scholarly journals RETRACTED – Mental health in UK Biobank: development, implementation and results from an online questionnaire completed by 157 366 participants

BJPsych Open ◽  
2018 ◽  
Vol 4 (3) ◽  
pp. 83-90 ◽  
Author(s):  
Katrina A. S. Davis ◽  
Jonathan R. I. Coleman ◽  
Mark Adams ◽  
Naomi Allen ◽  
Gerome Breen ◽  
...  
Keyword(s):  
Mental Health ◽  
Mental Disorders ◽  
Expert Witness ◽  
Bipolar Affective Disorder ◽  
Face Validity ◽  
Uk Biobank ◽  
Post Traumatic Stress ◽  
Online Questionnaire ◽  
Case Definitions ◽  
Mental Health Questionnaire

Background UK Biobank is a well-characterised cohort of over 500 000 participants that offers unique opportunities to investigate multiple diseases and risk factors. Aims An online mental health questionnaire completed by UK Biobank participants was expected to expand the potential for research into mental disorders. Method An expert working group designed the questionnaire, using established measures where possible, and consulting with a patient group regarding acceptability. Case definitions were defined using operational criteria for lifetime depression, mania, anxiety disorder, psychotic-like experiences and self-harm, as well as current post-traumatic stress and alcohol use disorders. Results 157 366 completed online questionnaires were available by August 2017. Comparison of self-reported diagnosed mental disorder with a contemporary study shows a similar prevalence, despite respondents being of higher average socioeconomic status than the general population across a range of indicators. Thirty-five per cent (55 750) of participants had at least one defined syndrome, of which lifetime depression was the most common at 24% (37 434). There was extensive comorbidity among the syndromes. Mental disorders were associated with high neuroticism score, adverse life events and long-term illness; addiction and bipolar affective disorder in particular were associated with measures of deprivation. Conclusions The questionnaire represents a very large mental health survey in itself, and the results presented here show high face validity, although caution is needed owing to selection bias. Built into UK Biobank, these data intersect with other health data to offer unparalleled potential for crosscutting biomedical research involving mental health. Declaration of interest G.B. received grants from the National Institute for Health Research during the study; and support from Illumina Ltd. and the European Commission outside the submitted work. B.C. received grants from the Scottish Executive Chief Scientist Office and from The Dr Mortimer and Theresa Sackler Foundation during the study. C.S. received grants from the Medical Research Council and Wellcome Trust during the study, and is the Chief Scientist for UK Biobank. M.H. received grants from the Innovative Medicines Initiative via the RADAR-CNS programme and personal fees as an expert witness outside the submitted work.

scholarly journals Mental Health in UK Biobank Revised – development, implementation and results from an online questionnaire completed by 157,366 participants

2019 ◽  
Author(s):  
Katrina A. S. Davis ◽  
Jonathan R. I. Coleman ◽  
Mark Adams ◽  
Naomi Allen ◽  
Gerome Breen ◽  
...  
Keyword(s):  
Mental Health ◽  
Alcohol Use ◽  
Mental Disorders ◽  
Alcohol Use Disorder ◽  
Bipolar Affective Disorder ◽  
Face Validity ◽  
Common Finding ◽  
Uk Biobank ◽  
Post Traumatic Stress ◽  
Mental Health Questionnaire

AbstractThis paper corrects and updates a paper published in BJPsych Open 2018 “Mental Health in UK Biobank” (https://doi.org/10.1192/bjo.2018.12) that was voluntarily retracted following the finding of errors in the coding of the variable for alcohol use disorder. Notably, the percentage of participants reaching threshold for alcohol use disorder on the Alcohol Use Disorder Identification Tool increased from 7% to 21%.BackgroundUK Biobank is a well-characterised cohort of over 500,000 participants that offers unique opportunities to investigate multiple diseases and risk factors. An online mental health questionnaire completed by UK Biobank participants expands the potential for research into mental disorders.MethodsAn expert working group designed the questionnaire, using established measures where possible, and consulting with a service user group regarding acceptability. Operational criteria were agreed for defining likely disorder and risk states, including lifetime depression, mania/hypomania, generalised anxiety disorder, unusual experiences and self-harm, and current post-traumatic stress and alcohol use disorders.Results157,366 completed online questionnaires were available by August 2017. Comparison of self-reported diagnosed mental disorder with a contemporary study shows a similar prevalence, despite respondents being of higher average socioeconomic status. Lifetime depression was the most common finding in 24% of participants (37,434), with current alcohol use disorder criteria met by 21% (32,602), while other criteria were met by less than 8% of the participants. There was extensive comorbidity among the syndromes. Mental disorders were associated with a high neuroticism score, adverse life events and long-term illness; addiction and bipolar affective disorder in particular were associated with measures of deprivation.ConclusionsThe questionnaire represents a very large mental health survey in itself, and the results presented here show high face validity, although caution is needed due to selection bias. Built into UK Biobank, these data intersect with other health data to offer unparalleled potential for crosscutting biomedical research involving mental health.

scholarly journals Mental health in UK Biobank – development, implementation and results from an online questionnaire completed by 157 366 participants: a reanalysis

BJPsych Open ◽  
2020 ◽  
Vol 6 (2) ◽  
Author(s):  
Katrina A. S. Davis ◽  
Jonathan R. I. Coleman ◽  
Mark Adams ◽  
Naomi Allen ◽  
Gerome Breen ◽  
...  
Keyword(s):  
Mental Health ◽  
Alcohol Use ◽  
Bipolar Affective Disorder ◽  
Environmental Data ◽  
Face Validity ◽  
Common Finding ◽  
Uk Biobank ◽  
Post Traumatic Stress ◽  
Harmful Alcohol ◽  
Mental Health Questionnaire

Background UK Biobank is a well-characterised cohort of over 500 000 participants including genetics, environmental data and imaging. An online mental health questionnaire was designed for UK Biobank participants to expand its potential. Aims Describe the development, implementation and results of this questionnaire. Method An expert working group designed the questionnaire, using established measures where possible, and consulting a patient group. Operational criteria were agreed for defining likely disorder and risk states, including lifetime depression, mania/hypomania, generalised anxiety disorder, unusual experiences and self-harm, and current post-traumatic stress and hazardous/harmful alcohol use. Results A total of 157 366 completed online questionnaires were available by August 2017. Participants were aged 45–82 (53% were ≥65 years) and 57% women. Comparison of self-reported diagnosed mental disorder with a contemporary study shows a similar prevalence, despite respondents being of higher average socioeconomic status. Lifetime depression was a common finding, with 24% (37 434) of participants meeting criteria and current hazardous/harmful alcohol use criteria were met by 21% (32 602), whereas other criteria were met by less than 8% of the participants. There was extensive comorbidity among the syndromes. Mental disorders were associated with a high neuroticism score, adverse life events and long-term illness; addiction and bipolar affective disorder in particular were associated with measures of deprivation. Conclusions The UK Biobank questionnaire represents a very large mental health survey in itself, and the results presented here show high face validity, although caution is needed because of selection bias. Built into UK Biobank, these data intersect with other health data to offer unparalleled potential for crosscutting biomedical research involving mental health.

Economic evaluation and costs of telepsychiatry programmes: A systematic review

2020 ◽  
pp. 1357633X2093891 ◽  
Author(s):  
John A Naslund ◽  
Lauren M Mitchell ◽  
Udita Joshi ◽  
Dipal Nagda ◽  
Chunling Lu
Keyword(s):  
Mental Health ◽  
Systematic Review ◽  
Economic Evaluation ◽  
Cost Effectiveness ◽  
Mental Disorders ◽  
Clinical Care ◽  
Mental Illnesses ◽  
Economic Evaluations ◽  
Schizophrenia Spectrum Disorders ◽  
Post Traumatic Stress

Objective Telepsychiatry involves use of telecommunications technology to deliver psychiatric care and offers promise to reduce costs and increase access to mental health services. This systematic review examined cost reporting of telepsychiatry programmes for mental healthcare. Methods We systematically searched electronic databases for studies reporting costs, including economic evaluations such as cost-effectiveness analyses, or costs of developing telepsychiatry programmes for clinical care of mental disorders. Included studies enrolled participants with mental disorders and involved telepsychiatry for depression, anxiety disorders, serious mental illnesses including schizophrenia spectrum disorders and bipolar disorder, post-traumatic stress disorder, dementia or epilepsy. Results Twenty-six unique studies met inclusion criteria (17,967 participants), with most targeting depression ( n = 7; 27%), general mental disorders and screening ( n = 7; 27%), child mental health ( n = 4; 15%) and geriatric mental health ( n = 4; 15%). Nearly all studies ( n = 25; 96%) compared telepsychiatry programme costs with either standard in-person consultation or usual care, with 15 (60%) reporting that telepsychiatry programmes were less expensive, and 8 (32%) showing telepsychiatry programmes were more expensive. Three studies reported cost-effectiveness analyses, favouring telepsychiatry programmes, but at highly elevated cost-effectiveness thresholds. Few studies reported costs of developing or delivering telepsychiatry programmes. Conclusion Costs of telepsychiatry programmes varied widely, with substantial heterogeneity in how costs were defined and reported. Some programmes cost less than in-person services while others cost more. Therefore, rigorous cost-effectiveness studies following established standards in economic evaluation are needed to inform implementation and sustainability of these programmes in health systems.

Lifetime and 12-month prevalence of mental disorders in the Nigerian Survey of Mental Health and Well-Being

2006 ◽  
Vol 188 (5) ◽  
pp. 465-471 ◽  
Author(s):  
Oye Gureje ◽  
Victor O. Lasebikan ◽  
Lola Kola ◽  
Victor A. Makanjuola
Keyword(s):  
Mental Health ◽  
Mental Disorders ◽  
Large Scale ◽  
Unmet Need ◽  
Composite International Diagnostic Interview ◽  
Well Being ◽  
Traditional Healers ◽  
Assessment Tools ◽  
Sub Saharan Africa ◽  
Post Traumatic Stress

BackgroundLarge-scale community studies of the prevalence of mental disorders using standardised assessment tools are rare in sub-Saharan Africa.AimsTo conduct such a study.MethodMultistage stratified clustered sampling of households in the Yoruba-speaking parts of Nigeria. Face-to-face interviews used the World Mental Health version of the Composite International Diagnostic Interview (WMH-CIDI).ResultsOf the 4984 people interviewed (response rate 79.9%), 12.1% had a lifetime rate of at least one DSM–IV disorder and 5.8% had 12-month disorders. Anxiety disorders were the most common (5.7% lifetime, 4.1% 12-month rates) but virtually no generalised anxiety or post-traumatic stress disorder were identified. Of the 23% who had seriously disabling disorders, only about 8% had received treatment in the preceding 12 months. Treatment was mostly provided by general medical practitioners; only a few were treated by alternative practitioners such as traditional healers.ConclusionsThe observed low rates seem to reflect demographic and ascertainment factors. There was a large burden of unmet need for care among people with serious disorders.

scholarly journals Multiple measures of depression to enhance validity of major depressive disorder in the UK Biobank

BJPsych Open ◽  
2021 ◽  
Vol 7 (2) ◽  
Author(s):  
Kylie P. Glanville ◽  
Jonathan R. I. Coleman ◽  
David M. Howard ◽  
Oliver Pain ◽  
Ken B. Hanscombe ◽  
...  
Keyword(s):  
Mental Health ◽  
Major Depressive Disorder ◽  
Depressive Disorder ◽  
Genetic Correlations ◽  
Genetic Contribution ◽  
Uk Biobank ◽  
Major Depressive ◽  
Multiple Measures ◽  
The Uk ◽  
Mental Health Questionnaire

Background The UK Biobank contains data with varying degrees of reliability and completeness for assessing depression. A third of participants completed a Mental Health Questionnaire (MHQ) containing the gold-standard Composite International Diagnostic Interview (CIDI) criteria for assessing mental health disorders. Aims To investigate whether multiple observations of depression from sources other than the MHQ can enhance the validity of major depressive disorder (MDD). Method In participants who did not complete the MHQ, we calculated the number of other depression measures endorsed, for example from hospital episode statistics and interview data. We compared cases defined this way with CIDI-defined cases for several estimates: the variance explained by polygenic risk scores (PRS), area under the curve attributable to PRS, single nucleotide polymorphisms (SNPs)-based heritability and genetic correlations with summary statistics from the Psychiatric Genomics Consortium MDD genome-wide association study. Results The strength of the genetic contribution increased with the number of measures endorsed. For example, SNP-based heritability increased from 7% in participants who endorsed only one measure of depression, to 21% in those who endorsed four or five measures of depression. The strength of the genetic contribution to cases defined by at least two measures approximated that for CIDI-defined cases. Most genetic correlations between UK Biobank and the Psychiatric Genomics Consortium MDD study exceeded 0.7, but there was variability between pairwise comparisons. Conclusions Multiple measures of depression can serve as a reliable approximation for case status where the CIDI measure is not available, indicating sample size can be optimised using the entire suite of UK Biobank data.

scholarly journals Anxiety Disorders and PTSD in Palestine: Litreture review

2020 ◽  
Author(s):  
Mohammad Mohammad-Zeyad Marie ◽  
Sana SaadAdeen ◽  
Maher Battat
Keyword(s):  
Mental Health ◽  
Mental Disorders ◽  
Anxiety Disorders ◽  
Political Violence ◽  
Common Mental Disorders ◽  
Significant Proportion ◽  
Continuous Exposure ◽  
Post Traumatic Stress ◽  
West Bank And Gaza ◽  
Study Type

Abstract Background The WHO reports that anxiety disorders are the most common mental disorders worldwide. Most people who experience such events recover from it; however, people with post-traumatic stress disorder (PTSD) continue to be severely depressed and anxious for several months or even years following the event. Palestinians are particularly at a higher risk for developing anxiety disorders and PTSD due to the continuous exposure to political violence, prolonged displacement, and other limitation on professional, educational, financial opportunities, and mental health services. This paper aims to provide a systematic review of the literature and established studies concerning Anxiety disorders besides PTSD in Palestine.Methods PubMed, Science Direct, Google Scholar was used to search for materials for the critical analysis of empirical articles. The following aspects were taken into consideration: study type, sample, and key findings.Results In this review, we included about twenty-four studies from Palestine (West Bank and Gaza). Five studies relate to children, five relate to adolescents, three relate to women, three relate to physical diseases, and four relate to gender and age differences. Results show that anxiety disorders and PTSD are one of the most common mental disorders in Palestine. Anxiety and PTSD develop from a complex set of risk factors, including genetics, personality, and life events. They are mostly associated with low quality of life and disability. The results indicate that a significant proportion of Palestinian experiencing serious issues that deal with several challenges, distinct barriers including; inconsistent availability of medications, absence of multidisciplinary teamwork, insufficient specialists, fragmented mental health system, and occupation.Conclusion As primary prevention, the occupation has to have considered as the main source of anxiety and other mental health disorders in Palestine. Besides, there is a need to implement a mental health care system through multidisciplinary work and raising awareness regarding the prevalence of mental disorders.

scholarly journals O3B.5 The mental health of police, firefighters and paramedics in the UK biobank: a comparison with the general working population

2019 ◽  
Vol 76 (Suppl 1) ◽  
pp. A24.3-A25
Author(s):  
Sharon Stevelink ◽  
Nicola Fear ◽  
Matthew Hotopf
Keyword(s):  
Mental Health ◽  
Random Sample ◽  
Emergency Services ◽  
Life Time ◽  
Uk Biobank ◽  
Post Traumatic Stress ◽  
Emergency Services Personnel ◽  
Working People ◽  
Using Data ◽  
The Uk

It is our responsibility to protect and look after the health of members of the emergency services as this directly impacts on the country’s readiness to respond to these disasters and is a critical part of our duty of care towards this important group of workers. This study examined the mental health outcomes and associations with individual and job characteristics among emergency services personnel compared to a random sample of working people, thereby using data from the UK Biobank. This data source contains data on over half a million adults in the UK, who were at the time of recruitment between 40–69 years. Over 2 80 000 reported being in work. Current emergency services personnel were identified based on Standard Occupational Classification (SOC) 2000 codes. A random sample of age and sex matched people working in other occupations were selected from the UK Biobank for comparative purposes. The prevalence of the outcomes of interest, based on current and life time measures of depression, anxiety, alcohol misuse, post-traumatic stress disorder, suicide and trauma will be presented. The findings will be discussed in the light of current policies and strategies and recommendations for further practice will be outlined.

Mental health

2021 ◽  
pp. 767-794
Author(s):  
Charlotte Hanlon ◽  
Asnake Limenhe
Keyword(s):  
Mental Health ◽  
Substance Abuse ◽  
Mental Disorders ◽  
Children And Adolescents ◽  
Learning Disability ◽  
Common Mental Disorders ◽  
Adjustment Disorders ◽  
Post Traumatic Stress ◽  
Self Harm ◽  
Post Traumatic

Suicide and deliberate self-harm?, Acute behavioural disturbance?, Common mental disorders?, Severe mental disorders psychoses?, Disorders due to substance abuse?, Withdrawal states?, Adjustment disorders and bereavement?, Post-traumatic stress disorder?, Intellectual learning disability?, Disorders in children and adolescents?

scholarly journals Mental health in UK Biobank: development, implementation and results from an online questionnaire completed by 157 366 participants – CORRIGENDUM

BJPsych Open ◽  
2018 ◽  
Vol 4 (3) ◽  
pp. 136-136 ◽  
Author(s):  
Katrina A. S. Davis ◽  
Jonathan R. I. Coleman ◽  
Mark Adams ◽  
Naomi Allen ◽  
Gerome Breen ◽  
...  
Keyword(s):  
Mental Health ◽  
Uk Biobank ◽  
Online Questionnaire

scholarly journals Anxiety disorders and PTSD in Palestine: a literature review

2020 ◽  
Vol 20 (1) ◽  
Author(s):  
Mohammad Marie ◽  
Sana SaadAdeen ◽  
Maher Battat
Keyword(s):  
Mental Health ◽  
Mental Disorders ◽  
Anxiety Disorders ◽  
Political Violence ◽  
Common Mental Disorders ◽  
Significant Proportion ◽  
Continuous Exposure ◽  
Post Traumatic Stress ◽  
West Bank And Gaza ◽  
Study Type

Abstract Background The WHO reports that anxiety disorders are the most common mental disorders worldwide. Most people who experience such events recover from it; however, people with post-traumatic stress disorder (PTSD) continue to be severely depressed and anxious for several months or even years following the event. Palestinians are particularly at a higher risk for developing anxiety disorders and PTSD due to the continuous exposure to political violence, prolonged displacement, and other limitation on professional, educational, financial opportunities, and mental health services. This paper aims to provide a systematic review of the literature and established studies concerning Anxiety disorders besides PTSD in Palestine. Methods PubMed, Science Direct, Google Scholar was used to search for materials for the critical analysis of empirical articles. The following aspects were taken into consideration: study type, sample, and key findings. Results In this review, we included about twenty-four studies from Palestine (West Bank and Gaza). Five studies relate to children, five relate to adolescents, three relate to women, three relate to physical diseases, and four relate to gender and age differences. Results show that anxiety disorders and PTSD are one of the most common mental disorders in Palestine. Anxiety and PTSD develop from a complex set of risk factors, including genetics, personality, and life events. They are mostly associated with low quality of life and disability. The results indicate that a significant proportion of Palestinian experiencing serious issues that deal with several challenges, distinct barriers including; inconsistent availability of medications, absence of multidisciplinary teamwork, insufficient specialists, fragmented mental health system, and occupation. Conclusion As primary prevention, the occupation has to have considered as the main source of anxiety and other mental health disorders in Palestine. Besides, there is a need to implement a mental health care system through multidisciplinary work and raising awareness regarding the prevalence of mental disorders.

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