Blood Samples ◽  
Arterial Blood ◽  
Female Wistar Rats ◽  
Left And Right

Hemodynamic and hormonal responses were studied during swimming (SW) and running (R) and in cage-confined (C) female Wistar rats at base line and 4 and 8 wk of training. Myocardial tissue levels of norepinephrine (NE) and epinephrine (EPI) were also measured at the end of 8 wk of training. Mean arterial blood pressure (BP), heart rate (HR), and blood samples for arterial lactate, plasma NE and EPI, and blood gases were obtained at rest and at 20, 40, and 60 min of exercise. After 4 wk of SW, a resting bradycardia was observed, and HR response for the remaining 4 wk was attenuated with SW compared with HR during R. BP and blood gases remained unchanged between the two groups. R resulted in increased arterial lactate concentrations compared with C and SW at base line but was not different from SW at 4 wk. SW elicited higher plasma levels of NE and EPI compared with C at base line and C and R at 4 wk. Myocardial tissue NE and EPI concentrations were markedly increased in both the left and right ventricle of the SW group compared with both R and C. These results indicate that BP and blood gases are not different between chronic R and SW and suggest a possible sympathoadrenal role in the differences observed in cardiac adaptations between R and SW.

scholarly journals Telmisartan Prevents Myocardial Fibrosis via Decreasing Fraction of Colagen Type 1 Volume in Myocardial Tissue in Wistar Rats-Induced High Salt Intake

2017 ◽  
Vol 1 (1) ◽  
pp. 28-34
Author(s):  
Radiyati Umi Partan ◽  
Rachmat Hidayat ◽  
Mgs Irsan Saleh ◽  
Nita Parisa ◽  
Evi Lusiana ◽  
...  
Keyword(s):  
Body Weight ◽  
Myocardial Fibrosis ◽  
Wistar Rats ◽  
Collagen Type ◽  
Volume Fraction ◽  
Myocardial Tissue ◽  
Group 3 ◽  
Group 2 ◽  
Collagen Type 1

Myocardial fibrosis is a pathological condition that responsible for initiation of heart failure. Neurohormonal endogen, angiotensin II, has a potential role to activate endothelin I, TGF-β1, myocardial fibroblast, extracelullar matrix deposition, structural changes and decreasing of cardiac function. Fibrotic process is also influenced by PPAR γ. Telmisartan has a potential effect to inactivate angiotensinergic system and to activate PPAR γ. It is expected that telmisartan has optimal effect to protect myocardial fibrosis. To know the role of variation dose of telmisartan to decrease collagen type 1 fraction volume in cardiac tissue of Wistar rats. Ten-week-old male Wistar Rat (n = 30) were randomized into five groups, and each group consisted of 6 rats. Group 1 : negative control. Group 2 : rats were induced by intake Nacl 8% doses 2% body weight for eight weeks. Group 3 : rats were induced by intake Nacl 8% doses 2% body weight and telmisartan 3 mg/kgBB for eight weeks. Group 4 : rats were induced by intake Nacl 8% doses 2% body weight and telmisartan 6 mg/kgBB for eight weeks. Group 5 : rats were induced by intake Nacl 8% doses 2% body weight and telmisartan 12 mg/kgBB for eight weeks. Collagen volume fraction was assessed by immunohistochemistry and ImageJ program. ANOVA test followed pos hoc test was used to analyzed each variable. Collagen volume fraction significantly decreased in group 3, 4 and 5 compared in group 2. Telmisartan decreases collagen type 1 volume fraction of myocardial tissue .

scholarly journals Cardioprotective activity of fruit of Garcinia pedunculata on isoprenaline-induced myocardial infarction in rat

2016 ◽  
Vol 11 (1) ◽  
pp. 231 ◽  
Author(s):  
Ravi Mundugaru ◽  
Padmaja Udaykumar ◽  
Sivanesan Senthilkumar ◽  
Sudhakara Bhat
Keyword(s):  
Myocardial Infarction ◽  
Protective Effect ◽  
Rat Model ◽  
Wistar Rats ◽  
Treated Group ◽  
Degenerative Changes ◽  
Cardioprotective Effect ◽  
Myocardial Tissue ◽  
Fruit Extract ◽  
Once Daily

<p>The present study reveals the protective effect of<em> Garcinia pedunculata</em> aqueous fruit extract in isoprenaline-induced myocardial infarction in Wistar rats. Isoprenaline (200 mg/kg) administration subcutaneous once daily for two consecutive days significantly (p&lt;0.01) increased the CK-MB, AST, ALT, ALP activity and CRP (p&lt;0.05) levels. Pretreatment with extract (400 mg/kg) orally for 14 consecutive days significantly ameliorated the effect of isoprenaline by reducing the activity of CK-MB and the levels of ALP, SGPT respectively. No significant changes were seen in the case of SGOT activity and CRP levels. Severe necrotic lesions in the myocardial tissue were observed in isoprenaline-treated group. In extract-treated group, mild degenerative changes of myo-cardial tissues to nearly normal cytoarchitecture were seen. The results indicate the cardioprotective effect of <em>G. pedunculata</em> against isoprenaline- induced myocardial infarction rat model.</p><p> </p>

scholarly journals The pre‐exposure to nitric oxide donor ([Ru(terpy)(bdq)NO]3 3 )TERPY induced tolerance endothelium‐dependent in Wistar rats and SHR aortas (851.9)

2014 ◽  
Vol 28 (S1) ◽  
Author(s):  
Simone Potje ◽  
Jssica Troiano ◽  
Murilo Graton ◽  
Roberto Silva ◽  
Lusiane Bendhack ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Wistar Rats ◽  
Nitric Oxide Donor ◽  
Induced Tolerance

Ultrastructural Investigation of Spontaneous Pituitary Adenomas in Aging Sprague-Dawley Rats

1982 ◽  
Vol 40 ◽  
pp. 216-217
Author(s):  
D. J. McComb ◽  
J. Beri ◽  
F. Zak ◽  
K. Kovacs
Keyword(s):  
Microscopic Study ◽  
Pituitary Adenomas ◽  
Wistar Rats ◽  
Microscopic Level ◽  
Sprague Dawley ◽  
Prolactin Cells ◽  
Light Microscopic Level ◽  
Ultrastructural Investigation ◽  
Sprague Dawley Rats ◽  
Long Evans

Investigation of the spontaneous pituitary adenomas in rat have been limited mainly to light microscopic study. Furth et al. (1973) described them as chromophobic, secreting prolactin. Kovacs et al. (1977) in an ul trastructural investigation of adenomas of old female Long-Evans rats, found that they were composed of prolactin cells. Berkvens et al. (1980) using immunocytochemistry at the light microscopic level, demonstrated that some spontaneous tumors of old Wistar rats could contain GH, TSH or ACTH as well as PRL.

Light and electron microscopic investigation of adenohypophyses of germfree, food-restricted, and germfree-food restricted aging, male lobund-wistar rats

1988 ◽  
Vol 46 ◽  
pp. 352-353
Author(s):  
G. Ilse ◽  
K. Kovacs ◽  
N. Ryan ◽  
T. Sano ◽  
L. Stefaneanu ◽  
...  
Keyword(s):  
Wistar Rats ◽  
Microscopic Investigation ◽  
Electron Microscopic Investigation ◽  
Aging Male ◽  
Sprague Dawley ◽  
Electron Microscopic ◽  
Sprague Dawley Rats ◽  
Old Rats ◽  
Ad Libitum ◽  
Microscopic Findings

Germfree state and food restriction have been shown to increase life span and delay tumor occurrence in rats. We report here the histologic, immunocytochemical and electron microscopic findings of adenohypophyses of aging, male Lobund-Wistar rats raised at Lobund Laboratories. In our previous study, the morphologic changes in the adenohypophyses of old rats have been extensively investigated by histology, immunocytochemistry and electron microscopy. Lactotroph adenomas were frequent in Long-Evans and Sprague-Dawley rats, whereas gonadotroph adenomas were frequent in Sprague-Dawley and Wistar rats.Male Lobund-Wistar rats were divided into four groups: 1) conventional, which were raised under normal non-germfree environment and received food ad libitum; 2) germfree-food ad libitum; 3) conventional environment-food restricted and 4) germfree-food restricted. The adenohypophyses were removed from 6-month-, 18-month- and 30-month-old rats. For light microscopy, adenohypophyses were fixed in formalin and embedded in paraffin.

Surface epithelial ultrastructure of the polycystic ovary in the BB wistar rat

1986 ◽  
Vol 44 ◽  
pp. 252-253
Author(s):  
R. C. Kaufmann ◽  
F. K. Khosho ◽  
K. S. Amankwah
Keyword(s):  
Electron Microscopy ◽  
Scanning Electron Microscopy ◽  
Wistar Rats ◽  
Polycystic Ovary ◽  
Wistar Rat ◽  
Polycystic Ovaries ◽  
Chemical Diabetes ◽  
Scanning Electron

Diabetes decreases the fertility of females, but the mechanisms are not completely understood. In our investigations, we have found that 13% of the female BB Wistar rats that spontaneously developed chemical diabetes had persistent estrous. In this study the ovaries of these rats were examined by scanning electron microscopy(SEM) and compared to normal-cycling controls as well as to rats that had developed polycystic ovaries(PCO) by exposure to constant 1ight.

Structural and functional renal alterations in five-sixth nephrectomized rats on unrestricted diet

1986 ◽  
Vol 44 ◽  
pp. 342-343
Author(s):  
I. Stachura ◽  
M. Pardo ◽  
J. Costello ◽  
D.M. Landwehr
Keyword(s):  
Wistar Rats ◽  
Renal Damage ◽  
Standard Diet ◽  
Experimental Conditions ◽  
Phosphate Intake ◽  
Dietary Restrictions ◽  
Severe Reduction ◽  
Male Wistar Rats ◽  
Unrestricted Diet ◽  
Progressive Renal Insufficiency

Under experimental conditions severe reduction of renal mass results in the hyperfiltration of the remaining nephrons leading to a progressive renal insufficiency. Similar changes are observed in patients with various renal disorders associated with a loss of the functioning nephrons. The progression of renal damage is accelerated by high protein and phosphate intake, and may be modified by the dietary restrictions.We studied 50 five-sixth nephrectarrized male Wistar rats on a standard diet (Rodent Laboratory Chow 5001 Ralston Purina Co., Richmond, Indiana; containing 23.4% protein) over a 20 week period.

Parathyroid gland before and after cisplatin treatment

1987 ◽  
Vol 45 ◽  
pp. 860-861
Author(s):  
S.K. Aggarwal ◽  
J.M. Fadool
Keyword(s):  
Parathyroid Gland ◽  
Wistar Rats ◽  
Antitumor Agent ◽  
The Body ◽  
Cross Linking ◽  
Limiting Factor ◽  
Hormonal Changes ◽  
Primary Mechanism ◽  
Before And After ◽  
Dna Strands

Cisplatin (CDDP) a potent antitumor agent suffers from severe toxic side effects with nephrotoxicity being the major dose-limiting factor, The primary mechanism of its action has been proposed to be through its cross-linking DNA strands. It has also been shown to inactivate various transport enzymes and induce hypocalcemia and hypomagnesemia that may be the underlying cause for some of its toxicities. The present is an effort to study its influence on the parathyroid gland for any hormonal changes that control calcium levels in the body.Male Swiss Wistar rats (Crl: (WI) BR) weighing 200-300 g and of 60 days in age were injected (ip) with cisplatin (7mg/kg in normal saline). The controls received saline injections only. The animals were injected (iv) with calcium (0.5 ml of 10% calcium gluconate/day) and were killed by decapitation on day 1 through 5. Trunk blood was collected in heparinized tubes.

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