Premorbid Personality in First-Onset Psychosis

1994 ◽  
Vol 164 (2) ◽  
pp. 202-207 ◽  
Author(s):  
Tim Dalkin ◽  
Patrice Murphy ◽  
Cris Glazebrook ◽  
Ian Medley ◽  
Glynn Harrison
Keyword(s):  
Age Of Onset ◽  
Adolescent Adjustment ◽  
Severe Mental Disorders ◽  
Psychotic Illness ◽  
Illness Episode ◽  
Premorbid Personality ◽  
Men And Women ◽  
First Onset ◽  
Organic Psychoses ◽  
Childhood Adjustment

The data presented are those from a two-year prospective study of 69 patients identified in the Nottingham field centre of the WHO Study of Determinants of Outcome of Severe Mental Disorders. Premorbid personality, childhood adjustment and adolescent adjustment were assessed at the patients' first presentation to psychiatric services with a psychotic illness. Ratings were made blind to diagnosis. Premorbid explosive and paranoid traits were commoner in patients with schizophrenia than in patients with other non-organic psychoses, and these traits were associated with later onset of schizophrenia. Premorbid schizoid traits were significantly commoner in patients with schizophrenia compared to patients with other psychoses, but only in those patients for whom a parent was the informant. Schizoid traits were no commoner in men with schizophrenia than in women, and were not associated with earlier age of onset. The findings suggest that premorbid personality, in men and women, may shape the expression of symptoms produced during an illness episode.

A 15-year follow-up of schizophrenia in Ireland

2002 ◽  
Vol 19 (4) ◽  
pp. 108-114
Author(s):  
Aine Finnerty ◽  
Fiona Keogh ◽  
Anne O'Grady-Walsh ◽  
Dermot Walsh
Keyword(s):  
Functional Outcomes ◽  
International Study ◽  
High Rate ◽  
Similar Proportion ◽  
Severe Mental Disorders ◽  
Psychotic Illness ◽  
First Onset ◽  
Schizophrenic Patients ◽  
Illness Outcome

AbstractObjectives: Psychiatric hospitalisation rates in Ireland have been high. Recent studies indicate that this is not a consequence of raised incidence. This study explored the possibility that poor outcome may have been responsible for this high hospitalisation prevalence.Method: Through participation in the WHO Study, Determinants of Outcome of Severe Mental Disorders (DOSMeD), we followed up a cohort of 67 first-onset schizophrenic patients over 15 years to determine symptomatic and functional outcomes and to compare these with outcomes of the cohorts recruited to the International Study of Schizophrenia (ISoS).Results: Thirty-seven (55%) of the original 67 were successfully followed up over 15 years and, of these, 43% were continuously psychotic for most of the period; a similar proportion had recurrent episodes of illness; two-thirds of subjects had moderate to severe symptoms for most of the time; and, in terms of functional outcome, over four-fifths were unemployed at follow-up.Conclusions: Outcome for the majority of followed-up patients was poor in symptomatic and functional terms. While this outcome was one of the poorest among the DOSMeD groups the question whether functional psychotic illness outcome is inherently poorer in Ireland than elsewhere remains unanswered. The high rate of attrition (45%) from the group during the follow-up period vitiated interpretation of outcome overall. The high number of suicides among the group was noteworthy.

scholarly journals The relationship of the age of onset of obesity to the success of its treatment in the adult

1975 ◽  
Vol 34 (2) ◽  
pp. 201-204 ◽  
Author(s):  
Margaret Ashwell
Keyword(s):  
Early Onset ◽  
Age Of Onset ◽  
Maximum Weight ◽  
Men And Women ◽  
Loss Of Weight ◽  
Relationship Of ◽  
The Relationship

1. A survey was done of 2333 men and women who claimed experience of slimming.2. Their loss of weight was determined from their maximum stated weight and their present weight. The loss of weight was calculated as the percentage of the maximum weight and was related to the stated age of onset of obesity.3. The results showed that those people in the survey who had been fat since childhood had lost just as much weight as those people who had become fat as adults.4. These results suggest that the treatment of early-onset obesity may not be an unrealistic objective.

Psychiatric morbidity in male remanded and sentenced committals to Irish prisons

2009 ◽  
Vol 26 (4) ◽  
pp. 169-173 ◽  
Author(s):  
Katharine Curtin ◽  
Stephen Monks ◽  
Brenda Wright ◽  
Dearbhia Duffy ◽  
Sally Linehan ◽  
...  
Keyword(s):  
Medical Records ◽  
Substance Misuse ◽  
Psychiatric Morbidity ◽  
Treatment Needs ◽  
Psychotic Illness ◽  
Major Depressive ◽  
Current Prevalence ◽  
Icd 10 ◽  
Organic Psychoses ◽  
A Current

AbstractObjectives: To describe the prevalence of psychiatric morbidity and the treatment needs of new committals to Irish prisons.Methods: A population survey of 615 prisoners representing 7.9% of male committals to Irish prisons in the year of survey, 313 remands (9.6% of total remand committals) and 302 sentenced committals (6.4% of total sentenced committals). The main outcome measures were ICD-10 diagnoses of mental disorder based on interviews using SADS-L and prison medical records.Results: Current prevalence rates of any psychotic illness were 3.8% (remand) and 0.3% (sentenced), six month prevalence rate 5.1% (remand) and 2.6% (sentenced) and lifetime rate 9.3% (remand) and 6.6% (sentenced). Schizophrenia and drug/organic psychoses were the most common psychoses. Major depressive disorder had a current prevalence of 4.5% (remand) and 4.6% (sentenced), a six month prevalence of 4.8% (remand) and 6.0% (sentenced), and a lifetime prevalence of 8.6% (remand) and 15.9% (sentenced). Sixty-point-six per cent of the sample had a current substance misuse problem.Conclusions: There is significant psychiatric morbidity in committal prisoners.

scholarly journals Relationship between substance abuse and first-episode psychosis - a South African perspective

2003 ◽  
Vol 9 (1) ◽  
pp. 5 ◽  
Author(s):  
Sandra Brink ◽  
Piet Oosthuizen ◽  
Robin Emsley ◽  
Irene Mbanga ◽  
Natasha Keyter
Keyword(s):  
Substance Abuse ◽  
South African ◽  
Age Of Onset ◽  
First Episode Psychosis ◽  
First Episode ◽  
Younger Age ◽  
Co Morbidity ◽  
Episode Psychosis ◽  
First Onset ◽  
African Perspective

Background. Co-morbidity between substance abuse and psy- chotic disorders is high. Few studies have examined therelationship between first-episode psychosis and substance abuse. Several questions emerge from this common relationship and many of them remain unanswered.Objectives. To determine the effect of substance abuse on psychosis in terms of onset, duration, severity of symptoms, use of medication and outcome.Method. Thirty - three subjects with first-episode psychosis, as well as primary caregivers, were interviewed re g a rding substance abuse and its relation to illness. Thirty-six control subjects were also interv i e w e d .Results. Twenty-seven per cent of subjects abused substances in the 3 months before onset of illness, and 77.8% of the abusers w e re male. Subjects in the first-episode psychosis group were m o re likely to choose cannabis as their substance of abuse than c o n t rols. They also started abusing substances at a younger age than controls. Subjects with first-episode psychosis who abused substances presented at an earlier age than non-abusers. Substances affected symptoms at baseline presentation .Conclusions. Substance abuse has a significant impact on first- onset psychosis as far as age of onset and symptom severity are c o n c e rned. Subjects with an underlying vulnerability to psychosis seem to start abusing substances at an earlier age than the general population. Males are more likely to abuse substances than females.

Age of onset distribution in schizophrenia for men and women: Normal mixture density analysis

1997 ◽  
Vol 24 (1-2) ◽  
pp. 259-260
Author(s):  
Nori Takei ◽  
Kathryn Abel ◽  
Brain Everitt ◽  
Peter Jones ◽  
Robin M. Murray
Keyword(s):  
Age Of Onset ◽  
Normal Mixture ◽  
Men And Women ◽  
Mixture Density ◽  
Density Analysis

What about the guys? An assessment of gender differences in hereditary colorectal cancer testing.

2017 ◽  
Vol 35 (4_suppl) ◽  
pp. 537-537
Author(s):  
Carin Espenschied ◽  
Jonathan Pepper ◽  
Rachel E. McFarland
Keyword(s):  
Colorectal Cancer ◽  
Gender Differences ◽  
Age Of Onset ◽  
Test Results ◽  
Men And Women ◽  
Exact Test ◽  
Counseling And Testing ◽  
Increased Risk ◽  
Males And Females ◽  
Risk Reduction Measures

537 Background: Approximately 5-10% of colorectal cancer (CRC) is due to hereditary causes. Identification of an inherited cause may impact surgical and treatment decisions for CRC patients and may identify increased risks for other cancers that warrant increased screening and/or risk reduction measures. Men have testing for hereditary breast and ovarian cancer less often than women, even though these genes may also cause increased risk for cancer in men and men are as likely as women to carry mutations in these genes and pass them onto their children. We aimed to explore whether similar gender differences exist related to testing for hereditary CRC. Methods: We retrospectively reviewed clinical data and test results from consecutive CRC cases, who had a multi-gene panel with 13-49 genes at our laboratory, between March 2012 and June 2016. Statistical comparisons between males and females were conducted using Fisher’s exact test. Results: Of CRC cases (n = 7142), 61.1% were female and 12.8% were positive for mutation or likely pathogenic variant. Average age of CRC onset for men was 47.2, and for women was 49.5. Women with CRC before age 20 had the highest mutation rate (31.8%), but men were more likely to test positive than women overall (14.1% vs 12.0%, p = 1.1e-2). Mutations were most frequent in the same three genes for both men and women, but in different orders: MLH1, CHEK2, and MSH2 for males and CHEK2, MSH2, and MLH1 for females. The only genes with significant differences in mutation rates between men and women were MLH1 (3.2% vs 1.5%, p = 2.0e-6) and MSH6(1.7% vs 0.8%, p = 3.0e-3). Conclusions: Hereditary CRC is expected to affect men and women equally. In our cohort, however, the majority of individuals tested were women, while men were more likely to test positive. Possible explanations include smaller sample size and earlier age of onset in men, perceptions of referring clinicians, and different levels of interest in genetic counseling and testing between male and female patients. These data highlight an important opportunity for educating and identifying more men with hereditary CRC who may benefit from genetic information. Further studies are needed to confirm these results and explore reasons for the differences.

Premorbid personality in patients with first onset psychoses

1993 ◽  
Vol 9 (2-3) ◽  
pp. 96-97
Author(s):  
T. Dalkin ◽  
P. Murphy ◽  
C. Walder ◽  
I. Medley ◽  
G. Harrison
Keyword(s):  
Premorbid Personality ◽  
First Onset

Clinical and Laboratory Differences Between Early-Onset and Late-Onset Adult Atopic Dermatitis

2020 ◽  
Vol 24 (4) ◽  
pp. 360-366
Author(s):  
Dae-Lyong Ha ◽  
Geun-Hwi Park ◽  
Hoon-Soo Kim ◽  
Hyun-Chang Ko ◽  
Moon-Bum Kim ◽  
...  
Keyword(s):  
Atopic Dermatitis ◽  
Early Onset ◽  
Age Of Onset ◽  
Late Onset ◽  
Severity Index ◽  
Total Serum ◽  
Significant Difference ◽  
First Onset ◽  
Onset Group ◽  
Early Onset Group

Background Atopic dermatitis (AD) in adults is not uncommon, and its prevalence has been increasing in the recent decades. However, there is a paucity of data about the differences between early-onset and late-onset adult AD. Objective The objective of this study is to investigate the clinical and laboratory characteristics of adult AD, focusing on the differences between early-onset and late-onset adult AD. Methods We retrospectively reviewed the medical records and clinical photos of 214 adult AD patients (≥18 years of age) over a 3-year period. We classified the patients into 2 groups: early-onset (first onset of AD before 12 years of age) and late-onset (first onset of AD at 12 years of age or later). Results Among 214 patients, 151 patients (70.6%) belonged to the early-onset group (mean age 24.5 years), while 63 patients belonged to the late-onset group (mean age 29.5 years). An association with allergic asthma or rhinitis, a family history of atopic disease, elevated total serum IgE, and sensitivity to food allergens were more commonly seen in the early-onset group. The late-onset group had a significant likelihood of nonflexural involvement (38.1% vs 13.2%). There was no significant difference in the mean eczema area severity index score, eosinophil count, and sensitivity to aeroallergens between 2 groups. Conclusion Adult AD shows different clinical and laboratory characteristics depending on the age of onset. This study could help to create awareness about the heterogeneity of AD in adulthood and encourage further studies on clinical outcomes and different therapeutic methods depending on the age of onset.

Prevalence and severity of substance use disorders and onset of psychosis in first-admission psychotic patients

1998 ◽  
Vol 28 (6) ◽  
pp. 1411-1419 ◽  
Author(s):  
J. RABINOWITZ ◽  
E. J. BROMET ◽  
J. LAVELLE ◽  
G. CARLSON ◽  
B. KOVASZNAY ◽  
...  
Keyword(s):  
Substance Abuse ◽  
Substance Use ◽  
Substance Use Disorders ◽  
Age Of Onset ◽  
Antisocial Behaviour ◽  
Life Time ◽  
Psychotic Illness ◽  
Current Cigarette Smoking ◽  
Severity Rating ◽  
First Admission

Background. Past studies have found inconsistent evidence that substance use disorders are related to earlier onset of schizophrenia or more severe symptoms. This study examines prevalence and severity of current substance use disorders and onset of psychotic illness in a multi-facility sample.Methods. Data are from the Suffolk County Mental Health Project, an epidemiological study of first admission psychosis. The SCID and instruments measuring symptomatology, personality and background characteristics were administered. Respondents were stratified into three groups: (a) no life-time substance diagnosis; (b) in remission or reporting current mild use at admission; and (c) current moderate–severe substance abuse at admission.Results. Using the SCID severity rating, 17·4% of males and 6·2% of the females had moderate or severe current substance abuse, while 41·5% of males and 68·2% of females had no lifetime substance diagnosis. In almost all cases categorized as moderate–severe, the substance diagnosis predated onset of psychosis. Females categorized as moderate–severe had an earlier age of onset of psychosis than did females in the other groups. There were only slight differences in symptom severity among the groups but more marked antisocial behaviour in the moderate–severe group. Variables discriminating the moderate–severe from non-abuse groups were BPRS thought disturbance, adult anti-social behaviour and current cigarette smoking for males and adult antisocial behaviour and child–teen antisocial behaviour for females.Conclusions. Severity of substance abuse does not appear to be a pivotal correlate of the early features of psychotic illness.

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