scholarly journals Association between schizophrenia and social inequality at birth: case–control study

2001 ◽  
Vol 179 (4) ◽  
pp. 346-350 ◽  
Author(s):  
Glynn Harrison ◽  
David Gunnell ◽  
Cris Glazebrook ◽  
Kim Page ◽  
Rosemary Kwiecinski
Keyword(s):  
Social Class ◽  
Social Inequality ◽  
Odds Ratio ◽  
Positive Family History ◽  
Case Control ◽  
Birth Certificates ◽  
First Episode ◽  
Adult Onset ◽  
Increased Risk ◽  
And Gender

BackgroundThe association between social inequality at birth and subsequent risk of schizophrenia is uncertain.AimsTo investigate the relationship between adult-onset schizophrenia and two indicators of social inequality at birth: social class and area of residence.MethodA matched case–control design was used with data from birth certificates of first-episode cases and age— and gender-matched controls.ResultsRisk increased with increasing levels of deprivation at birth. Subjects whose fathers were social class IV–V or who were born in deprived areas were at increased risk of schizophrenia (odds ratio=2.1; 95% Cl=0.8–5.5). Risk was greater in those with both of these indicators (odds ratio=8.1; 95% CI=2.7–23.9). There was some evidence that associations were stronger in older subjects. Exclusion of African–Caribbeans or cases with positive family history somewhat attenuated the association.ConclusionsIndicators of social inequality at birth are associated with increased risk of adult-onset schizophrenia, suggesting that environmental factors are important determinants of schizophrenic disorders.

Human anthrax outbreak associated with livestock exposure: Georgia, 2012

2015 ◽  
Vol 144 (1) ◽  
pp. 76-87 ◽  
Author(s):  
A. NAVDARASHVILI ◽  
T. J. DOKER ◽  
M. GELEISHVILI ◽  
D. L. HABERLING ◽  
G. A. KHAROD ◽  
...  
Keyword(s):  
Odds Ratio ◽  
Management Practices ◽  
Public Awareness ◽  
Case Control ◽  
Livestock Management ◽  
Investigate Risk Factor ◽  
Increased Risk ◽  
Country Of Georgia ◽  
And Gender ◽  
Multivariable Modelling

SUMMARYHuman anthrax cases reported in the country of Georgia increased 75% from 2011 (n= 81) to 2012 (n= 142). This increase prompted a case-control investigation using 67 culture- or PCR-confirmed cases and 134 controls matched by residence and gender to investigate risk factor(s) for infection during the month before case onset. Independent predictors most strongly associated with disease in the multivariable modelling were slaughtering animals [odds ratio (OR) 7·3, 95% confidence interval (CI) 2·9–18·1,P< 0·001] and disposing of dead animals (OR 13·6, 95% CI 1·5–119·8,P= 0·02). Participants owning or working with livestock (n= 131) were additionally interviewed about livestock management practices during the previous 6 months: 53 (44%) of 121 respondents vaccinated livestock against anthrax; 19 (16%) of 116 moved livestock >1 km; 15 (12%) of 125 had sick livestock; and 11 (9%) of 128 respondents reported finding dead livestock. We recommend joint public health and veterinary anthrax case investigations to identify areas of increased risk for livestock anthrax outbreaks, annual anthrax vaccination of livestock in those areas, and public awareness education.

scholarly journals Psychosis in children of separated parents: A systematic review and meta-analysis

2020 ◽  
Vol 63 (1) ◽  
Author(s):  
Luis Ayerbe ◽  
María Pérez-Piñar ◽  
Quintí Foguet-Boreu ◽  
Salma Ayis
Keyword(s):  
Systematic Review ◽  
Odds Ratio ◽  
Psychotic Disorders ◽  
Meta Analysis ◽  
Childhood Adversity ◽  
Case Control ◽  
Parental Separation ◽  
Cross Sectional ◽  
Increased Risk ◽  
Cross Sectional Studies

Abstract Background. Parental separation is a very common childhood adversity. The association between other adverse childhood experiences and an increased risk of psychosis has been reported. However, the evidence on the risk of psychosis for children of separated parents is limited. In this systematic review, cohort, case–control, and cross-sectional studies, comparing the risk of psychotic disorders for people with and without separated parents, were searched, critically appraised, and summarized. Methods. Studies were searched in PubMed, EMBASE, PsycINFO, and the Web of Science, from database inception to September 2019. A meta-analysis, using random-effects models, was undertaken to obtain pooled estimates of the risk of psychosis among participants with separated parents. Results. Twelve studies, with 305,652 participants from 22 countries, were included in the review. A significantly increased risk of psychosis for those with separated parents was observed, with a pooled odds ratio: 1.53 (95% confidence interval [CI]: 1.29–1.76), p < 0.001. The association remained significant when cohort, case–control, and cross-sectional studies were analyzed separately. The five cohort studies included in this review showed and increased risk of psychosis with odds ratio: 1.47 (95% CI: 1.26–1.69), p < 0.001. Conclusions. Parental separation is a common childhood adversity associated with an increased risk of psychosis. Although the risk for an individual child of separated parents is still low, given the high proportion of couple that separate, the increased rates of psychosis may be substantial in the population. Further studies on the risk of psychosis in those with separated parents, and the explanatory factors for this association, are required.

scholarly journals Genetic predisposition to longer telomere length and risk of childhood, adolescent and adult-onset ependymoma

2020 ◽  
Vol 8 (1) ◽  
Author(s):  
Chenan Zhang ◽  
◽  
Quinn T. Ostrom ◽  
Eleanor C. Semmes ◽  
Vijay Ramaswamy ◽  
...  
Keyword(s):  
Telomere Length ◽  
Genetic Predisposition ◽  
Control Sample ◽  
Population Based ◽  
Case Control ◽  
Telomere Maintenance ◽  
Adult Onset ◽  
Increased Risk ◽  
Sick Children ◽  
Control Study

Abstract Ependymoma is the third most common brain tumor in children, with well-described molecular characterization but poorly understood underlying germline risk factors. To investigate whether genetic predisposition to longer telomere length influences ependymoma risk, we utilized case–control data from three studies: a population-based pediatric and adolescent ependymoma case–control sample from California (153 cases, 696 controls), a hospital-based pediatric posterior fossa type A (EPN-PF-A) ependymoma case–control study from Toronto’s Hospital for Sick Children and the Children’s Hospital of Philadelphia (83 cases, 332 controls), and a multicenter adult-onset ependymoma case–control dataset nested within the Glioma International Case-Control Consortium (GICC) (103 cases, 3287 controls). In the California case–control sample, a polygenic score for longer telomere length was significantly associated with increased risk of ependymoma diagnosed at ages 12–19 (P = 4.0 × 10−3), but not with ependymoma in children under 12 years of age (P = 0.94). Mendelian randomization supported this observation, identifying a significant association between genetic predisposition to longer telomere length and increased risk of adolescent-onset ependymoma (ORPRS = 1.67; 95% CI 1.18–2.37; P = 3.97 × 10−3) and adult-onset ependymoma (PMR-Egger = 0.042), but not with risk of ependymoma diagnosed before age 12 (OR = 1.12; 95% CI 0.94–1.34; P = 0.21), nor with EPN-PF-A (PMR-Egger = 0.59). These findings complement emerging literature suggesting that augmented telomere maintenance is important in ependymoma pathogenesis and progression, and that longer telomere length is a risk factor for diverse nervous system malignancies.

scholarly journals Intake of sugar sweetened soft drinks among adolescents: Trends and social inequality in Denmark 2002-2018

2020 ◽  
Vol 26 (1) ◽  
pp. 3-8
Author(s):  
Bjørn E. Holstein ◽  
Mogens Trab Damsgaard ◽  
Pernille Due ◽  
Rikke Fredenslund Krølner ◽  
Trine Pagh Pedersen ◽  
...  
Keyword(s):  
Social Class ◽  
Social Inequality ◽  
Health Behaviour ◽  
Odds Ratio ◽  
Soft Drinks ◽  
School Aged Children ◽  
Occupational Social Class ◽  
Nationally Representative ◽  
Representative Samples

Background: Intake of sugar sweetened soft drinks (SSSD) has decreased among adolescents, but trends in social inequality in SSSD intake are unknown. Aim: Examine trends in social inequality in SSSD intake among adolescents in Denmark during 2002–2018. Methods: Five Health Behaviour in School-aged Children surveys with data on SSSD intake and parents’ occupational social class (OSC) from nationally representative samples of 11, 13 and 15 year olds, n =20,112. Results: The overall prevalence of daily SSSD intake decreased from 10.1% in 2002 to 6.4% in 2018. The prevalence decreased in both high OSC (from 8% to 5%) and middle OSC (from 10% to 6%) but remained around 12% in low OSC. The odds ratio (OR) estimates of low compared with high OSC increased over the years around an overall OR of 2.01 (1.74–2.34). Conclusions: Danish adolescents’ SSSD intake decreased during 2002–2018 and was higher the lower the parents’ OSC. Thus, social inequality increased during 2002–2018.

Hyperhomocysteinemia in cerebral vein thrombosis

Blood ◽  
2003 ◽  
Vol 102 (4) ◽  
pp. 1363-1366 ◽  
Author(s):  
Ida Martinelli ◽  
Tullia Battaglioli ◽  
Paola Pedotti ◽  
Marco Cattaneo ◽  
Pier M. Mannucci
Keyword(s):  
Plasma Levels ◽  
Odds Ratio ◽  
High Plasma ◽  
Serum Folate ◽  
First Episode ◽  
Cerebral Vein ◽  
Cerebral Vein Thrombosis ◽  
Vein Thrombosis ◽  
Control Subjects ◽  
Increased Risk

Abstract High plasma levels of total homocysteine (tHcy) are a risk factor for deep vein thrombosis. Because no information on the relationship between cerebral vein thrombosis and hyperhomocysteinemia is available, a case–control study of 121 patients with a first episode of cerebral vein thrombosis and 242 healthy control subjects was carried out. Fasting plasma levels of tHcy and their postmethionine load (PML) increments, together with other laboratory markers of thrombophilia, were measured in plasma or DNA. Hyperhomocysteinemia (high fasting tHcy and/or PML increments) was diagnosed in 33 patients (27%) and 20 control subjects (8%) (odds ratio, 4.2; 95% confidence interval [CI], 2.3-7.6). Low levels of serum folate and the 677TT methylene tetrahydrofolate reductase were associated with hyperhomocysteinemia, but in a multivariate model hyperhomocysteinemia only was associated with an increased risk of cerebral vein thrombosis. Oral contraceptive intake was associated with the disease with an odds ratio of 6.1 (95% CI, 3.3-11.0). The combined presence of the latter and hyperhomocysteinemia increased the risk of the disease with an odds ratio of 19.5 (95% CI, 5.7-67.3). In conclusion, hyperhomocysteinemia is associated with a 4-fold increased risk of cerebral vein thrombosis; whether or not its correction with vitamins reduces the risk of the disease remains to be demonstrated.

Transitions to adulthood and psychological distress in young adults born 12 years apart: constraints on and resources for development

2009 ◽  
Vol 40 (2) ◽  
pp. 301-313 ◽  
Author(s):  
A. Sacker ◽  
N. Cable
Keyword(s):  
Young Adults ◽  
Psychological Distress ◽  
Social Class ◽  
Transition To Adulthood ◽  
Well Being ◽  
Structural Constraints ◽  
Increased Risk ◽  
And Gender ◽  
Adult Roles

BackgroundLater transitions to adult roles and responsibilities have been linked with better psychological well-being yet psychological distress has risen despite young people making the transition to adulthood at older ages over recent years.MethodWe examine the role of structural constraints and adolescent resources in the relationship between the timing of transitions and psychological distress in early adult life in the 1958 National Child Development Study and the 1970 British Cohort Study. Graphical chain models were used to examine the influences on timing of four key transitions and their relationship with psychological distress (Malaise Inventory). The role of structural factors at birth (gender, social class) and adolescent resources (psychosocial problems, exam grades) were modelled.ResultsAn earlier transition to adult roles was associated with an increased risk for psychological distress but so was failing to make some key transitions. Structural constraints had negative effects on successful development. Persistent social class and gender inequalities in psychological distress were evident in both cohorts. Social class constraints were mediated by educational resources whereas gender constraints were mediated by psychosocial resources. The influence of structural constraints on the timing of transitions to adult roles was more complex with evidence of positive and negative mediation and moderation effects.ConclusionsDelaying transition to adulthood promotes psychological health but failure of transition to independent living is associated with psychological distress. Life-course transitions are constrained by social origin and gender and possibly economic environment. Adolescent resources help young adults to make timely transitions to adult roles.

scholarly journals Artistic creativity and risk for schizophrenia, bipolar disorder and unipolar depression: a Swedish population-based case–control study and sib-pair analysis

2018 ◽  
Vol 212 (6) ◽  
pp. 370-376 ◽  
Author(s):  
J. H. MacCabe ◽  
A. Sariaslan ◽  
C. Almqvist ◽  
P. Lichtenstein ◽  
H. Larsson ◽  
...  
Keyword(s):  
Bipolar Disorder ◽  
Mental Disorder ◽  
Odds Ratio ◽  
Case Control Study ◽  
Tertiary Education ◽  
Unipolar Depression ◽  
Population Based ◽  
Case Control ◽  
Increased Risk ◽  
Control Study

BackgroundMany studies have addressed the question of whether mental disorder is associated with creativity, but high-quality epidemiological evidence has been lacking.AimsTo test for an association between studying a creative subject at high school or university and later mental disorder.MethodIn a case–control study using linked population-based registries in Sweden (N = 4 454 763), we tested for associations between tertiary education in an artistic field and hospital admission with schizophrenia (N = 20 333), bipolar disorder (N = 28 293) or unipolar depression (N = 148 365).ResultsCompared with the general population, individuals with an artistic education had increased odds of developing schizophrenia (odds ratio = 1.90, 95% CI = [1.69; 2.12]) bipolar disorder (odds ratio = 1.62 [1.50; 1.75]) and unipolar depression (odds ratio = 1.39 [1.34; 1.44]. The results remained after adjustment for IQ and other potential confounders.ConclusionsStudents of artistic subjects at university are at increased risk of developing schizophrenia, bipolar disorder and unipolar depression in adulthood.Declaration of interestNone.

scholarly journals A Single Nucleotide Polymorphism in the MMP9 Promoter Affects Lung Cancer and Clinicopathological Properties in Iranian Population

2021 ◽  
Vol 2 (12) ◽  
pp. 1274-1282
Author(s):  
Somayeh Taghvaei ◽  
Leila Saremi ◽  
Majid Motovali-bashi
Keyword(s):  
Lung Cancer ◽  
Family History ◽  
Cancer Patients ◽  
Odds Ratio ◽  
Case Control Study ◽  
Positive Family History ◽  
Case Control ◽  
Healthy Controls ◽  
Lung Cancer Patients ◽  
Control Study

Background: Lung cancer is the most common cancer with 2,206,771 new cases in 2020 in worldwide. MMP9 is a member of matrix metalloproteinase family that is also known as gelatinase B or IV type collagenase (92KD). MMP9 through degrading of Extracellular Matrix (ECM) and releasing of growth factors has fundamental role in the tumorigenesis process. The C -1562 T SNP in the MMP9 promoter increases MMP9 expression and susceptibility to lung cancer. Then, the aim of this present case-control study was to investigate whether genetic variations of the MMP9 gene may constitute markers for lung cancer risk in males and in positive family history people in Iran. Methods: This is a case-control study including 120 lung cancer patients and 100 healthy controls. Polymorphism in the C -1562 T region was genotyped by PCR-RFLP assay. Odds Ratio (ORs) and 95% Confidence Intervals (CIs) were estimated by chi-square test from comparison of genotypes between lung cancer patients and healthy controls, using SPSS version 26.0. T-test and Image J software was also used. Results: The distribution of C-1562T genotype was significantly associated with the risk of lung cancer (Odds Ratio [OR] = 2.56, 95% Confidence Interval [CI] = 0.06-23.82). The further stratification analyses shown that males and patients with positive family history may increase risk of lung cancer. Conclusion: Our results indicated that the MMP9 C -1562 T polymorphism affects risk of lung cancer. In addition, men with T allele (OR = 3.94, CI = 1.47-10`.55) and patients with TT genotype and family history (OR = 2.18, CI = 1.03-4.59) exposure to higher risk of lung cancer.

Absolute annual incidences of first events of venous thromboembolism and arterial vascular events in individuals with elevated FVIII:c

2007 ◽  
Vol 98 (11) ◽  
pp. 1040-1044 ◽  
Author(s):  
Marlène van de Poel ◽  
Michiel Coppens ◽  
Karly Hamulyák ◽  
Martin Prins ◽  
Jan van der Meer ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Venous Thromboembolism ◽  
Odds Ratio ◽  
Average Duration ◽  
Positive Family History ◽  
Vascular Events ◽  
Common Risk Factor ◽  
Increased Risk ◽  
History Of ◽  
Asymptomatic Individuals

SummaryElevated levels of factor VIII:c (elevated FVIII:c) are associated with an increased risk for venous thromboembolism (VTE) and arterial vascular events, and are at least in part determined genetically. We prospectively followed 192 asymptomatic individuals with elevated FVIII:c (>150%) and 340 with normal levels for an average duration of 31 months (range 7 to 56 months) to investigate the risk of VTE and arterial vascular events. Participants were first degree relatives of consecutive patients with elevated FVIII:c and VTE or arterial vascular events before the age of 50 years. The incidences ofVTE were 1.25% (0.46–2.73) per year in the subjects with elevated FVIII:c, versus 0.23% (0.03–0.82) in those with normal levels (OR 5.5 [1.1–27.3]). The annual incidences of arterial vascular events were 1.04% (0.34–2.42) and 0.23% (0.03–0.82) in relatives with and without elevated levels of FVIII:c, respectively (OR: 4.5 [0.9–23.5]). After adjustment for age, smoking, known diabetes mellitus, hyperlipidemia, and hypertension, the odds ratio for any event was 3.7 (1.1–13.1). In conclusion, asymptomatic individuals with elevated FVIII:c levels and a positive family history of VTE or arterial vascular events before the age of 50 appear to have a high annual incidence of first VTE and arterial vascular events. Elevated FVIII:c may be a common risk factor for both clinical entities.

The C1542G and G505A Polymorphisms of Thrombin-Activatable Fibrinolysis Inhibitor (TAFI) in Patients with Thrombotic Microangiopathies.

Blood ◽  
2005 ◽  
Vol 106 (11) ◽  
pp. 2141-2141
Author(s):  
Christoph Sucker ◽  
Firuseh Farokhzad ◽  
Fieras Dahhan ◽  
Michael Schmitz ◽  
Gerd R. Hetzel ◽  
...  
Keyword(s):  
Odds Ratio ◽  
Arterial Thrombosis ◽  
Case Control ◽  
Thrombotic Microangiopathies ◽  
Thrombin Activatable Fibrinolysis Inhibitor ◽  
Increased Risk ◽  
Fibrinolysis Inhibitor ◽  
Inflammatory Processes ◽  
History Of

Abstract Background Thrombotic microangiopathies are characterized by vascular microthromboses, microangiopathic hemolytic anemia, and thrombocytopenia. Although recent research has elucidated the pathogenesis of these rare thrombotic disorders to some extent, the determinants contributing to the onset and modulating the severity are largely unknown. It is likely that risk factors of venous and arterial thrombosis also play a role in this clinical setting. Patients and Methods In the present study, we used a case-control and a case-only design, enrolling 23 patients (mean age [± SD] 35 ± 11 years) with a history of thrombotic microangiopathy and 689 control subjects to assess the role of gene polymorphisms of the thrombin-activatable fibrinolysis inhibitor (TAFI). Results The prevalence of the TAFI decreasing G/G genotype of the C1542G polymorphism was significantly higher in patients compared to controls (odds ratio 3.88; 95 % CI 1.07 – 11.47; p=0.02). In addition, in a case-only design the TAFI 1542 G allele was more prevalent in patients suffering from a severe course compared to those with a mild or moderate course (odds ratio 20; 95 % CI 1.85 – 216.17; p=0.009). By contrast, no such association was found for the TAFI G505A polymorphism. Conclusions Our study shows an association of the TAFI decreasing 1542 G/G genotype with an increased risk for thrombotic microangiopathies and a more severe course. This finding might be explained by the role of TAFI as an inhibitor of local inflammatory processes.

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