scholarly journals Economic components of the morbidity and rehabilitation of the musculoskeletal system as factors of the organization of the system of physical therapy at the ambulatory stage

2020 ◽  
Vol 6 (1) ◽  
pp. 57
Author(s):  
S. М. Fedorenko ◽  
M. S. Balazh ◽  
V. V. Vitomskyi ◽  
О.B. Lazarіeva ◽  
M. V. Vitomskа
Keyword(s):  
Physical Therapy ◽  
Musculoskeletal System ◽  
Economic Feasibility ◽  
Economic Consequences ◽  
Medical Reform ◽  
High Incidence ◽  
Permanent Loss ◽  
Need For Rehabilitation

<p><strong>The aim</strong>:  to consider the economic consequences of morbidity and rehabilitation of the musculoskeletal system (MSS) among the able-bodied population to confirm the economic feasibility of using physical therapy and the development of its system in the country in order to reduce losses from MSS pathologies in Ukraine.</p><p><strong>Material and methods</strong>: the data of 63 literature sources on the prevalence of MSS diseases among the working population, their economic consequences (payments for treatment, employers' losses), the role of rehabilitation, physical therapy in reducing financial costs, and the needs of the population in rehabilitation and physical therapy were analyzed.</p><p><strong>Results.</strong> Occupational diseases of the MSS are characterized by long-term disability and a high incidence of disability. The effectiveness of rehabilitation, including economic, with injuries and diseases of the MSS was given great attention in the works of domestic and foreign authors. A significant amount of research has confirmed that the funds spent on the implementation of rehabilitation are reimbursed many times by reducing the periods of temporary and permanent loss of working capacity.</p><p><strong>Conclusion.</strong> The economic feasibility of directing the funds for rehabilitation and physical therapy in pathologies of the MSS is reflected in the short duration of disability, the period of adaptation of patients to work, and the need for rehabilitation. Therefore, channeling funds into building a rehabilitation and physical therapy system in Ukraine is appropriate in the framework of medical reform and will have long-term positive economic consequences.</p>

scholarly journals Development of Algorithm for Clinical Management of Sickle Cell Bone Disease: Evidence for a Role of Vertebral Fractures in Patient Follow-up

2020 ◽  
Vol 9 (5) ◽  
pp. 1601 ◽  
Author(s):  
Lucia De Franceschi ◽  
Daniele Gabbiani ◽  
Andrea Giusti ◽  
Gianluca Forni ◽  
Filippo Stefanoni ◽  
...  
Keyword(s):  
Bone Density ◽  
Sickle Cell ◽  
Bone Disease ◽  
Vertebral Fractures ◽  
Cell Disease ◽  
High Incidence ◽  
The Mean

Sickle-cell disease (SCD) is a worldwide distributed hemoglobinopathy, characterized by hemolytic anemia associated with vaso-occlusive events. These result in acute and chronic multiorgan damage. Bone is early involved, leading to long-term disability, chronic pain and fractures. Here, we carried out a retrospective study to evaluate sickle bone disease (SBD) in a cohort of adults with SCD. We assessed bone density, metabolism and turnover. We also evaluated the presence of fractures and the correlation between SCD severity and skeletal manifestations. A total of 71 patients with SCD were analyzed. The mean age of population was 39 ± 10 years, 56% of which were females. We found osteoporosis in a range between 7% and 18% with a high incidence of vertebral fractures. LDH and AST were predictive for the severity of vertebral fractures, while bone density was not. Noteworthy, we identified -1.4 Standard Deviations T-score as the cutoff for detecting the presence of fractures in patients with SCD. Collectively our data allowed us to develop an algorithm for the management of SBD, which may be useful in daily clinical practice to early intersect and treat SBD.

Monoclonal antibody erenumab for migraine prevention: a review of new data

2021 ◽  
Vol 26 (2) ◽  
pp. 11-16
Author(s):  
A. R. Аrtemenkо ◽  
A. M. Plieva ◽  
D. A. Shmidt ◽  
E. V. Ekusheva ◽  
A. L. Kurenkov ◽  
...  
Keyword(s):  
Monoclonal Antibody ◽  
Economic Feasibility ◽  
Migraine Prevention ◽  
Cgrp Receptor ◽  
Results Of Treatment ◽  
Clinical Observations ◽  
Calcitonin Gene ◽  
Real Clinical Practice

Monoclonal antibodies (mAT) to calcitonin-gene-related peptide (CGRP) have become the fi rst class of preventive medications specifically designed to treat migraines. The article examines the mechanism of action of mAT from the standpoint of a modern view of the pathophysiology of migraine, discusses the issues of immunogenicity and drug interaction. The review describes in detail the monoclonal antibody erenumab, which became available in Russia from February 2020. The action of erenumab is associated with blocking the CGRP receptor, since it is the only one of the existing mAT that competes with the CGRP molecule for binding to the receptor. This review summarizes the pharmacological characteristics of erenumab, presents in detail the results of clinical trials with an emphasis on the publications of the last year. The article also presents the role of this method of treatment in real clinical practice: the eff ectiveness and safety of erenumab in various forms of migraine are described in detail, the possibility of transition (“reverse transformation”) from chronic migraine to episodic form on erenumab therapy is shown, impressive results of treatment of intractable cases in resistant and refractory migraines are presented. Erenumab is the only one of the mAT drugs for which the results of five-year clinical observations have been published, which have proved the sustained effectiveness and safety in long-term use, as well as the economic feasibility of using this therapeutic approach.

Reverse shoulder arthroplasty: the role of physical therapy on the clinical outcome in the mid-term to long-term follow-up

2018 ◽  
Vol 138 (12) ◽  
pp. 1647-1652 ◽  
Author(s):  
Stephan Uschok ◽  
Sebastian Herrmann ◽  
Stephan Pauly ◽  
Carsten Perka ◽  
Stefan Greiner
Keyword(s):  
Physical Therapy ◽  
Clinical Outcome ◽  
Shoulder Arthroplasty ◽  
Reverse Shoulder Arthroplasty ◽  
Long Term Follow Up

scholarly journals “Health For All”. The Medical System in Wallachia Under Protomedicus Nicolae Gussi 1848-1859

2021 ◽  
Vol 18 (2) ◽  
pp. 251-272
Author(s):  
Lidia Trausan-Matu
Keyword(s):  
Life Expectancy ◽  
Public Service ◽  
Medical System ◽  
Increase Life Expectancy ◽  
Medical Reform ◽  
The Poor ◽  
Reform Project ◽  
Poor Population

The main objective of this study is to provide an overview of the evolution of the medical system in Wallachia between 1840 and 1860 and the very important role of physician Nicolae Gussi (1802-1869), protomedicus of Wallachia between 1840 and 1859, to transform medicine into a modern public service, accessible to the entire population. Particularly, we will refer to the medical reform project of 1853, which Gussi implemented during the time he headed the medical-sanitary administration. We will insist on the details of the project because it was designed to create a network of county hospitals that would improve the health of the population and, in the medium and long term, would reduce mortality and increase life expectancy. Another dimension of the study aims at the tenure of physicians in county hospitals and describes the medical services they provided to patients, particularly from the poor population.

scholarly journals Can strategic corporate social responsibility drive corporate innovation?

2021 ◽  
Vol 52 (1) ◽  
Author(s):  
Zhenzhen Yang ◽  
Hanning Su ◽  
Wenzhang Sun
Keyword(s):  
Corporate Social Responsibility ◽  
Social Responsibility ◽  
Market Competition ◽  
Economic Consequences ◽  
Business And Society ◽  
Corporate Innovation ◽  
Strategic Csr ◽  
Corporate Social

Purpose: In practice, an increasing number of economic entities have begun to consider strategic corporate social responsibility (CSR) as an opportunity to create a win-win situation for the organisation and the society. The existing literature has yet to soundly corroborate the role of strategic CSR in corporate innovation. This study examines the relationship between strategic CSR and innovation.Design/methodology/approach: The empirical regression models are estimated to analyse the data collected from 2817 firms yielding 18 845 firm–year observations from 2001 to 2014 in the United States.Findings/results: The findings indicate that firms with strategic CSR generate more and better innovation outputs. The positive effect is more pronounced when institutional ownership is lower, when firm size is larger, and when product market competition is more intense. In terms of economic consequences, firms with strategic CSR actually have higher commercial value and are less likely to suffer loss from failed innovation.Practical implications: To establish a sustainable relationship with stakeholders and realise the long-term development of business and society, enterprises should engage in strategic CSR in a planned manner based on their own resources and professional expertise.Originality/value: The study sheds light on a growing body of literature that investigates the real consequences of firms’ strategic CSR, and explains the growing recognition of the importance of strategic CSR.

Critical Review of Neoadjuvant Chemotherapy Followed by Surgery for Locally Advanced Cervical Cancer

2010 ◽  
Vol 20 (Suppl 2) ◽  
pp. S47-S48 ◽  
Author(s):  
Nicoletta Colombo ◽  
Michele Peiretti
Keyword(s):  
Cervical Cancer ◽  
Neoadjuvant Chemotherapy ◽  
Locally Advanced ◽  
Standard Of Care ◽  
Advanced Cervical Cancer ◽  
Therapeutic Approaches ◽  
Locally Advanced Cervical Cancer ◽  
High Incidence

Cervical cancer is the second most common cause of female cancer mortality worldwide. Concurrent chemoradiotherapy represents the standard of care for patients with stage IB2-IIIB cervical cancer. However, the lack of radiotherapy departments, especially in developing countries, the presumed high incidence of long-term complications, and the poor control of metastatic disease have brought about the development of different therapeutic approaches such as neoadjuvant chemotherapy followed by surgery. We reviewed the literature concerning the role of neoadjuvant chemotherapy for locally advanced cervical cancer.

scholarly journals The role of Helicobacter pylori in metabolic and cardiovascular diseases

2021 ◽  
pp. 86-95
Author(s):  
T. E. Kugler ◽  
G. G. Taradin ◽  
R. Pellicano
Keyword(s):  
Helicobacter Pylori ◽  
Cardiovascular Diseases ◽  
Diagnostic Methods ◽  
Alcoholic Fatty Liver ◽  
High Prevalence ◽  
High Incidence ◽  
H Pylori ◽  
Alcoholic Fatty Liver Disease

Helicobacter pylori (H. pylori) infection is one of the most common in the world. More than 50% of the world’s population is infected and infection rates are especially high in countries with poor socio-economic conditions. H. pylori causes gastroduodenal and extra-gastroduodenal diseases including such metabolic disorders as obesity, diabetes mellitus and non-alcoholic fatty liver disease. Recent epidemiological and clinical studies showed that the long-term persistence of H. pylori infection is associated with the development and progression of atherosclerosis and consequently cardiovascular diseases. However, the correlation between these conditions is ambiguous and there is not enough evidence to confirm it. The lack of consensus might be related to differences in diagnostic methods used for H. pylori and the variety of its genotypes. Considering high prevalence of H. pylori infection as well as high incidence of metabolic and cardiovascular diseases, a verified correlation between these can be of great epidemiological, prophylactic and clinical significance.

scholarly journals The Role of Physical Therapy in the Intensive Care Unit

2021 ◽  
Vol 8 (3) ◽  
pp. 171-178
Author(s):  
Zofia Kosson ◽  
Marek Paśnicki ◽  
Marcin Kołacz
Keyword(s):  
Physical Therapy ◽  
Physical Therapist ◽  
Term Treatment ◽  
Treatment Protocols ◽  
The Past ◽  
Long Term Treatment ◽  
Intensive Development ◽  
Icu Treatment

Recent years have seen intensive development of ICU treatment protocols. Today it is possible to treat patients who in the past would not have had a chance of survival. People under the care of the unit typically suffer from cardiovascular or respiratory failure. Therefore, the aim of this paper is to discuss the basic techniques used by physiotherapeutic staff and the contribution they make to the treatment of patients at the ICU. In our article, we analyzed the risks associated with long-term hospitalization and the characteristics of the ICU patient, and presented the ways in which a physical therapist can improve the patient’s health. We have identified the main goals of ICU physical therapy and specified the intention with which specific physiotherapeutic procedures are introduced. The physical therapist should be part of a medical team whose goal is for the patient recover as quickly as possible. The role of the physical therapist in the ICU is not only to help the patient to improve in the shortest time possible, but also to prevent the undesirable effects of hypokinesia and long-term treatment in the ICU.

scholarly journals Opisthorchosis is a topical health problem (problem overview and analysis)

2020 ◽  
Vol 14 (4) ◽  
pp. 38-49
Author(s):  
O. I. Bibik
Keyword(s):  
Life Cycles ◽  
Annual Reports ◽  
International Agency ◽  
Herbal Products ◽  
High Incidence ◽  
Causative Agents ◽  
Long Course ◽  
Group 1

The purpose of the research is analyzing literature sources to establish the role of opisthorchosis in health care and assessing the relevance of histological and histochemical methods in determining the efficacy of drugs against helminths which are causative agents of opisthorchosis.Materials and methods. We analyzed literature sources on the study of opisthorchosis, its pathogen spread and its significance for public health. We also reviewed the official documentation of the annual reports presented on the official websites.Results and discussion. In 2018, more than 19.0 thousand cases of opisthorchosis were recorded in the country (rate is 12.99 per 100 thousand population), which made up 79.5% of all recorded bio-helminthosis in the population. Opisthorchosis is characterized by long course and proceeds with frequent exacerbations. The most serious complication is cancer in the liver, bile ducts and pancreas, which are organs of opisthorchis parasitism. The works of many authors reveal the connection and high incidence of cholangiocarcinoma in patients with opisthorchosis in countries with endemic sites of Opisthorchiidae family representative’s infection. Long-term opisthorchosis infection reduces the efficacy of anthelmintic therapy and leads to the appearance of the disease recurrent forms. Opisthorchis viverrini was officially recognized as a Group 1 biological carcinogen by the International Agency for Research on Cancer in 2009. The carcinogenic role of O. felineus has not yet been sufficiently studied. However, life cycles, morphology and localization in the human body of O. viverrini and O. felineus are similar. In the list of established medicinal products with opisthorchocidal action, special attention and interest are paid to herbal products. Histological and histochemical research methods confirmed the efficacy against such herbal preparations as ecorsol, erlim and artemisin.

scholarly journals Non-coding RNA and neuroinflammation: implications for the therapy of stroke

2019 ◽  
Vol 4 (2) ◽  
pp. 96-98 ◽  
Author(s):  
Ling Shen ◽  
Ying Bai ◽  
Bing Han ◽  
Honghong Yao
Keyword(s):  
Central Nervous System ◽  
Potential Role ◽  
Economic Consequences ◽  
Circular Rnas ◽  
Nervous System Diseases ◽  
Central Nervous System Diseases ◽  
Clinical Biomarkers ◽  
Non Coding Rna

Stroke is the major leading cause of death and serious, long-term disability with major economic consequences. At present, the lack of rapid diagnostic, prognostic biomarkers and effective treatment methods are two major challenges facing stroke. Circular RNAs (circRNAs) are potential clinical biomarkers in central nervous system diseases. However, the potential role of circRNAs in neuroinflammation and neuron functional recovery in acute ischaemic stroke (AIS) remains largely unknown. This review aimed to give an overview of the function of circRNAs in AIS and summarise the latest achievements in this field.

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