Use of modafinil to moderate the relationship between cancer-related fatigue and depression in 541 patients receiving chemotherapy: A URCC CCOP study.

2013 ◽  
Vol 31 (15_suppl) ◽  
pp. 9572-9572
Author(s):  
Claire Conley ◽  
Charles E Heckler ◽  
Gary R. Morrow ◽  
Karen Michelle Mustian ◽  
Charles Stewart Kamen ◽  
...  
Keyword(s):  
Negative Affect ◽  
Positive Affect ◽  
Secondary Analysis ◽  
Depression Scale ◽  
Epidemiologic Studies ◽  
Symptoms Of Depression ◽  
Affective Symptoms ◽  
Brief Fatigue Inventory ◽  
Post Test ◽  
The Relationship

9572 Background: Over 50% patients with cancer report symptoms of depression; 15% meet diagnostic criteria for Major Depressive Disorder. Depression is associated with increased insomnia, fatigue and reduced quality of life. We previously found that modafinil is effective for reducing high levels of fatigue among patients undergoing chemotherapy. This study aims to test whether modafinil can alleviate symptoms of depression by reducing fatigue. Methods: This study is a secondary analysis of 541 cancer patients receiving chemotherapy and experiencing fatigue (Brief Fatigue Inventory (BFI) >=3) that were randomized to receive either 200 mg of modafinil (N=260) or placebo (N=281) daily from baseline (Cycle 2) until post-test (Cycle 4). Depression was measured by the Center for Epidemiologic Studies Depression Scale (CES-D) at baseline and post-test. The CES-D total score and its subscales (Positive Affect, Negative Affect, Somatic Symptoms, and Interpersonal Symptoms) were analyzed. A linear model with CES-D post (outcome) and BFI baseline, Arm, and BFI*Arm interaction term (independent variables) was used to address the hypothesis; p<0.05 indicates significance. Results: We found no overall effect of modafinil on depression; however, the model demonstrated a significant moderating effect of modafinil on the relationship between baseline fatigue and CES-D total scores (p = 0.04). For subjects with severe fatigue (BFI ≥ 7), the drug reduced CES-D scores by 3-4. Modafinil also significantly moderated the relationship between baseline fatigue and Positive Affect subscale scores (p = 0.003), but not the relationship between baseline fatigue and Somatic, Negative Affect, or Interpersonal subscales. Conclusions: Modafinil differentially impacts depression based on a patient’s level of fatigue; reduced depressive symptoms occurred in those with extreme fatigue. This effect is driven by increases in positive affective symptoms. These results have significant implications for intervention; in patients with high levels of fatigue, modafinil might also reduce depression. Future RCTs are needed to confirm these results. Funding: U10CA37420, K07CA120025, K07CA132916.

scholarly journals Reliability and Validity of the Center for Epidemiologic Studies Depression (Ces-D) Scale for Adolescents in Lao Pdr

2020 ◽  
Author(s):  
Sachi Tomokawa ◽  
Takashi Asakura ◽  
Ngouay Keosada ◽  
Vannasouk Bouasangthong ◽  
Vanthala Souvanhxay ◽  
...  
Keyword(s):  
Factor Analysis ◽  
Negative Affect ◽  
Positive Affect ◽  
Factor Model ◽  
Age Groups ◽  
Lao Pdr ◽  
Depression Scale ◽  
Reliability And Validity ◽  
Epidemiologic Studies ◽  
Least Square

This study aimed to develop a Laotian adolescent version of the Center for Epidemiologic Studies Depression Scale (CES-D), determine its reliability and validity, and examine its factorial properties. The study targeted at 7,554 students in lower secondary schools and teacher training colleges in Lao PDR. Self-administered questionnaires were collected from 2012 to 2014. Exploratory factor analysis performed in three age groups using the weighted least square mean and variance adjusted estimation with robust maximum likelihood methods. The factor structure for each age group was the same; therefore, data from the full sample were analyzed further. The model was then tested by confirmatory factor analysis. A 2-factor model was determined as a common model among the age groups by using paralleled analysis. We determined a best-fitting structure comprising two factors: &ldquo;Negative affect&rdquo; and &ldquo;Positive affect.&rdquo; The Cronbach&rsquo;s alpha was .81. &ldquo;Effort&rdquo; items loaded on the &ldquo;Somatic and retarded activity&rdquo; factor in the original model but loaded on the &ldquo;Positive affect&rdquo; factor in the adolescent model. &ldquo;Depressed affect,&rdquo; &ldquo;Somatic and retarded activity,&rdquo; and &ldquo;Interpersonal&rdquo; items were combined into the &ldquo;Negative affect&rdquo; factor in the adolescent model.

scholarly journals Association between Bullying Victimization and Symptoms of Depression among Adolescents: A Moderated Mediation Analysis

2021 ◽  
Vol 18 (6) ◽  
pp. 3316
Author(s):  
Songli Mei ◽  
Yueyang Hu ◽  
Mengzi Sun ◽  
Junsong Fei ◽  
Chuanen Li ◽  
...  
Keyword(s):  
Depressive Symptoms ◽  
Social Anxiety ◽  
Sleep Duration ◽  
Depression Scale ◽  
Moderated Mediation ◽  
Epidemiologic Studies ◽  
Bullying Victimization ◽  
Symptoms Of Depression ◽  
Moderated Mediation Model ◽  
The Relationship

Background: Bullying victimization and its effect on symptoms of depression have received attention from researchers, but few studies have considered the potential mechanism. The aim of this study was to examine a moderated mediation model for the association between bullying victimization and depressive symptoms in terms of it being mediated by social anxiety, and investigated whether sleep duration would show moderating effects in this relationship. Methods: In this study, there were 2956 students, who completed three questionnaires, including a bullying victimization scale, as well as a social anxiety and epidemiologic studies depression scale. Results: Bullying victimization’s effects on depressive symptoms were mediated by social anxiety. Furthermore, sleep duration moderated the relationship between bullying victimization and depressive symptoms. Conclusions: The research contributes by clarifying the mechanisms underlying the relationship between bullying victimization and depressive symptoms.

Psychological capital and career commitment: the mediating effect of subjective well-being

2018 ◽  
Vol 56 (2) ◽  
pp. 458-473 ◽  
Author(s):  
Hansika Singhal ◽  
Renu Rastogi
Keyword(s):  
Life Satisfaction ◽  
Negative Affect ◽  
Positive Affect ◽  
Psychological Capital ◽  
Career Commitment ◽  
Well Being ◽  
Subjective Well Being ◽  
Content Type ◽  
The Relationship

Purpose The purpose of this paper is to discover the role of psychological capital (PsyCap) as a predictor of subjective well-being (SWB) and career commitment (CC). Further, it aims to analyze the mediating role of SWB in the relationship between PsyCap and CC in the Indian manufacturing sector. Design/methodology/approach A quantitative survey-based research design employing data from 300 employees in the National Capital Region (NCR) of India was used in the present research. Findings The results demonstrated that PsyCap acted as a predictor for SWB and CC. Additionally, SWB partially mediated the relationship between PsyCap and CC. Research limitations/implications The limitations of the present research would have to do with the purposive sample set chosen during the data collection. The sample consisted of middle- and upper-middle-class Indian employees working in the NCR having knowledge of English language and computer skills. Perhaps, future research works should take into account a wider sample in terms of the regions across India and not only the NCR. Although the findings showed that SWB reduced the relationship between PsyCap and CC, still that relationship was significant statistically. Further research studies might also explore various moderators while simultaneously studying SWB. In the research, SWB acted as a significant mediator of the relation between PsyCap and CC, yet at the same time, it may be the scenario that employees who are committed toward their career would be more inclined to espouse a greater sense of SWB (i.e. mediator is caused by the outcome). Hence, the authors duly recognize the need to test this substitute model. Since, SWB places chief emphasis on respondent’s own experiences and perspectives; it does not denote a consummate understanding of their mental health as people may have psychological disorders even if they experience happiness. Hence, the use of other measures in addition to SWB in comprehending a person’s psychological health is desirable (Diener et al., 1997). Practical implications This study suggests that in order for organizations to have a workforce committed to their career and hence, their profession, the supervisors will need to train the employees having a higher incidence of PsyCap to increase their SWB. Consequently, the supervisors will, in turn, need to recruit employees already having the four dimensions of PsyCap, i.e. hope, efficacy, resilience and optimism at the workplace in order for them to have a higher life satisfaction, positive affect, reduced negative affect (three components of SWB) and increased CC. Social implications Employees who develop within themselves a state of being hopeful, efficacious, resilient and optimistic will also be strongly oriented toward having greater life satisfaction, positive affect and lower levels of negative affect. This, in part, would help them achieve the required commitment toward their career and hence, help them in sticking with their jobs. Originality/value The present study advances the existing work on positive organizational behavior by exhibiting the noteworthy role of PsyCap in predicting SWB and CC. Further, it helps in demonstrating the inevitable role of SWB in partially mediating the relationship between PsyCap and CC.

scholarly journals Clarifying the two facets of Self-Oriented Perfectionism: influences on affect and the Big Five traits of personality in children

2019 ◽  
Vol 35 (2) ◽  
pp. 280-289
Author(s):  
María Vicent ◽  
Cándido J. Inglés ◽  
Ricardo Sanmartín ◽  
Carolina Gonzálvez ◽  
María del Pilar Aparicio-Flores ◽  
...  
Keyword(s):  
Regression Analysis ◽  
Negative Affect ◽  
Positive Affect ◽  
Big Five ◽  
Openness To Experience ◽  
Effect Sizes ◽  
Big Five Traits ◽  
Student’S T ◽  
The Relationship ◽  
Student’S T Test

This study analyses the relationship between the perfectionism dimensions, i.e. Self-Oriented Perfectionism-Critical (SOP-C) and Self-Oriented Perfectionism-Striving (SOP-S), and affect and the Big Five traits of personality in a sample of 804 Spanish students aged 8 to 11 (M  = 9.57; DE = 1.12). Student’s t test, Cohen’s d index and logistic regression analysis were used. The high SOP-C group scored significantly higher than their peers having low SOP-C on Negative Affect and Neuroticism, and lower on Positive Affect, Agreeableness, Consciousness and Openness to Experience. To the contrary, students with high SOP-S scored significantly higher on all adaptive dimensions (i.e. Positive Affect, Extraversion, Agreeableness, Consciousness and Openness to Experience), and lower on Negative Affect and Neuroticism. Effect sizes were small for most of statistically significant differences. These findings were also supported by regression analysis. Results are discussed in light of the debate on the adaptive or maladaptive nature of Self-Oriented Perfectionism.

scholarly journals Sleep Quality and Self-Control: The Mediating Roles of Positive and Negative Affects

2020 ◽  
Vol 11 ◽  
Author(s):  
Jinru Liu ◽  
Lin Zhu ◽  
Conghui Liu
Keyword(s):  
Negative Affect ◽  
Sleep Quality ◽  
Positive Affect ◽  
Self Control ◽  
Self Report ◽  
Poor Sleep ◽  
Poor Sleep Quality ◽  
Negative Affects ◽  
The Relationship ◽  
Positive And Negative Affects

This study examined the mediating roles of both positive and negative affects in the relationship between sleep quality and self-control. A sample of 1,507 Chinese adults (37% men; mean age = 32.5 years) completed self-report questionnaires measuring sleep quality, positive and negative emotions, and self-control. Poor sleep quality was positively correlated with negative affect and negatively correlated with positive affect and self-control. Positive affect was positively correlated with self-control, while negative affect was negatively correlated with self-control. Both positive and negative affects significantly mediated the relationship between sleep quality and self-control. Improving individuals’ sleep qualities may lead to more positive emotions and less negative emotion, and these mood changes may increase resources for self-control. Regulating positive and negative affects may reduce the negative effects of poor sleep quality on self-control.

Coping Strategies That Mitigate Against Symptoms of Depression Among Latino Farmworkers

2018 ◽  
Vol 40 (1) ◽  
pp. 57-72 ◽  
Author(s):  
Samuel R. Terrazas ◽  
Adam McCormick
Keyword(s):  
Adult Population ◽  
Depression Scale ◽  
The United States ◽  
Epidemiologic Studies ◽  
Farm Work ◽  
Labor Policies ◽  
Symptoms Of Depression ◽  
Latino Farmworkers ◽  
General Adult Population ◽  
Female Farmworkers

Latino farmworkers have a higher rate of depression when compared with other Latinos and the general adult population in the United States. Researchers have suggested oppressive labor policies, acculturation stressor, anti-immigrant polices and attitudes, and the dangers associated to farm work as culprits to high rates of depression among farmworkers. We examined the traits farmworkers reported that helped them mitigate symptoms of depression. Our sample consisted of 64 adult male and female farmworkers who lived in western Texas and worked in Eastern New Mexico. We used the Center for Epidemiologic Studies Depression Scale Revised (CESD-R) and self-reports of symptoms of depression to assess for depression. We found that, among this sample, the rates of depression were similar to other studies and that farmworkers used cognitive restructuring strategies to mitigate symptoms of depression.

scholarly journals Depressive symptoms in community-dwelling persons aged ≥60 years in Inanda, Ntuzuma and KwaMashu in eThekwini, KwaZulu-Natal

2015 ◽  
Vol 21 (1) ◽  
pp. 6 ◽  
Author(s):  
Jayalakshmi Narainsamy ◽  
Jennifer Chipps ◽  
Bilkish Cassim
Keyword(s):  
Logistic Regression ◽  
Depressive Symptoms ◽  
Univariate Analysis ◽  
Secondary Analysis ◽  
Depression Scale ◽  
The Elderly ◽  
Epidemiologic Studies ◽  
Household Size ◽  
Community Dwelling ◽  
Primary Study

<p><strong>Background. </strong>Physical and psychological ailments increase with age; while the physical ailments are well documented, mental health issues have received less attention. </p><p><strong>Objective.</strong> To determine the prevalence of depressive symptoms and associated risk factors in individuals aged <strong>≥</strong>60 years living in a low-resource peri-urban area in South Africa. </p><p><strong>Methods. </strong>Secondary analysis was performed on data obtained from a primary study conducted to determine the influence of socioeconomic and environmental factors on the health status and quality of life in older persons living in the Inanda, Ntuzuma and KwaMashu (INK) area. The Center for Epidemiologic Studies Short Depression Scale (CES-D 10) was used to screen for depressive symptoms in the week preceding the interview, and respondents were categorised as having no (score &lt;10), mild (10 - 14), or severe (&gt;14) depressive symptoms. Risk factor associations were tested using Pearson’s χ<sup>2</sup> tests and logistic regression. </p><p><strong>Results. </strong>There were 1 008 respondents (mean (standard deviation) age 68.9 (7.4) years), of whom 503 (49.1%) did not meet criteria for depressive symptoms. Of the 505 (50.1%) respondents who met the CES-D 10 criteria for depressive symptoms, 422 (41.9%) had mild and 83 (8.2%) had severe depressive symptoms. In the univariate analysis, significant associations were found with age (<em>p=</em>0.011), household size (<em>p=</em>0.007), income (<em>p=</em>0.033), disability (<em>p=</em>0.001), nutritional status (<em>p</em>≤0.001), the inability to count on family (<em>p=</em>0.008) and lack of mastery (<em>p</em>≤0.001). In direct binary logistic regression, there were significant associations with lack of mastery (<em>p≤</em>0.001), inability to count on family (<em>p=</em>0.027), malnutrition (<em>p</em>≤0.001) and household size (<em>p=</em>0.024).</p><p><strong>Conclusion. </strong>This study highlights the high prevalence of depressive symptoms in the elderly in the INK area, and the need to promote successful ageing of the elderly population in this area.</p>

scholarly journals 1089 Water Intake Moderates the Relationship Between Sleep Quality and Depressive Symptoms: The Latino Health and Well-Being Study

SLEEP ◽  
2020 ◽  
Vol 43 (Supplement_1) ◽  
pp. A414-A415
Author(s):  
J Blanc ◽  
N Williams ◽  
G Jean-Louis ◽  
S Lemon ◽  
M Rosal
Keyword(s):  
Depressive Symptoms ◽  
Sleep Quality ◽  
Water Intake ◽  
Depression Scale ◽  
Well Being ◽  
Epidemiologic Studies ◽  
Community Based ◽  
Latino Adults ◽  
The Relationship ◽  
Health And Well Being

Abstract Introduction This study examined the relationships between sleep quality and depressive symptoms, and whether this relationship is moderated by frequency of water intake in a sample of Latino adults. Methods Participants in this community-based study were 574 Latino adults from Lawrence, Massachusetts. Assessments included surveys and anthropological measures. Variables in this study included sleep quality (Pittsburgh Sleep Quality Index- PSQI), depressive symptoms (Center for Epidemiologic Studies Depression Scale -CES-D) and frequency of water intake in the previous three months (investigator-developed question). Covariates included demographics, stress (Perceived Stress Scale-PSS), and body mass index (BMI). Multiple linear regression analyses were conducted to explore associations between sleep and depressive symptoms. Potential moderating effect of frequency of water intake was assessed using hierarchical, moderated, multiple regression analysis. Results The sample was 51.2% female, with a mean age of 46.6 years (SD=15.4) and mean BMI of 29.6 (SD=5.9); 31% of the sample had CES-D scores &gt; 22 (cut off for elevated depressive symptoms), the mean PSQI score was 13.11(SD=3.4) and 92% reported water intake two or more times daily. Sleep quality correlated positively with depression (r=.558; p=.000). After adjusting for covariates, sleep quality was strongly associated with depression (B = .417; SE=13; p =.000). The relationship between sleep quality and depressive symptoms was moderated by frequency of water intake (B= -.186, SE =1.107; p= 0.11). Conclusion This study is among the first to examine the association between sleep quality and depressive symptoms among Latino adults, and to show that frequency of water intake may moderate this association in this population. Support This study was supported by funding from the NIH: R01 MH085653; 1U48DP006381; and T32HL129953.

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