scholarly journals Long-term assessment of risk factors for canine tumors registered in Xi’an, China

2021 ◽  
Vol 1 (1) ◽  
Author(s):  
Wei Wang ◽  
Weihui Li ◽  
Dianfeng Chu ◽  
Jinlian Hua ◽  
Xinke Zhang ◽  
...  
Keyword(s):  
Reproductive System ◽  
Breast Tumors ◽  
Tumor Incidence ◽  
Medical Surveillance ◽  
High Susceptibility ◽  
Comparative Oncology ◽  
Pet Dogs ◽  
High Incidence ◽  
Canine Tumors

AbstractTumors are one of the leading causes to death in pet dogs among diseases. The tumor incidence of pet dogs has been increasing, raising widespread concern.The tumor incidence of pet dogs has been increasing, raising widespread concern. In this study, retrospective analysis was performed with 246 tumor cases registered in Xi’an Animal Hospital, Northwest A&F University from 2009 to 2018. Correlations of sex, age and breed with tumor incidences were evaluated. The results showed that reproductive system tumors occupied the highest proportion (39.84%), followed by cutaneous tumors (28.05%), digestive tumors (18.70%) and ocular tumor (4.47%). Among the reproductive system tumors, breast tumors are the most common tumor in female pet dogs, especially for Pekingese (11.43%). Female dogs with high susceptibility to breast tumors were at the ages of 6–18 years old. As far as cutaneous tumors were concerned, the male pet dogs at all ages, particularly Golden Retrievers (17.39%), showed a high incidence. By contrast, male Samoyed aged from 4 to 13 years had the highest incidence (15.22%) of digestive tumors. In addition, pet dogs with ocular tumors mainly happened at the ages of 0–1 years and 6–13 years. Collectively, our findings are significant to develop effective measures of medical surveillance for pet dogs’ health and will provide insights for comparative oncology.

Apophysites – Revue de la littérature et ­nouvelles directions

2014 ◽  
Vol 62 (3) ◽  
Keyword(s):  
Scientific Evidence ◽  
Ossification Center ◽  
Health Staff ◽  
Optimal Management ◽  
Long Term Effect ◽  
High Incidence ◽  
Youth Athlete ◽  
Pathology Education ◽  
Main Factor

Apophysitis are part of the growth-related diseases within youth athlete population. Despite their high incidence within this growing cohort, many doubts remain. The physiopathology is still debated. Initially, the fragmentation of the ossification center was seen as the main factor of the disease. For few years, this theory has been questioned due to consistent signs of tendon suffering. Apophysitis may have some negative long-term effect on a sporting career. There is currently poor scientific evidence on the optimal management and no treatment has been widely accepted. Prevention remains the most powerful intervention in this particular pathology. Education of the athlete’s sporting entourage (family, coaches and health staff) and the athlete himself is necessary to act quickly and adapt the training load to decrease mechanical stress on the suffering apophysis.

scholarly journals Generation of a Novel Mesothelin-Targeted Oncolytic Herpes Virus and Implemented Strategies for Manufacturing

2021 ◽  
Vol 22 (2) ◽  
pp. 477
Author(s):  
Guendalina Froechlich ◽  
Chiara Gentile ◽  
Luigia Infante ◽  
Carmen Caiazza ◽  
Pasqualina Pagano ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Cancer Cells ◽  
Reproductive System ◽  
Tumor Cell Line ◽  
Breast Tumors ◽  
Oncolytic Viruses ◽  
Female Reproductive System ◽  
Viral Glycoprotein ◽  
Preclinical Development ◽  
Biological Drugs

Background: HER2-based retargeted viruses are in advanced phases of preclinical development of breast cancer models. Mesothelin (MSLN) is a cell-surface tumor antigen expressed in different subtypes of breast and non-breast cancer. Its recent identification as a marker of some triple-negative breast tumors renders it an attractive target, presently investigated in clinical trials employing antibody drug conjugates and CAR-T cells. The availability of MSLN-retargeted oncolytic viruses may complement the current immunotherapeutic panel of biological drugs against HER2-negative breast and non-breast tumors. Methods: A fully virulent, tumor-targeted oncolytic Herpes simplex virus-1 (MSLN-THV) with a selectivity for mesothelin-expressing cancer cells was generated. Recombineering technology was used to replace an essential moiety of the viral glycoprotein D with antibody fragments derived from clinically validated MSLN monoclonal antibodies, and to allow IL12 cargo expression in infected cells. Panels of breast and female reproductive system cell lines were used to verify the oncolytic potential of the viral constructs. A platform for production of the retargeted viruses was developed in HEK 293 cells, providing stable expression of a suitable chimeric receptor. Results: We demonstrated the selectivity of viral infection and cytotoxicity by MSLN-retargeted viruses in a panel of mesothelin-positive cancer cells, originating from breast and female reproductive system tumors. We also developed a second-generation oncolytic MSLN-THV, encoding IL12, to enhance the immunotherapeutic potential of the viral backbone. A non-tumor cell line expressing a chimeric MSLN/Nectin-1 receptor, de-sensitized from antiviral responses by genetic inactivation of the Stimulator of Interferon Genes (STING)-dependent pathway was engineered, to optimize viral yields. Conclusions: Our proof-of-concept study proposes MSLN-retargeted herpesviruses as potential cancer immunotherapeutics for assessments in preclinical models of MSLN-positive tumors, complementing the available panel of oncolytic viruses to HER2-negative breast tumors.

Exploring behaviours perceived as important for human—dog bonding and their translation to a robotic platform

2021 ◽  
Author(s):  
Katie Riddoch ◽  
Roxanne Hawkins ◽  
Emily S. Cross
Keyword(s):  
Thematic Analysis ◽  
Social Bonds ◽  
Artificial Agents ◽  
Robotic Platform ◽  
Pet Dogs ◽  
Potential Barriers ◽  
Physical Affection ◽  
Social Robotic ◽  
Insight Into

To facilitate long-term engagement with social robots, emerging evidence suggests that modelling robots on social animals with whom many people form enduring social bonds – specifically, pet dogs – may be useful. However, scientific understanding of the features of pet dogs that are important for establishing and maintaining social bonds remains limited to broad qualities that are liked, as opposed to specific behaviours. To better understand dog behaviours that are perceived as important for facilitating social bonds between owner and pet, we surveyed current dog owners (n = 153) with open-ended questions about their dogs’ behaviours. Thematic analysis identified 7 categories of behaviours perceived as important to human-dog bonding, including: 1) attunement, 2) communication, 3) consistency and predictability, 4) physical affection, 5) positivity and enthusiasm, 6) proximity, and 7) shared activities. We consider the feasibility of translating these behaviours into a social robotic platform, and signpost potential barriers moving forward. In addition to providing insight into important behaviours for human—dog bonding, this work provides a springboard for those hoping to implement dog behaviours into animal-like artificial agents designed for social roles.

RISK-ORIENTED MODEL OF PREVENTION WORKERS’ REPRODUCTIVE HEALTH DISORDERS USING DIGITAL TECHNOLOGIES

2021 ◽  
Author(s):  
M.A. Fesenko ◽  
◽  
P.A. Vuytsik ◽  
A.V. Miskevich
Keyword(s):  
Reproductive System ◽  
Digital Technologies ◽  
Occupational Risk ◽  
Machine Learning Algorithms ◽  
Expert Assessment ◽  
Female Workers ◽  
Production Factors ◽  
Health Disorders ◽  
Combined Impact

Abstract: The article touches the issue of creating programs for assessing occupational risk and predicting violations of the reproductive system of female workers when exposed to harmful production factors, using machine learning algorithms. As a result of long-term research, the production-related nature of a significant number of diseases of the reproductive system has been proven. Based on the data obtained, a formula for calculating the occupational risk of developing diseases of the reproductive system in female workers was proposed, which is based on expert assessment and takes into account the combined impact of working conditions and lifestyle.

scholarly journals Economic components of the morbidity and rehabilitation of the musculoskeletal system as factors of the organization of the system of physical therapy at the ambulatory stage

2020 ◽  
Vol 6 (1) ◽  
pp. 57
Author(s):  
S. М. Fedorenko ◽  
M. S. Balazh ◽  
V. V. Vitomskyi ◽  
О.B. Lazarіeva ◽  
M. V. Vitomskа
Keyword(s):  
Physical Therapy ◽  
Musculoskeletal System ◽  
Economic Feasibility ◽  
Economic Consequences ◽  
Medical Reform ◽  
High Incidence ◽  
Permanent Loss ◽  
Need For Rehabilitation

<p><strong>The aim</strong>:  to consider the economic consequences of morbidity and rehabilitation of the musculoskeletal system (MSS) among the able-bodied population to confirm the economic feasibility of using physical therapy and the development of its system in the country in order to reduce losses from MSS pathologies in Ukraine.</p><p><strong>Material and methods</strong>: the data of 63 literature sources on the prevalence of MSS diseases among the working population, their economic consequences (payments for treatment, employers' losses), the role of rehabilitation, physical therapy in reducing financial costs, and the needs of the population in rehabilitation and physical therapy were analyzed.</p><p><strong>Results.</strong> Occupational diseases of the MSS are characterized by long-term disability and a high incidence of disability. The effectiveness of rehabilitation, including economic, with injuries and diseases of the MSS was given great attention in the works of domestic and foreign authors. A significant amount of research has confirmed that the funds spent on the implementation of rehabilitation are reimbursed many times by reducing the periods of temporary and permanent loss of working capacity.</p><p><strong>Conclusion.</strong> The economic feasibility of directing the funds for rehabilitation and physical therapy in pathologies of the MSS is reflected in the short duration of disability, the period of adaptation of patients to work, and the need for rehabilitation. Therefore, channeling funds into building a rehabilitation and physical therapy system in Ukraine is appropriate in the framework of medical reform and will have long-term positive economic consequences.</p>

scholarly journals Autoregulation in Resistance Training for Lower Limb Tendinopathy: A Potential Method for Addressing Individual Factors, Intervention Issues and Inadequate Outcomes

2020 ◽  
Author(s):  
Ian Burton
Keyword(s):  
Resistance Training ◽  
Musculoskeletal Disorders ◽  
Lower Limb ◽  
Potential Method ◽  
Future Research ◽  
Individual Factors ◽  
Recurrence Rates ◽  
High Incidence ◽  
Training Protocols

Musculoskeletal disorders such as tendinopathy are having an increasing burden on society and health systems. Tendinopathy is responsible for up to 30% of musculoskeletal disorders, having a high incidence in athletes and the general population. Although resistance training has shown short-term effectiveness for treating lower limb tendinopathy, more comprehensive exercise protocols and progression methods are required due to poor long-term outcomes. The most common resistance training protocols are pre-determined and standardised, which presents significant limitations. Current standardized protocols do not adhere to scientific resistance training principles and do not consider individual factors or take the importance of individualised training into account. Resistance training programs in tendinopathy are currently not achieving required intensity and dosage, leading to high recurrence rates. Therefore, better methods for individualising and progressing resistance training are required to improve outcomes. One potential method is autoregulation, which allows individuals to progress training at their own rate, taking individual factors into account. Despite being found effective for increasing strength in healthy athletes, autoregulation methods have not been investigated in tendinopathy. The purpose of this article was threefold: first to give an overview of individual factors in tendinopathy and current resistance training protocols in tendinopathy and their limitations. Secondly, to give an overview of the history, methods and application of autoregulation strategies both in sports performance and physiotherapy. Finally, a theoretical adaptation of a tendinopathy resistance training protocol with autoregulation methods is presented, providing an example of how the method could be implemented in clinical practice or future research.

scholarly journals CHRONIC TRAUMATIC DISLOCATION OF II-V METACARPAL BONES: CASE REPORT

2014 ◽  
Vol 2 (4) ◽  
pp. 61-65
Author(s):  
Vladimir Ivanovich Zavarukhin ◽  
Ekaterina Sergeevna Morenko ◽  
Sergey Ivanovich Golyana ◽  
Anton Vladimirovich Govorov
Keyword(s):  
Clinical Manifestations ◽  
Primary Treatment ◽  
Long Term Results ◽  
Carpometacarpal Joints ◽  
Results Of Treatment ◽  
Metacarpal Bones ◽  
High Incidence ◽  
Traumatic Dislocation ◽  
Type Of Injury

Dislocations in the carpometacarpal joints of three-phalanx fingers are rare form of injury. Their clinical manifestations are often veiled by swelling, and radiographs in standard views provide little information, which leads to difficulty in diagnosis and a high incidence of unidentified dislocations in the primary treatment. The article describes the basic provisions of the diagnosis and treatment of this type of injury, a clinical case of surgical treatment of undiagnosed dislocations of II-V metacarpal bones in the acute period, and long-term results of treatment.

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