Population-based analysis of the rising incidence of renal cancer: Evaluation of age-specific trends (1975-2006).

357 Background: Multiple studies show an increasing incidence of renal cancer, possibly related to the rising use of cross sectional imaging. We explored if the increase in renal cancer incidence differs across age groups. Methods: Using the Surveillance, Epidemiology, and End Results (SEER) cancer registry data for the years 1975-2006, we ascertained incident cases of renal cancer. Urothelial histology was excluded. Yearly incidence rates of renal cancer were calculated, age-adjusted to the United States 2,000 standard adult population, and stratified by age group (20-39, 40-49, 50-59, 60-69, 70-79, 80+). Age-specific trends in renal cancer diagnosis over time were evaluated with Poisson regression. Results: 63,843 incident renal cancer cases were identified in 544,684,745 person-years of observation. From 1975 to 2006, overall age-adjusted renal cancer incidence rose 238% from 7.4 to 17.6 per 100,000 adults. The mean age at diagnosis was 61.7 years in 1975, increased to 64.7 years in 1991, and then declined to 62.7 years by 2006. Using 1991 (the year of peak renal cancer age at diagnosis) as the dividing point, the average annual percentage increase in renal cancer incidence was 3.6% from 1976-1990 and 2.9% from 1991- 2006. The age-specific incidence rates of renal cancer increased in all age groups from 1975 to 2006; however the age-specific incidence rates changed at different rates (p<0.0001). Younger age groups showed a more rapid increase in renal cancer incidence over the second half of the study than did the older age groups. For example, for patients age 20-39 years the annual percentage change increased from 4.5% in 1975-1990 to 5.2% in 1991-2006 while annual percentage change decreased from 6.7% in 1975-1990 to 0.9% in 1991-2006 in those over 79 years old. The proportion of patients diagnosed younger than age 65 increased from 45.9% in 1991 to 55.3% in 2006. Conclusions: The incidence of renal cancer has risen steadily since 1975 and continues to increase in all age groups. In the last 15 years, mean age at diagnosis of renal cancer has decreased driven by an increased incidence in younger patients with proportionally less increase in older patients. No significant financial relationships to disclose.

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Evaluating the Rising Secular Trends of Incidence and Partial Prevalence of Colorectal Cancer in Iran: Join point regression

10.21203/rs.2.11099/v1 ◽

2019 ◽

Author(s):

Mouhebat Vali ◽

Hossein Molavi Vardanjani ◽

Jafar Hassanzadeh

Keyword(s):

Colorectal Cancer ◽

Age Groups ◽

Incidence Rates ◽

Percentage Change ◽

Annual Percentage Change ◽

Gender And Age ◽

Population Information ◽

Colon And Rectum ◽

Join Point

Abstract Background Colorectal cancer (CRC) is expected to be of the most common cancers in developing countries, where the its mortality is high and less services are avaiable for cancer survivors. Methods To assess the incidence rate, firstly, the incidence rates of colon and rectum reported in the two sites of http://globocan.iarc.fr and http://healthdata.org from 1990 to 2017 were extracted based on gender and age groups (less than 40 and more than 40 years old), In the next step, according to the incidence and APC(annual percentage change) provided in the previous step, we predicted the incidence for the next years according to the formulas. we Estimated the prevalence of 1-year, 2-3 year and 4-5 year using survival and incidence according to the formula. At the end we predicted prevalence by 2030 in Iran. Results In our study, AAPC(average annual percentage change) for women was found to be 4.07%(CI: 3.76-4.39) in all age groups and AAPC= 4.30%(CI: 4.14-4.47) for men in all age groups. the predicted incidence in the group under 40 that in men it reaches from about 12 to 15 per 100,000 and for women from about 10 to 11 per 100,000. While the increase of 100/ 10000 was found in the women over 40 years and the increase of 150/100,000 was obtained in men. And In all groups, predicted prevalence rate increases. In the group under 40 and the group over 40 prevalence increase about 2000 and 26000 numbers respectively in women and men from 2000 to 2030. Conclusions With regard to the above mentioned cases, there is a strong need for cancers registry, which is the population information and follow-up of patients, and the establishment of research institutes to determine the basic needs of patients.

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Effect of Population-Wide Hepatitis B Vaccination in Preventing Liver Cancer Among Children and Young Adults in the United States

Journal of Global Oncology ◽

10.1200/jgo.18.73700 ◽

2018 ◽

Vol 4 (Supplement 2) ◽

pp. 11s-11s

Author(s):

A.Z. Shams ◽

V. Winkler ◽

H. Pohlabeln ◽

V. Arndt ◽

U. Haug

Keyword(s):

Liver Cancer ◽

Cancer Incidence ◽

Cancer Registries ◽

The United States ◽

Incidence Rates ◽

Age Group ◽

Incidence Data ◽

Hbv Vaccination ◽

The Us ◽

Incident Cases

Background: Liver cancer is the second most common cause of death from cancer worldwide1. In 2013, 79,2000 new cases of liver cancer and 818,000 deaths occurred globally2,3. Chronic infection with HBV accounts for at least 50% of liver cancer globally4. In the United States (US), liver cancer constitute the ninth leading cause of cancer death. The incidence of the cancer has persistently increased in the recent decades. Universal HBV vaccination was introduced in 1992 in the US. However, incidence trends of liver cancer among US children is poorly researched or relevant studies are not up-to-date5. Aim: This study aims to explore the effect of HBV population-wide vaccination program in reducing liver cancer incidence in the vaccinated children and adolescents in the US. Methods: Liver cancer incidence data were obtained from Cancer Incidence in Five Continents (CI5) databases (volumes I to X) from International Agency for Cancer Research (IARC). Data acquisition and analysis covered available incidence data between 1978-2007 from 9 cancer registries from Surveillance, Epidemiology, and End Results Program (SEER) from the US presented in the CI5 databases. Age-specific incidence rates of liver cancer (based on 5 year age groups ie 5-9 year, 10-14 year and 15-19 years) were calculated using age and sex-disaggregated incidence and population data from the SEER cancer registries. Stata software version 14.0 (StataCorp, USA) was used to calculate age-specific incidence rates, using number of liver cancer incident cases in each age group by the number of population in the respective age group. Age-specific rates were analyzed by period of diagnosis and by birth year. Rate ratios were estimated from age-group-specific Poisson regressions. Results: A total of 140 liver cancer incident cases were registered in the 9 SEER registries between 1978 to 2007 in the US. The incidence rate of liver cancer in children 5 to 9 years of age from 1978-1982 was 0.10 per 100,000 children. The incidence increased to 0.16 for the period from 2003-2007. The same trend is seen for the age group 10-14 and 15-19 years of age. Overall, age-specific incidence rates for liver cancer increased across age groups of 5-9, 10-14 and 15-19 year in the population covered by the 9 SEER registries in the US. However, risk estimates (incidence rate ratios, resulted from age-group-specific Poisson regressions did not show statistical significant effects. Conclusion: While the global response to implement population-wide HBV vaccination program is out of question, efforts to establish processes to evaluate the effect of such programs seems to be incomparably limited. Estimating the effect of HBV vaccination will relatively improve with time as further incidence data become available eg upon publication of data from new volume of CI5 databases.

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Anal Cancer Risk Among People With HIV Infection in the United States

Journal of Clinical Oncology ◽

10.1200/jco.2017.74.9291 ◽

2018 ◽

Vol 36 (1) ◽

pp. 68-75 ◽

Cited By ~ 54

Author(s):

Vivian Colón-López ◽

Meredith S. Shiels ◽

Mark Machin ◽

Ana P. Ortiz ◽

Howard Strickler ◽

...

Keyword(s):

General Population ◽

Hiv Infection ◽

Anal Cancer ◽

Cancer Incidence ◽

Cumulative Incidence ◽

Temporal Trends ◽

The United States ◽

Hiv Treatment ◽

Percentage Change ◽

Annual Percentage Change

Purpose People with HIV infection have an elevated risk of anal cancer. However, recent calendar trends are incompletely described, and which population subgroups might benefit from cancer screening is unknown. Methods We used linked data from HIV and cancer registries in nine US areas (1996 to 2012). We calculated standardized incidence ratios to compare anal cancer incidence in people with HIV infection with the general population, used Poisson regression to evaluate anal cancer incidence among subgroups of people with HIV and to assess temporal trends, and estimated the cumulative incidence of anal cancer to measure absolute risk. Results Among 447,953 people with HIV infection, anal cancer incidence was much higher than in the general population (standardized incidence ratio, 19.1; 95% CI, 18.1 to 20.0). Anal cancer incidence was highest among men who have sex with men (MSM), increased with age, and was higher in people with AIDS than in those without AIDS (ie, HIV only; adjusted incidence rate ratio, 3.82; 95% CI, 3.27 to 4.46). Incidence among people with HIV increased steeply during 1996 to 2000 (annual percentage change, 32.8%; 95% CI, −1.0% to 78.2%), reached a plateau during 2001 to 2008, and declined during 2008 to 2012 (annual percentage change, −7.2%; 95% CI, −14.4% to 0.6%). Cumulative incidence after a 5-year period was high for MSM with HIV only age 45 to 59 or ≥ 60 years (0.32% to 0.33%) and MSM with AIDS age 30 to 44, 45 to 59, or ≥ 60 years (0.29% to 0.65%). Conclusion Anal cancer incidence is markedly elevated among people with HIV infection, especially in MSM, older individuals, and people with AIDS. Recent declines may reflect delayed benefits of HIV treatment. Groups with high cumulative incidence of anal cancer may benefit from screening.

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Trends in Multiple Myeloma Incidence in the United States (US): Demographic and Geographic Considerations and Focus on Young Adults

Blood ◽

10.1182/blood-2018-99-114105 ◽

2018 ◽

Vol 132 (Supplement 1) ◽

pp. 5575-5575

Author(s):

Gordon Ruan ◽

Gaurav Goyal ◽

Shahrukh K. Hashmi ◽

Prashant Kapoor ◽

Ronald S. Go

Keyword(s):

Multiple Myeloma ◽

Young Adults ◽

New Jersey ◽

Los Angeles ◽

Research Funding ◽

Age Groups ◽

The United States ◽

Incidence Rates ◽

Age At Diagnosis ◽

The Us

Abstract Background: The incidence of multiple myeloma (MM) in the US is increasing among non-Hispanic (NH) White males and females as well as NH Black males (Costa LJ, Blood Advances 2017). However, more specific incidence studies accounting for geographic and age subgroups are limited. There is also a growing concern that incidence of many cancers is increasing in the younger population. Utilizing the Surveillance, Epidemiology, and End Results Program (SEER), we investigated the trends in MM incidence in the US according to demographic and geographic subgroups with a focus on the young adults. Methods: Incidence rates (case/100,0000) were calculated using SEER*Stat and 2000-2015 data from SEER-18 registries age-adjusted to the U.S. 2000 standard population. We calculated the annual percentage change (APC) of incidence rates according to age groups and stratified by sex, race, and registry. Age at diagnosis was analyzed in 10-year intervals starting at 20 years. All analyses used ICD-O-3 codes 9732/3 with microscopically confirmed MM. Results: There were 69,613 MM patients included in the analysis. The mean age at diagnosis was 68 years and decreased over time from 68.5 years in 2000 to 67.6 years in 2015. Men comprised 55.5% of the population. Patients <50 years constituted 7.9% of the population with 6.6% between 40-49 years. The incidence significantly (all p values <0.01) increased from 2000-2015 for the entire cohort (incidence 6.9-9.5; APC 1.1) and for males (8.6-9.5; 1.1) and females (5.7-6.3; 0.8). The highest increase in incidence among the age groups (Figure) was in 40-49 years (1.9-2.7; 2.1). When analyzing the trends for age groups stratified by sex, women ages 40-49 years had the highest increase in incidence (1.6-2.6; 2.4). The APCs of SEER-18 registries stratified by age and sex are reported in the Table. The highest APCs (>3.0) were observed in the registries of Atlanta, Greater Georgia, Hawaii, and New Jersey. When the SEER-18 registries were further stratified by race, white men ages 40-49 years in Seattle and New Jersey had APCs of 5.5 and 2.9 respectively, while Black women ages 40-49 years in Greater Georgia had an APC of 3.3. Only 3 groups of individuals had a significant decline in the incidence: Asian women ≥70 years in Los Angeles (APC -6.4), White women ≥70 years in Los Angeles (APC -1.9), and men 50-59 years in San Jose (APC -1.5). Conclusions: The overall incidence of MM is increasing in the US with the highest increment among young adults between the age groups 40-49 years. We observed geographic and demographic differences in the incidence rates, which may reflect genetic and environmental influences. Interestingly, a few geo-demographic subgroups had a decline in the incidence. Further research is needed to determine the reasons behind the observed trends. Disclosures Kapoor: Celgene: Research Funding; Takeda: Research Funding.

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Incidence and Trends of the Leading Cancers with Elevated Incidence Among American Indian and Alaska Native Populations, 2012–2016

American Journal of Epidemiology ◽

10.1093/aje/kwaa222 ◽

2020 ◽

Author(s):

Stephanie C Melkonian ◽

Hannah K Weir ◽

Melissa A Jim ◽

Bailey Preikschat ◽

Donald Haverkamp ◽

...

Keyword(s):

American Indian ◽

Cancer Incidence ◽

Alaska Native ◽

Cancer Registries ◽

Population Based ◽

Incidence Rates ◽

Breast Cancers ◽

Age Adjusted Rates ◽

Incident Cases ◽

Hispanic White

Abstract Cancer incidence varies among American Indian and Alaska Native (AI/AN) populations, as well as between AI/AN and White populations. This study examined trends for cancers with elevated incidence among AI/AN compared with non-Hispanic White populations and estimated potentially avoidable incident cases among AI/AN populations. Incident cases diagnosed during 2012–2016 were identified from population-based cancer registries and linked with the Indian Health Service patient registration databases to improve racial classification of AI/AN populations. Age-adjusted rates (per 100,000) and trends were calculated for cancers with elevated incidence among AI/AN compared with non-Hispanic White populations (rate ratio >1.0), by region. Trends were estimated using joinpoint regression analyses. Expected cancers were estimated by applying age-specific cancer incidence rates among non-Hispanic White populations to population estimates for AI/AN populations. Excess cancer cases among AI/AN populations were defined as observed minus expected cases. Liver, stomach, kidney, lung, colorectal and female breast cancers had higher incidence rate among AI/AN populations across most regions. Between 2012 and 2016, nearly 5,200 excess cancers were diagnosed among AI/AN populations, with the largest number of excess cancers (1,925) occurring in the Southern Plains region. Culturally informed efforts may reduce cancer disparities associated with these and other cancers among AI/AN populations.

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Spatial and Temporal Analysis of Lung Cancer in Shenzhen, 2008–2018

International Journal of Environmental Research and Public Health ◽

10.3390/ijerph18010026 ◽

2020 ◽

Vol 18 (1) ◽

pp. 26

Author(s):

Lin Lei ◽

Anyan Huang ◽

Weicong Cai ◽

Ling Liang ◽

Yirong Wang ◽

...

Keyword(s):

Lung Cancer ◽

Spatial Autocorrelation ◽

Incidence Rate ◽

Cancer Incidence ◽

Southern China ◽

Percentage Change ◽

Spatial Autocorrelation Analysis ◽

Lung Cancer Incidence ◽

Annual Percentage Change ◽

Autocorrelation Analysis

Lung cancer is the most commonly diagnosed cancer in China. The incidence trend and geographical distribution of lung cancer in southern China have not been reported. The present study explored the temporal trend and spatial distribution of lung cancer incidence in Shenzhen from 2008 to 2018. The lung cancer incidence data were obtained from the registered population in the Shenzhen Cancer Registry System between 2008 and 2018. The standardized incidence rates of lung cancer were analyzed by using the joinpoint regression model. The Moran’s I method was used for spatial autocorrelation analysis and to further draw a spatial cluster map in Shenzhen. From 2008 to 2018, the average crude incidence rate of lung cancer was 27.1 (1/100,000), with an annual percentage change of 2.7% (p < 0.05). The largest average proportion of histological type of lung cancer was determined as adenocarcinoma (69.1%), and an increasing trend was observed in females, with an average annual percentage change of 14.7%. The spatial autocorrelation analysis indicated some sites in Shenzhen as a high incidence rate spatial clustering area. Understanding the incidence patterns of lung cancer is useful for monitoring and prevention.

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Colorectal Cancer in Young and Older Adults in Uruguay: Changes in Recent Incidence and Mortality Trends

International Journal of Environmental Research and Public Health ◽

10.3390/ijerph18158232 ◽

2021 ◽

Vol 18 (15) ◽

pp. 8232

Author(s):

Carina Musetti ◽

Mariela Garau ◽

Rafael Alonso ◽

Marion Piñeros ◽

Isabelle Soerjomataram ◽

...

Keyword(s):

Colorectal Cancer ◽

Older Adults ◽

Cancer Incidence ◽

Age Groups ◽

Incidence Rates ◽

Mortality Trends ◽

Screening Programs ◽

Lifestyle Risk Factors ◽

Incidence And Mortality ◽

Colorectal Cancer Incidence

Uruguay has the highest colorectal cancer incidence rates in Latin America. Previous studies reported a stable incidence and a slight increase in mortality among males. We aimed to assess colorectal cancer incidence (2002–2017) and mortality trends (1990–2017) by age groups and sex, using data from the National Cancer Registry. Annual percent changes (APCs) were estimated using joinpoint regression models. We included 27,561 colorectal cancer cases and 25,403 deaths. We found an increasing incidence among both males and females aged 40–49, with annual increases of 3.1% (95%CI: 1.21–5.03) and 2.1% (95%CI: 0.49–3.66), respectively, and an increasein the rate in older males (70+) of 0.60% (95%CI: 0.02–1.20) per year between 2002 and 2017. Mortality remained stable among those younger than 50, whereas it decreased for older females aged 50–69 and 70+ (APC: −0.61% (−1.07–0.14) and −0.68% (−1.02–0.34), respectively), and increased for the oldest males (70+; APC: 0.74 (0.47–1.01)). In conclusion, we found rising colorectal cancer incidence accompanied by stable mortality in young adults. Sex disparities were also found among the older adults, with a more favorable pattern for females. Exposures to dietary and lifestyle risk factors, and inequalities in access to and awareness of screening programs, are probably among the main underlying causes and deserve further investigation.

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Incidence of Invasive Breast Cancer by Hormone Receptor Status From 1992 to 1998

Journal of Clinical Oncology ◽

10.1200/jco.2003.03.088 ◽

2003 ◽

Vol 21 (1) ◽

pp. 28-34 ◽

Cited By ~ 150

Author(s):

Christopher I. Li ◽

Janet R. Daling ◽

Kathleen E. Malone

Keyword(s):

Breast Cancer ◽

United States ◽

Cancer Incidence ◽

Hormone Receptor ◽

Breast Cancer Incidence ◽

The United States ◽

Incidence Rates ◽

Hormone Receptor Status ◽

Receptor Status ◽

Cancer Incidence Rates

Purpose: Between 1987 and 1998, breast cancer incidence rates rose 0.5%/yr in the United States. A question of potential etiologic and clinical importance is whether the hormone receptor status of breast tumors is also changing over time. This is because hormone receptor status may reflect different etiologic pathways and is useful in predicting response to adjuvant therapy and prognosis. Methods: Age-adjusted, age-specific breast cancer incidence rates by estrogen receptor (ER) and progesterone receptor (PR) status from 1992 to 1998 were obtained and compared from 11 population-based cancer registries in the United States that participate in the National Cancer Institute’s Surveillance, Epidemiology, and End Results (SEER) Program. Results: From 1992 to1998, the overall proportion of breast cancers that were ER-positive and PR-positive increased from 75.4% to 77.5% (P = .0002) and from 65.0% to 67.7% (P < .0001), respectively, continuing trends observed before 1992. These increases were limited to women 40 to 69 years of age. The proportions of ER-positive/PR-positive tumors increased from 56.7% to 62.3% (P = .0010) among 40- to 49-year-olds, from 58.0% to 63.2% (P = .0002) among 50- to 59-year-olds, and from 63.2% to 67.9% (P = .0020) among 60- to 69-year-olds. Conclusion: From 1992 to 1998, the proportion of tumors that are hormone receptor–positive rose as the proportion of hormone receptor–negative tumors declined. Because the incidence rates of hormone receptor–negative tumors remained fairly constant over these years, the overall rise in breast cancer incidence rates in the United States seems to be primarily a result of the increase in the incidence of hormone receptor–positive tumors. Hormonal factors may account for this trend.

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Analysis of Breslow Tumor Thickness Distribution of Skin Melanoma in the Italian Region of Romagna, 1986–1991

Tumori Journal ◽

10.1177/030089169408000602 ◽

1994 ◽

Vol 80 (6) ◽

pp. 416-421 ◽

Cited By ~ 6

Author(s):

Ignazio Stanganelli ◽

Antonio Ascari Raccagni ◽

Laura Baldassari ◽

Donato Calista ◽

Monica Serafini ◽

...

Keyword(s):

Thickness Distribution ◽

Descriptive Analysis ◽

Age Groups ◽

Incidence Rates ◽

Cutaneous Malignant Melanoma ◽

Skin Melanoma ◽

Italian Region ◽

Major Implication ◽

Incident Cases ◽

Southern European Countries

Aims and Background In southern European countries, the availability of epidemiologic data on cutaneous malignant melanoma is limited. A descriptive analysis was performed on melanoma cases diagnosed in the Italian region of Romagna (population 600,000), 1986-91. Methods The main end point was the proportion of cases less than 1.5 mm thick by sex, age, and site. Results A total of 297 incident cases was evaluated. The average annual age-standardized (World) incidence rates were 6.2 (95% CI 5.2–7.2) per 100,000 females and 4.5 (95% CI 3.6–5.3) per 100,000 males. Females presented with significantly thinner melanomas than males. The proportion of cases less than 1.5 mm thick decreased significantly with increasing age in both sexes, with the most pronounced decrease (approximately from 2/3 to 1/3) being observed above 60 years for females and above 40 for males. Comparing sexes by 10-year age groups, a significant F:M advantage in thickness distribution was found only at age 40–49 and 50–59 years. Among females under 60, melanomas of the legs and those of the trunk showed no difference in thickness distribution, in both sexes, incidence appeared to increase progressively with age. No apparent elevation in incidence rates was observed in the age groups with the highest frequency of thin melanomas. Conclusions The major implication of these data is that in public education programs specific messages should be aimed at those subgroups that show the poorest levels of self-surveillance.

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