Gastrointestinal involvement and multiple lymphomatous polyposis in mantle-zone lymphoma.

The clinical, histologic, and immunologic features of three cases of lymphoma presenting with gastrointestinal symptoms and involving the gastrointestinal tract were studied. Two of the cases had involvement of long segments of the bowel with polypoid lesions, a rare presentation of gastrointestinal lymphoma referred to as multiple lymphomatous polyposis (MLP). All cases were classified as mantle-zone lymphoma (MZL), a follicular variant of intermediate lymphocytic lymphoma (ILL) characterized by the proliferation of small atypical lymphoid cells as wide mantles surrounding benign-appearing germinal centers. The patients were typical of other patients with MZL in that they were male, middle age or older, and their clinical courses were not aggressive despite the presence of disease at an advanced stage. Our review of the literature suggests that there is an inordinate number of cases of MZL with gastrointestinal involvement. We also note that most reports of cases of MLP have described histologic lesions remarkably similar to what we have observed. We conclude that MZL may have predilection for involvement of the gastrointestinal tract, that this involvement is often in the manner of MLP, and that most cases of MLP probably have MZL or ILL.

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Carcinosarcoma of the Rectum: Report of a Rare Colorectal Malignancy and Review of the Literature

Case Reports in Surgery ◽

10.1155/2015/412918 ◽

2015 ◽

Vol 2015 ◽

pp. 1-4 ◽

Cited By ~ 1

Author(s):

Alexis Sudlow ◽

Ming Ho Liu ◽

Geoffrey Waters ◽

Vamsi R. Velchuru

Keyword(s):

Gastrointestinal Tract ◽

Respiratory Tract ◽

Treatment Guidelines ◽

Specific Treatment ◽

Distant Metastases ◽

Reproductive Organs ◽

Review Of The Literature ◽

Rare Presentation ◽

Colorectal Malignancy ◽

Female Reproductive Organs

Carcinosarcoma (CS) is a rare mixed mesodermal malignancy most commonly affecting the female reproductive organs, respiratory tract, head, and neck. Though infrequent, it may affect the gastrointestinal tract, most often the oesophagus and only very rarely the rectum. Histologically, it is composed of two distinct elements of epithelial and mesenchymal origin. Clinically, it is a very aggressive tumour with many patients presenting with metastatic lymph nodes or distant metastases at the time of diagnosis. Prognosis is poor despite intervention with the majority of patients dying within six months. Due to the rarity of this condition, there are no specific treatment guidelines presently available. We describe the case of an 80-year-old patient with carcinosarcoma of the rectum with discussion of the immunohistochemistry and review the available literature pertaining to this rare presentation.

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Virus discharge and initial gastrointestinal involvement are negatively associated with circulating lymphocyte count in COVID-19

10.21203/rs.3.rs-40462/v1 ◽

2020 ◽

Author(s):

Wei Chen ◽

Kenneth I. Zheng ◽

Saiduo Liu ◽

Chongyong Xu ◽

Chao Xing ◽

...

Keyword(s):

Gastrointestinal Tract ◽

Lymphocyte Count ◽

Respiratory Symptoms ◽

Gastrointestinal Symptoms ◽

Gastrointestinal Involvement ◽

Negatively Associated ◽

Qrt Pcr ◽

Medical University ◽

Positive Results

Abstract Background: It’s reported SARS-CoV-2 could transmit via gastrointestinal tract, with or without pulmonary symptoms. However, as far as we know, there is no convenient marker to predict the virus discharge in stool and initial gastrointestinal involvement of COVID-19.Aims: We aimed to investigate the biomarker predicting virus discharge in stool and initial gastrointestinal involvement of COVID-19, which may assist the clinicians to better combat and prevent COVID-19.Methods: The patients complained of initial gastrointestinal involvement, including vomiting, diarrhea, with or without respiratory symptoms, attending the Sixth People’s Hospital of Wenzhou, and the Second Affiliated Hospital of Wenzhou Medical University, were screened by qRT-PCR for SARS-CoV-2. The Confirmed COVID-19 patients without contaminated ingestion were all enrolled to investigate the association between circulating lymphocyte count and virus discharge, initial gastrointestinal involvement.Results: 76 COVID-19 patients were finally enrolled in this study (mean age 44.5, male 44.7%), with 24 (31.5%) complained of initial gastrointestinal symptoms. Significantly lower circulating lymphocyte count was found in the patients with positive results of qRT-PCR on stool (p = 0.012). Furthermore, when the circulating lymphocyte count increased from bottom tertile to the 2nd and 3rd tertiles, the risk of initial gastrointestinal involvement decreased by nearly 75% (OR = 0.25, 95% CI: 0.07, 0.98, p = 0.047), 83% (OR = 0.17, 95% CI: 0.05, 0.63, p = 0.008), adjusted for possible confounders.Conclusions: The circulating lymphocyte count is negatively associated with virus discharge in stool in COVID-19 patients, and the risk of initial gastrointestinal involvement also.

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Lupus Gastrointestinal Tract Vasculopathy: Lupus “Enteritis” Involving the Entire Gastrointestinal Tract from Esophagus to Rectum

Case Reports in Gastroenterology ◽

10.1159/000455826 ◽

2017 ◽

Vol 11 (1) ◽

pp. 48-53 ◽

Cited By ~ 1

Author(s):

Joseph Bert ◽

Elie Gertner

Keyword(s):

Systemic Lupus Erythematosus ◽

Gastrointestinal Tract ◽

Lupus Erythematosus ◽

Intestinal Tract ◽

Gastrointestinal Symptoms ◽

Gastrointestinal Involvement ◽

Systemic Lupus ◽

Lupus Enteritis ◽

Upper Gastrointestinal ◽

Entire Gastrointestinal Tract

Gastrointestinal symptoms are very common in systemic lupus erythematosus (SLE). Lupus “enteritis” is very responsive to treatment but can have devastating consequences if not detected. Most descriptions of enteritis involve the small and large bowel. This is the first report of lupus “enteritis” involving the entire gastrointestinal tract from the esophagus and stomach to the rectum. Lupus “enteritis” is another cause of upper gastrointestinal involvement in SLE (involving even the esophagus and stomach) in addition to involvement of the lower intestinal tract.

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Crohn’s Disease of the Vulva: a Case Report

Folia Medica ◽

10.3897/folmed.63.e58002 ◽

2021 ◽

Vol 63 (6) ◽

pp. 990-993

Author(s):

Kalliopi Kokkali ◽

Christos Iavazzo ◽

Efthimia Souka ◽

Sofia Lekka ◽

Alexandros Fotiou ◽

...

Keyword(s):

Case Report ◽

Gastrointestinal Tract ◽

Inflammatory Disease ◽

Gastrointestinal Symptoms ◽

Granulomatous Inflammation ◽

Chronic Inflammatory Disease ◽

Rare Entity ◽

Gastrointestinal Involvement ◽

History Of ◽

Granulomatous Diseases

Crohn’s disease is a multi-systemic chronic inflammatory disease that can affect various organs besides the gastrointestinal tract such as joints, uvea, and the skin. Vulvar Crohn’s disease is a rare entity occurring with vulvar lesions that show typical Crohn’s disease granulomatous inflammation but are not contiguous with the gastrointestinal involvement. Vulvar Crohn’s disease can be easily confused with other granulomatous diseases and awareness that such involvement may precede gastrointestinal symptoms must be raised. Few cases of vulvar Crohn’s disease have been reported in the literature to date. Here, we report a case of a 43-year-old woman with a 6-month history of a vulvar lesion; the patient was diagnosed with Crohn’s disease of the large bowel just over a year ago.

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Pneumomediastinum: A Rare Presentation of Inflicted Injuries in Infants

Journal of Pediatric Intensive Care ◽

10.1055/s-0040-1716857 ◽

2020 ◽

Author(s):

Adam Lee ◽

Adam Bajinting ◽

Abby Lunneen ◽

Colleen M. Fitzpatrick ◽

Gustavo A. Villalona

Keyword(s):

Literature Review ◽

Retrospective Review ◽

Review Of The Literature ◽

Rare Presentation ◽

Spontaneous Pneumomediastinum ◽

Nonaccidental Trauma ◽

Comprehensive Literature Review ◽

Healthy Infants ◽

History Of

AbstractReports of incidental pneumomediastinum in infants secondary to inflicted trauma are limited. A retrospective review of infants with pneumomediastinum and history of inflicted trauma was performed. A comprehensive literature review was performed. Three infants presented with pneumomediastinum associated with inflicted trauma. Mean age was 4.6 weeks. All patients underwent diagnostic studies, as well as a standardized evaluation for nonaccidental trauma. All patients with pneumomediastinum were resolved at follow-up. Review of the literature identified other cases with similar presentations with related oropharyngeal injuries. Spontaneous pneumomediastinum in previously healthy infants may be associated with inflicted injuries. Clinicians should be aware of the possibility of an oropharyngeal perforation related to this presentation.

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Premalignant and Malignant Lesions of the Heterotopic Pancreas in the Esophagus: a Case Report and Review of the Literature

Journal of Gastrointestinal and Liver Diseases ◽

10.15403/jgld.2014.1121.242.uly ◽

2015 ◽

Vol 24 (2) ◽

pp. 235-239 ◽

Cited By ~ 9

Author(s):

Jan Ulrych ◽

Vladimir Fryba ◽

Helena Skalova ◽

Zdenek Krska ◽

Tomas Krechler ◽

...

Keyword(s):

Case Report ◽

Gastrointestinal Tract ◽

Unusual Case ◽

Accurate Diagnosis ◽

Heterotopic Pancreas ◽

Premalignant Lesions ◽

Resected Specimen ◽

Review Of The Literature ◽

Severe Dysphagia ◽

Malignant Lesions

Heterotopic pancreas is a congenital pathology of the gastrointestinal tract, particularly rare in the esophagus. Both symptomatology and findings during preoperative examinations are non-specific and therefore do not often lead to an accurate diagnosis, which is usually revealed only by histopathological assessment of a resected specimen. We report an unusual case of a patient suffering from severe dysphagia caused by heterotopic pancreas in the distal esophagus with chronic inflammation and foci of premalignant changes. This article also reviews 14 adult cases of heterotopic pancreas in the esophagus previously reported in the literature, with the aim of determining the clinical features of this disease and possible complications including rare premalignant lesions and malignant transformation. Especially with regard to those complications, we suggest that both symptomatic and incidentally found asymptomatic lesions should be resected.

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Detection of influenza virus in rectal swabs of patients admitted in hospital for febrile illnesses in Thailand

SAGE Open Medicine ◽

10.1177/2050312121989631 ◽

2021 ◽

Vol 9 ◽

pp. 205031212198963

Author(s):

Artit Sangkakam ◽

Pasin Hemachudha ◽

Abhinbhen W Saraya ◽

Benjamard Thaweethee-Sukjai ◽

Thaniwan Cheun-Arom ◽

...

Keyword(s):

Influenza Virus ◽

Gastrointestinal Tract ◽

Hospital Stay ◽

Rectal Swab ◽

Average Length ◽

Gastrointestinal Symptoms ◽

Virus Detection ◽

Length Of Hospital Stay ◽

Nasopharyngeal Swab ◽

Influenza Virus Detection

Introduction: Influenza virus favours the respiratory tract as its primary site of host entry and replication, and it is transmitted mainly via respiratory secretions. Nasopharyngeal swab is the gold standard specimen type for influenza detection, but several studies have also suggested that the virus replicates in the human gastrointestinal tract. Methods: A retrospective study was conducted on all patients positive for influenza virus and initially recruited as part of the PREDICT project from 2017 to 2018. The objectives of the study were to investigate whether rectal swab could aid in improving influenza detection, and if there was any correlation between gastrointestinal disturbances and severity of infection, using length of hospital stay as an indicator of severity. Results: Of the 51 influenza-positive patients, 12 had detectable influenza virus in their rectal swab. Among these 12 rectal swab positive patients, influenza virus was not detected in the nasopharyngeal swab of three of them. Gastrointestinal symptoms were observed for 28.2% patients with a negative rectal swab negative and 25.0% patients with a positive rectal swab. Average length of hospital stay was 4.2 days for rectal swab positive group and 3.7 days for rectal swab negative group. This difference was not statistically significant (p = 0.288). Conclusions: There is no correlation between influenza virus detection in rectal swab and gastrointestinal disturbances or disease severity, and there is currently insufficient evidence to support replicative ability in the gastrointestinal tract.

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Diffuse Large B-Cell Lymphoma Presenting as Multiple Lymphomatous Polyposis of the Gastrointestinal Tract

Clinical Lymphoma & Myeloma ◽

10.3816/clm.2008.n.023 ◽

2008 ◽

Vol 8 (3) ◽

pp. 179-183 ◽

Cited By ~ 6

Author(s):

Swati Andhavarapu ◽

Arturo M. Tolentino ◽

Chandra Jha ◽

Jyotsna Ravi ◽

Richard Carlson ◽

...

Keyword(s):

Gastrointestinal Tract ◽

B Cell ◽

Cell Lymphoma ◽

B Cell Lymphoma ◽

Large B Cell Lymphoma ◽

Multiple Lymphomatous Polyposis ◽

Large B Cell

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Eosinophilic Gastrointestinal Diseases: Review and Update

ISRN Gastroenterology ◽

10.5402/2012/463689 ◽

2012 ◽

Vol 2012 ◽

pp. 1-8 ◽

Cited By ~ 14

Author(s):

Mahreema Jawairia ◽

Ghulamullah Shahzad ◽

Paul Mustacchia

Keyword(s):

Gastrointestinal Tract ◽

Clinical Features ◽

Gastrointestinal Symptoms ◽

Gastrointestinal Diseases ◽

Gastrointestinal Disorders ◽

Diverse Group ◽

Intestinal Diseases ◽

Gastrointestinal Inflammation ◽

Eosinophilic Gastrointestinal Disorders

Eosinophilic gastrointestinal disorders (EGIDs) are a progressively more frequent diverse group of intestinal diseases. The intention of this paper is to present the newest developments in the care of patients with EGIDs and to sum up a rising literature defining the clinical features and mechanistic elements of eosinophils and their intricate associations with the gastrointestinal tract. Clinicians ought to stay sensitive to EGIDs as a diagnostic likelihood for patients with general gastrointestinal symptoms. Further research is warranted to establish various methods leading to dysfunction coupled with eosinophilic gastrointestinal inflammation.

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Metastatic Melanoma Presenting as Intussusception in an 80-Year-Old Man: A Case Report

Case Reports in Pathology ◽

10.1155/2013/672816 ◽

2013 ◽

Vol 2013 ◽

pp. 1-3 ◽

Cited By ~ 1

Author(s):

Sarah Alghamdi ◽

Yumna Omarzai

Keyword(s):

Differential Diagnosis ◽

Small Intestine ◽

Gastrointestinal Tract ◽

Metastatic Melanoma ◽

Clinical Presentation ◽

Gastrointestinal Symptoms ◽

Common Site ◽

Neoplastic Process ◽

History Of ◽

Uncommon Neoplasm

Malignant melanoma of the gastrointestinal tract is an uncommon neoplasm that could be primary or metastatic. Small intestine represents the most common site for the metastatic melanoma; however, it could be found anywhere in the gastrointestinal tract. Intussusception is a rare cause of intestinal obstruction in adults compared to children. In 90% of the cases, the underlying cause can be found, and in 65% of the cases, intussusception is caused by the neoplastic process. The majority of the neoplasms are benign, and about 15% are malignant. Metastatic melanoma is one of the most common metastatic malignancies to the gastrointestinal tract; however, the premortem diagnosis is rarely made. Here, we report an uncommon clinical presentation of metastatic melanoma causing intussusception in an 80-year-old man. This diagnosis should be considered in a differential diagnosis in any patient who presents with gastrointestinal symptoms and a history of melanoma.

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